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Entry version 195 (31 Jul 2019)
Sequence version 1 (01 May 1997)
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Protein

Myeloid differentiation primary response protein MyD88

Gene

MYD88

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response (PubMed:15361868, PubMed:18292575). Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:15361868, PubMed:24316379, PubMed:19506249). Increases IL-8 transcription (PubMed:9013863). Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity).By similarity6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processImmunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1236974 ER-Phagosome pathway
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
R-HSA-1810476 RIP-mediated NFkB activation via ZBP1
R-HSA-209543 p75NTR recruits signalling complexes
R-HSA-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production
R-HSA-5602498 MyD88 deficiency (TLR2/4)
R-HSA-5602680 MyD88 deficiency (TLR5)
R-HSA-5603037 IRAK4 deficiency (TLR5)
R-HSA-5603041 IRAK4 deficiency (TLR2/4)
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-9020702 Interleukin-1 signaling
R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-975155 MyD88 dependent cascade initiated on endosome
R-HSA-975871 MyD88 cascade initiated on plasma membrane

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q99836

SIGNOR Signaling Network Open Resource

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SIGNORi
Q99836

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myeloid differentiation primary response protein MyD88
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYD88Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:7562 MYD88

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602170 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q99836

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

MYD88 deficiency (MYD88D)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionPatients suffer from autosomal recessive, life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease, and die between 1 and 11 months of age. Surviving patients are otherwise healthy, with normal resistance to other microbes, and their clinical status improved with age.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07289452Missing in MYD88D; loss of NF-kappa-B complex activation. 2 Publications1
Natural variantiVAR_04795393L → P in MYD88D; results in a loss of function; loss of NF-kappa-B complex activation. 3 PublicationsCorresponds to variant dbSNP:rs137853065Ensembl.1
Natural variantiVAR_047954196R → C in MYD88D; results in a loss of function; decreases NF-kappa-B complex activation. 4 PublicationsCorresponds to variant dbSNP:rs137853064Ensembl.1
Defects in MYD88 are frequently found in many hematological malignancies, such as activated B-cell type diffuse large B-cell lymphoma (ABC-DLBCL), Waldenstroem macroglobulinemia, cutaneous diffuse large B cell lymphoma (CBCL) and primary central nervous system lymphoma (PCNSL).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi196R → A: Reduced interaction with TIRAP, and strongly reduced activity. Strongly reduced interaction with TIRAP; when associated with A-288. 1 Publication1
Mutagenesisi197D → A: Slightly reduced activity. 1 Publication1
Mutagenesisi217R → A: Strongly reduced activity. 1 Publication1
Mutagenesisi282K → A: Slightly reduced activity. 1 Publication1
Mutagenesisi288R → A: Slightly reduced activity, and reduced interaction with TIRAP. Strongly reduced interaction with TIRAP; when associated with A-196. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

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DisGeNETi
4615

MalaCards human disease database

More...
MalaCardsi
MYD88
MIMi612260 phenotype

Open Targets

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OpenTargetsi
ENSG00000172936

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
183713 Pyogenic bacterial infections due to MyD88 deficiency
33226 Waldenstroem macroglobulinemia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA31361

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL5919

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
MYD88

Domain mapping of disease mutations (DMDM)

More...
DMDMi
18202671

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000966661 – 296Myeloid differentiation primary response protein MyD88Add BLAST296

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei244PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination. OTUD4 specifically hydrolyzes 'Lys-63'-linked polyubiquitinated MYD88.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q99836

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q99836

MaxQB - The MaxQuant DataBase

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MaxQBi
Q99836

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q99836

PeptideAtlas

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PeptideAtlasi
Q99836

PRoteomics IDEntifications database

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PRIDEi
Q99836

ProteomicsDB human proteome resource

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ProteomicsDBi
78500 [Q99836-1]
78501 [Q99836-2]
78502 [Q99836-3]
78503 [Q99836-4]

Consortium for Top Down Proteomics

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TopDownProteomicsi
Q99836-4 [Q99836-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q99836

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q99836

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000172936 Expressed in 221 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q99836 baseline and differential

Organism-specific databases

Human Protein Atlas

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HPAi
CAB009104

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, TLR5, IRAK1, IRAK2 and IRAK4 via their respective TIR domains.

