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Entry version 158 (13 Nov 2019)
Sequence version 1 (01 Jun 2001)
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Protein

Peroxisomal NADH pyrophosphatase NUDT12

Gene

NUDT12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)+, ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity, Mn2+By similarity

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=11 µM for NADH1 Publication
  2. KM=16 µM for NADPH1 Publication
  3. KM=190 µM for NAD1 Publication

    pH dependencei

    Optimum pH is 8-9.1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi370Magnesium or manganeseBy similarity1
    Metal bindingi374Magnesium or manganeseBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase
    LigandMagnesium, Manganese, Metal-binding, NAD, NADP

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-197264 Nicotinamide salvaging

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Peroxisomal NADH pyrophosphatase NUDT12 (EC:3.6.1.221 Publication)
    Alternative name(s):
    Nucleoside diphosphate-linked moiety X motif 12
    Short name:
    Nudix motif 12
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:NUDT121 PublicationImported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:18826 NUDT12

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    609232 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q9BQG2

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm, Peroxisome

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi460 – 462Missing : Abolishes localization to peroxisomes. 1 Publication3

    Organism-specific databases

    Open Targets

    More...
    OpenTargetsi
    ENSG00000112874

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA38699

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q9BQG2

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    NUDT12

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    68565930

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000569561 – 462Peroxisomal NADH pyrophosphatase NUDT12Add BLAST462

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei185N6-succinyllysineBy similarity1
    Modified residuei292N6-succinyllysineBy similarity1

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q9BQG2

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q9BQG2

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q9BQG2

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q9BQG2

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9BQG2

    PeptideAtlas

    More...
    PeptideAtlasi
    Q9BQG2

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9BQG2

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    78677

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9BQG2

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q9BQG2

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000112874 Expressed in 190 organ(s), highest expression level in kidney

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9BQG2 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9BQG2 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA045449

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    WithEntry#Exp.IntActNotes
    Q138677EBI-10230612,EBI-718504

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    123690, 20 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q9BQG2, 14 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000230792

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q9BQG2

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati11 – 40ANK 1Add BLAST30
    Repeati45 – 74ANK 2Add BLAST30
    Repeati78 – 98ANK 3Add BLAST21
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini319 – 453Nudix hydrolasePROSITE-ProRule annotationAdd BLAST135

    Motif

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi355 – 376Nudix boxAdd BLAST22
    Motifi460 – 462Microbody targeting signal1 Publication3

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the Nudix hydrolase family. NudC subfamily.Curated

    Keywords - Domaini

    ANK repeat, Repeat

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG0504 Eukaryota
    KOG3084 Eukaryota
    COG2816 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000157592

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000247937

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9BQG2

    KEGG Orthology (KO)

    More...
    KOi
    K03426

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    PRQTIAH

    Database of Orthologous Groups

    More...
    OrthoDBi
    1436400at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9BQG2

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF106352

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.25.40.20, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR002110 Ankyrin_rpt
    IPR020683 Ankyrin_rpt-contain_dom
    IPR036770 Ankyrin_rpt-contain_sf
    IPR015375 NADH_PPase-like_N
    IPR015797 NUDIX_hydrolase-like_dom_sf
    IPR020084 NUDIX_hydrolase_CS
    IPR000086 NUDIX_hydrolase_dom
    IPR015376 Znr_NADH_PPase

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF12796 Ank_2, 1 hit
    PF00293 NUDIX, 1 hit
    PF09296 NUDIX-like, 1 hit
    PF09297 zf-NADH-PPase, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00248 ANK, 3 hits

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF48403 SSF48403, 1 hit
    SSF55811 SSF55811, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50297 ANK_REP_REGION, 1 hit
    PS50088 ANK_REPEAT, 1 hit
    PS51462 NUDIX, 1 hit
    PS00893 NUDIX_BOX, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q9BQG2-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MSSVKRSLKQ EIVTQFHCSA AEGDIAKLTG ILSHSPSLLN ETSENGWTAL
    60 70 80 90 100
    MYAARNGHPE IVQFLLEKGC DRSIVNKSRQ TALDIAVFWG YKHIANLLAT
    110 120 130 140 150
    AKGGKKPWFL TNEVEECENY FSKTLLDRKS EKRNNSDWLL AKESHPATVF
    160 170 180 190 200
    ILFSDLNPLV TLGGNKESFQ QPEVRLCQLN YTDIKDYLAQ PEKITLIFLG
    210 220 230 240 250
    VELEIKDKLL NYAGEVPREE EDGLVAWFAL GIDPIAAEEF KQRHENCYFL
    260 270 280 290 300
    HPPMPALLQL KEKEAGVVAQ ARSVLAWHSR YKFCPTCGNA TKIEEGGYKR
    310 320 330 340 350
    LCLKEDCPSL NGVHNTSYPR VDPVVIMQVI HPDGTKCLLG RQKRFPPGMF
    360 370 380 390 400
    TCLAGFIEPG ETIEDAVRRE VEEESGVKVG HVQYVACQPW PMPSSLMIGC
    410 420 430 440 450
    LALAVSTEIK VDKNEIEDAR WFTREQVLDV LTKGKQQAFF VPPSRAIAHQ
    460
    LIKHWIRINP NL
    Length:462
    Mass (Da):52,076
    Last modified:June 1, 2001 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1A470B93707DB1D5
    GO
    Isoform 2 (identifier: Q9BQG2-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         52-69: Missing.

