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Entry version 119 (18 Sep 2019)
Sequence version 3 (10 Jul 2007)
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Protein

Protein FAM83C

Gene

FAM83C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in MAPK signaling.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM83CCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM83CImported
Synonyms:C20orf128Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16121 FAM83C

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BQN1

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
128876

Open Targets

More...
OpenTargetsi
ENSG00000125998

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25669

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAM83C

Domain mapping of disease mutations (DMDM)

More...
DMDMi
152031601

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000794591 – 747Protein FAM83CAdd BLAST747

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BQN1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BQN1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BQN1

PeptideAtlas

More...
PeptideAtlasi
Q9BQN1

PRoteomics IDEntifications database

More...
PRIDEi
Q9BQN1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
78702

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BQN1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BQN1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000125998 Expressed in 74 organ(s), highest expression level in gingival epithelium

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BQN1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB034227
HPA049978

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May interact with RAF1.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
126173, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q9BQN1, 2 interactors

Molecular INTeraction database

More...
MINTi
Q9BQN1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000363529

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9BQN1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM83 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IG1F Eukaryota
ENOG4110G08 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160254

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231831

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BQN1

Identification of Orthologs from Complete Genome Data

More...
OMAi
ITKYHQL

Database of Orthologous Groups

More...
OrthoDBi
421095at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BQN1

TreeFam database of animal gene trees

More...
TreeFami
TF330777

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012461 FAM83_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07894 FAM83, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9BQN1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFGGPGPGVL GAQGMAGPLR GRVEELKLPW WRESSPLVLR HSEAARLAAD
60 70 80 90 100
ALLERGEAAY LRVISEEREL PFLSALDVDY MTSHVRGGPE LSEAQGQEAS
110 120 130 140 150
GPDRLSLLSE VTSGTYFPMA SDIDPPDLDL GWPEVPQATG FSPTQAVVHF
160 170 180 190 200
QRDKAKNIKD LLRFLFSQAH TVVAVVMDIF TDMELLCDLM EASSRRGVPV
210 220 230 240 250
YLLLAQEHLR HFLEMCYKMD LNGEHLPNMR VRSTCGDTYC SKAGRRFTGQ
260 270 280 290 300
ALEKFVLIDC EQVVAGSYSF TWLCSQAHTS MVLQLRGRIV EDFDREFRCL
310 320 330 340 350
YAESQPVEGF CGGEDPLSPR ALRPPPVALA FRPDVPSPTS SLPSSTSLSS
360 370 380 390 400
IKQSPLMGRS SYLALPGGGD CSDTGVVSSS LGPARREASG QPSLHRQLSD
410 420 430 440 450
PNHGSPPGLY RANLGKLGAY PWSQSSPALN HNSTSPLTLA VGSPLLPRSR
460 470 480 490 500
PLLQFHRGAP ALSRFPENGL PGSQEPSPLR GRWVPGTTLE TVEEKEKKAS
510 520 530 540 550
PSQSRGQLDL LVPFPRAREV GDPDSGVTPN SGPLRPGEQA PEDRRLSPSQ
560 570 580 590 600
ADSQLDLLSR ALGTGGAPEL GSLRPGDRAL EDRRLSLNQS RGQSDLLMQY
610 620 630 640 650
PKAQGSRVPL ETNSSARPAR RAPDERRQTL GHSQLDLITK FGPFRGEGPG
660 670 680 690 700
PNGLPISSPA RTAGAGSGDE KRLTLGHSKL DLITKYHQLH GARQGTEPGG
710 720 730 740
PKGGHLNGGN SDLVRDEKRL TLGHSKLDLI TKYNKSKFKQ LRSRFES
Length:747
Mass (Da):81,078
Last modified:July 10, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0EC47DAA84D59683
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC03594 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti442G → E in BAC03594 (PubMed:14702039).Curated1
Sequence conflicti728D → V in BAC03594 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053900134E → K. Corresponds to variant dbSNP:rs35162625Ensembl.1
Natural variantiVAR_053901600Y → H. Corresponds to variant dbSNP:rs35560631Ensembl.1
Natural variantiVAR_021946621R → Q. Corresponds to variant dbSNP:rs2425049Ensembl.1
Natural variantiVAR_053902645R → C. Corresponds to variant dbSNP:rs35518957Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL121753 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76218.1
BC113483 mRNA Translation: AAI13484.1
AK091138 mRNA Translation: BAC03594.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13251.1

NCBI Reference Sequences

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RefSeqi
NP_848563.1, NM_178468.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000374408; ENSP00000363529; ENSG00000125998

Database of genes from NCBI RefSeq genomes

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GeneIDi
128876

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:128876

UCSC genome browser

More...
UCSCi
uc021wck.2 human

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121753 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76218.1
BC113483 mRNA Translation: AAI13484.1
AK091138 mRNA Translation: BAC03594.1 Different initiation.
CCDSiCCDS13251.1
RefSeqiNP_848563.1, NM_178468.5

3D structure databases

SMRiQ9BQN1
ModBaseiSearch...

Protein-protein interaction databases

BioGridi126173, 1 interactor
IntActiQ9BQN1, 2 interactors
MINTiQ9BQN1
STRINGi9606.ENSP00000363529

PTM databases

iPTMnetiQ9BQN1
PhosphoSitePlusiQ9BQN1

Polymorphism and mutation databases

BioMutaiFAM83C
DMDMi152031601

Proteomic databases

jPOSTiQ9BQN1
MassIVEiQ9BQN1
PaxDbiQ9BQN1
PeptideAtlasiQ9BQN1
PRIDEiQ9BQN1
ProteomicsDBi78702

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374408; ENSP00000363529; ENSG00000125998
GeneIDi128876
KEGGihsa:128876
UCSCiuc021wck.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
128876
DisGeNETi128876

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FAM83C
HGNCiHGNC:16121 FAM83C
HPAiCAB034227
HPA049978
neXtProtiNX_Q9BQN1
OpenTargetsiENSG00000125998
PharmGKBiPA25669

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IG1F Eukaryota
ENOG4110G08 LUCA
GeneTreeiENSGT00940000160254
HOGENOMiHOG000231831
InParanoidiQ9BQN1
OMAiITKYHQL
OrthoDBi421095at2759
PhylomeDBiQ9BQN1
TreeFamiTF330777

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FAM83C human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
128876

Pharos

More...
Pharosi
Q9BQN1

Protein Ontology

More...
PROi
PR:Q9BQN1

Gene expression databases

BgeeiENSG00000125998 Expressed in 74 organ(s), highest expression level in gingival epithelium
GenevisibleiQ9BQN1 HS

Family and domain databases

InterProiView protein in InterPro
IPR012461 FAM83_N
PfamiView protein in Pfam
PF07894 FAM83, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFA83C_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BQN1
Secondary accession number(s): Q14D67, Q5JWN6, Q8N276
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: July 10, 2007
Last modified: September 18, 2019
This is version 119 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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