Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 207 (16 Oct 2019)
Sequence version 2 (27 Mar 2002)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Neurogenic locus notch homolog protein 4

Gene

NOTCH4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, Receptor
Biological processDifferentiation, Notch signaling pathway, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1912399 Pre-NOTCH Processing in the Endoplasmic Reticulum
R-HSA-1912408 Pre-NOTCH Transcription and Translation
R-HSA-1912420 Pre-NOTCH Processing in Golgi
R-HSA-350054 Notch-HLH transcription pathway
R-HSA-5083630 Defective LFNG causes SCDO3
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription
R-HSA-9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus
R-HSA-9604323 Negative regulation of NOTCH4 signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q99466

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q99466

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neurogenic locus notch homolog protein 4Curated
Short name:
Notch 4
Short name:
hNotch4
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NOTCH4Imported
Synonyms:INT3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7884 NOTCH4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
164951 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q99466

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 1447ExtracellularSequence analysisAdd BLAST1424
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1448 – 1468HelicalSequence analysisAdd BLAST21
Topological domaini1469 – 2003CytoplasmicSequence analysisAdd BLAST535

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
4855

Open Targets

More...
OpenTargetsi
ENSG00000204301

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31686

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q99466

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3407321

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NOTCH4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20139103

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000770124 – 2003Neurogenic locus notch homolog protein 4Add BLAST1980
ChainiPRO_00000077021432 – 2003Notch 4 extracellular truncationBy similarityAdd BLAST572
ChainiPRO_00000077031467 – 2003Notch 4 intracellular domainBy similarityAdd BLAST537

