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Entry version 185 (31 Jul 2019)
Sequence version 1 (01 Dec 2001)
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Protein

Msx2-interacting protein

Gene

SPEN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA.By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi1 – 573By similarityAdd BLAST573

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Repressor, RNA-binding
Biological processHost-virus interaction, Notch signaling pathway, Transcription, Transcription regulation

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q96T58

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Msx2-interacting protein
Alternative name(s):
SMART/HDAC1-associated repressor protein
SPEN homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPEN
Synonyms:KIAA0929, MINT, SHARP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:17575 SPEN

Online Mendelian Inheritance in Man (OMIM)

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MIMi
613484 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q96T58

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23013

Open Targets

More...
OpenTargetsi
ENSG00000065526

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134895302

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SPEN

Domain mapping of disease mutations (DMDM)

More...
DMDMi
41688816

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000816271 – 3664Msx2-interacting proteinAdd BLAST3664

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei99PhosphoserineCombined sources1
Modified residuei108Omega-N-methylarginineCombined sources1
Modified residuei188PhosphoserineCombined sources1
Modified residuei190PhosphoserineCombined sources1
Modified residuei309PhosphoserineCombined sources1
Modified residuei623PhosphoserineCombined sources1
Modified residuei725PhosphoserineCombined sources1
Modified residuei727PhosphoserineCombined sources1
Modified residuei736PhosphoserineCombined sources1
Modified residuei740PhosphoserineCombined sources1
Modified residuei770PhosphoserineCombined sources1
Modified residuei830PhosphoserineBy similarity1
Modified residuei833PhosphoserineBy similarity1
Modified residuei847PhosphoserineCombined sources1
Modified residuei1062PhosphoserineCombined sources1
Modified residuei1140PhosphothreonineCombined sources1
Modified residuei1168PhosphoserineCombined sources1
Modified residuei1194PhosphoserineCombined sources1
Modified residuei1222PhosphoserineCombined sources1
Modified residuei1252PhosphoserineCombined sources1
Modified residuei1261PhosphoserineCombined sources1
Modified residuei1268PhosphoserineCombined sources1
Modified residuei1278PhosphoserineCombined sources1
Modified residuei1283PhosphoserineCombined sources1
Modified residuei1287PhosphoserineCombined sources1
Modified residuei1333PhosphoserineCombined sources1
Modified residuei1380PhosphoserineCombined sources1
Modified residuei1382PhosphoserineCombined sources1
Modified residuei1439PhosphothreonineCombined sources1
Modified residuei1441PhosphothreonineCombined sources1
Modified residuei1619PhosphothreonineCombined sources1
Modified residuei1633PhosphothreonineCombined sources1
Modified residuei1826PhosphothreonineCombined sources1
Modified residuei1897PhosphoserineCombined sources1
Modified residuei1918PhosphoserineCombined sources1
Modified residuei1947PhosphothreonineCombined sources1
Modified residuei2101PhosphoserineCombined sources1
Modified residuei2120PhosphoserineCombined sources1
Modified residuei2126PhosphoserineCombined sources1
Modified residuei2159PhosphoserineCombined sources1
Modified residuei2163PhosphothreonineCombined sources1
Modified residuei2366PhosphoserineCombined sources1
Modified residuei2393PhosphothreonineCombined sources1
Modified residuei2421PhosphothreonineCombined sources1
Modified residuei2452PhosphoserineCombined sources1
Modified residuei2456PhosphoserineCombined sources1
Modified residuei2460PhosphothreonineCombined sources1
Modified residuei2481PhosphoserineCombined sources1
Modified residuei2486PhosphoserineCombined sources1
Modified residuei2493PhosphoserineCombined sources1
Modified residuei2938PhosphothreonineCombined sources1
Modified residuei2950PhosphothreonineCombined sources1
Modified residuei3113Asymmetric dimethylarginineCombined sources1
Modified residuei3121Asymmetric dimethylarginineCombined sources1
Modified residuei3433PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q96T58

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q96T58

MaxQB - The MaxQuant DataBase

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MaxQBi
Q96T58

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q96T58

PeptideAtlas

More...
PeptideAtlasi
Q96T58

PRoteomics IDEntifications database

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PRIDEi
Q96T58

ProteomicsDB human proteome resource

More...
ProteomicsDBi
78197

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q96T58

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q96T58

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q96T58

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at high level in brain, testis, spleen and thymus. Expressed at intermediate level in kidney, liver, mammary gland and skin.

