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Entry version 162 (16 Oct 2019)
Sequence version 2 (10 May 2004)
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Protein

Rho GTPase-activating protein 9

Gene

ARHGAP9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward RHOA. Has a role in regulating adhesion of hematopoietic cells to the extracellular matrix. Binds phosphoinositides, and has the highest affinity for phosphatidylinositol 3,4,5-trisphosphate, followed by phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation
LigandLipid-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-194840 Rho GTPase cycle
R-HSA-6798695 Neutrophil degranulation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9BRR9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho GTPase-activating protein 9
Alternative name(s):
Rho-type GTPase-activating protein 9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARHGAP9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14130 ARHGAP9

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610576 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BRR9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi343K → A: Strongly reduced affinity for phosphoinositides. 1 Publication1
Mutagenesisi399R → A: Reduced affinity for phosphoinositides. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
64333

Open Targets

More...
OpenTargetsi
ENSG00000123329

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24962

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BRR9

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ARHGAP9

Domain mapping of disease mutations (DMDM)

More...
DMDMi
47117294

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000567121 – 750Rho GTPase-activating protein 9Add BLAST750

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei475PhosphoserineCombined sources1
Modified residuei500PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BRR9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BRR9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BRR9

PeptideAtlas

More...
PeptideAtlasi
Q9BRR9

PRoteomics IDEntifications database

More...
PRIDEi
Q9BRR9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
19770
78819 [Q9BRR9-1]
78820 [Q9BRR9-2]
78821 [Q9BRR9-3]
78822 [Q9BRR9-4]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1716

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BRR9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BRR9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in peripheral blood leukocytes, spleen, and thymus.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000123329 Expressed in 184 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BRR9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BRR9 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FASLG.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122140, 12 interactors

Protein interaction database and analysis system

More...
IntActi
Q9BRR9, 19 interactors

Molecular INTeraction database

More...
MINTi
Q9BRR9

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000377380

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1750
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BRR9

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9BRR9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 88SH3PROSITE-ProRule annotationAdd BLAST67
Domaini213 – 247WWPROSITE-ProRule annotationAdd BLAST35
Domaini322 – 435PHPROSITE-ProRule annotationAdd BLAST114
Domaini542 – 749Rho-GAPPROSITE-ProRule annotationAdd BLAST208

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni342 – 345Lipid binding4
Regioni397 – 399Lipid binding3
Regioni432 – 669Lipid bindingAdd BLAST238

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

A region including the PH domain and partially overlapping with the Rho-GAP domain mediates interaction with phosphoinositides.1 Publication

Keywords - Domaini

SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1450 Eukaryota
ENOG410ZP6T LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182860

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000294167

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BRR9

KEGG Orthology (KO)

More...
KOi
K20634

Database of Orthologous Groups

More...
OrthoDBi
1300981at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BRR9

TreeFam database of animal gene trees

More...
TreeFami
TF329345

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12143 SH3_ARHGAP9, 1 hit
cd00201 WW, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.555.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035465 ARHGAP9_SH3
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR001202 WW_dom
IPR036020 WW_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00169 PH, 1 hit
PF00620 RhoGAP, 1 hit
PF00018 SH3_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233 PH, 1 hit
SM00324 RhoGAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350 SSF48350, 1 hit
SSF50044 SSF50044, 1 hit
SSF51045 SSF51045, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50238 RHOGAP, 1 hit
PS50002 SH3, 1 hit
PS50020 WW_DOMAIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BRR9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLSSRWWPSS WGILGLGPRS PPRGSQLCAL YAFTYTGADG QQVSLAEGDR
60 70 80 90 100
FLLLRKTNSD WWLARRLEAP STSRPIFVPA AYMIEESIPS QSPTTVIPGQ
110 120 130 140 150
LLWTPGPKLF HGSLEELSQA LPSRAQASSE QPPPLPRKMC RSVSTDNLSP
160 170 180 190 200
SLLKPFQEGP SGRSLSQEDL PSEASASTAG PQPLMSEPPV YCNLVDLRRC
210 220 230 240 250
PRSPPPGPAC PLLQRLDAWE QHLDPNSGRC FYINSLTGCK SWKPPRRSRS
260 270 280 290 300
ETNPGSMEGT QTLKRNNDVL QPQAKGFRSD TGTPEPLDPQ GSLSLSQRTS
310 320 330 340 350
QLDPPALQAP RPLPQLLDDP HEVEKSGLLN MTKIAQGGRK LRKNWGPSWV
360 370 380 390 400
VLTGNSLVFY REPPPTAPSS GWGPAGSRPE SSVDLRGAAL AHGRHLSSRR
410 420 430 440 450
NVLHIRTIPG HEFLLQSDHE TELRAWHRAL RTVIERLVRW VEARREAPTG
460 470 480 490 500
RDQGSGDREN PLELRLSGSG PAELSAGEDE EEESELVSKP LLRLSSRRSS
510 520 530 540 550
IRGPEGTEQN RVRNKLKRLI AKRPPLQSLQ ERGLLRDQVF GCQLESLCQR
560 570 580 590 600
EGDTVPSFLR LCIAAVDKRG LDVDGIYRVS GNLAVVQKLR FLVDRERAVT
610 620 630 640 650
SDGRYVFPEQ PGQEGRLDLD STEWDDIHVV TGALKLFLRE LPQPLVPPLL
660 670 680 690 700
LPHFRAALAL SESEQCLSQI QELIGSMPKP NHDTLRYLLE HLCRVIAHSD
710 720 730 740 750
KNRMTPHNLG IVFGPTLFRP EQETSDPAAH ALYPGQLVQL MLTNFTSLFP
Length:750
Mass (Da):83,260
Last modified:May 10, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7E769DBC3678DB49
GO
Isoform 2 (identifier: Q9BRR9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     438-456: Missing.