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi28 ↔ 41By similarity
Disulfide bondi35 ↔ 51By similarity
Disulfide bondi53 ↔ 62By similarity
Disulfide bondi68 ↔ 80By similarity
Disulfide bondi74 ↔ 103By similarity
Disulfide bondi105 ↔ 114By similarity
Disulfide bondi122 ↔ 133By similarity
Disulfide bondi127 ↔ 143By similarity
Disulfide bondi145 ↔ 154By similarity
Disulfide bondi160 ↔ 171By similarity
Disulfide bondi165 ↔ 180By similarity
Disulfide bondi182 ↔ 191By similarity
Disulfide bondi198 ↔ 211By similarity
Disulfide bondi205 ↔ 220By similarity
Disulfide bondi222 ↔ 231By similarity
Disulfide bondi238 ↔ 249By similarity
Disulfide bondi243 ↔ 262By similarity
Disulfide bondi264 ↔ 273By similarity
Disulfide bondi280 ↔ 291By similarity
Disulfide bondi285 ↔ 300By similarity
Disulfide bondi302 ↔ 311By similarity
Disulfide bondi318 ↔ 332By similarity
Disulfide bondi326 ↔ 341By similarity
Disulfide bondi343 ↔ 352By similarity
Disulfide bondi359 ↔ 370By similarity
Disulfide bondi364 ↔ 379By similarity
Disulfide bondi381 ↔ 390By similarity
Disulfide bondi396 ↔ 407By similarity
Disulfide bondi401 ↔ 418By similarity
Disulfide bondi420 ↔ 429By similarity
Disulfide bondi436 ↔ 452By similarity
Disulfide bondi446 ↔ 461By similarity
Disulfide bondi463 ↔ 472By similarity
Disulfide bondi479 ↔ 490By similarity
Disulfide bondi484 ↔ 499By similarity
Disulfide bondi501 ↔ 510By similarity
Disulfide bondi517 ↔ 528By similarity
Disulfide bondi522 ↔ 537By similarity
Disulfide bondi539 ↔ 548By similarity
Disulfide bondi555 ↔ 566By similarity
Disulfide bondi560 ↔ 575By similarity
Disulfide bondi577 ↔ 586By similarity
Disulfide bondi593 ↔ 604By similarity
Disulfide bondi598 ↔ 613By similarity
Disulfide bondi615 ↔ 624By similarity
Disulfide bondi629 ↔ 640By similarity
Disulfide bondi634 ↔ 649By similarity
Disulfide bondi651 ↔ 658By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi664N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi665 ↔ 672By similarity
Disulfide bondi667 ↔ 677By similarity
Disulfide bondi679 ↔ 688By similarity
Disulfide bondi695 ↔ 706By similarity
Disulfide bondi700 ↔ 715By similarity
Glycosylationi714N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi717 ↔ 726By similarity
Disulfide bondi733 ↔ 744By similarity
Disulfide bondi738 ↔ 753By similarity
Disulfide bondi755 ↔ 764By similarity
Disulfide bondi771 ↔ 782By similarity
Disulfide bondi776 ↔ 791By similarity
Disulfide bondi793 ↔ 802By similarity
Disulfide bondi810 ↔ 821By similarity
Disulfide bondi815 ↔ 830By similarity
Disulfide bondi832 ↔ 841By similarity
Disulfide bondi848 ↔ 859By similarity
Disulfide bondi853 ↔ 868By similarity
Disulfide bondi870 ↔ 879By similarity
Disulfide bondi886 ↔ 907By similarity
Disulfide bondi901 ↔ 916By similarity
Disulfide bondi918 ↔ 927By similarity
Disulfide bondi934 ↔ 945By similarity
Disulfide bondi939 ↔ 954By similarity
Disulfide bondi956 ↔ 965By similarity
Glycosylationi964N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi972 ↔ 983By similarity
Disulfide bondi977 ↔ 992By similarity
Disulfide bondi994 ↔ 1003By similarity
Disulfide bondi1010 ↔ 1023By similarity
Disulfide bondi1015 ↔ 1032By similarity
Disulfide bondi1034 ↔ 1043By similarity
Disulfide bondi1050 ↔ 1061By similarity
Disulfide bondi1055 ↔ 1073By similarity
Disulfide bondi1075 ↔ 1084By similarity
Disulfide bondi1091 ↔ 1102By similarity
Disulfide bondi1096 ↔ 1114By similarity
Disulfide bondi1116 ↔ 1125By similarity
Disulfide bondi1134 ↔ 1146By similarity
Disulfide bondi1140 ↔ 1159By similarity
Glycosylationi1143N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1161 ↔ 1170By similarity
Disulfide bondi1178 ↔ 1191By similarity
Disulfide bondi1187 ↔ 1203By similarity
Disulfide bondi1214 ↔ 1238By similarity
Disulfide bondi1220 ↔ 1233By similarity
Disulfide bondi1229 ↔ 1245By similarity
Disulfide bondi1251 ↔ 1277By similarity
Disulfide bondi1259 ↔ 1272By similarity
Disulfide bondi1268 ↔ 1284By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane (By similarity).By similarity
Phosphorylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q99466

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q99466

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q99466

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q99466

PeptideAtlas

More...
PeptideAtlasi
Q99466

PRoteomics IDEntifications database

More...
PRIDEi
Q99466

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
78281 [Q99466-1]
78282 [Q99466-2]
78283 [Q99466-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99466

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99466

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in the heart, moderately in the lung and placenta and at low levels in the liver, skeletal muscle, kidney, pancreas, spleen, lymph node, thymus, bone marrow and fetal liver. No expression was seen in adult brain or peripheral blood leukocytes.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000204301 Expressed in 220 organ(s), highest expression level in right lung

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q99466 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q99466 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of a C-terminal fragment N(TM) and a N-terminal fragment N(EC) which are probably linked by disulfide bonds (By similarity).

Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH4.