Interacts with IL18R1.

Interacts with BMX, IL1RL1, IKBKE and IRF7.

Interacts with LRRFIP1 and LRRFIP2; this interaction positively regulates Toll-like receptor (TLR) signaling in response to agonist.

Interacts with FLII. LRRFIP1 and LRRFIP2 compete with FLII for MYD88-binding.

Interacts with IRF1. Upon IL1B treatment, forms a complex with PELI1, IRAK1, IRAK4 and TRAF6; this complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation. Direct binding of SMAD6 to PELI1 prevents the complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression. May interact with PIK3AP1.

Interacts (via TIR domain) with DHX9 (via H2A and OB-fold regions); this interaction is direct (PubMed:20696886).

Interacts with OTUD4 deubiquitinase; the interaction is direct (PubMed:29395066).

15 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110700, 63 interactors

Database of interacting proteins

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DIPi
DIP-31349N

Protein interaction database and analysis system

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IntActi
Q99836, 46 interactors

Molecular INTeraction database

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MINTi
Q99836

STRING: functional protein association networks

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STRINGi
9606.ENSP00000401399

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1296
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q99836

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
Q99836

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini54 – 109DeathPROSITE-ProRule annotationAdd BLAST56
Domaini159 – 296TIRPROSITE-ProRule annotationAdd BLAST138

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni110 – 155Intermediate domainBy similarityAdd BLAST46

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The intermediate domain (ID) is required for the phosphorylation and activation of IRAK.By similarity

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IIN8 Eukaryota
ENOG410ZIY0 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00510000048324

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000070050

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q99836

KEGG Orthology (KO)

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KOi
K04729

Database of Orthologous Groups

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OrthoDBi
890418at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q99836

TreeFam database of animal gene trees

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TreeFami
TF326264

Family and domain databases

Conserved Domains Database

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CDDi
cd08312 Death_MyD88, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.50.10140, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR034249 MyD88_Death
IPR017281 Myelin_different_resp_MyD88
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR15079 PTHR15079, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00531 Death, 1 hit
PF01582 TIR, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF037756 MyD88, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00005 DEATH, 1 hit
SM00255 TIR, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47986 SSF47986, 1 hit
SSF52200 SSF52200, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS50104 TIR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99836-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAGGPGAGS AAPVSSTSSL PLAALNMRVR RRLSLFLNVR TQVAADWTAL
60 70 80 90 100
AEEMDFEYLE IRQLETQADP TGRLLDAWQG RPGASVGRLL ELLTKLGRDD
110 120 130 140 150
VLLELGPSIE EDCQKYILKQ QQEEAEKPLQ VAAVDSSVPR TAELAGITTL
160 170 180 190 200
DDPLGHMPER FDAFICYCPS DIQFVQEMIR QLEQTNYRLK LCVSDRDVLP
210 220 230 240 250
GTCVWSIASE LIEKRCRRMV VVVSDDYLQS KECDFQTKFA LSLSPGAHQK
260 270 280 290
RLIPIKYKAM KKEFPSILRF ITVCDYTNPC TKSWFWTRLA KALSLP
Length:296
Mass (Da):33,233
Last modified:May 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCEAE3F6B99524333
GO
Isoform 2 (identifier: Q99836-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     110-154: Missing.

