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Entry version 164 (13 Nov 2019)
Sequence version 1 (01 Jun 2001)
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Protein

Katanin p80 WD40 repeat-containing subunit B1

Gene

KATNB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.UniRule annotation1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • dynein complex binding Source: Ensembl
  • microtubule binding Source: UniProtKB
  • protein heterodimerization activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9BVA0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Katanin p80 WD40 repeat-containing subunit B1UniRule annotation
Short name:
Katanin p80 subunit B1UniRule annotation
Alternative name(s):
p80 kataninUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KATNB1UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6217 KATNB1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602703 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BVA0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Lissencephaly 6, with microcephaly (LIS6)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of lissencephaly, a disorder of cortical development characterized by agyria or pachygyria and disorganization of the clear neuronal lamination of normal six-layered cortex. LIS6 features include hypoplasia of the corpus callosum, severe microcephaly and developmental delay.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07331933G → W in LIS6. 1 PublicationCorresponds to variant dbSNP:rs730880259EnsemblClinVar.1
Natural variantiVAR_073320535S → L in LIS6; causes reduced interaction with KATNA1 and NDEL1. 1 PublicationCorresponds to variant dbSNP:rs730880257EnsemblClinVar.1
Natural variantiVAR_073321540L → R in LIS6. 1 PublicationCorresponds to variant dbSNP:rs730880258EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Lissencephaly

Organism-specific databases

DisGeNET

More...
DisGeNETi
10300

MalaCards human disease database

More...
MalaCardsi
KATNB1
MIMi616212 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000140854

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
1083 Microlissencephaly

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30018

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BVA0

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3879844

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KATNB1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
60390213

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000510491 – 655Katanin p80 WD40 repeat-containing subunit B1Add BLAST655

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei395PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9BVA0

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9BVA0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BVA0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BVA0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BVA0

PeptideAtlas

More...
PeptideAtlasi
Q9BVA0

PRoteomics IDEntifications database

More...
PRIDEi
Q9BVA0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
79189

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BVA0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BVA0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000140854 Expressed in 216 organ(s), highest expression level in right frontal lobe

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BVA0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BVA0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA041165
HPA041839

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PAFAH1B1 (By similarity).

Interacts with KATNA1 (PubMed:10751153, PubMed:26929214). This interaction enhances the microtubule binding and severing activity of KATNA1 and also targets this activity to the centrosome (PubMed:10751153). This interaction is weakly competed by KATNBL1 which has a lower affinity for it (PubMed:26929214).

Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM (By similarity).

Interacts with dynein, microtubules and NDEL1 (PubMed:16203747).

Interacts with KATNAL1; this interaction is weakly competed by KATNBL1 which has a lower affinity for it (PubMed:26929214).

Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches (PubMed:24486153).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115588, 24 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9BVA0

Protein interaction database and analysis system

More...
IntActi
Q9BVA0, 41 interactors

Molecular INTeraction database

More...
MINTi
Q9BVA0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000368982

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BVA0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati18 – 58WD 1Add BLAST41
Repeati61 – 100WD 2Add BLAST40
Repeati103 – 142WD 3Add BLAST40
Repeati145 – 184WD 4Add BLAST40
Repeati187 – 226WD 5Add BLAST40
Repeati229 – 269WD 6Add BLAST41

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 300Interaction with centrosomesAdd BLAST300
Regioni1 – 284Interaction with dyneinBy similarityAdd BLAST284
Regioni285 – 434Interaction with PAFAH1B1By similarityAdd BLAST150
Regioni433 – 655Interaction with KATNA1 and NDEL1By similarityAdd BLAST223

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat KATNB1 family.UniRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0267 Eukaryota
ENOG410XQAC LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157918

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000008039

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BVA0

KEGG Orthology (KO)

More...
KOi
K18643

Identification of Orthologs from Complete Genome Data

More...
OMAi
FESMCTI

Database of Orthologous Groups

More...
OrthoDBi
425951at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BVA0

TreeFam database of animal gene trees

More...
TreeFami
TF332359

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 2 hits

HAMAP database of protein families

More...
HAMAPi
MF_03022 Katanin_p80_B1, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR026962 Katanin_bsu1
IPR028021 Katanin_C-terminal
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13925 Katanin_con80, 1 hit
PF00400 WD40, 5 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00320 GPROTEINBRPT

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678 WD_REPEATS_1, 3 hits
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q9BVA0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATPVVTKTA WKLQEIVAHA SNVSSLVLGK ASGRLLATGG DDCRVNLWSI
60 70 80 90 100
NKPNCIMSLT GHTSPVESVR LNTPEELIVA GSQSGSIRVW DLEAAKILRT
110 120 130 140 150
LMGHKANICS LDFHPYGEFV ASGSQDTNIK LWDIRRKGCV FRYRGHSQAV
160 170 180 190 200
RCLRFSPDGK WLASAADDHT VKLWDLTAGK MMSEFPGHTG PVNVVEFHPN
210 220 230 240 250
EYLLASGSSD RTIRFWDLEK FQVVSCIEGE PGPVRSVLFN PDGCCLYSGC
260 270 280 290 300
QDSLRVYGWE PERCFDVVLV NWGKVADLAI CNDQLIGVAF SQSNVSSYVV
310 320 330 340 350
DLTRVTRTGT VARDPVQDHR PLAQPLPNPS APLRRIYERP STTCSKPQRV
360 370 380 390 400
KQNSESERRS PSSEDDRDER ESRAEIQNAE DYNEIFQPKN SISRTPPRRS
410 420 430 440 450
EPFPAPPEDD AATAKEAAKP SPAMDVQFPV PNLEVLPRPP VVASTPAPKA
460 470 480 490 500
EPAIIPATRN EPIGLKASDF LPAVKIPQQA ELVDEDAMSQ IRKGHDTMCV
510 520 530 540 550
VLTSRHKNLD TVRAVWTMGD IKTSVDSAVA INDLSVVVDL LNIVNQKASL
560 570 580 590 600
WKLDLCTTVL PQIEKLLQSK YESYVQTGCT SLKLILQRFL PLITDMLAAP
610 620 630 640 650
PSVGVDISRE ERLHKCRLCY KQLKSISGLV KSKSGLSGRH GSTFRELHLL