By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110917, 8 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q99466

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q99466

Protein interaction database and analysis system

More...
IntActi
Q99466, 1 interactor

Molecular INTeraction database

More...
MINTi
Q99466

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000364163

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q99466

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q99466

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 63EGF-like 1PROSITE-ProRule annotationAdd BLAST40
Domaini64 – 115EGF-like 2PROSITE-ProRule annotationAdd BLAST52
Domaini118 – 155EGF-like 3PROSITE-ProRule annotationAdd BLAST38
Domaini156 – 192EGF-like 4PROSITE-ProRule annotationAdd BLAST37
Domaini194 – 232EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini234 – 274EGF-like 6PROSITE-ProRule annotationAdd BLAST41
Domaini276 – 312EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini314 – 353EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini355 – 391EGF-like 9; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini392 – 430EGF-like 10PROSITE-ProRule annotationAdd BLAST39
Domaini432 – 473EGF-like 11; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini475 – 511EGF-like 12; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini513 – 549EGF-like 13; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini551 – 587EGF-like 14; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini589 – 625EGF-like 15; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini626 – 659EGF-like 16PROSITE-ProRule annotationAdd BLAST34
Domaini661 – 689EGF-like 17PROSITE-ProRule annotationAdd BLAST29
Domaini691 – 727EGF-like 18PROSITE-ProRule annotationAdd BLAST37
Domaini729 – 765EGF-like 19PROSITE-ProRule annotationAdd BLAST37
Domaini767 – 803EGF-like 20PROSITE-ProRule annotationAdd BLAST37
Domaini806 – 842EGF-like 21PROSITE-ProRule annotationAdd BLAST37
Domaini844 – 880EGF-like 22PROSITE-ProRule annotationAdd BLAST37
Domaini882 – 928EGF-like 23PROSITE-ProRule annotationAdd BLAST47
Domaini930 – 966EGF-like 24PROSITE-ProRule annotationAdd BLAST37
Domaini968 – 1004EGF-like 25PROSITE-ProRule annotationAdd BLAST37
Domaini1006 – 1044EGF-like 26PROSITE-ProRule annotationAdd BLAST39
Domaini1046 – 1085EGF-like 27PROSITE-ProRule annotationAdd BLAST40
Domaini1087 – 1126EGF-like 28PROSITE-ProRule annotationAdd BLAST40
Domaini1130 – 1171EGF-like 29PROSITE-ProRule annotationAdd BLAST42
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1170 – 1213LNR 1Add BLAST44
Repeati1214 – 1250LNR 2Add BLAST37
Repeati1251 – 1294LNR 3Add BLAST44
Repeati1633 – 1665ANK 1Add BLAST33
Repeati1666 – 1698ANK 2Add BLAST33
Repeati1700 – 1732ANK 3Add BLAST33
Repeati1733 – 1765ANK 4Add BLAST33
Repeati1766 – 1798ANK 5Add BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1472 – 1476Poly-Arg5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NOTCH family.Curated

Keywords - Domaini

ANK repeat, EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IR7G Eukaryota
COG0666 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163287

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99466

KEGG Orthology (KO)

More...
KOi
K20996

Identification of Orthologs from Complete Genome Data

More...
OMAi
CHGEAQC

Database of Orthologous Groups

More...
OrthoDBi
7525at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q99466

TreeFam database of animal gene trees

More...
TreeFami
TF351641

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR008297 Notch
IPR035993 Notch-like_dom_sf
IPR022355 Notch_4
IPR000800 Notch_dom
IPR010660 Notch_NOD_dom
IPR011656 Notch_NODP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 1 hit
PF00008 EGF, 12 hits
PF07645 EGF_CA, 5 hits
PF12661 hEGF, 3 hits
PF06816 NOD, 1 hit
PF07684 NODP, 1 hit
PF00066 Notch, 3 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002279 Notch, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01452 LNOTCHREPEAT
PR01987 NOTCH4

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 5 hits
SM00181 EGF, 29 hits
SM00179 EGF_CA, 22 hits
SM00004 NL, 3 hits
SM01338 NOD, 1 hit
SM01339 NODP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit
SSF57184 SSF57184, 5 hits
SSF90193 SSF90193, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits
PS00010 ASX_HYDROXYL, 11 hits
PS00022 EGF_1, 28 hits
PS01186 EGF_2, 21 hits
PS50026 EGF_3, 28 hits
PS01187 EGF_CA, 9 hits
PS50258 LNR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Experimental confirmation may be lacking for some isoforms.