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By 17-beta-estradiol.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000065526 Expressed in 234 organ(s), highest expression level in vagina

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q96T58 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q96T58 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA015825
HPA050257

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MSX2 and HIPK3 (By similarity).

Interacts with NCOR2, HDAC1, HDAC2, RBBP4, MBD3 and MTA1L1.

Interacts with RBPSUH; this interaction may prevent the interaction between RBPSUH and NOTCH1.

Interacts with the nuclear receptors RAR and PPARD.

Interacts with RAR in absence of ligand. Binds to the steroid receptor RNA coactivator SRA.

By similarity3 Publications

(Microbial infection)

Interacts with Epstein-Barr virus BSFL2/BMLF1.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116655, 54 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q96T58

Database of interacting proteins

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DIPi
DIP-34569N

Protein interaction database and analysis system

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IntActi
Q96T58, 30 interactors

Molecular INTeraction database

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MINTi
Q96T58

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000364912

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

13664
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q96T58

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q96T58

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 81RRM 1PROSITE-ProRule annotationAdd BLAST76
Domaini335 – 415RRM 2PROSITE-ProRule annotationAdd BLAST81
Domaini438 – 513RRM 3PROSITE-ProRule annotationAdd BLAST76
Domaini517 – 589RRM 4PROSITE-ProRule annotationAdd BLAST73
Domaini2201 – 2707RIDAdd BLAST507
Domaini3498 – 3664SPOCPROSITE-ProRule annotationAdd BLAST167

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2130 – 2464Interaction with MSX2By similarityAdd BLAST335
Regioni2709 – 2870Interaction with RBPSUHBy similarityAdd BLAST162

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili688 – 715Sequence analysisAdd BLAST28
Coiled coili977 – 1004Sequence analysisAdd BLAST28
Coiled coili1170 – 1191Sequence analysisAdd BLAST22
Coiled coili1408 – 1428Sequence analysisAdd BLAST21
Coiled coili1496 – 1529Sequence analysisAdd BLAST34
Coiled coili1592 – 1612Sequence analysisAdd BLAST21
Coiled coili1928 – 1944Sequence analysisAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi125 – 277Arg-richAdd BLAST153
Compositional biasi240 – 325Ser-richAdd BLAST86
Compositional biasi616 – 810Arg-richAdd BLAST195
Compositional biasi624 – 697Tyr-richAdd BLAST74
Compositional biasi2428 – 2520Pro-richAdd BLAST93
Compositional biasi3220 – 3482Pro-richAdd BLAST263

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RID domain mediates the interaction with nuclear receptors.By similarity
The SPOC domain, which mediates the interaction with NCOR2, is essential for the repressive activity.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RRM Spen family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0112 Eukaryota
ENOG410XSAC LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157087

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231295

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q96T58

Identification of Orthologs from Complete Genome Data

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OMAi
YDYSQDR

Database of Orthologous Groups

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OrthoDBi
367857at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q96T58

TreeFam database of animal gene trees

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TreeFami
TF315637

Family and domain databases

Conserved Domains Database

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CDDi
cd12348 RRM1_SHARP, 1 hit
cd12349 RRM2_SHARP, 1 hit
cd12350 RRM3_SHARP, 1 hit
cd12351 RRM4_SHARP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.40.290.10, 1 hit
3.30.70.330, 4 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034172 SHARP_RRM1
IPR034173 SHARP_RRM2
IPR034174 SHARP_RRM3
IPR034175 SHARP_RRM4
IPR016194 SPOC-like_C_dom_sf
IPR012921 SPOC_C
IPR010912 SPOC_met