Show »
Length:731
Mass (Da):81,150
Checksum:iB63901EACA109D02
GO
Isoform 3 (identifier: Q9BRR9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-184: Missing.

Show »
Length:566
Mass (Da):63,292
Checksum:i68FC77CAF2B9321E
GO
Isoform 4 (identifier: Q9BRR9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-184: Missing.
     438-456: Missing.

Show »
Length:547
Mass (Da):61,183
Checksum:iBA337CC08F1B433B
GO
Isoform 5 (identifier: Q9BRR9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     438-456: Missing.
     659-750: ALSESEQCLS...MLTNFTSLFP → G

Note: No experimental confirmation available.
Show »
Length:640
Mass (Da):70,869
Checksum:i163BA91817EE36F2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KPQ4J3KPQ4_HUMAN
Rho GTPase activating protein 9, is...
ARHGAP9 hCG_39668
821Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GN15R4GN15_HUMAN
Rho GTPase-activating protein 9
ARHGAP9
736Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VW89F8VW89_HUMAN
Rho GTPase-activating protein 9
ARHGAP9
296Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VQR0F8VQR0_HUMAN
Rho GTPase-activating protein 9
ARHGAP9
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VR90F8VR90_HUMAN
Rho GTPase-activating protein 9
ARHGAP9
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W1N6F8W1N6_HUMAN
Rho GTPase-activating protein 9
ARHGAP9
174Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VSD0F8VSD0_HUMAN
Rho GTPase-activating protein 9
ARHGAP9
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YI36H0YI36_HUMAN
Rho GTPase-activating protein 9
ARHGAP9
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YI33H0YI33_HUMAN
Rho GTPase-activating protein 9
ARHGAP9
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VQY5F8VQY5_HUMAN
Rho GTPase-activating protein 9
ARHGAP9
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti152L → F in AAH06107 (Ref. 2) Curated1
Sequence conflicti195V → A in BAC03969 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05583050R → G. Corresponds to variant dbSNP:rs33927108Ensembl.1
Natural variantiVAR_055831137R → C. Corresponds to variant dbSNP:rs3802989EnsemblClinVar.1
Natural variantiVAR_055832370S → A2 PublicationsCorresponds to variant dbSNP:rs11544238EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0103401 – 184Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST184
Alternative sequenceiVSP_010325438 – 456Missing in isoform 2, isoform 4 and isoform 5. 4 PublicationsAdd BLAST19
Alternative sequenceiVSP_046391659 – 750ALSES…TSLFP → G in isoform 5. 1 PublicationAdd BLAST92

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB051853 mRNA Translation: BAB56159.1
AB030239 mRNA Translation: BAB83128.1
AK092763 mRNA Translation: BAC03969.1
AK301095 mRNA Translation: BAG62695.1
AC022506 Genomic DNA No translation available.
BC006107 mRNA Translation: AAH06107.1
BC011820 mRNA Translation: AAH11820.1
AL713803 mRNA Translation: CAD28552.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44928.1 [Q9BRR9-4]
CCDS44929.1 [Q9BRR9-5]
CCDS81705.1 [Q9BRR9-1]
CCDS8941.2 [Q9BRR9-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
JC7701

NCBI Reference Sequences

More...
RefSeqi
NP_001073625.1, NM_001080156.2 [Q9BRR9-4]
NP_001073626.1, NM_001080157.1 [Q9BRR9-5]
NP_001306779.1, NM_001319850.1 [Q9BRR9-1]
NP_001306780.1, NM_001319851.1
NP_001306781.1, NM_001319852.1 [Q9BRR9-3]
NP_115885.2, NM_032496.3 [Q9BRR9-2]
XP_005269140.1, XM_005269083.2 [Q9BRR9-3]
XP_011536958.1, XM_011538656.2 [Q9BRR9-2]
XP_011536961.1, XM_011538659.2 [Q9BRR9-5]
XP_016875289.1, XM_017019800.1 [Q9BRR9-3]
XP_016875290.1, XM_017019801.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000393791; ENSP00000377380; ENSG00000123329 [Q9BRR9-2]
ENST00000424809; ENSP00000394307; ENSG00000123329 [Q9BRR9-5]
ENST00000430041; ENSP00000397950; ENSG00000123329 [Q9BRR9-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
64333