Note: No experimental confirmation available.
Show »
Length:251
Mass (Da):28,280
Checksum:i1841504370960C90
GO
Isoform 3 (identifier: Q99836-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     156-296: HMPERFDAFI...TRLAKALSLP → AAGWWWLSLM...ASLQVPIRSD

Note: No experimental confirmation available.
Show »
Length:191
Mass (Da):20,777
Checksum:i5995DBBBA11780B8
GO
Isoform 4 (identifier: Q99836-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     110-110: E → G
     111-155: Missing.
     156-296: HMPERFDAFI...TRLAKALSLP → AAGWWWLSLM...ASLQVPIRSD

Note: No experimental confirmation available.
Show »
Length:146
Mass (Da):15,823
Checksum:i6791101414C872CA
GO
Isoform 5 (identifier: Q99836-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: MAAGGPGAGSAAPVSSTSSLPL → M

Show »
Length:275
Mass (Da):31,496
Checksum:i06D06EECD46F5E2F
GO
Isoform 6 (identifier: Q99836-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     215-215: R → RLARRPRGG

Show »
Length:304
Mass (Da):34,097
Checksum:iC6CE78108FE60498
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y4G9H0Y4G9_HUMAN
Myeloid differentiation primary res...
MYD88
317Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MS70A0A0A0MS70_HUMAN
Myeloid differentiation primary res...
MYD88
309Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MSI9A0A0A0MSI9_HUMAN
Myeloid differentiation primary res...
MYD88
264Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C0J8A0A494C0J8_HUMAN
Myeloid differentiation primary res...
MYD88
245Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ITY3A0A3B3ITY3_HUMAN
Myeloid differentiation primary res...
MYD88
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3F2YP85A0A3F2YP85_HUMAN
Myeloid differentiation primary res...
MYD88
204Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAG60822 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAG60834 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence EAW64521 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti190K → T in BI524129 (PubMed:15489334).Curated1
Sequence conflicti223 – 224VS → WL in BI524129 (PubMed:15489334).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07289334S → Y Rare functional polymorphism; loss of NF-kappa-B complex activation; loss of interaction with IRAK4; reduces homooligomerization. 2 PublicationsCorresponds to variant dbSNP:rs1319438Ensembl.1
Natural variantiVAR_07325239V → M Found in hematological malignancies; somatic mutation; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs770387646Ensembl.1
Natural variantiVAR_07289452Missing in MYD88D; loss of NF-kappa-B complex activation. 2 Publications1
Natural variantiVAR_04795393L → P in MYD88D; results in a loss of function; loss of NF-kappa-B complex activation. 3 PublicationsCorresponds to variant dbSNP:rs137853065Ensembl.1
Natural variantiVAR_07289598R → C Found in hematological malignancies; somatic mutation; unknown pathological significance; loss of NF-kappa-B complex activation; loss of interaction with IRAK4; reduces homooligomerization. 3 PublicationsCorresponds to variant dbSNP:rs199396Ensembl.1
Natural variantiVAR_073253136S → G Found in hematological malignancies; somatic mutation; unknown pathological significance. 1 Publication1
Natural variantiVAR_073254136S → I Found in hematological malignancies; somatic mutation; unknown pathological significance. 1 Publication1
Natural variantiVAR_072896178M → I Found in hematological malignancies; somatic mutation; unknown pathological significance; no effect on NF-kappaB complex activation. 2 PublicationsCorresponds to variant dbSNP:rs41285117Ensembl.1
Natural variantiVAR_047954196R → C in MYD88D; results in a loss of function; decreases NF-kappa-B complex activation. 4 PublicationsCorresponds to variant dbSNP:rs137853064Ensembl.1
Natural variantiVAR_073255204V → F Found in hematological malignancies; somatic mutation; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs776995408Ensembl.1
Natural variantiVAR_073256205W → R Found in hematological malignancies; somatic mutation; unknown pathological significance. 1 Publication1
Natural variantiVAR_073257206S → C Found in hematological malignancies; somatic mutation; unknown pathological significance. 1 Publication1
Natural variantiVAR_073258207I → T Found in hematological malignancies; somatic mutation; unknown pathological significance. 1 Publication1
Natural variantiVAR_073259209S → R Found in hematological malignancies; somatic mutation; unknown pathological significance; constitutively activates NF-kappaB complex activation. 1 Publication1
Natural variantiVAR_073260219M → T Found in hematological malignancies; somatic mutation; unknown pathological significance; constitutively activates NF-kappaB complex activation. 1 Publication1
Natural variantiVAR_073261230S → N Found in hematological malignancies; somatic mutation; unknown pathological significance; constitutively activates NF-kappaB complex activation. 1 PublicationCorresponds to variant dbSNP:rs1353791431Ensembl.1
Natural variantiVAR_073262252L → P Found in hematological malignancies; common mutation in Waldenstroem macroglobulinemia; somatic mutation; unknown pathological significance; constitutively activates NF-kappaB complex activation; gain-of-function mutation; does not affect interaction with IRAK4. 3 PublicationsCorresponds to variant dbSNP:rs387907272EnsemblClinVar.1
Natural variantiVAR_073263281T → P Found in hematological malignancies; somatic mutation; unknown pathological significance; no effect on NF-kappaB complex activation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0537641 – 22MAAGG…SSLPL → M in isoform 5. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_038887110 – 154Missing in isoform 2. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_043498110E → G in isoform 4. 1 Publication1
Alternative sequenceiVSP_043499111 – 155Missing in isoform 4. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_043500156 – 296HMPER…ALSLP → AAGWWWLSLMITCRARNVTS RPNLHSASLQVPIRSD in isoform 3 and isoform 4. 1 PublicationAdd BLAST141
Alternative sequenceiVSP_053765215R → RLARRPRGG in isoform 6. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U70451 mRNA Translation: AAB49967.1
U84408 mRNA Translation: AAC50954.1
AB446470 mRNA Translation: BAG55247.1
BT007376 mRNA Translation: AAP36040.1
AK296570 mRNA Translation: BAG59190.1
AK296716 mRNA Translation: BAG59306.1
AK298650 mRNA Translation: BAG60822.1 Different initiation.
AK298666 mRNA Translation: BAG60834.1 Different initiation.
AP006309 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64521.1 Sequence problems.
BC013589 mRNA Translation: AAH13589.1
BI524129 mRNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS2674.2 [Q99836-1]
CCDS54565.1 [Q99836-6]
CCDS54566.1 [Q99836-3]
CCDS54567.1 [Q99836-2]
CCDS54568.1 [Q99836-4]