MASLD
Length:655
Mass (Da):72,334
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i411903E306B6EC16
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BTU7H3BTU7_HUMAN
Katanin p80 WD40 repeat-containing ...
KATNB1
276Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPK1H3BPK1_HUMAN
Katanin p80 WD40 repeat-containing ...
KATNB1
210Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPD8H3BPD8_HUMAN
Katanin p80 WD40 repeat-containing ...
KATNB1
208Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BTV8H3BTV8_HUMAN
Katanin p80 WD40 repeat-containing ...
KATNB1
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BT67H3BT67_HUMAN
Katanin p80 WD40 repeat-containing ...
KATNB1
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti104H → L in AAC09328 (PubMed:9568719).Curated1
Sequence conflicti211R → G in AAC09328 (PubMed:9568719).Curated1
Sequence conflicti226C → R in AAC09328 (PubMed:9568719).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07331933G → W in LIS6. 1 PublicationCorresponds to variant dbSNP:rs730880259EnsemblClinVar.1
Natural variantiVAR_062099181M → V. Corresponds to variant dbSNP:rs60158050Ensembl.1
Natural variantiVAR_073320535S → L in LIS6; causes reduced interaction with KATNA1 and NDEL1. 1 PublicationCorresponds to variant dbSNP:rs730880257EnsemblClinVar.1
Natural variantiVAR_073321540L → R in LIS6. 1 PublicationCorresponds to variant dbSNP:rs730880258EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF052432 mRNA Translation: AAC09328.1
BT007022 mRNA Translation: AAP35668.1
CR456762 mRNA Translation: CAG33043.1
AC092118 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW82951.1
BC001353 mRNA Translation: AAH01353.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS10788.1

NCBI Reference Sequences

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RefSeqi
NP_005877.2, NM_005886.2
XP_016878352.1, XM_017022863.1
XP_016878353.1, XM_017022864.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000379661; ENSP00000368982; ENSG00000140854

Database of genes from NCBI RefSeq genomes

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GeneIDi
10300

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10300

UCSC genome browser

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UCSCi
uc002eml.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF052432 mRNA Translation: AAC09328.1
BT007022 mRNA Translation: AAP35668.1
CR456762 mRNA Translation: CAG33043.1
AC092118 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW82951.1
BC001353 mRNA Translation: AAH01353.1
CCDSiCCDS10788.1
RefSeqiNP_005877.2, NM_005886.2
XP_016878352.1, XM_017022863.1
XP_016878353.1, XM_017022864.1

3D structure databases

SMRiQ9BVA0
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115588, 24 interactors
CORUMiQ9BVA0
IntActiQ9BVA0, 41 interactors
MINTiQ9BVA0
STRINGi9606.ENSP00000368982

Chemistry databases

ChEMBLiCHEMBL3879844

PTM databases

iPTMnetiQ9BVA0
PhosphoSitePlusiQ9BVA0

Polymorphism and mutation databases

BioMutaiKATNB1
DMDMi60390213

Proteomic databases

EPDiQ9BVA0
jPOSTiQ9BVA0
MassIVEiQ9BVA0
MaxQBiQ9BVA0
PaxDbiQ9BVA0
PeptideAtlasiQ9BVA0
PRIDEiQ9BVA0
ProteomicsDBi79189

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
10300

Genome annotation databases

EnsembliENST00000379661; ENSP00000368982; ENSG00000140854
GeneIDi10300
KEGGihsa:10300
UCSCiuc002eml.2 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10300
DisGeNETi10300

GeneCards: human genes, protein and diseases

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GeneCardsi
KATNB1
HGNCiHGNC:6217 KATNB1
HPAiHPA041165
HPA041839
MalaCardsiKATNB1
MIMi602703 gene
616212 phenotype
neXtProtiNX_Q9BVA0
OpenTargetsiENSG00000140854
Orphaneti1083 Microlissencephaly
PharmGKBiPA30018

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0267 Eukaryota
ENOG410XQAC LUCA
GeneTreeiENSGT00940000157918
HOGENOMiHOG000008039
InParanoidiQ9BVA0
KOiK18643
OMAiFESMCTI
OrthoDBi425951at2759
PhylomeDBiQ9BVA0
TreeFamiTF332359

Enzyme and pathway databases

SignaLinkiQ9BVA0

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
KATNB1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
KATNB1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10300
PharosiQ9BVA0

Protein Ontology

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PROi
PR:Q9BVA0

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000140854 Expressed in 216 organ(s), highest expression level in right frontal lobe
ExpressionAtlasiQ9BVA0 baseline and differential
GenevisibleiQ9BVA0 HS

Family and domain databases

Gene3Di2.130.10.10, 2 hits
HAMAPiMF_03022 Katanin_p80_B1, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR026962 Katanin_bsu1
IPR028021 Katanin_C-terminal
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF13925 Katanin_con80, 1 hit
PF00400 WD40, 5 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 3 hits
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKTNB1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BVA0
Secondary accession number(s): A6NCG6, O60620
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: June 1, 2001
Last modified: November 13, 2019
This is version 164 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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