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Entry version 167 (31 Jul 2019)
Sequence version 2 (16 Jun 2003)
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Protein

CDK5 regulatory subunit-associated protein 1

Gene

CDK5RAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Specifically inhibits CDK5 activation by CDK5R1.

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi109Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi145Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi183Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi258Iron-sulfur (4Fe-4S-S-AdoMet)By similarity1
Metal bindingi262Iron-sulfur (4Fe-4S-S-AdoMet)By similarity1
Metal bindingi265Iron-sulfur (4Fe-4S-S-AdoMet)By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CDK5 regulatory subunit-associated protein 1
Alternative name(s):
CDK5 activator-binding protein C42
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDK5RAP1
Synonyms:C20orf34
ORF Names:CGI-05, HSPC167
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15880 CDK5RAP1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
608200 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96SZ6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
51654

Open Targets

More...
OpenTargetsi
ENSG00000101391

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26313

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CDK5RAP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
32129446

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001417641 – 601CDK5 regulatory subunit-associated protein 1Add BLAST601

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q96SZ6

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96SZ6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q96SZ6

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96SZ6

PeptideAtlas

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PeptideAtlasi
Q96SZ6

PRoteomics IDEntifications database

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PRIDEi
Q96SZ6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
65981
78165 [Q96SZ6-1]
78166 [Q96SZ6-2]
78167 [Q96SZ6-3]
78168 [Q96SZ6-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96SZ6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q96SZ6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000101391 Expressed in 226 organ(s), highest expression level in small intestine Peyer's patch

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96SZ6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96SZ6 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA066301

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CDK5R1 (p35 form). CDK5RAP1, CDK5RAP2 and CDK5RAP3 show competitive binding to CDK5R1.

Forms a complex with CDK5R1 and CDK5.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
119661, 26 interactors

Protein interaction database and analysis system

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IntActi
Q96SZ6, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000217372

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini100 – 220MTTase N-terminalAdd BLAST121
Domaini515 – 590TRAMAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni22 – 157CDK5 activation inhibitionAdd BLAST136
Regioni475 – 586CDK5R1-bindingAdd BLAST112

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2492 Eukaryota
COG0621 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160361

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96SZ6

Identification of Orthologs from Complete Genome Data

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OMAi
FGCQMNK

Database of Orthologous Groups

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OrthoDBi
835984at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q96SZ6

TreeFam database of animal gene trees

More...
TreeFami
TF101033

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.50.12160, 1 hit
3.80.30.20, 1 hit

HAMAP database of protein families

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HAMAPi
MF_01864 tRNA_metthiotr_MiaB, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR006638 Elp3/MiaB/NifB
IPR005839 Methylthiotransferase
IPR020612 Methylthiotransferase_CS
IPR013848 Methylthiotransferase_N
IPR038135 Methylthiotransferase_N_sf
IPR006463 MiaB_methiolase
IPR007197 rSAM
IPR023404 rSAM_horseshoe
IPR002792 TRAM_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04055 Radical_SAM, 1 hit
PF01938 TRAM, 1 hit
PF00919 UPF0004, 1 hit

Structure-Function Linkage Database

More...
SFLDi
SFLDF00273 (dimethylallyl)adenosine_tRNA_, 1 hit
SFLDS00029 Radical_SAM, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00729 Elp3, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00089 TIGR00089, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51449 MTTASE_N, 1 hit
PS01278 MTTASE_RADICAL, 1 hit
PS50926 TRAM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q96SZ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHPLQCVLQV QRSLGWGPLA SVSWLSLRMC RAHSSLSSTM CPSPERQEDG
60 70 80 90 100
ARKDFSSRLA AGPTFQHFLK SASAPQEKLS SEVEDPPPYL MMDELLGRQR
110 120 130 140 150
KVYLETYGCQ MNVNDTEIAW SILQKSGYLR TSNLQEADVI LLVTCSIREK
160 170 180 190 200
AEQTIWNRLH QLKALKTRRP RSRVPLRIGI LGCMAERLKE EILNREKMVD
210 220 230 240 250
ILAGPDAYRD LPRLLAVAES GQQAANVLLS LDETYADVMP VQTSASATSA
260 270 280 290 300
FVSIMRGCDN MCSYCIVPFT RGRERSRPIA SILEEVKKLS EQVFLPPRPP
310 320 330 340 350
KVLGLQGLKE VTLLGQNVNS FRDNSEVQFN SAVPTNLSRG FTTNYKTKQG
360 370 380 390 400
GLRFAHLLDQ VSRVDPEMRI RFTSPHPKDF PDEVLQLIHE RDNICKQIHL
410 420 430 440 450
PAQSGSSRVL EAMRRGYSRE AYVELVHHIR ESIPGVSLSS DFIAGFCGET
460 470 480 490 500
EEDHVQTVSL LREVQYNMGF LFAYSMRQKT RAYHRLKDDV PEEVKLRRLE
510 520 530 540 550
ELITIFREEA TKANQTSVGC TQLVLVEGLS KRSATDLCGR NDGNLKVIFP
560 570 580 590 600
DAEMEDVNNP GLRVRAQPGD YVLVKITSAS SQTLRGHVLC RTTLRDSSAY

C
Note: May be due to intron retention. No experimental confirmation available.
Length:601
Mass (Da):67,689
Last modified:June 16, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4AEBFD7DA5400902
GO
Isoform 2 (identifier: Q96SZ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: Missing.
     293-306: Missing.

