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Entry version 169 (31 Jul 2019)
Sequence version 3 (30 May 2000)
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Protein

Amyloid-beta A4 precursor protein-binding family A member 2

Gene

APBA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6794361 Neurexins and neuroligins

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.24.2.3 the ezrin/radixin/moesin-binding phosphoprotein 50 (ebp50) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Amyloid-beta A4 precursor protein-binding family A member 2
Alternative name(s):
Adapter protein X11beta
Neuron-specific X11L protein
Neuronal Munc18-1-interacting protein 2
Short name:
Mint-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:APBA2
Synonyms:MINT2, X11L
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:579 APBA2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602712 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q99767

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
321

Open Targets

More...
OpenTargetsi
ENSG00000034053

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24870

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
APBA2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
6226950

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000646161 – 749Amyloid-beta A4 precursor protein-binding family A member 2Add BLAST749

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei11PhosphoserineCombined sources1
Modified residuei208PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q99767

MaxQB - The MaxQuant DataBase

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MaxQBi
Q99767

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q99767

PeptideAtlas

More...
PeptideAtlasi
Q99767

PRoteomics IDEntifications database

More...
PRIDEi
Q99767

ProteomicsDB human proteome resource

More...
ProteomicsDBi
20327
78469 [Q99767-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99767

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99767

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000034053 Expressed in 191 organ(s), highest expression level in Brodmann (1909) area 23

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q99767 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q99767 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB037065

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of a multimeric complex containing STXBP1 and syntaxin-1. Binds to the cytoplasmic domain of amyloid-beta protein, and to the nuclear factor NF-kappa-B/p65 via its PDZ domain.

Interacts with the N-terminal domain of APBA2BP.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
106818, 30 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q99767

Protein interaction database and analysis system

More...
IntActi
Q99767, 15 interactors

Molecular INTeraction database

More...
MINTi
Q99767

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000453293

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q99767

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini368 – 555PIDPROSITE-ProRule annotationAdd BLAST188
Domaini568 – 654PDZ 1PROSITE-ProRule annotationAdd BLAST87
Domaini659 – 734PDZ 2PROSITE-ProRule annotationAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni185 – 270STXBP1-bindingAdd BLAST86

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi92 – 95Poly-Glu4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Composed of an N-terminal domain that binds STXBP1, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the amyloid-beta precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane.

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3605 Eukaryota
ENOG410XSBD LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158943

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000033981

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99767

KEGG Orthology (KO)

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KOi
K20055

Identification of Orthologs from Complete Genome Data

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OMAi
YPAEANG

Database of Orthologous Groups

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OrthoDBi
436779at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q99767

TreeFam database of animal gene trees

More...
TreeFami
TF315245

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR030529 Apba2
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom

The PANTHER Classification System

More...
PANTHERi
PTHR12345:SF12 PTHR12345:SF12, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00595 PDZ, 2 hits
PF00640 PID, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00228 PDZ, 2 hits
SM00462 PTB, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50156 SSF50156, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50106 PDZ, 2 hits
PS01179 PID, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99767-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAHRKLESVG SGMLDHRVRP GPVPHSQEPE SEDMELPLEG YVPEGLELAA
60 70 80 90 100
LRPESPAPEE QECHNHSPDG DSSSDYVNNT SEEEDYDEGL PEEEEGITYY
110 120 130 140 150
IRYCPEDDSY LEGMDCNGEE YLAHSAHPVD TDECQEAVEE WTDSAGPHPH
160 170 180 190 200
GHEAEGSQDY PDGQLPIPED EPSVLEAHDQ EEDGHYCASK EGYQDYYPEE
210 220 230 240 250
ANGNTGASPY RLRRGDGDLE DQEEDIDQIV AEIKMSLSMT SITSASEASP
260 270 280 290 300
EHGPEPGPED SVEACPPIKA SCSPSRHEAR PKSLNLLPEA KHPGDPQRGF
310 320 330 340 350
KPKTRTPEER LKWPHEQVCN GLEQPRKQQR SDLNGPVDNN NIPETKKVAS
360 370 380 390 400
FPSFVAVPGP CEPEDLIDGI IFAANYLGST QLLSERNPSK NIRMMQAQEA
410 420 430 440 450
VSRVKRMQKA AKIKKKANSE GDAQTLTEVD LFISTQRIKV LNADTQETMM
460 470 480 490 500
DHALRTISYI ADIGNIVVLM ARRRMPRSAS QDCIETTPGA QEGKKQYKMI
510 520 530 540 550
CHVFESEDAQ LIAQSIGQAF SVAYQEFLRA NGINPEDLSQ KEYSDIINTQ
560 570 580 590 600
EMYNDDLIHF SNSENCKELQ LEKHKGEILG VVVVESGWGS ILPTVILANM
610 620 630 640 650
MNGGPAARSG KLSIGDQIMS INGTSLVGLP LATCQGIIKG LKNQTQVKLN
660 670 680 690 700
IVSCPPVTTV LIKRPDLKYQ LGFSVQNGII CSLMRGGIAE RGGVRVGHRI
710 720 730 740
IEINGQSVVA TAHEKIVQAL SNSVGEIHMK TMPAAMFRLL TGQETPLYI
Length:749
Mass (Da):82,512
Last modified:May 30, 2000 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC15AE9CFAEF51D85
GO
Isoform 2 (identifier: Q99767-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     406-417: Missing.

