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Entry version 148 (03 Jul 2019)
Sequence version 2 (01 Mar 2004)
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Protein

Leucine zipper putative tumor suppressor 2

Gene

LZTS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.UniRule annotation4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis, Wnt signaling pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine zipper putative tumor suppressor 2UniRule annotation
Short name:
hLZTS2
Alternative name(s):
Protein LAPSER1UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LZTS2UniRule annotation
Synonyms:KIAA1813, LAPSER1UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:29381 LZTS2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
610454 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BRK4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi638L → A: Induces nuclear accumulation. Impairs nuclear exclusion of beta-catenin; when associated with A-640. 1 Publication1
Mutagenesisi640L → A: Induces nuclear accumulation. Impairs nuclear exclusion of beta-catenin; when associated with A-38. 1 Publication1

Organism-specific databases

DisGeNET

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DisGeNETi
84445

Open Targets

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OpenTargetsi
ENSG00000107816

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134944540

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
LZTS2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
46396501

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001829741 – 669Leucine zipper putative tumor suppressor 2Add BLAST669

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei249PhosphoserineBy similarity1
Modified residuei296PhosphoserineBy similarity1
Modified residuei570PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9BRK4

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9BRK4

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9BRK4

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9BRK4

PeptideAtlas

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PeptideAtlasi
Q9BRK4

PRoteomics IDEntifications database

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PRIDEi
Q9BRK4

ProteomicsDB human proteome resource

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ProteomicsDBi
78778

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9BRK4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9BRK4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in prostate and testis, and at slightly lower levels in spleen, thymus, uterus, small intestine and colon.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By inhibition of NF-kappa-B signaling.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000107816 Expressed in 189 organ(s), highest expression level in esophagogastric junction muscularis propria

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9BRK4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9BRK4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA044956

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with KATNB1.

Also interacts with CTNNB1, gamma-tubulin and KIF23.