Note: No experimental confirmation available.
Show »
Length:497
Mass (Da):56,223
Checksum:iC8FFBA14A5C3EB09
GO
Isoform 3 (identifier: Q96SZ6-3) [UniParc]FASTAAdd to basket
Also known as: a

The sequence of this isoform differs from the canonical sequence as follows:
     293-306: Missing.

Show »
Length:587
Mass (Da):66,146
Checksum:i314E826B35C346EB
GO
Isoform 4 (identifier: Q96SZ6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     293-383: Missing.

Note: No experimental confirmation available.
Show »
Length:510
Mass (Da):57,413
Checksum:i8F0DFB3B71E135BB
GO
Isoform 5 (identifier: Q96SZ6-5) [UniParc]FASTAAdd to basket
Also known as: CDK5RAP1_v4

The sequence of this isoform differs from the canonical sequence as follows:
     292-305: Missing.
     435-440: GVSLSS → EDTGIS
     441-601: Missing.

Note: Mainly expressed in brain, placenta and testis.
Show »
Length:426
Mass (Da):48,072
Checksum:iD74ADCD179EA4FDC
GO
Isoform 6 (identifier: Q96SZ6-6) [UniParc]FASTAAdd to basket
Also known as: CDK5RAP1_v3

The sequence of this isoform differs from the canonical sequence as follows:
     292-305: Missing.
     576-601: ITSASSQTLRGHVLCRTTLRDSSAYC → VRSPFGLLACTVK

Note: High expression in placenta and lung.
Show »
Length:574
Mass (Da):64,709
Checksum:iA542DA7E2496A56B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y721H0Y721_HUMAN
CDK5 regulatory subunit-associated ...
CDK5RAP1
256Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD34147 differs from that shown. Reason: Frameshift at positions 3, 32, 128, 133 and 569.Curated
The sequence AAF29131 differs from that shown. Reason: Frameshift at positions 213, 244, 267 and 282.Curated
The sequence BAB55120 differs from that shown. Reason: Erroneous termination at position 500. Translated as Glu.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti213R → Q in AAH01215 (PubMed:15489334).Curated1
Sequence conflicti217V → D (PubMed:11042152).Curated1
Sequence conflicti269F → L in BAB55120 (PubMed:14702039).Curated1
Sequence conflicti282I → T in BAB55120 (PubMed:14702039).Curated1
Sequence conflicti323D → G in BAB55120 (PubMed:14702039).Curated1
Sequence conflicti464V → A in BAB14760 (PubMed:14702039).Curated1
Sequence conflicti511T → S in AAF29131 (PubMed:11042152).Curated1
Sequence conflicti579Missing (PubMed:10810093).Curated1
Sequence conflicti585R → K in BAB14760 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0075601 – 90Missing in isoform 2. 1 PublicationAdd BLAST90
Alternative sequenceiVSP_047799292 – 305Missing in isoform 5 and isoform 6. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_007561293 – 383Missing in isoform 4. 1 PublicationAdd BLAST91
Alternative sequenceiVSP_007562293 – 306Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST14
Alternative sequenceiVSP_047800435 – 440GVSLSS → EDTGIS in isoform 5. 1 Publication6
Alternative sequenceiVSP_047801441 – 601Missing in isoform 5. 1 PublicationAdd BLAST161
Alternative sequenceiVSP_047802576 – 601ITSAS…SSAYC → VRSPFGLLACTVK in isoform 6. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF152097 mRNA Translation: AAD34147.1 Frameshift.
AF161516 mRNA Translation: AAF29131.1 Frameshift.
AY462283 mRNA Translation: AAS18317.1
AY462284 mRNA Translation: AAS18318.1
AK023992 mRNA Translation: BAB14760.1
AK027449 mRNA Translation: BAB55120.1 Sequence problems.
AK292075 mRNA Translation: BAF84764.1
AL355392 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76319.1
CH471077 Genomic DNA Translation: EAW76322.1
CH471077 Genomic DNA Translation: EAW76323.1
BC001215 mRNA Translation: AAH01215.1
BC050706 mRNA Translation: AAH50706.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13219.1 [Q96SZ6-3]
CCDS63255.1 [Q96SZ6-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001265097.1, NM_001278168.1 [Q96SZ6-4]
NP_001265098.1, NM_001278169.1
NP_057166.4, NM_016082.4
NP_057492.2, NM_016408.3 [Q96SZ6-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000339269; ENSP00000341840; ENSG00000101391 [Q96SZ6-4]
ENST00000346416; ENSP00000217372; ENSG00000101391 [Q96SZ6-3]
ENST00000357886; ENSP00000350558; ENSG00000101391 [Q96SZ6-1]
ENST00000473997; ENSP00000476857; ENSG00000101391 [Q96SZ6-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
51654