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99466-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQPPSLLLLL LLLLLLCVSV VRPRGLLCGS FPEPCANGGT CLSLSLGQGT
60 70 80 90 100
CQCAPGFLGE TCQFPDPCQN AQLCQNGGSC QALLPAPLGL PSSPSPLTPS
110 120 130 140 150
FLCTCLPGFT GERCQAKLED PCPPSFCSKR GRCHIQASGR PQCSCMPGWT
160 170 180 190 200
GEQCQLRDFC SANPCVNGGV CLATYPQIQC HCPPGFEGHA CERDVNECFQ
210 220 230 240 250
DPGPCPKGTS CHNTLGSFQC LCPVGQEGPR CELRAGPCPP RGCSNGGTCQ
260 270 280 290 300
LMPEKDSTFH LCLCPPGFIG PDCEVNPDNC VSHQCQNGGT CQDGLDTYTC
310 320 330 340 350
LCPETWTGWD CSEDVDECET QGPPHCRNGG TCQNSAGSFH CVCVSGWGGT
360 370 380 390 400
SCEENLDDCI AATCAPGSTC IDRVGSFSCL CPPGRTGLLC HLEDMCLSQP
410 420 430 440 450
CHGDAQCSTN PLTGSTLCLC QPGYSGPTCH QDLDECLMAQ QGPSPCEHGG
460 470 480 490 500
SCLNTPGSFN CLCPPGYTGS RCEADHNECL SQPCHPGSTC LDLLATFHCL
510 520 530 540 550
CPPGLEGQLC EVETNECASA PCLNHADCHD LLNGFQCICL PGFSGTRCEE
560 570 580 590 600
DIDECRSSPC ANGGQCQDQP GAFHCKCLPG FEGPRCQTEV DECLSDPCPV
610 620 630 640 650
GASCLDLPGA FFCLCPSGFT GQLCEVPLCA PNLCQPKQIC KDQKDKANCL
660 670 680 690 700
CPDGSPGCAP PEDNCTCHHG HCQRSSCVCD VGWTGPECEA ELGGCISAPC
710 720 730 740 750
AHGGTCYPQP SGYNCTCPTG YTGPTCSEEM TACHSGPCLN GGSCNPSPGG
760 770 780 790 800
YYCTCPPSHT GPQCQTSTDY CVSAPCFNGG TCVNRPGTFS CLCAMGFQGP
810 820 830 840 850
RCEGKLRPSC ADSPCRNRAT CQDSPQGPRC LCPTGYTGGS CQTLMDLCAQ
860 870 880 890 900
KPCPRNSHCL QTGPSFHCLC LQGWTGPLCN LPLSSCQKAA LSQGIDVSSL
910 920 930 940 950
CHNGGLCVDS GPSYFCHCPP GFQGSLCQDH VNPCESRPCQ NGATCMAQPS
960 970 980 990 1000
GYLCQCAPGY DGQNCSKELD ACQSQPCHNH GTCTPKPGGF HCACPPGFVG