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:64333

UCSC genome browser

More...
UCSCi
uc001snz.4 human [Q9BRR9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051853 mRNA Translation: BAB56159.1
AB030239 mRNA Translation: BAB83128.1
AK092763 mRNA Translation: BAC03969.1
AK301095 mRNA Translation: BAG62695.1
AC022506 Genomic DNA No translation available.
BC006107 mRNA Translation: AAH06107.1
BC011820 mRNA Translation: AAH11820.1
AL713803 mRNA Translation: CAD28552.1
CCDSiCCDS44928.1 [Q9BRR9-4]
CCDS44929.1 [Q9BRR9-5]
CCDS81705.1 [Q9BRR9-1]
CCDS8941.2 [Q9BRR9-2]
PIRiJC7701
RefSeqiNP_001073625.1, NM_001080156.2 [Q9BRR9-4]
NP_001073626.1, NM_001080157.1 [Q9BRR9-5]
NP_001306779.1, NM_001319850.1 [Q9BRR9-1]
NP_001306780.1, NM_001319851.1
NP_001306781.1, NM_001319852.1 [Q9BRR9-3]
NP_115885.2, NM_032496.3 [Q9BRR9-2]
XP_005269140.1, XM_005269083.2 [Q9BRR9-3]
XP_011536958.1, XM_011538656.2 [Q9BRR9-2]
XP_011536961.1, XM_011538659.2 [Q9BRR9-5]
XP_016875289.1, XM_017019800.1 [Q9BRR9-3]
XP_016875290.1, XM_017019801.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2P0DX-ray1.81A321-440[»]
2P0FX-ray1.91A321-440[»]
2P0HX-ray1.90A321-440[»]
SMRiQ9BRR9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi122140, 12 interactors
IntActiQ9BRR9, 19 interactors
MINTiQ9BRR9
STRINGi9606.ENSP00000377380

PTM databases

GlyConnecti1716
iPTMnetiQ9BRR9
PhosphoSitePlusiQ9BRR9

Polymorphism and mutation databases

BioMutaiARHGAP9
DMDMi47117294

Proteomic databases

jPOSTiQ9BRR9
MassIVEiQ9BRR9
PaxDbiQ9BRR9
PeptideAtlasiQ9BRR9
PRIDEiQ9BRR9
ProteomicsDBi19770
78819 [Q9BRR9-1]
78820 [Q9BRR9-2]
78821 [Q9BRR9-3]
78822 [Q9BRR9-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
64333

Genome annotation databases

EnsembliENST00000393791; ENSP00000377380; ENSG00000123329 [Q9BRR9-2]
ENST00000424809; ENSP00000394307; ENSG00000123329 [Q9BRR9-5]
ENST00000430041; ENSP00000397950; ENSG00000123329 [Q9BRR9-4]
GeneIDi64333
KEGGihsa:64333
UCSCiuc001snz.4 human [Q9BRR9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64333
DisGeNETi64333

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ARHGAP9
HGNCiHGNC:14130 ARHGAP9
MIMi610576 gene
neXtProtiNX_Q9BRR9
OpenTargetsiENSG00000123329
PharmGKBiPA24962

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1450 Eukaryota
ENOG410ZP6T LUCA
GeneTreeiENSGT00950000182860
HOGENOMiHOG000294167
InParanoidiQ9BRR9
KOiK20634
OrthoDBi1300981at2759
PhylomeDBiQ9BRR9
TreeFamiTF329345

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle
R-HSA-6798695 Neutrophil degranulation
SignaLinkiQ9BRR9

Miscellaneous databases

EvolutionaryTraceiQ9BRR9

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ARHGAP9

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
64333
PharosiQ9BRR9

Protein Ontology

More...
PROi
PR:Q9BRR9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000123329 Expressed in 184 organ(s), highest expression level in blood
ExpressionAtlasiQ9BRR9 baseline and differential
GenevisibleiQ9BRR9 HS

Family and domain databases

CDDicd12143 SH3_ARHGAP9, 1 hit
cd00201 WW, 1 hit
Gene3Di1.10.555.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035465 ARHGAP9_SH3
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF00620 RhoGAP, 1 hit
PF00018 SH3_1, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00324 RhoGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
SSF50044 SSF50044, 1 hit
SSF51045 SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50238 RHOGAP, 1 hit
PS50002 SH3, 1 hit
PS50020 WW_DOMAIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRHG09_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BRR9
Secondary accession number(s): B4DVI3
, E9PDX9, Q8NAF3, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: October 16, 2019
This is version 162 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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