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00076 RRM_1, 4 hits
PF07744 SPOC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00360 RRM, 4 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF100939 SSF100939, 1 hit
SSF54928 SSF54928, 2 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50102 RRM, 4 hits
PS50917 SPOC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q96T58-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVRETRHLWV GNLPENVREE KIIEHFKRYG RVESVKILPK RGSEGGVAAF
60 70 80 90 100
VDFVDIKSAQ KAHNSVNKMG DRDLRTDYNE PGTIPSAARG LDDTVSIASR
110 120 130 140 150
SREVSGFRGG GGGPAYGPPP SLHAREGRYE RRLDGASDNR ERAYEHSAYG
160 170 180 190 200
HHERGTGGFD RTRHYDQDYY RDPRERTLQH GLYYASRSRS PNRFDAHDPR
210 220 230 240 250
YEPRAREQFT LPSVVHRDIY RDDITREVRG RRPERNYQHS RSRSPHSSQS
260 270 280 290 300
RNQSPQRLAS QASRPTRSPS GSGSRSRSSS SDSISSSSST SSDSSDSSSS
310 320 330 340 350
SSDDSPARSV QSAAVPAPTS QLLSSLEKDE PRKSFGIKVQ NLPVRSTDTS
360 370 380 390 400
LKDGLFHEFK KFGKVTSVQI HGTSEERYGL VFFRQQEDQE KALTASKGKL
410 420 430 440 450
FFGMQIEVTA WIGPETESEN EFRPLDERID EFHPKATRTL FIGNLEKTTT
460 470 480 490 500
YHDLRNIFQR FGEIVDIDIK KVNGVPQYAF LQYCDIASVC KAIKKMDGEY
510 520 530 540 550
LGNNRLKLGF GKSMPTNCVW LDGLSSNVSD QYLTRHFCRY GPVVKVVFDR
560 570 580 590 600
LKGMALVLYN EIEYAQAAVK ETKGRKIGGN KIKVDFANRE SQLAFYHCME
610 620 630 640 650
KSGQDIRDFY EMLAERREER RASYDYNQDR TYYESVRTPG TYPEDSRRDY
660 670 680 690 700
PARGREFYSE WETYQGDYYE SRYYDDPREY RDYRNDPYEQ DIREYSYRQR
710 720 730 740 750
ERERERERFE SDRDRDHERR PIERSQSPVH LRRPQSPGAS PSQAERLPSD
760 770 780 790 800
SERRLYSRSS DRSGSCSSLS PPRYEKLDKS RLERYTKNEK TDKERTFDPE
810 820 830 840 850
RVERERRLIR KEKVEKDKTD KQKRKGKVHS PSSQSSETDQ ENEREQSPEK
860 870 880 890 900
PRSCNKLSRE KADKEGIAKN RLELMPCVVL TRVKEKEGKV IDHTPVEKLK
910 920 930 940 950
AKLDNDTVKS SALDQKLQVS QTEPAKSDLS KLESVRMKVP KEKGLSSHVE
960 970 980 990 1000
VVEKEGRLKA RKHLKPEQPA DGVSAVDLEK LEARKRRFAD SNLKAEKQKP
1010 1020 1030 1040 1050
EVKKSSPEME DARVLSKKQP DVSSREVILL REGEAERKPV RKEILKRESK
1060 1070 1080 1090 1100
KIKLDRLNTV ASPKDCQELA SISVGSGSRP SSDLQARLGE LAGESVENQE
1110 1120 1130 1140 1150
VQSKKPIPSK PQLKQLQVLD DQGPEREDVR KNYCSLRDET PERKSGQEKS
1160 1170 1180 1190 1200
HSVNTEEKIG IDIDHTQSYR KQMEQSRRKQ QMEMEIAKSE KFGSPKKDVD
1210 1220 1230 1240 1250
EYERRSLVHE VGKPPQDVTD DSPPSKKKRM DHVDFDICTK RERNYRSSRQ
1260 1270 1280 1290 1300
ISEDSERTGG SPSVRHGSFH EDEDPIGSPR LLSVKGSPKV DEKVLPYSNI
1310 1320 1330 1340 1350
TVREESLKFN PYDSSRREQM ADMAKIKLSV LNSEDELNRW DSQMKQDAGR
1360 1370 1380 1390 1400
FDVSFPNSII KRDSLRKRSV RDLEPGEVPS DSDEDGEHKS HSPRASALYE