NCBI Reference Sequences

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RefSeqi
NP_001166037.1, NM_001172566.1 [Q99836-4]
NP_001166039.1, NM_001172568.1 [Q99836-2]
NP_001166040.1, NM_001172569.1 [Q99836-3]
NP_002459.2, NM_002468.4 [Q99836-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000396334; ENSP00000379625; ENSG00000172936 [Q99836-1]
ENST00000421516; ENSP00000391753; ENSG00000172936 [Q99836-6]
ENST00000424893; ENSP00000389979; ENSG00000172936 [Q99836-2]
ENST00000443433; ENSP00000390565; ENSG00000172936 [Q99836-3]
ENST00000495303; ENSP00000417848; ENSG00000172936 [Q99836-4]
ENST00000650905; ENSP00000498360; ENSG00000172936 [Q99836-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
4615

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:4615

UCSC genome browser

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UCSCi
uc011ayj.3 human [Q99836-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70451 mRNA Translation: AAB49967.1
U84408 mRNA Translation: AAC50954.1
AB446470 mRNA Translation: BAG55247.1
BT007376 mRNA Translation: AAP36040.1
AK296570 mRNA Translation: BAG59190.1
AK296716 mRNA Translation: BAG59306.1
AK298650 mRNA Translation: BAG60822.1 Different initiation.
AK298666 mRNA Translation: BAG60834.1 Different initiation.
AP006309 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64521.1 Sequence problems.
BC013589 mRNA Translation: AAH13589.1
BI524129 mRNA No translation available.
CCDSiCCDS2674.2 [Q99836-1]
CCDS54565.1 [Q99836-6]
CCDS54566.1 [Q99836-3]
CCDS54567.1 [Q99836-2]
CCDS54568.1 [Q99836-4]
RefSeqiNP_001166037.1, NM_001172566.1 [Q99836-4]
NP_001166039.1, NM_001172568.1 [Q99836-2]
NP_001166040.1, NM_001172569.1 [Q99836-3]
NP_002459.2, NM_002468.4 [Q99836-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JS7NMR-A146-296[»]
2Z5VNMR-A148-296[»]
3MOPX-ray3.40A/B/C/D/E/F20-117[»]
4DOMX-ray1.80A157-296[»]
4EO7X-ray1.45A157-296[»]
SMRiQ99836
ModBaseiSearch...