UniRule annotation2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
A8K9323EBI-741037,EBI-10174671
P0C2064EBI-741037,EBI-9675596From Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A).
Q95HA43EBI-741037,EBI-10236795
Q9H6F03EBI-741037,EBI-10307481
ABT1Q9ULW33EBI-741037,EBI-2602396
AENQ8WTP83EBI-741037,EBI-8637627
ANKRD36BP1Q96IX93EBI-741037,EBI-744859
AP1M1Q9BXS53EBI-741037,EBI-541426
ARHGAP32A7KAX93EBI-741037,EBI-308663
ARMC7Q9H6L43EBI-741037,EBI-742909
ATPAF2Q8N5M16EBI-741037,EBI-1166928
BAHD1Q8TBE06EBI-741037,EBI-742750
BEX2Q9BXY83EBI-741037,EBI-745073
BYSLQ138955EBI-741037,EBI-358049
C1orf109Q9NX045EBI-741037,EBI-8643161
C8orf33Q9H7E93EBI-741037,EBI-715389
CARD9Q9H2573EBI-741037,EBI-751319
CBX8Q9HC525EBI-741037,EBI-712912
CCDC198Q9NVL83EBI-741037,EBI-10238351
CCNCP248633EBI-741037,EBI-395261
CCNG1P519593EBI-741037,EBI-3905829
CCNKO759093EBI-741037,EBI-739806
CDC23Q9UJX23EBI-741037,EBI-396137
CDK18Q070023EBI-741037,EBI-746238
CDKL3Q8IVW43EBI-741037,EBI-3919850
CEP57L1Q8IYX83EBI-741037,EBI-1104570
CEP57L1Q8IYX8-23EBI-741037,EBI-10181988
CFAP206Q8IYR03EBI-741037,EBI-749051
CHCHD3Q9NX633EBI-741037,EBI-743375
CLIP4Q8N3C73EBI-741037,EBI-5655540
CNNM3Q8NE013EBI-741037,EBI-741032
CNNM3Q8NE01-33EBI-741037,EBI-10269984
CWF19L2Q2TBE03EBI-741037,EBI-5453285
DCUN1D1Q96GG95EBI-741037,EBI-740086
DGCR6LQ9BY273EBI-741037,EBI-742953
DYRK1AQ136273EBI-741037,EBI-1053596
DYRK1BQ9Y4633EBI-741037,EBI-634187
DYRK2Q926303EBI-741037,EBI-749432
EHHADHQ084263EBI-741037,EBI-2339219
EIF3DO153713EBI-741037,EBI-353818
EIF4E2O605733EBI-741037,EBI-398610
FAM107AO95990-33EBI-741037,EBI-10192902
FAM124BQ9H5Z63EBI-741037,EBI-741626
FAM161AQ3B8205EBI-741037,EBI-719941
FAM74A6Q5TZK33EBI-741037,EBI-10247271
FANCLQ9NW383EBI-741037,EBI-2339898
FBF1Q8TES7-63EBI-741037,EBI-10244131
FEM1CQ96JP03EBI-741037,EBI-2515330
FGF12P613283EBI-741037,EBI-6657662
FKBP6O753446EBI-741037,EBI-744771
FNDC11Q9BVV23EBI-741037,EBI-744935
FRG1Q143313EBI-741037,EBI-2515248
FRMD6Q96NE93EBI-741037,EBI-741729
GATA1P15976-23EBI-741037,EBI-9090198
GCC1Q96CN93EBI-741037,EBI-746252
GEMP550405EBI-741037,EBI-744104
GMCL2Q8NEA95EBI-741037,EBI-745707
GNL3LQ9NVN83EBI-741037,EBI-746682
GPANK1O958723EBI-741037,EBI-751540
GPATCH2LQ9NWQ43EBI-741037,EBI-5666657
GRB2P629933EBI-741037,EBI-401755
HM13Q8TCT93EBI-741037,EBI-347472
HOMER2Q9NSB83EBI-741037,EBI-2126733
HOXB9P174823EBI-741037,EBI-745290
HSPD1P108097EBI-741037,EBI-352528
IQCNQ9H0B33EBI-741037,EBI-745878
KAT5Q929935EBI-741037,EBI-399080
KAZNQ674X73EBI-741037,EBI-949239
KIFC3Q9BVG83EBI-741037,EBI-2125614
KPNA2P522923EBI-741037,EBI-349938
LASP1Q148473EBI-741037,EBI-742828
LCKP062393EBI-741037,EBI-1348
LIN37Q96GY33EBI-741037,EBI-748884
LMO1P258003EBI-741037,EBI-8639312
LMO2P257913EBI-741037,EBI-739696
MAB21L3Q8N8X95EBI-741037,EBI-10268010
MAGEB4O154813EBI-741037,EBI-751857
MEMO1Q9Y3163EBI-741037,EBI-1104564
MORF4L1Q9UBU83EBI-741037,EBI-399246
MORF4L2Q150143EBI-741037,EBI-399257