1010 1020 1030 1040 1050
LRCEGDVDEC LDQPCHPTGT AACHSLANAF YCQCLPGHTG QWCEVEIDPC
1060 1070 1080 1090 1100
HSQPCFHGGT CEATAGSPLG FICHCPKGFE GPTCSHRAPS CGFHHCHHGG
1110 1120 1130 1140 1150
LCLPSPKPGF PPRCACLSGY GGPDCLTPPA PKGCGPPSPC LYNGSCSETT
1160 1170 1180 1190 1200
GLGGPGFRCS CPHSSPGPRC QKPGAKGCEG RSGDGACDAG CSGPGGNWDG
1210 1220 1230 1240 1250
GDCSLGVPDP WKGCPSHSRC WLLFRDGQCH PQCDSEECLF DGYDCETPPA
1260 1270 1280 1290 1300
CTPAYDQYCH DHFHNGHCEK GCNTAECGWD GGDCRPEDGD PEWGPSLALL
1310 1320 1330 1340 1350
VVLSPPALDQ QLFALARVLS LTLRVGLWVR KDRDGRDMVY PYPGARAEEK
1360 1370 1380 1390 1400
LGGTRDPTYQ ERAAPQTQPL GKETDSLSAG FVVVMGVDLS RCGPDHPASR
1410 1420 1430 1440 1450
CPWDPGLLLR FLAAMAAVGA LEPLLPGPLL AVHPHAGTAP PANQLPWPVL
1460 1470 1480 1490 1500
CSPVAGVILL ALGALLVLQL IRRRRREHGA LWLPPGFTRR PRTQSAPHRR
1510 1520 1530 1540 1550
RPPLGEDSIG LKALKPKAEV DEDGVVMCSG PEEGEEVGQA EETGPPSTCQ
1560 1570 1580 1590 1600
LWSLSGGCGA LPQAAMLTPP QESEMEAPDL DTRGPDGVTP LMSAVCCGEV
1610 1620 1630 1640 1650
QSGTFQGAWL GCPEPWEPLL DGGACPQAHT VGTGETPLHL AARFSRPTAA
1660 1670 1680 1690 1700
RRLLEAGANP NQPDRAGRTP LHAAVAADAR EVCQLLLRSR QTAVDARTED
1710 1720 1730 1740 1750
GTTPLMLAAR LAVEDLVEEL IAAQADVGAR DKWGKTALHW AAAVNNARAA
1760 1770 1780 1790 1800
RSLLQAGADK DAQDNREQTP LFLAAREGAV EVAQLLLGLG AARELRDQAG
1810 1820 1830 1840 1850
LAPADVAHQR NHWDLLTLLE GAGPPEARHK ATPGREAGPF PRARTVSVSV
1860 1870 1880 1890 1900
PPHGGGALPR CRTLSAGAGP RGGGACLQAR TWSVDLAARG GGAYSHCRSL
1910 1920 1930 1940 1950
SGVGAGGGPT PRGRRFSAGM RGPRPNPAIM RGRYGVAAGR GGRVSTDDWP
1960 1970 1980 1990 2000
CDWVALGACG SASNIPIPPP CLTPSPERGS PQLDCGPPAL QEMPINQGGE

