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Entry version 175 (03 Jul 2019)
Sequence version 2 (30 Nov 2010)
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Protein

Plakophilin-4

Gene

PKP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cadherin binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q99569

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Plakophilin-4
Alternative name(s):
p0071
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PKP4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9026 PKP4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604276 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q99569

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8502

Open Targets

More...
OpenTargetsi
ENSG00000144283

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33359

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PKP4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104155

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000642891 – 1192Plakophilin-4Add BLAST1192

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei75PhosphoserineCombined sources1
Modified residuei84PhosphothreonineCombined sources1
Modified residuei106PhosphoserineCombined sources1
Modified residuei132PhosphoserineBy similarity1
Modified residuei136PhosphoserineBy similarity1
Modified residuei139PhosphoserineBy similarity1
Modified residuei221PhosphoserineCombined sources1
Modified residuei231PhosphoserineCombined sources1
Modified residuei236PhosphoserineCombined sources1
Modified residuei254Omega-N-methylarginineBy similarity1
Modified residuei270Omega-N-methylarginineBy similarity1
Modified residuei273PhosphoserineCombined sources1
Modified residuei281PhosphoserineCombined sources1
Modified residuei314PhosphoserineCombined sources1
Modified residuei327PhosphoserineCombined sources1
Modified residuei337PhosphoserineCombined sources1
Modified residuei372PhosphotyrosineBy similarity1
Modified residuei392PhosphoserineCombined sources1
Modified residuei403PhosphoserineCombined sources1
Modified residuei406PhosphoserineCombined sources1
Modified residuei412PhosphothreonineBy similarity1
Modified residuei415PhosphotyrosineCombined sources1
Modified residuei422PhosphoserineBy similarity1
Modified residuei427PhosphoserineBy similarity1
Modified residuei438PhosphoserineBy similarity1
Modified residuei478PhosphotyrosineBy similarity1
Modified residuei510PhosphoserineBy similarity1
Modified residuei512PhosphoserineBy similarity1
Modified residuei515PhosphoserineBy similarity1
Modified residuei776PhosphoserineCombined sources1
Modified residuei1013PhosphothreonineBy similarity1
Modified residuei1017PhosphothreonineBy similarity1
Modified residuei1045PhosphoserineBy similarity1
Modified residuei1091PhosphoserineBy similarity1
Modified residuei1100PhosphoserineBy similarity1
Modified residuei1135PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q99569

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q99569

MaxQB - The MaxQuant DataBase

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MaxQBi
Q99569

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q99569

PeptideAtlas

More...
PeptideAtlasi
Q99569

PRoteomics IDEntifications database

More...
PRIDEi
Q99569

ProteomicsDB human proteome resource

More...
ProteomicsDBi
78328
78329 [Q99569-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99569

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99569

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q99569

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000144283 Expressed in 221 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q99569 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q99569 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB037334
HPA066647
HPA070648

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PDZD2 (By similarity).

Interacts (via the C-terminus) with FRMPD2 (via the PDZ 2 domain).

Interacts with RHOA; the interaction is detected at the midbody.

Interacts with ECT2; the interaction is detected at the midbody.

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114074, 62 interactors

Protein interaction database and analysis system

More...
IntActi
Q99569, 38 interactors

Molecular INTeraction database

More...
MINTi
Q99569

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000374409

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q99569

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati415 – 455ARM 1Add BLAST41
Repeati518 – 557ARM 2Add BLAST40
Repeati560 – 599ARM 3Add BLAST40
Repeati604 – 644ARM 4Add BLAST41
Repeati660 – 702ARM 5Add BLAST43
Repeati706 – 751ARM 6Add BLAST46
Repeati815 – 855ARM 7Add BLAST41
Repeati862 – 901ARM 8Add BLAST40
Repeati950 – 993ARM 9Add BLAST44

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili36 – 70Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi788 – 794Poly-Lys7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the beta-catenin family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1048 Eukaryota
ENOG410Y21Q LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155773

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231863

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99569

Database of Orthologous Groups

More...
OrthoDBi
233858at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q99569

TreeFam database of animal gene trees

More...
TreeFami
TF321877

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR028443 Plakophilin-4
IPR028435 Plakophilin/d_Catenin