MORN3Q6PF183EBI-741037,EBI-9675802
MOSP005403EBI-741037,EBI-1757866
MTA1Q133303EBI-741037,EBI-714236
NCBP2P522983EBI-741037,EBI-464729
NCK2O436396EBI-741037,EBI-713635
NEBLO760413EBI-741037,EBI-2880203
NEK6Q9HC983EBI-741037,EBI-740364
NIP7Q9Y2213EBI-741037,EBI-749003
OTUB2Q96DC93EBI-741037,EBI-746259
PKP4Q995693EBI-741037,EBI-726447
PLEKHN1Q494U13EBI-741037,EBI-10241513
POLDIP3Q8WUT15EBI-741037,EBI-10276663
POLR1CO151603EBI-741037,EBI-1055079
PPP1R18Q6NYC83EBI-741037,EBI-2557469
PQBP1O608286EBI-741037,EBI-713867
PRKAB2O437414EBI-741037,EBI-1053424
PRPF31Q8WWY33EBI-741037,EBI-1567797
PSMA1P257863EBI-741037,EBI-359352
QARSP478975EBI-741037,EBI-347462
QARSP47897-23EBI-741037,EBI-10209725
RAC1P630003EBI-741037,EBI-413628
RAD51DO757718EBI-741037,EBI-1055693
RAMACQ9BTL33EBI-741037,EBI-744023
RBM15Q96T373EBI-741037,EBI-2514922
RBM41Q96IZ53EBI-741037,EBI-740773
RCOR3Q9P2K33EBI-741037,EBI-743428
RHNO1Q9BSD33EBI-741037,EBI-9658624
RIN1Q136718EBI-741037,EBI-366017
RNF41Q9H4P43EBI-741037,EBI-2130266
RTP5Q14D333EBI-741037,EBI-10217913
RUNX1T1Q06455-43EBI-741037,EBI-10224192
RYDENQ9NUL53EBI-741037,EBI-10313866
SCNM1Q9BWG63EBI-741037,EBI-748391
SFRS2Q6NXQ03EBI-741037,EBI-10251550
SH2D4AQ9H7883EBI-741037,EBI-747035
SH3RF2Q08AM83EBI-741037,EBI-10225873
SLC15A3Q05CH43EBI-741037,EBI-10223741
SLC25A6P122363EBI-741037,EBI-356254
SLU7O953913EBI-741037,EBI-750559
SMIM3Q9BZL33EBI-741037,EBI-741850
SNW1Q135733EBI-741037,EBI-632715
SNX31Q8N9S93EBI-741037,EBI-9380649
SPATA2Q9UM823EBI-741037,EBI-744066
SPATA24Q86W543EBI-741037,EBI-3916986
SPATC1LQ9H0A93EBI-741037,EBI-372911
SPG7Q9UQ903EBI-741037,EBI-717201
STACQ8WUK83EBI-741037,EBI-10276615
SUPV3L1Q8IYB83EBI-741037,EBI-2876787
SUV39H1O434635EBI-741037,EBI-349968
taxP034105EBI-741037,EBI-9676218From Human T-cell leukemia virus 2.
TBC1D7Q9P0N93EBI-741037,EBI-3258000
TCEA2Q155603EBI-741037,EBI-710310
TCHPQ9BT923EBI-741037,EBI-740781
TEAD4D3DUQ63EBI-741037,EBI-10176734
THAP10Q9P2Z03EBI-741037,EBI-745404
THAP7Q9BT495EBI-741037,EBI-741350
TNIP3Q96KP65EBI-741037,EBI-2509913
TRIM29Q141344EBI-741037,EBI-702370
TRIM42Q8IWZ53EBI-741037,EBI-5235829
TSNAXQ995983EBI-741037,EBI-742638
TTC23Q5W5X93EBI-741037,EBI-6447954
TXNL4AP838763EBI-741037,EBI-746539
USF2Q158533EBI-741037,EBI-1055994
USP2O756045EBI-741037,EBI-743272
UTP14CQ08E774EBI-741037,EBI-10225961
WDYHV1Q96HA83EBI-741037,EBI-741158
WT1-ASQ062503EBI-741037,EBI-10223946
ZBTB25P242783EBI-741037,EBI-739899
ZGPATA0A0S2Z6H04EBI-741037,EBI-16428984
ZGPATQ8N5A53EBI-741037,EBI-3439227
ZGPATQ8N5A5-28EBI-741037,EBI-10183064
ZKSCAN3Q9BRR03EBI-741037,EBI-1965777
ZMAT2Q96NC03EBI-741037,EBI-2682299
ZMYND19Q96E354EBI-741037,EBI-746595
ZNF20P170243EBI-741037,EBI-717634
ZNF250P15622-33EBI-741037,EBI-10177272
ZNF417Q8TAU35EBI-741037,EBI-740727
ZNF426Q9BUY53EBI-741037,EBI-743265
ZNF446Q9NWS9-23EBI-741037,EBI-740232
ZNF490Q9ULM23EBI-741037,EBI-1105370
ZNF572Q7Z3I75EBI-741037,EBI-10172590
ZNF581Q9P0T44EBI-741037,EBI-745520

