UniProtKB - Q9BW61 (DDA1_HUMAN)
Protein
DET1- and DDB1-associated protein 1
Gene
DDA1
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD-E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins.1 Publication
GO - Biological processi
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: GO_Central
- post-translational protein modification Source: Reactome
Keywordsi
Biological process | Ubl conjugation pathway |
Enzyme and pathway databases
Reactomei | R-HSA-8951664 Neddylation |
Names & Taxonomyi
Protein namesi | Recommended name: DET1- and DDB1-associated protein 1Alternative name(s): Placenta cross-immune reaction antigen 1 Short name: PCIA-1 |
Gene namesi | Name:DDA1 Synonyms:C19orf58, PCIA1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28360 DDA1 |
neXtProti | NX_Q9BW61 |
Subcellular locationi
Nucleus
- nucleoplasm Source: Reactome
Other locations
- Cul4-RING E3 ubiquitin ligase complex Source: UniProtKB
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 79016 |
OpenTargetsi | ENSG00000130311 |
PharmGKBi | PA162383418 |
Miscellaneous databases
Pharosi | Q9BW61 |
Polymorphism and mutation databases
BioMutai | DDA1 |
DMDMi | 74733400 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000310270 | 2 – 102 | DET1- and DDB1-associated protein 1Add BLAST | 101 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 33 | PhosphoserineCombined sources | 1 | |
Modified residuei | 95 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9BW61 |
jPOSTi | Q9BW61 |
MassIVEi | Q9BW61 |
MaxQBi | Q9BW61 |
PaxDbi | Q9BW61 |
PeptideAtlasi | Q9BW61 |
PRIDEi | Q9BW61 |
ProteomicsDBi | 79255 |
TopDownProteomicsi | Q9BW61 |
PTM databases
iPTMneti | Q9BW61 |
PhosphoSitePlusi | Q9BW61 |
Expressioni
Gene expression databases
Bgeei | ENSG00000130311 Expressed in 187 organ(s), highest expression level in testis |
ExpressionAtlasi | Q9BW61 baseline and differential |
Genevisiblei | Q9BW61 HS |
Organism-specific databases
HPAi | HPA042134 HPA055272 |
Interactioni
Subunit structurei
Part of the DDD core complex containing DET1, DDA1 and DDB1. The DDD core complex recruits a specific UBE2E enzyme, such as UBE2E1, UBE2E2 UBE2E3, to form specific DDD-E2 complexes.
1 PublicationBinary interactionsi
Protein-protein interaction databases
BioGridi | 122485, 92 interactors |
DIPi | DIP-53527N |
IntActi | Q9BW61, 67 interactors |
MINTi | Q9BW61 |
STRINGi | 9606.ENSP00000352928 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9BW61 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the DDA1 family.Curated
Phylogenomic databases
eggNOGi | KOG4816 Eukaryota ENOG41120QM LUCA |
GeneTreei | ENSGT00390000007029 |
HOGENOMi | HOG000006384 |
InParanoidi | Q9BW61 |
KOi | K11792 |
OMAi | MARTDSE |
OrthoDBi | 1521756at2759 |
PhylomeDBi | Q9BW61 |
TreeFami | TF323534 |
Family and domain databases
InterProi | View protein in InterPro IPR033575 DDA1 IPR018276 DDA1_N |
PANTHERi | PTHR31879 PTHR31879, 1 hit |
Pfami | View protein in Pfam PF10172 DDA1, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9BW61-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADFLKGLPV YNKSNFSRFH ADSVCKASNR RPSVYLPTRE YPSEQIIVTE
60 70 80 90 100
KTNILLRYLH QQWDKKNAAK KRDQEQVELE GESSAPPRKV ARTDSPDMHE