Note: No experimental confirmation available.
Show »
Length:737
Mass (Da):81,129
Checksum:iE5395EC6D8D00307
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YMS0H0YMS0_HUMAN
Amyloid-beta A4 precursor protein-b...
APBA2
263Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YL28H0YL28_HUMAN
Amyloid-beta A4 precursor protein-b...
APBA2
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YNG7H0YNG7_HUMAN
Amyloid-beta A4 precursor protein-b...
APBA2
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YNE8H0YNE8_HUMAN
Amyloid-beta A4 precursor protein-b...
APBA2
27Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti135Q → H in BAA34734 (PubMed:9890987).Curated1
Sequence conflicti163G → R in AAC39767 (PubMed:9614075).Curated1
Sequence conflicti170 – 214DEPSV…YRLRR → MSPPSLRPMTRKKMVTMCQQ RGLPGLLPRGGQREHRRLPL PPEA in AAC39767 (PubMed:9614075).CuratedAdd BLAST45
Sequence conflicti344E → K in BAA34734 (PubMed:9890987).Curated1
Sequence conflicti354F → L in BAA34734 (PubMed:9890987).Curated1
Sequence conflicti364 – 365ED → KN in BAA34734 (PubMed:9890987).Curated2
Sequence conflicti604G → C in AAC39767 (PubMed:9614075).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050665311L → P1 PublicationCorresponds to variant dbSNP:rs8040932Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_045692406 – 417Missing in isoform 2. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF047348 mRNA Translation: AAC39767.1
AB014719 mRNA Translation: BAA34734.1
AC024474 Genomic DNA No translation available.
AC127522 Genomic DNA No translation available.
AC174469 Genomic DNA No translation available.
BC082986 mRNA Translation: AAH82986.1
AF029108 mRNA Translation: AAC05306.1
U79255 mRNA Translation: AAB50203.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10022.1 [Q99767-1]
CCDS45197.1 [Q99767-2]

NCBI Reference Sequences

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RefSeqi
NP_001123886.1, NM_001130414.1 [Q99767-2]
NP_005494.2, NM_005503.3 [Q99767-1]
XP_011519790.1, XM_011521488.2 [Q99767-1]
XP_011519791.1, XM_011521489.2 [Q99767-1]
XP_011519792.1, XM_011521490.2 [Q99767-1]
XP_011519793.1, XM_011521491.1 [Q99767-1]
XP_011519794.1, XM_011521492.2 [Q99767-1]
XP_016877590.1, XM_017022101.1
XP_016877591.1, XM_017022102.1
XP_016877592.1, XM_017022103.1
XP_016877593.1, XM_017022104.1
XP_016877594.1, XM_017022105.1
XP_016877595.1, XM_017022106.1
XP_016877596.1, XM_017022107.1
XP_016877597.1, XM_017022108.1
XP_016877598.1, XM_017022109.1
XP_016877599.1, XM_017022110.1 [Q99767-1]
XP_016877600.1, XM_017022111.1
XP_016877601.1, XM_017022112.1 [Q99767-1]
XP_016877602.1, XM_017022113.1
XP_016877603.1, XM_017022114.1
XP_016877604.1, XM_017022115.1
XP_016877605.1, XM_017022116.1
XP_016877606.1, XM_017022117.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000411764; ENSP00000409312; ENSG00000034053 [Q99767-2]
ENST00000558259; ENSP00000454171; ENSG00000034053 [Q99767-1]
ENST00000558330; ENSP00000452722; ENSG00000034053 [Q99767-2]
ENST00000558402; ENSP00000453293; ENSG00000034053 [Q99767-1]
ENST00000561069; ENSP00000453144; ENSG00000034053 [Q99767-1]
ENST00000612449; ENSP00000483174; ENSG00000276495 [Q99767-2]
ENST00000620457; ENSP00000480384; ENSG00000276495 [Q99767-1]
ENST00000631894; ENSP00000488107; ENSG00000276495 [Q99767-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
321