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
124083, 289 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BRK4, 253 interactors

Molecular INTeraction database

More...
MINTi
Q9BRK4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000359240

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BRK4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 332Required for centrosomal localizationBy similarityAdd BLAST332
Regioni447 – 669Sufficient for interaction with CTNNB11 PublicationAdd BLAST223
Regioni450 – 669Sufficient for interaction with KATNB1 and for inhibition of katanin-mediated microtubule severingBy similarityAdd BLAST220

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili328 – 649UniRule annotationAdd BLAST322

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi631 – 640Nuclear export signal10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi188 – 306Ser-richAdd BLAST119

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LZTS2 family.UniRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IGJE Eukaryota
ENOG4111JZA LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154078

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000230889

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9BRK4

Identification of Orthologs from Complete Genome Data

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OMAi
KQRRCER

Database of Orthologous Groups

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OrthoDBi
1014871at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9BRK4

TreeFam database of animal gene trees

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TreeFami
TF331420

Family and domain databases

HAMAP database of protein families

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HAMAPi
MF_03026 LZTS2, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR028597 LZTS2

The PANTHER Classification System

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PANTHERi
PTHR19354:SF4 PTHR19354:SF4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9BRK4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAIVQTLPVP LEPAPEAATA PQAPVMGSVS SLISGRPCPG GPAPPRHHGP
60 70 80 90 100
PGPTFFRQQD GLLRGGYEAQ EPLCPAVPPR KAVPVTSFTY INEDFRTESP
110 120 130 140 150
PSPSSDVEDA REQRAHNAHL RGPPPKLIPV SGKLEKNMEK ILIRPTAFKP
160 170 180 190 200
VLPKPRGAPS LPSFMGPRAT GLSGSQGSLT QLFGGPASSS SSSSSSSAAD
210 220 230 240 250
KPLAFSGWAS GCPSGTLSDS GRNSLSSLPT YSTGGAEPTT SSPGGHLPSH
260 270 280 290 300
GSGRGALPGP ARGVPTGPSH SDSGRSSSSK STGSLGGRVA GGLLGSGTRA
310 320 330 340 350
SPDSSSCGER SPPPPPPPPS DEALLHCVLE GKLRDREAEL QQLRDSLDEN
360 370 380 390 400
EATMCQAYEE RQRHWQRERE ALREDCAAQA QRAQRAQQLL QLQVFQLQQE
410 420 430 440 450
KRQLQDDFAQ LLQEREQLER RCATLEREQR ELGPRLEETK WEVCQKSGEI
460 470 480 490 500
SLLKQQLKES QAELVQKGSE LVALRVALRE ARATLRVSEG RARGLQEAAR
510 520 530 540 550
ARELELEACS QELQRHRQEA EQLREKAGQL DAEAAGLREP PVPPATADPF
560 570 580 590 600
LLAESDEAKV QRAAAGVGGS LRAQVERLRV ELQRERRRGE EQRDSFEGER
610 620 630 640 650
LAWQAEKEQV IRYQKQLQHN YIQMYRRNRQ LEQELQQLSL ELEARELADL
660
GLAEQAPCIC LEEITATEI
Length:669
Mass (Da):72,759
Last modified:March 1, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1274FD9A36A217E6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AL13B1AL13_HUMAN
Leucine zipper putative tumor suppr...
LZTS2
240Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AL12B1AL12_HUMAN
Leucine zipper putative tumor suppr...
LZTS2
220Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AL11B1AL11_HUMAN
Leucine zipper putative tumor suppr...
LZTS2
198Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3W7S4R3W7_HUMAN
Leucine zipper putative tumor suppr...
LZTS2
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB47442 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti289V → L in AAH58938 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036364121R → H in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs367898512Ensembl.1
Natural variantiVAR_036365291G → R in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1235690743Ensembl.1
Natural variantiVAR_018277299R → W. Corresponds to variant dbSNP:rs2275381Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB058716 mRNA Translation: BAB47442.1 Different initiation.
AL133215 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49790.1
CH471066 Genomic DNA Translation: EAW49791.1
CH471066 Genomic DNA Translation: EAW49792.1
BC006212 mRNA Translation: AAH06212.2
BC058938 mRNA Translation: AAH58938.1
AY029201 mRNA Translation: AAK31577.1
AL834338 mRNA Translation: CAD39005.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS7507.1