The PANTHER Classification System

More...
PANTHERi
PTHR10372 PTHR10372, 1 hit
PTHR10372:SF8 PTHR10372:SF8, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00514 Arm, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00185 ARM, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50176 ARM_REPEAT, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99569-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPAPEQASLV EEGQPQTRQE AASTGPGMEP ETTATTILAS VKEQELQFQR
60 70 80 90 100
LTRELEVERQ IVASQLERCR LGAESPSIAS TSSTEKSFPW RSTDVPNTGV
110 120 130 140 150
SKPRVSDAVQ PNNYLIRTEP EQGTLYSPEQ TSLHESEGSL GNSRSSTQMN
160 170 180 190 200
SYSDSGYQEA GSFHNSQNVS KADNRQQHSF IGSTNNHVVR NSRAEGQTLV
210 220 230 240 250
QPSVANRAMR RVSSVPSRAQ SPSYVISTGV SPSRGSLRTS LGSGFGSPSV
260 270 280 290 300
TDPRPLNPSA YSSTTLPAAR AASPYSQRPA SPTAIRRIGS VTSRQTSNPN
310 320 330 340 350
GPTPQYQTTA RVGSPLTLTD AQTRVASPSQ GQVGSSSPKR SGMTAVPQHL
360 370 380 390 400
GPSLQRTVHD MEQFGQQQYD IYERMVPPRP DSLTGLRSSY ASQHSQLGQD
410 420 430 440 450
LRSAVSPDLH ITPIYEGRTY YSPVYRSPNH GTVELQGSQT ALYRTGSVGI
460 470 480 490 500
GNLQRTSSQR STLTYQRNNY ALNTTATYAE PYRPIQYRVQ ECNYNRLQHA
510 520 530 540 550
VPADDGTTRS PSIDSIQKDP REFAWRDPEL PEVIHMLQHQ FPSVQANAAA
560 570 580 590 600
YLQHLCFGDN KVKMEVCRLG GIKHLVDLLD HRVLEVQKNA CGALRNLVFG
610 620 630 640 650
KSTDENKIAM KNVGGIPALL RLLRKSIDAE VRELVTGVLW NLSSCDAVKM
660 670 680 690 700
TIIRDALSTL TNTVIVPHSG WNNSSFDDDH KIKFQTSLVL RNTTGCLRNL
710 720 730 740 750
SSAGEEARKQ MRSCEGLVDS LLYVIHTCVN TSDYDSKTVE NCVCTLRNLS
760 770 780 790 800
YRLELEVPQA RLLGLNELDD LLGKESPSKD SEPSCWGKKK KKKKRTPQED
810 820 830 840 850
QWDGVGPIPG LSKSPKGVEM LWHPSVVKPY LTLLAESSNP ATLEGSAGSL
860 870 880 890 900
QNLSAGNWKF AAYIRAAVRK EKGLPILVEL LRMDNDRVVS SVATALRNMA
910 920 930 940 950
LDVRNKELIG KYAMRDLVNR LPGGNGPSVL SDETMAAICC ALHEVTSKNM
960 970 980 990 1000
ENAKALADSG GIEKLVNITK GRGDRSSLKV VKAAAQVLNT LWQYRDLRSI
1010 1020 1030 1040 1050
YKKDGWNQNH FITPVSTLER DRFKSHPSLS TTNQQMSPII QSVGSTSSSP
1060 1070 1080 1090 1100
ALLGIRDPRS EYDRTQPPMQ YYNSQGDATH KGLYPGSSKP SPIYISSYSS
1110 1120 1130 1140 1150
PAREQNRRLQ HQQLYYSQDD SNRKNFDAYR LYLQSPHSYE DPYFDDRVHF
1160 1170 1180 1190
PASTDYSTQY GLKSTTNYVD FYSTKRPSYR AEQYPGSPDS WV
Length:1,192
Mass (Da):131,868
Last modified:November 30, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i48EA1579E323E019
GO
Isoform 2 (identifier: Q99569-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1043-1085: Missing.

Show »
Length:1,149
Mass (Da):127,144
Checksum:i060914C3E7947CB2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0D9SF60A0A0D9SF60_HUMAN
Plakophilin-4
PKP4
1,208Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EMY7E7EMY7_HUMAN
Plakophilin-4
PKP4
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EST6E7EST6_HUMAN
Plakophilin-4
PKP4
216Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YFB1H0YFB1_HUMAN
Plakophilin-4
PKP4
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EP40E7EP40_HUMAN
Plakophilin-4
PKP4
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PHJ1E9PHJ1_HUMAN
Plakophilin-4
PKP4
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA57478 differs from that shown. Reason: Frameshift at positions 334, 337, 864 and 874.Curated
The sequence CAA57478 differs from that shown. Reason: Erroneous termination at position 1193. Translated as stop.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti41V → M in AAH50308 (PubMed:15489334).Curated1
Sequence conflicti223S → Y in AAH50308 (PubMed:15489334).Curated1
Sequence conflicti235G → W in AAH50308 (PubMed:15489334).Curated1
Sequence conflicti335S → V in CAA57478 (PubMed:8937994).Curated1
Sequence conflicti336S → V in CAA57478 (PubMed:8937994).Curated1
Sequence conflicti447S → V in CAA57478 (PubMed:8937994).Curated1
Sequence conflicti448V → S in CAA57478 (PubMed:8937994).Curated1
Sequence conflicti538Q → E in CAA57478 (PubMed:8937994).Curated1
Sequence conflicti701S → T in CAA57478 (PubMed:8937994).Curated1
Sequence conflicti766N → D in AAH50308 (PubMed:15489334).Curated1
Sequence conflicti856G → S in CAA57478 (PubMed:8937994).Curated1
Sequence conflicti865R → G in CAA57478 (PubMed:8937994).Curated1
Sequence conflicti892V → G in CAA57478 (PubMed:8937994).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0067371043 – 1085Missing in isoform 2. 2 PublicationsAdd BLAST43