1410 1420 1430 1440 1450
SSRLSFLLRD REDKLRERDE RLSSSLERNK FYSFALDKTI TPDTKALLER
1460 1470 1480 1490 1500
AKSLSSSREE NWSFLDWDSR FANFRNNKDK EKVDSAPRPI PSWYMKKKKI
1510 1520 1530 1540 1550
RTDSEGKMDD KKEDHKEEEQ ERQELFASRF LHSSIFEQDS KRLQHLERKE
1560 1570 1580 1590 1600
EDSDFISGRI YGKQTSEGAN STTDSIQEPV VLFHSRFMEL TRMQQKEKEK
1610 1620 1630 1640 1650
DQKPKEVEKQ EDTENHPKTP ESAPENKDSE LKTPPSVGPP SVTVVTLESA
1660 1670 1680 1690 1700
PSALEKTTGD KTVEAPLVTE EKTVEPATVS EEAKPASEPA PAPVEQLEQV
1710 1720 1730 1740 1750
DLPPGADPDK EAAMMPAGVE EGSSGDQPPY LDAKPPTPGA SFSQAESNVD
1760 1770 1780 1790 1800
PEPDSTQPLS KPAQKSEEAN EPKAEKPDAT ADAEPDANQK AEAAPESQPP
1810 1820 1830 1840 1850
ASEDLEVDPP VAAKDKKPNK SKRSKTPVQA AAVSIVEKPV TRKSERIDRE
1860 1870 1880 1890 1900
KLKRSNSPRG EAQKLLELKM EAEKITRTAS KNSAADLEHP EPSLPLSRTR
1910 1920 1930 1940 1950
RRNVRSVYAT MGDHENRSPV KEPVEQPRVT RKRLERELQE AAAVPTTPRR
1960 1970 1980 1990 2000
GRPPKTRRRA DEEEENEAKE PAETLKPPEG WRSPRSQKTA AGGGPQGKKG
2010 2020 2030 2040 2050
KNEPKVDATR PEATTEVGPQ IGVKESSMEP KAAEEEAGSE QKRDRKDAGT
2060 2070 2080 2090 2100
DKNPPETAPV EVVEKKPAPE KNSKSKRGRS RNSRLAVDKS ASLKNVDAAV
2110 2120 2130 2140 2150
SPRGAAAQAG ERESGVVAVS PEKSESPQKE DGLSSQLKSD PVDPDKEPEK
2160 2170 2180 2190 2200
EDVSASGPSP EATQLAKQME LEQAVEHIAK LAEASASAAY KADAPEGLAP
2210 2220 2230 2240 2250
EDRDKPAHQA SETELAAAIG SIINDISGEP ENFPAPPPYP GESQTDLQPP
2260 2270 2280 2290 2300
AGAQALQPSE EGMETDEAVS GILETEAATE SSRPPVNAPD PSAGPTDTKE
2310 2320 2330 2340 2350
ARGNSSETSH SVPEAKGSKE VEVTLVRKDK GRQKTTRSRR KRNTNKKVVA
2360 2370 2380 2390 2400
PVESHVPESN QAQGESPAAN EGTTVQHPEA PQEEKQSEKP HSTPPQSCTS
2410 2420 2430 2440 2450
DLSKIPSTEN SSQEISVEER TPTKASVPPD LPPPPQPAPV DEEPQARFRV
2460 2470 2480 2490 2500
HSIIESDPVT PPSDPSIPIP TLPSVTAAKL SPPVASGGIP HQSPPTKVTE
2510 2520 2530 2540 2550
WITRQEEPRA QSTPSPALPP DTKASDVDTS SSTLRKILMD PKYVSATSVT
2560 2570 2580 2590 2600
STSVTTAIAE PVSAAPCLHE APPPPVDSKK PLEEKTAPPV TNNSEIQASE
2610 2620 2630 2640 2650
VLVAADKEKV APVIAPKITS VISRMPVSID LENSQKITLA KPAPQTLTGL
2660 2670 2680 2690 2700
VSALTGLVNV SLVPVNALKG PVKGSVTTLK SLVSTPAGPV NVLKGPVNVL
2710 2720 2730 2740 2750
TGPVNVLTTP VNATVGTVNA APGTVNAAAS AVNATASAVT VTAGAVTAAS
2760 2770 2780 2790 2800
GGVTATTGTV TMAGAVIAPS TKCKQRASAN ENSRFHPGSM PVIDDRPADA
2810 2820 2830 2840 2850
GSGAGLRVNT SEGVVLLSYS GQKTEGPQRI SAKISQIPPA SAMDIEFQQS
2860 2870 2880 2890 2900
VSKSQVKPDS VTASQPPSKG PQAPAGYANV ATHSTLVLTA QTYNASPVIS
2910 2920 2930 2940 2950
SVKADRPSLE KPEPIHLSVS TPVTQGGTVK VLTQGINTPP VLVHNQLVLT
2960 2970 2980 2990 3000
PSIVTTNKKL ADPVTLKIET KVLQPANLGS TLTPHHPPAL PSKLPTEVNH
3010 3020 3030 3040 3050