NCBI Reference Sequences

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RefSeqi
NP_001305028.1, NM_001318099.1
NP_001305029.1, NM_001318100.1
NP_001305030.1, NM_001318101.1
NP_115805.1, NM_032429.3
XP_005270279.1, XM_005270222.4
XP_016872269.1, XM_017016780.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000370220; ENSP00000359240; ENSG00000107816
ENST00000370223; ENSP00000359243; ENSG00000107816

Database of genes from NCBI RefSeq genomes

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GeneIDi
84445

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:84445

UCSC genome browser

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UCSCi
uc001ksj.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058716 mRNA Translation: BAB47442.1 Different initiation.
AL133215 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49790.1
CH471066 Genomic DNA Translation: EAW49791.1
CH471066 Genomic DNA Translation: EAW49792.1
BC006212 mRNA Translation: AAH06212.2
BC058938 mRNA Translation: AAH58938.1
AY029201 mRNA Translation: AAK31577.1
AL834338 mRNA Translation: CAD39005.1
CCDSiCCDS7507.1
RefSeqiNP_001305028.1, NM_001318099.1
NP_001305029.1, NM_001318100.1
NP_001305030.1, NM_001318101.1
NP_115805.1, NM_032429.3
XP_005270279.1, XM_005270222.4
XP_016872269.1, XM_017016780.1

3D structure databases

SMRiQ9BRK4
ModBaseiSearch...

Protein-protein interaction databases

BioGridi124083, 289 interactors
IntActiQ9BRK4, 253 interactors
MINTiQ9BRK4
STRINGi9606.ENSP00000359240

PTM databases

iPTMnetiQ9BRK4
PhosphoSitePlusiQ9BRK4

Polymorphism and mutation databases

BioMutaiLZTS2
DMDMi46396501

Proteomic databases

EPDiQ9BRK4
jPOSTiQ9BRK4
MaxQBiQ9BRK4
PaxDbiQ9BRK4
PeptideAtlasiQ9BRK4
PRIDEiQ9BRK4
ProteomicsDBi78778

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
84445
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370220; ENSP00000359240; ENSG00000107816
ENST00000370223; ENSP00000359243; ENSG00000107816
GeneIDi84445
KEGGihsa:84445
UCSCiuc001ksj.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84445
DisGeNETi84445

GeneCards: human genes, protein and diseases

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GeneCardsi
LZTS2
HGNCiHGNC:29381 LZTS2
HPAiHPA044956
MIMi610454 gene
neXtProtiNX_Q9BRK4
OpenTargetsiENSG00000107816
PharmGKBiPA134944540

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGJE Eukaryota
ENOG4111JZA LUCA
GeneTreeiENSGT00940000154078
HOGENOMiHOG000230889
InParanoidiQ9BRK4
OMAiKQRRCER
OrthoDBi1014871at2759
PhylomeDBiQ9BRK4
TreeFamiTF331420

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
LZTS2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84445

Protein Ontology

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PROi
PR:Q9BRK4

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000107816 Expressed in 189 organ(s), highest expression level in esophagogastric junction muscularis propria
ExpressionAtlasiQ9BRK4 baseline and differential
GenevisibleiQ9BRK4 HS

Family and domain databases

HAMAPiMF_03026 LZTS2, 1 hit
InterProiView protein in InterPro
IPR028597 LZTS2
PANTHERiPTHR19354:SF4 PTHR19354:SF4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLZTS2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BRK4
Secondary accession number(s): B1AL14
, D3DR72, Q8N3I0, Q96J79, Q96JL2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2004
Last modified: July 3, 2019
This is version 148 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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