    Show »
    Length:444
    Mass (Da):50,052
    Checksum:i21271BD881834399
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    E7EM93E7EM93_HUMAN
    Peroxisomal NADH pyrophosphatase NU...
    NUDT12
    444Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti82A → V in BAG64925 (PubMed:14702039).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034157129K → E. Corresponds to variant dbSNP:rs35903418Ensembl.1
    Natural variantiVAR_034158235I → V. Corresponds to variant dbSNP:rs34468716Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_06039552 – 69Missing in isoform 2. Add BLAST18

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AL136592 mRNA Translation: CAB66527.1
    AK098066 mRNA Translation: BAG53574.1
    AK304010 mRNA Translation: BAG64925.1
    CH471086 Genomic DNA Translation: EAW49073.1
    BC026748 mRNA Translation: AAH26748.1
    BC041099 mRNA Translation: AAH41099.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS4096.1 [Q9BQG2-1]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001287670.1, NM_001300741.1 [Q9BQG2-2]
    NP_113626.1, NM_031438.3 [Q9BQG2-1]
    XP_005272152.1, XM_005272095.1 [Q9BQG2-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000230792; ENSP00000230792; ENSG00000112874 [Q9BQG2-1]
    ENST00000507423; ENSP00000424521; ENSG00000112874 [Q9BQG2-2]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    83594

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:83594

    UCSC genome browser

    More...
    UCSCi
    uc003koi.4 human [Q9BQG2-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AL136592 mRNA Translation: CAB66527.1
    AK098066 mRNA Translation: BAG53574.1
    AK304010 mRNA Translation: BAG64925.1
    CH471086 Genomic DNA Translation: EAW49073.1
    BC026748 mRNA Translation: AAH26748.1
    BC041099 mRNA Translation: AAH41099.1
    CCDSiCCDS4096.1 [Q9BQG2-1]
    RefSeqiNP_001287670.1, NM_001300741.1 [Q9BQG2-2]
    NP_113626.1, NM_031438.3 [Q9BQG2-1]
    XP_005272152.1, XM_005272095.1 [Q9BQG2-1]

    3D structure databases

    SMRiQ9BQG2
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGridi123690, 20 interactors
    IntActiQ9BQG2, 14 interactors
    STRINGi9606.ENSP00000230792

    PTM databases

    iPTMnetiQ9BQG2
    PhosphoSitePlusiQ9BQG2

    Polymorphism and mutation databases

    BioMutaiNUDT12
    DMDMi68565930

    Proteomic databases

    EPDiQ9BQG2
    jPOSTiQ9BQG2
    MassIVEiQ9BQG2
    MaxQBiQ9BQG2
    PaxDbiQ9BQG2
    PeptideAtlasiQ9BQG2
    PRIDEiQ9BQG2
    ProteomicsDBi78677

    Protocols and materials databases

    ABCD curated depository of sequenced antibodies

    More...
    ABCDi
    Q9BQG2

    The DNASU plasmid repository

    More...
    DNASUi
    83594

    Genome annotation databases

    EnsembliENST00000230792; ENSP00000230792; ENSG00000112874 [Q9BQG2-1]
    ENST00000507423; ENSP00000424521; ENSG00000112874 [Q9BQG2-2]
    GeneIDi83594
    KEGGihsa:83594
    UCSCiuc003koi.4 human [Q9BQG2-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    83594

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    NUDT12
    HGNCiHGNC:18826 NUDT12
    HPAiHPA045449
    MIMi609232 gene
    neXtProtiNX_Q9BQG2
    OpenTargetsiENSG00000112874
    PharmGKBiPA38699

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG0504 Eukaryota
    KOG3084 Eukaryota
    COG2816 LUCA
    GeneTreeiENSGT00940000157592
    HOGENOMiHOG000247937
    InParanoidiQ9BQG2
    KOiK03426
    OMAiPRQTIAH
    OrthoDBi1436400at2759
    PhylomeDBiQ9BQG2
    TreeFamiTF106352

    Enzyme and pathway databases

    ReactomeiR-HSA-197264 Nicotinamide salvaging

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    NUDT12 human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    NUDT12

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    83594
    PharosiQ9BQG2

    Protein Ontology

    More...
    PROi
    PR:Q9BQG2

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000112874 Expressed in 190 organ(s), highest expression level in kidney
    ExpressionAtlasiQ9BQG2 baseline and differential
    GenevisibleiQ9BQG2 HS

    Family and domain databases

    Gene3Di1.25.40.20, 1 hit
    InterProiView protein in InterPro
    IPR002110 Ankyrin_rpt
    IPR020683 Ankyrin_rpt-contain_dom
    IPR036770 Ankyrin_rpt-contain_sf
    IPR015375 NADH_PPase-like_N
    IPR015797 NUDIX_hydrolase-like_dom_sf
    IPR020084 NUDIX_hydrolase_CS
    IPR000086 NUDIX_hydrolase_dom
    IPR015376 Znr_NADH_PPase
    PfamiView protein in Pfam
    PF12796 Ank_2, 1 hit
    PF00293 NUDIX, 1 hit
    PF09296 NUDIX-like, 1 hit
    PF09297 zf-NADH-PPase, 1 hit
    SMARTiView protein in SMART
    SM00248 ANK, 3 hits
    SUPFAMiSSF48403 SSF48403, 1 hit
    SSF55811 SSF55811, 1 hit
    PROSITEiView protein in PROSITE
    PS50297 ANK_REP_REGION, 1 hit
    PS50088 ANK_REPEAT, 1 hit
    PS51462 NUDIX, 1 hit
    PS00893 NUDIX_BOX, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNUD12_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BQG2
    Secondary accession number(s): B3KUW2, B4E1W3, Q8TAL7
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: June 1, 2001
    Last modified: November 13, 2019
    This is version 158 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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