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:321

UCSC genome browser

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UCSCi
uc001zck.4 human [Q99767-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047348 mRNA Translation: AAC39767.1
AB014719 mRNA Translation: BAA34734.1
AC024474 Genomic DNA No translation available.
AC127522 Genomic DNA No translation available.
AC174469 Genomic DNA No translation available.
BC082986 mRNA Translation: AAH82986.1
AF029108 mRNA Translation: AAC05306.1
U79255 mRNA Translation: AAB50203.1
CCDSiCCDS10022.1 [Q99767-1]
CCDS45197.1 [Q99767-2]
RefSeqiNP_001123886.1, NM_001130414.1 [Q99767-2]
NP_005494.2, NM_005503.3 [Q99767-1]
XP_011519790.1, XM_011521488.2 [Q99767-1]
XP_011519791.1, XM_011521489.2 [Q99767-1]
XP_011519792.1, XM_011521490.2 [Q99767-1]
XP_011519793.1, XM_011521491.1 [Q99767-1]
XP_011519794.1, XM_011521492.2 [Q99767-1]
XP_016877590.1, XM_017022101.1
XP_016877591.1, XM_017022102.1
XP_016877592.1, XM_017022103.1
XP_016877593.1, XM_017022104.1
XP_016877594.1, XM_017022105.1
XP_016877595.1, XM_017022106.1
XP_016877596.1, XM_017022107.1
XP_016877597.1, XM_017022108.1
XP_016877598.1, XM_017022109.1
XP_016877599.1, XM_017022110.1 [Q99767-1]
XP_016877600.1, XM_017022111.1
XP_016877601.1, XM_017022112.1 [Q99767-1]
XP_016877602.1, XM_017022113.1
XP_016877603.1, XM_017022114.1
XP_016877604.1, XM_017022115.1
XP_016877605.1, XM_017022116.1
XP_016877606.1, XM_017022117.1

3D structure databases

SMRiQ99767
ModBaseiSearch...

Protein-protein interaction databases

BioGridi106818, 30 interactors
ELMiQ99767
IntActiQ99767, 15 interactors
MINTiQ99767
STRINGi9606.ENSP00000453293

Protein family/group databases

TCDBi8.A.24.2.3 the ezrin/radixin/moesin-binding phosphoprotein 50 (ebp50) family

PTM databases

iPTMnetiQ99767
PhosphoSitePlusiQ99767

Polymorphism and mutation databases

BioMutaiAPBA2
DMDMi6226950

Proteomic databases

jPOSTiQ99767
MaxQBiQ99767
PaxDbiQ99767
PeptideAtlasiQ99767
PRIDEiQ99767
ProteomicsDBi20327
78469 [Q99767-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000411764; ENSP00000409312; ENSG00000034053 [Q99767-2]
ENST00000558259; ENSP00000454171; ENSG00000034053 [Q99767-1]
ENST00000558330; ENSP00000452722; ENSG00000034053 [Q99767-2]
ENST00000558402; ENSP00000453293; ENSG00000034053 [Q99767-1]
ENST00000561069; ENSP00000453144; ENSG00000034053 [Q99767-1]
ENST00000612449; ENSP00000483174; ENSG00000276495 [Q99767-2]
ENST00000620457; ENSP00000480384; ENSG00000276495 [Q99767-1]
ENST00000631894; ENSP00000488107; ENSG00000276495 [Q99767-1]
GeneIDi321
KEGGihsa:321
UCSCiuc001zck.4 human [Q99767-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
321
DisGeNETi321

GeneCards: human genes, protein and diseases

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GeneCardsi
APBA2
HGNCiHGNC:579 APBA2
HPAiCAB037065
MIMi602712 gene
neXtProtiNX_Q99767
OpenTargetsiENSG00000034053
PharmGKBiPA24870

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3605 Eukaryota
ENOG410XSBD LUCA
GeneTreeiENSGT00940000158943
HOGENOMiHOG000033981
InParanoidiQ99767
KOiK20055
OMAiYPAEANG
OrthoDBi436779at2759
PhylomeDBiQ99767
TreeFamiTF315245

Enzyme and pathway databases

ReactomeiR-HSA-6794361 Neurexins and neuroligins

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
APBA2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
APBA2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
321

Protein Ontology

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PROi
PR:Q99767

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000034053 Expressed in 191 organ(s), highest expression level in Brodmann (1909) area 23
ExpressionAtlasiQ99767 baseline and differential
GenevisibleiQ99767 HS

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR030529 Apba2
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
PANTHERiPTHR12345:SF12 PTHR12345:SF12, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 2 hits
PF00640 PID, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 2 hits
SM00462 PTB, 1 hit
SUPFAMiSSF50156 SSF50156, 2 hits
PROSITEiView protein in PROSITE
PS50106 PDZ, 2 hits
PS01179 PID, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAPBA2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99767
Secondary accession number(s): E9PGI4, O60571, Q5XKC0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: July 31, 2019
This is version 169 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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