VPSGPSIPAD RTVSHLAAAK LDAHSPRPSG PGPSSFPRAS HPSSTASTAL
3060 3070 3080 3090 3100
STNATVMLAA GIPVPQFISS IHPEQSVIMP PHSITQTVSL SHLSQGEVRM
3110 3120 3130 3140 3150
NTPTLPSITY SIRPEALHSP RAPLQPQQIE VRAPQRASTP QPAPAGVPAL
3160 3170 3180 3190 3200
ASQHPPEEEV HYHLPVARAT APVQSEVLVM QSEYRLHPYT VPRDVRIMVH
3210 3220 3230 3240 3250
PHVTAVSEQP RAADGVVKVP PASKAPQQPG KEAAKTPDAK AAPTPTPAPV
3260 3270 3280 3290 3300
PVPVPLPAPA PAPHGEARIL TVTPSNQLQG LPLTPPVVVT HGVQIVHSSG
3310 3320 3330 3340 3350
ELFQEYRYGD IRTYHPPAQL THTQFPAASS VGLPSRTKTA AQGPPPEGEP
3360 3370 3380 3390 3400
LQPPQPVQST QPAQPAPPCP PSQLGQPGQP PSSKMPQVSQ EAKGTQTGVE
3410 3420 3430 3440 3450
QPRLPAGPAN RPPEPHTQVQ RAQAETGPTS FPSPVSVSMK PDLPVSLPTQ
3460 3470 3480 3490 3500
TAPKQPLFVP TTSGPSTPPG LVLPHTEFQP APKQDSSPHL TSQRPVDMVQ
3510 3520 3530 3540 3550
LLKKYPIVWQ GLLALKNDTA AVQLHFVSGN NVLAHRSLPL SEGGPPLRIA
3560 3570 3580 3590 3600
QRMRLEATQL EGVARRMTVE TDYCLLLALP CGRDQEDVVS QTESLKAAFI
3610 3620 3630 3640 3650
TYLQAKQAAG IINVPNPGSN QPAYVLQIFP PCEFSESHLS RLAPDLLASI
3660
SNISPHLMIV IASV
Length:3,664
Mass (Da):402,248
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5228C58533E5B27B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6WRY4F6WRY4_HUMAN
Msx2-interacting protein
SPEN
373Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y5U7H0Y5U7_HUMAN
Msx2-interacting protein
SPEN
297Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91405 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14324 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAB51072 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti956G → D (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_017119970A → V. Corresponds to variant dbSNP:rs848208Ensembl.1
Natural variantiVAR_035483990D → H in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0171201091L → P1 PublicationCorresponds to variant dbSNP:rs848209Ensembl.1
Natural variantiVAR_0522081363D → E. Corresponds to variant dbSNP:rs12095818Ensembl.1
Natural variantiVAR_0354841488R → I in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0171212360N → D. Corresponds to variant dbSNP:rs848210Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF356524 mRNA Translation: AAK52750.1
AL034555 Genomic DNA No translation available.
AL450998 Genomic DNA No translation available.
AL096858 mRNA Translation: CAB51072.1 Different initiation.
AK000882 mRNA Translation: BAA91405.1 Different initiation.
AK022949 mRNA Translation: BAB14324.1 Different initiation.
AB023146 mRNA Translation: BAA76773.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS164.1