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:51654

UCSC genome browser

More...
UCSCi
uc002wyz.5 human [Q96SZ6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152097 mRNA Translation: AAD34147.1 Frameshift.
AF161516 mRNA Translation: AAF29131.1 Frameshift.
AY462283 mRNA Translation: AAS18317.1
AY462284 mRNA Translation: AAS18318.1
AK023992 mRNA Translation: BAB14760.1
AK027449 mRNA Translation: BAB55120.1 Sequence problems.
AK292075 mRNA Translation: BAF84764.1
AL355392 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76319.1
CH471077 Genomic DNA Translation: EAW76322.1
CH471077 Genomic DNA Translation: EAW76323.1
BC001215 mRNA Translation: AAH01215.1
BC050706 mRNA Translation: AAH50706.1
CCDSiCCDS13219.1 [Q96SZ6-3]
CCDS63255.1 [Q96SZ6-4]
RefSeqiNP_001265097.1, NM_001278168.1 [Q96SZ6-4]
NP_001265098.1, NM_001278169.1
NP_057166.4, NM_016082.4
NP_057492.2, NM_016408.3 [Q96SZ6-3]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi119661, 26 interactors
IntActiQ96SZ6, 6 interactors
STRINGi9606.ENSP00000217372

PTM databases

iPTMnetiQ96SZ6
PhosphoSitePlusiQ96SZ6

Polymorphism and mutation databases

BioMutaiCDK5RAP1
DMDMi32129446

Proteomic databases

EPDiQ96SZ6
jPOSTiQ96SZ6
MaxQBiQ96SZ6
PaxDbiQ96SZ6
PeptideAtlasiQ96SZ6
PRIDEiQ96SZ6
ProteomicsDBi65981
78165 [Q96SZ6-1]
78166 [Q96SZ6-2]
78167 [Q96SZ6-3]
78168 [Q96SZ6-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
51654
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339269; ENSP00000341840; ENSG00000101391 [Q96SZ6-4]
ENST00000346416; ENSP00000217372; ENSG00000101391 [Q96SZ6-3]
ENST00000357886; ENSP00000350558; ENSG00000101391 [Q96SZ6-1]
ENST00000473997; ENSP00000476857; ENSG00000101391 [Q96SZ6-2]
GeneIDi51654
KEGGihsa:51654
UCSCiuc002wyz.5 human [Q96SZ6-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51654
DisGeNETi51654

GeneCards: human genes, protein and diseases

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GeneCardsi
CDK5RAP1
HGNCiHGNC:15880 CDK5RAP1
HPAiHPA066301
MIMi608200 gene
neXtProtiNX_Q96SZ6
OpenTargetsiENSG00000101391
PharmGKBiPA26313

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2492 Eukaryota
COG0621 LUCA
GeneTreeiENSGT00940000160361
InParanoidiQ96SZ6
OMAiFGCQMNK
OrthoDBi835984at2759
PhylomeDBiQ96SZ6
TreeFamiTF101033

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CDK5RAP1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CDK5RAP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
51654

Protein Ontology

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PROi
PR:Q96SZ6

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000101391 Expressed in 226 organ(s), highest expression level in small intestine Peyer's patch
ExpressionAtlasiQ96SZ6 baseline and differential
GenevisibleiQ96SZ6 HS

Family and domain databases

Gene3Di3.40.50.12160, 1 hit
3.80.30.20, 1 hit
HAMAPiMF_01864 tRNA_metthiotr_MiaB, 1 hit
InterProiView protein in InterPro
IPR006638 Elp3/MiaB/NifB
IPR005839 Methylthiotransferase
IPR020612 Methylthiotransferase_CS
IPR013848 Methylthiotransferase_N
IPR038135 Methylthiotransferase_N_sf
IPR006463 MiaB_methiolase
IPR007197 rSAM
IPR023404 rSAM_horseshoe
IPR002792 TRAM_dom
PfamiView protein in Pfam
PF04055 Radical_SAM, 1 hit
PF01938 TRAM, 1 hit
PF00919 UPF0004, 1 hit
SFLDiSFLDF00273 (dimethylallyl)adenosine_tRNA_, 1 hit
SFLDS00029 Radical_SAM, 1 hit
SMARTiView protein in SMART
SM00729 Elp3, 1 hit
TIGRFAMsiTIGR00089 TIGR00089, 1 hit
PROSITEiView protein in PROSITE
PS51449 MTTASE_N, 1 hit
PS01278 MTTASE_RADICAL, 1 hit
PS50926 TRAM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCK5P1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96SZ6
Secondary accession number(s): A8K7R0
, Q5QP46, Q5QP47, Q5QP48, Q675N4, Q675N5, Q9BVG6, Q9BWZ5, Q9H859, Q9NZZ9, Q9Y3F0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: June 16, 2003
Last modified: July 31, 2019
This is version 167 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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