GKK
Length:2,003
Mass (Da):209,622
Last modified:March 27, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBED10283A43A0C14
GO
Isoform 2 (identifier: Q99466-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1414: Missing.

Show »
Length:589
Mass (Da):61,262
Checksum:i0B8F267B8A5EC76B
GO
Isoform 3 (identifier: Q99466-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     378-2003: Missing.

Show »
Length:377
Mass (Da):39,617
Checksum:i77CB39F5A34F1078
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140T8Y6A0A140T8Y6_HUMAN
NOTCH4
NOTCH4
2,003Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T9R5A0A140T9R5_HUMAN
NOTCH4
NOTCH4
2,005Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1U9X989A0A1U9X989_HUMAN
NOTCH4
NOTCH4
2,002Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA09708 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1431A → V in BAA09708 (PubMed:9168133).Curated1
Sequence conflicti1436A → E in BAA09708 (PubMed:9168133).Curated1
Sequence conflicti1445L → F in BAA09708 (PubMed:9168133).Curated1
Sequence conflicti1537 – 1539Missing in AAC63097 (PubMed:9693032).Curated3
Sequence conflicti1538G → A in BAA09708 (PubMed:9168133).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The poly-Leu region of NOTCH4 (in the signal peptide) is polymorphic and the number of Leu varies in the population (from 6 to 12).1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_012866117K → Q2 PublicationsCorresponds to variant dbSNP:rs915894Ensembl.1
Natural variantiVAR_033828204P → L. Corresponds to variant dbSNP:rs2071282Ensembl.1
Natural variantiVAR_033829206P → L. Corresponds to variant dbSNP:rs2071282Ensembl.1
Natural variantiVAR_033830244S → L. Corresponds to variant dbSNP:rs8192585Ensembl.1
Natural variantiVAR_012867272D → G. Corresponds to variant dbSNP:rs520692Ensembl.1
Natural variantiVAR_059271284Q → H. Corresponds to variant dbSNP:rs520803Ensembl.1
Natural variantiVAR_012868317E → Q1 Publication1
Natural variantiVAR_012869320T → A. Corresponds to variant dbSNP:rs422951Ensembl.1
Natural variantiVAR_033831534G → S. Corresponds to variant dbSNP:rs8192591Ensembl.1
Natural variantiVAR_048991809S → I. Corresponds to variant dbSNP:rs3132961Ensembl.1
Natural variantiVAR_012870851K → R. Corresponds to variant dbSNP:rs2022060Ensembl.1
Natural variantiVAR_048992942G → R. Corresponds to variant dbSNP:rs17604492Ensembl.1
Natural variantiVAR_0489931346R → P. Corresponds to variant dbSNP:rs8192573Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0014061 – 1414Missing in isoform 2. 1 PublicationAdd BLAST1414
Alternative sequenceiVSP_001407378 – 2003Missing in isoform 3. 1 PublicationAdd BLAST1626

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D63395 mRNA Translation: BAA09708.1 Frameshift.
D86566 Genomic DNA Translation: BAA13116.1
U95299 mRNA Translation: AAC32288.1
U89335 Genomic DNA Translation: AAC63097.1
AL662884 Genomic DNA No translation available.
BX284686 Genomic DNA No translation available.
BX284927 Genomic DNA No translation available.
CR812478 Genomic DNA No translation available.
CR933878 Genomic DNA No translation available.
AB023961 Genomic DNA Translation: BAB20317.1
AB024520 Genomic DNA Translation: BAA88951.1
AB024578 Genomic DNA Translation: BAA88952.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34420.1 [Q99466-1]

NCBI Reference Sequences

More...
RefSeqi
NP_004548.3, NM_004557.3 [Q99466-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000375023; ENSP00000364163; ENSG00000204301 [Q99466-1]
ENST00000425600; ENSP00000401321; ENSG00000238196
ENST00000439349; ENSP00000408335; ENSG00000223355
ENST00000457094; ENSP00000403447; ENSG00000234876 [Q99466-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4855

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4855

UCSC genome browser

More...
UCSCi
uc003obb.3 human [Q99466-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism, Triplet repeat expansion

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63395 mRNA Translation: BAA09708.1 Frameshift.
D86566 Genomic DNA Translation: BAA13116.1
U95299 mRNA Translation: AAC32288.1
U89335 Genomic DNA Translation: AAC63097.1
AL662884 Genomic DNA No translation available.
BX284686 Genomic DNA No translation available.
BX284927 Genomic DNA No translation available.
CR812478 Genomic DNA No translation available.
CR933878 Genomic DNA No translation available.
AB023961 Genomic DNA Translation: BAB20317.1
AB024520 Genomic DNA Translation: BAA88951.1
AB024578 Genomic DNA Translation: BAA88952.1
CCDSiCCDS34420.1 [Q99466-1]
RefSeqiNP_004548.3, NM_004557.3 [Q99466-1]

3D structure databases

SMRiQ99466
ModBaseiSearch...