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X81889 mRNA Translation: CAA57478.1 Sequence problems.
AC005042 Genomic DNA No translation available.
AC008070 Genomic DNA No translation available.
BC050308 mRNA Translation: AAH50308.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS33305.1 [Q99569-1]
CCDS33306.1 [Q99569-2]

NCBI Reference Sequences

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RefSeqi
NP_001005476.1, NM_001005476.2 [Q99569-2]
NP_001291898.1, NM_001304969.1
NP_001291899.1, NM_001304970.1
NP_003619.2, NM_003628.4 [Q99569-1]
XP_011510318.1, XM_011512016.1 [Q99569-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000389757; ENSP00000374407; ENSG00000144283 [Q99569-2]
ENST00000389759; ENSP00000374409; ENSG00000144283 [Q99569-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8502

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:8502

UCSC genome browser

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UCSCi
uc002tzv.4 human [Q99569-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81889 mRNA Translation: CAA57478.1 Sequence problems.
AC005042 Genomic DNA No translation available.
AC008070 Genomic DNA No translation available.
BC050308 mRNA Translation: AAH50308.1
CCDSiCCDS33305.1 [Q99569-1]
CCDS33306.1 [Q99569-2]
RefSeqiNP_001005476.1, NM_001005476.2 [Q99569-2]
NP_001291898.1, NM_001304969.1
NP_001291899.1, NM_001304970.1
NP_003619.2, NM_003628.4 [Q99569-1]
XP_011510318.1, XM_011512016.1 [Q99569-1]

3D structure databases

SMRiQ99569
ModBaseiSearch...

Protein-protein interaction databases

BioGridi114074, 62 interactors
IntActiQ99569, 38 interactors
MINTiQ99569
STRINGi9606.ENSP00000374409

PTM databases

iPTMnetiQ99569
PhosphoSitePlusiQ99569
SwissPalmiQ99569

Polymorphism and mutation databases

BioMutaiPKP4
DMDMi313104155

Proteomic databases

EPDiQ99569
jPOSTiQ99569
MaxQBiQ99569
PaxDbiQ99569
PeptideAtlasiQ99569
PRIDEiQ99569
ProteomicsDBi78328
78329 [Q99569-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389757; ENSP00000374407; ENSG00000144283 [Q99569-2]
ENST00000389759; ENSP00000374409; ENSG00000144283 [Q99569-1]
GeneIDi8502
KEGGihsa:8502
UCSCiuc002tzv.4 human [Q99569-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8502
DisGeNETi8502

GeneCards: human genes, protein and diseases

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GeneCardsi
PKP4

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0002526
HGNCiHGNC:9026 PKP4
HPAiCAB037334
HPA066647
HPA070648
MIMi604276 gene
neXtProtiNX_Q99569
OpenTargetsiENSG00000144283
PharmGKBiPA33359

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1048 Eukaryota
ENOG410Y21Q LUCA
GeneTreeiENSGT00940000155773
HOGENOMiHOG000231863
InParanoidiQ99569
OrthoDBi233858at2759
PhylomeDBiQ99569
TreeFamiTF321877

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope
SignaLinkiQ99569

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PKP4 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PKP4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8502

Protein Ontology

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PROi
PR:Q99569

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000144283 Expressed in 221 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ99569 baseline and differential
GenevisibleiQ99569 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR028443 Plakophilin-4
IPR028435 Plakophilin/d_Catenin
PANTHERiPTHR10372 PTHR10372, 1 hit
PTHR10372:SF8 PTHR10372:SF8, 1 hit
PfamiView protein in Pfam
PF00514 Arm, 3 hits
SMARTiView protein in SMART
SM00185 ARM, 6 hits
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50176 ARM_REPEAT, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPKP4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99569
Secondary accession number(s): Q86W91
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 30, 2010
Last modified: July 3, 2019
This is version 175 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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