DT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ090952 mRNA Translation: AAZ41375.1 AY563006 mRNA Translation: AAS66629.1 CH471106 Genomic DNA Translation: EAW84593.1 BC000615 mRNA Translation: AAH00615.1 |
CCDSi | CCDS12357.1 |
RefSeqi | NP_076955.1, NM_024050.5 |
Genome annotation databases
Ensembli | ENST00000359866; ENSP00000352928; ENSG00000130311 ENST00000593466; ENSP00000473086; ENSG00000130311 ENST00000596582; ENSP00000472171; ENSG00000130311 |
GeneIDi | 79016 |
KEGGi | hsa:79016 |
UCSCi | uc002ngd.4 human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ090952 mRNA Translation: AAZ41375.1 AY563006 mRNA Translation: AAS66629.1 CH471106 Genomic DNA Translation: EAW84593.1 BC000615 mRNA Translation: AAH00615.1 |
CCDSi | CCDS12357.1 |
RefSeqi | NP_076955.1, NM_024050.5 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6DSZ | X-ray | 3.09 | C/D | 1-19 | [»] | |
6PAI | X-ray | 2.90 | E | 1-102 | [»] | |
SMRi | Q9BW61 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGridi | 122485, 92 interactors |
DIPi | DIP-53527N |
IntActi | Q9BW61, 67 interactors |
MINTi | Q9BW61 |
STRINGi | 9606.ENSP00000352928 |
PTM databases
iPTMneti | Q9BW61 |
PhosphoSitePlusi | Q9BW61 |
Polymorphism and mutation databases
BioMutai | DDA1 |
DMDMi | 74733400 |
Proteomic databases
EPDi | Q9BW61 |
jPOSTi | Q9BW61 |
MassIVEi | Q9BW61 |
MaxQBi | Q9BW61 |
PaxDbi | Q9BW61 |
PeptideAtlasi | Q9BW61 |
PRIDEi | Q9BW61 |
ProteomicsDBi | 79255 |
TopDownProteomicsi | Q9BW61 |
Protocols and materials databases
DNASUi | 79016 |
Genome annotation databases
Ensembli | ENST00000359866; ENSP00000352928; ENSG00000130311 ENST00000593466; ENSP00000473086; ENSG00000130311 ENST00000596582; ENSP00000472171; ENSG00000130311 |
GeneIDi | 79016 |
KEGGi | hsa:79016 |
UCSCi | uc002ngd.4 human |
Organism-specific databases
CTDi | 79016 |
DisGeNETi | 79016 |
GeneCardsi | DDA1 |
HGNCi | HGNC:28360 DDA1 |
HPAi | HPA042134 HPA055272 |
neXtProti | NX_Q9BW61 |
OpenTargetsi | ENSG00000130311 |
PharmGKBi | PA162383418 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4816 Eukaryota ENOG41120QM LUCA |
GeneTreei | ENSGT00390000007029 |
HOGENOMi | HOG000006384 |
InParanoidi | Q9BW61 |
KOi | K11792 |
OMAi | MARTDSE |
OrthoDBi | 1521756at2759 |
PhylomeDBi | Q9BW61 |
TreeFami | TF323534 |
Enzyme and pathway databases
Reactomei | R-HSA-8951664 Neddylation |
Miscellaneous databases
ChiTaRSi | DDA1 human |
GenomeRNAii | 79016 |
Pharosi | Q9BW61 |
PROi | PR:Q9BW61 |
Gene expression databases
Bgeei | ENSG00000130311 Expressed in 187 organ(s), highest expression level in testis |
ExpressionAtlasi | Q9BW61 baseline and differential |
Genevisiblei | Q9BW61 HS |
Family and domain databases
InterProi | View protein in InterPro IPR033575 DDA1 IPR018276 DDA1_N |
PANTHERi | PTHR31879 PTHR31879, 1 hit |
Pfami | View protein in Pfam PF10172 DDA1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DDA1_HUMAN | |
Accessioni | Q9BW61Primary (citable) accession number: Q9BW61 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2007 |
Last sequence update: | June 1, 2001 | |
Last modified: | November 13, 2019 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families - PDB cross-references
Index of Protein Data Bank (PDB) cross-references