NCBI Reference Sequences

More...
RefSeqi
NP_055816.2, NM_015001.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000375759; ENSP00000364912; ENSG00000065526

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23013

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23013

UCSC genome browser

More...
UCSCi
uc001axk.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF356524 mRNA Translation: AAK52750.1
AL034555 Genomic DNA No translation available.
AL450998 Genomic DNA No translation available.
AL096858 mRNA Translation: CAB51072.1 Different initiation.
AK000882 mRNA Translation: BAA91405.1 Different initiation.
AK022949 mRNA Translation: BAB14324.1 Different initiation.
AB023146 mRNA Translation: BAA76773.1
CCDSiCCDS164.1
RefSeqiNP_055816.2, NM_015001.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OW1X-ray1.80A3470-3664[»]
2RT5NMR-A3496-3664[»]
4P6QX-ray2.00A335-620[»]
SMRiQ96T58
ModBaseiSearch...

Protein-protein interaction databases

BioGridi116655, 54 interactors
CORUMiQ96T58
DIPiDIP-34569N
IntActiQ96T58, 30 interactors
MINTiQ96T58
STRINGi9606.ENSP00000364912

PTM databases

iPTMnetiQ96T58
PhosphoSitePlusiQ96T58
SwissPalmiQ96T58

Polymorphism and mutation databases

BioMutaiSPEN
DMDMi41688816

Proteomic databases

EPDiQ96T58
jPOSTiQ96T58
MaxQBiQ96T58
PaxDbiQ96T58
PeptideAtlasiQ96T58
PRIDEiQ96T58
ProteomicsDBi78197

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375759; ENSP00000364912; ENSG00000065526
GeneIDi23013
KEGGihsa:23013
UCSCiuc001axk.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23013
DisGeNETi23013

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SPEN
HGNCiHGNC:17575 SPEN
HPAiHPA015825
HPA050257
MIMi613484 gene
neXtProtiNX_Q96T58
OpenTargetsiENSG00000065526
PharmGKBiPA134895302

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0112 Eukaryota
ENOG410XSAC LUCA
GeneTreeiENSGT00940000157087
HOGENOMiHOG000231295
InParanoidiQ96T58
OMAiYDYSQDR
OrthoDBi367857at2759
PhylomeDBiQ96T58
TreeFamiTF315637

Enzyme and pathway databases

SIGNORiQ96T58

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SPEN human
EvolutionaryTraceiQ96T58

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SPEN

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23013

Protein Ontology

More...
PROi
PR:Q96T58

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000065526 Expressed in 234 organ(s), highest expression level in vagina
ExpressionAtlasiQ96T58 baseline and differential
GenevisibleiQ96T58 HS

Family and domain databases

CDDicd12348 RRM1_SHARP, 1 hit
cd12349 RRM2_SHARP, 1 hit
cd12350 RRM3_SHARP, 1 hit
cd12351 RRM4_SHARP, 1 hit
Gene3Di2.40.290.10, 1 hit
3.30.70.330, 4 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034172 SHARP_RRM1
IPR034173 SHARP_RRM2
IPR034174 SHARP_RRM3
IPR034175 SHARP_RRM4
IPR016194 SPOC-like_C_dom_sf
IPR012921 SPOC_C
IPR010912 SPOC_met
PfamiView protein in Pfam
PF00076 RRM_1, 4 hits
PF07744 SPOC, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 4 hits
SUPFAMiSSF100939 SSF100939, 1 hit
SSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 4 hits
PS50917 SPOC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMINT_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q96T58
Secondary accession number(s): Q9H9A8
, Q9NWH5, Q9UQ01, Q9Y556
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 1, 2001
Last modified: July 31, 2019
This is version 185 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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