Protein-protein interaction databases

BioGridi110917, 8 interactors
CORUMiQ99466
ELMiQ99466
IntActiQ99466, 1 interactor
MINTiQ99466
STRINGi9606.ENSP00000364163

Chemistry databases

BindingDBiQ99466
ChEMBLiCHEMBL3407321

PTM databases

iPTMnetiQ99466
PhosphoSitePlusiQ99466

Polymorphism and mutation databases

BioMutaiNOTCH4
DMDMi20139103

Proteomic databases

jPOSTiQ99466
MassIVEiQ99466
MaxQBiQ99466
PaxDbiQ99466
PeptideAtlasiQ99466
PRIDEiQ99466
ProteomicsDBi78281 [Q99466-1]
78282 [Q99466-2]
78283 [Q99466-3]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
Q99466

Genome annotation databases

EnsembliENST00000375023; ENSP00000364163; ENSG00000204301 [Q99466-1]
ENST00000425600; ENSP00000401321; ENSG00000238196
ENST00000439349; ENSP00000408335; ENSG00000223355
ENST00000457094; ENSP00000403447; ENSG00000234876 [Q99466-1]
GeneIDi4855
KEGGihsa:4855
UCSCiuc003obb.3 human [Q99466-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4855
DisGeNETi4855

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NOTCH4
HGNCiHGNC:7884 NOTCH4
MIMi164951 gene
neXtProtiNX_Q99466
OpenTargetsiENSG00000204301
PharmGKBiPA31686

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IR7G Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000163287
InParanoidiQ99466
KOiK20996
OMAiCHGEAQC
OrthoDBi7525at2759
PhylomeDBiQ99466
TreeFamiTF351641

Enzyme and pathway databases

ReactomeiR-HSA-1912399 Pre-NOTCH Processing in the Endoplasmic Reticulum
R-HSA-1912408 Pre-NOTCH Transcription and Translation
R-HSA-1912420 Pre-NOTCH Processing in Golgi
R-HSA-350054 Notch-HLH transcription pathway
R-HSA-5083630 Defective LFNG causes SCDO3
R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription
R-HSA-9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus
R-HSA-9604323 Negative regulation of NOTCH4 signaling
SignaLinkiQ99466
SIGNORiQ99466

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NOTCH4 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
NOTCH4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4855
PharosiQ99466

Protein Ontology

More...
PROi
PR:Q99466

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000204301 Expressed in 220 organ(s), highest expression level in right lung
ExpressionAtlasiQ99466 baseline and differential
GenevisibleiQ99466 HS

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR008297 Notch
IPR035993 Notch-like_dom_sf
IPR022355 Notch_4
IPR000800 Notch_dom
IPR010660 Notch_NOD_dom
IPR011656 Notch_NODP_dom
PfamiView protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 1 hit
PF00008 EGF, 12 hits
PF07645 EGF_CA, 5 hits
PF12661 hEGF, 3 hits
PF06816 NOD, 1 hit
PF07684 NODP, 1 hit
PF00066 Notch, 3 hits
PIRSFiPIRSF002279 Notch, 1 hit
PRINTSiPR01452 LNOTCHREPEAT
PR01987 NOTCH4
SMARTiView protein in SMART
SM00248 ANK, 5 hits
SM00181 EGF, 29 hits
SM00179 EGF_CA, 22 hits
SM00004 NL, 3 hits
SM01338 NOD, 1 hit
SM01339 NODP, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF57184 SSF57184, 5 hits
SSF90193 SSF90193, 2 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits
PS00010 ASX_HYDROXYL, 11 hits
PS00022 EGF_1, 28 hits
PS01186 EGF_2, 21 hits
PS50026 EGF_3, 28 hits
PS01187 EGF_CA, 9 hits
PS50258 LNR, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNOTC4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99466
Secondary accession number(s): B0V183
, B0V1X5, O00306, Q5SSY7, Q99458, Q99940, Q9H3S8, Q9UII9, Q9UIJ0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: October 16, 2019
This is version 207 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again