Protein-protein interaction databases

BioGridi110700, 63 interactors
DIPiDIP-31349N
IntActiQ99836, 46 interactors
MINTiQ99836
STRINGi9606.ENSP00000401399

Chemistry databases

ChEMBLiCHEMBL5919

PTM databases

iPTMnetiQ99836
PhosphoSitePlusiQ99836

Polymorphism and mutation databases

BioMutaiMYD88
DMDMi18202671

Proteomic databases

EPDiQ99836
jPOSTiQ99836
MaxQBiQ99836
PaxDbiQ99836
PeptideAtlasiQ99836
PRIDEiQ99836
ProteomicsDBi78500 [Q99836-1]
78501 [Q99836-2]
78502 [Q99836-3]
78503 [Q99836-4]
TopDownProteomicsiQ99836-4 [Q99836-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4615
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396334; ENSP00000379625; ENSG00000172936 [Q99836-1]
ENST00000421516; ENSP00000391753; ENSG00000172936 [Q99836-6]
ENST00000424893; ENSP00000389979; ENSG00000172936 [Q99836-2]
ENST00000443433; ENSP00000390565; ENSG00000172936 [Q99836-3]
ENST00000495303; ENSP00000417848; ENSG00000172936 [Q99836-4]
ENST00000650905; ENSP00000498360; ENSG00000172936 [Q99836-1]
GeneIDi4615
KEGGihsa:4615
UCSCiuc011ayj.3 human [Q99836-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4615
DisGeNETi4615

GeneCards: human genes, protein and diseases

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GeneCardsi
MYD88
HGNCiHGNC:7562 MYD88
HPAiCAB009104
MalaCardsiMYD88
MIMi602170 gene
612260 phenotype
neXtProtiNX_Q99836
OpenTargetsiENSG00000172936
Orphaneti183713 Pyogenic bacterial infections due to MyD88 deficiency
33226 Waldenstroem macroglobulinemia
PharmGKBiPA31361

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IIN8 Eukaryota
ENOG410ZIY0 LUCA
GeneTreeiENSGT00510000048324
HOGENOMiHOG000070050
InParanoidiQ99836
KOiK04729
OrthoDBi890418at2759
PhylomeDBiQ99836
TreeFamiTF326264

Enzyme and pathway databases

ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
R-HSA-1810476 RIP-mediated NFkB activation via ZBP1
R-HSA-209543 p75NTR recruits signalling complexes
R-HSA-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production
R-HSA-5602498 MyD88 deficiency (TLR2/4)
R-HSA-5602680 MyD88 deficiency (TLR5)
R-HSA-5603037 IRAK4 deficiency (TLR5)
R-HSA-5603041 IRAK4 deficiency (TLR2/4)
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-9020702 Interleukin-1 signaling
R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-975155 MyD88 dependent cascade initiated on endosome
R-HSA-975871 MyD88 cascade initiated on plasma membrane
SignaLinkiQ99836
SIGNORiQ99836

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MYD88 human
EvolutionaryTraceiQ99836

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MYD88

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4615

Protein Ontology

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PROi
PR:Q99836

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000172936 Expressed in 221 organ(s), highest expression level in blood
ExpressionAtlasiQ99836 baseline and differential

Family and domain databases

CDDicd08312 Death_MyD88, 1 hit
Gene3Di3.40.50.10140, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR034249 MyD88_Death
IPR017281 Myelin_different_resp_MyD88
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR15079 PTHR15079, 1 hit
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF01582 TIR, 1 hit
PIRSFiPIRSF037756 MyD88, 1 hit
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM00255 TIR, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS50104 TIR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYD88_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99836
Secondary accession number(s): B4DKH8
, B4DKU4, B4DQ60, B4DQ72, J3KPU4, J3KQ87, J3KQJ6, P78397, Q53XS7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 1, 1997
Last modified: July 31, 2019
This is version 195 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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