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Entry version 111 (13 Feb 2019)
Sequence version 1 (01 Jun 2001)
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Protein

Protein MENT

Gene

MENT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in control of cellular proliferation. Onconcogenic modifier contributing to the tumor suppressor function of DNMT3B.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein MENT
Alternative name(s):
Methylated in normal thymocytes protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MENT
Synonyms:C1orf56
ORF Names:UNQ547/PRO1104
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000143443.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26045 C1orf56

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BUN1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
54964

Open Targets

More...
OpenTargetsi
ENSG00000143443

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672507

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C1orf56

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74752360

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000030496924 – 341Protein MENTAdd BLAST318

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation sites are present in the extracellular medium.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BUN1

PeptideAtlas

More...
PeptideAtlasi
Q9BUN1

PRoteomics IDEntifications database

More...
PRIDEi
Q9BUN1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
79111
79112 [Q9BUN1-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BUN1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BUN1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Plasma. Overexpressed in lymphomas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000143443 Expressed in 188 organ(s), highest expression level in left testis

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BUN1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA037429
HPA037430

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q9BUN1, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000357922

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9BUN1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BUN1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJ3P Eukaryota
ENOG4111C53 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000014288

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000111223

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG054510

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BUN1

Identification of Orthologs from Complete Genome Data

More...
OMAi
EHRPCTY

Database of Orthologous Groups

More...
OrthoDBi
1015642at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BUN1

TreeFam database of animal gene trees

More...
TreeFami
TF338845

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029292 MENT

The PANTHER Classification System

More...
PANTHERi
PTHR16240 PTHR16240, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15322 PMSI1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9BUN1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVPAAGALLW VLLLNLGPRA AGAQGLTQTP TEMQRVSLRF GGPMTRSYRS
60 70 80 90 100
TARTGLPRKT RIILEDENDA MADADRLAGP AAAELLAATV STGFSRSSAI
110 120 130 140 150
NEEDGSSEEG VVINAGKDST SRELPSATPN TAGSSSTRFI ANSQEPEIRL
160 170 180 190 200
TSSLPRSPGR STEDLPGSQA TLSQWSTPGS TPSRWPSPSP TAMPSPEDLR
210 220 230 240 250
LVLMPWGPWH CHCKSGTMSR SRSGKLHGLS GRLRVGALSQ LRTEHKPCTY
260 270 280 290 300
QQCPCNRLRE ECPLDTSLCT DTNCASQSTT STRTTTTPFP TIHLRSSPSL
310 320 330 340
PPASPCPALA FWKRVRIGLE DIWNSLSSVF TEMQPIDRNQ R
Length:341
Mass (Da):36,769
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF3C6BAE1C30F6CA3
GO
Isoform 2 (identifier: Q9BUN1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     167-176: GSQATLSQWS → CHLLRICGWC
     177-341: Missing.

Note: No experimental confirmation available.
Show »
Length:176
Mass (Da):18,583
Checksum:i1C15671CD6897BF7
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_028157167 – 176GSQATLSQWS → CHLLRICGWC in isoform 2. 1 Publication10
Alternative sequenceiVSP_028158177 – 341Missing in isoform 2. 1 PublicationAdd BLAST165

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY358436 mRNA Translation: AAQ88802.1
AK000526 mRNA Translation: BAA91231.1
AK315680 mRNA Translation: BAG38045.1
AL590133 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53481.1
BC002469 mRNA Translation: AAH02469.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS980.1 [Q9BUN1-1]

NCBI Reference Sequences

More...
RefSeqi
NP_060330.2, NM_017860.4 [Q9BUN1-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.549171

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000368926; ENSP00000357922; ENSG00000143443 [Q9BUN1-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54964

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54964

UCSC genome browser

More...
UCSCi
uc001ewn.4 human [Q9BUN1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358436 mRNA Translation: AAQ88802.1
AK000526 mRNA Translation: BAA91231.1
AK315680 mRNA Translation: BAG38045.1
AL590133 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53481.1
BC002469 mRNA Translation: AAH02469.1
CCDSiCCDS980.1 [Q9BUN1-1]
RefSeqiNP_060330.2, NM_017860.4 [Q9BUN1-1]
UniGeneiHs.549171

3D structure databases

ProteinModelPortaliQ9BUN1
SMRiQ9BUN1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9BUN1, 6 interactors
STRINGi9606.ENSP00000357922

PTM databases

iPTMnetiQ9BUN1
PhosphoSitePlusiQ9BUN1

Polymorphism and mutation databases

BioMutaiC1orf56
DMDMi74752360

Proteomic databases

PaxDbiQ9BUN1
PeptideAtlasiQ9BUN1
PRIDEiQ9BUN1
ProteomicsDBi79111
79112 [Q9BUN1-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368926; ENSP00000357922; ENSG00000143443 [Q9BUN1-1]
GeneIDi54964
KEGGihsa:54964
UCSCiuc001ewn.4 human [Q9BUN1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54964
DisGeNETi54964
EuPathDBiHostDB:ENSG00000143443.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
C1orf56
HGNCiHGNC:26045 C1orf56
HPAiHPA037429
HPA037430
neXtProtiNX_Q9BUN1
OpenTargetsiENSG00000143443
PharmGKBiPA142672507

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJ3P Eukaryota
ENOG4111C53 LUCA
GeneTreeiENSGT00390000014288
HOGENOMiHOG000111223
HOVERGENiHBG054510
InParanoidiQ9BUN1
OMAiEHRPCTY
OrthoDBi1015642at2759
PhylomeDBiQ9BUN1
TreeFamiTF338845

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
C1orf56 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
54964

Protein Ontology

More...
PROi
PR:Q9BUN1

Gene expression databases

BgeeiENSG00000143443 Expressed in 188 organ(s), highest expression level in left testis
GenevisibleiQ9BUN1 HS

Family and domain databases

InterProiView protein in InterPro
IPR029292 MENT
PANTHERiPTHR16240 PTHR16240, 1 hit
PfamiView protein in Pfam
PF15322 PMSI1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMENT_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BUN1
Secondary accession number(s): B2RDU8, Q9NWZ4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: June 1, 2001
Last modified: February 13, 2019
This is version 111 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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