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Entry version 122 (18 Sep 2019)
Sequence version 2 (29 Aug 2003)
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Protein

Glutathione hydrolase light chain 1

Gene

GGTLC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Corresponds to the light chain of other gamma-glutamyltransferase family members. Has no catalytic activity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei37NucleophileBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei55GlutamateBy similarity1
Binding sitei76GlutamateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

MEROPS protease database

More...
MEROPSi
T03.016

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glutathione hydrolase light chain 1
Alternative name(s):
Gamma-glutamyltransferase light chain 1
Gamma-glutamyltransferase-like activity 4
Gamma-glutamyltransferase-like protein 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GGTLC1
Synonyms:GGTLA4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16437 GGTLC1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612338 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BX51

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
92086

Open Targets

More...
OpenTargetsi
ENSG00000149435

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28671

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GGTLC1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
34395714

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002059831 – 225Glutathione hydrolase light chain 1Add BLAST225

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BX51

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BX51

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BX51

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BX51

PeptideAtlas

More...
PeptideAtlasi
Q9BX51

PRoteomics IDEntifications database

More...
PRIDEi
Q9BX51

ProteomicsDB human proteome resource

More...
ProteomicsDBi
79349

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1259

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000149435 Expressed in 90 organ(s), highest expression level in right lung

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BX51 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA045635
HPA047534

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124906, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q9BX51, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000337587

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BX51

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni107 – 108Glutamate bindingBy similarity2
Regioni129 – 130Glutamate bindingBy similarity2

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the gamma-glutamyltransferase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2410 Eukaryota
COG0405 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154601

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000074069

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BX51

Identification of Orthologs from Complete Genome Data

More...
OMAi
RERNHNT

Database of Orthologous Groups

More...
OrthoDBi
1419292at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BX51

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000101 GGT_peptidase
IPR029055 Ntn_hydrolases_N

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56235 SSF56235, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00462 G_GLU_TRANSPEPTIDASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9BX51-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSEFFSAQL RAQISDDTTH PISYYKPEFY MPDDGGTAHL SVVAEDGSAV
60 70 80 90 100
SATSTINLYF GSKVRSPVSG ILLNNEMDDF SSTSITNEFG VPPSPANFIQ
110 120 130 140 150
PGKQPLSSMC PTIMVGQDGQ VRMVVGAAGG TQITMATALA IIYNLWFGYD
160 170 180 190 200
VKWAVEEPRL HNQLLPNVTT VERNIDQEVT AALETRHHHT QITSTFIAVV
210 220
QAIVRMAGGW AAASDSRKGG EPAGY
Length:225
Mass (Da):24,274
Last modified:August 29, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i126947D3DBBE7536
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L20491 mRNA Translation: AAA02885.1
L20492 mRNA Translation: AAA35864.1
AL133466 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10125.1
CH471133 Genomic DNA Translation: EAX10129.1
CH471133 Genomic DNA Translation: EAX10130.1
CH471133 Genomic DNA Translation: EAX10131.1
BC040904 mRNA Translation: AAH40904.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13163.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B47739

NCBI Reference Sequences

More...
RefSeqi
NP_842563.1, NM_178311.2
NP_842564.1, NM_178312.2
XP_005260922.1, XM_005260865.4
XP_016883615.1, XM_017028126.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000278765; ENSP00000278765; ENSG00000149435
ENST00000286890; ENSP00000286890; ENSG00000149435
ENST00000335694; ENSP00000337587; ENSG00000149435

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
92086

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:92086

UCSC genome browser

More...
UCSCi
uc002wts.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20491 mRNA Translation: AAA02885.1
L20492 mRNA Translation: AAA35864.1
AL133466 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10125.1
CH471133 Genomic DNA Translation: EAX10129.1
CH471133 Genomic DNA Translation: EAX10130.1
CH471133 Genomic DNA Translation: EAX10131.1
BC040904 mRNA Translation: AAH40904.1
CCDSiCCDS13163.1
PIRiB47739
RefSeqiNP_842563.1, NM_178311.2
NP_842564.1, NM_178312.2
XP_005260922.1, XM_005260865.4
XP_016883615.1, XM_017028126.1

3D structure databases

SMRiQ9BX51
ModBaseiSearch...

Protein-protein interaction databases

BioGridi124906, 1 interactor
IntActiQ9BX51, 1 interactor
STRINGi9606.ENSP00000337587

Protein family/group databases

MEROPSiT03.016

PTM databases

GlyConnecti1259

Polymorphism and mutation databases

BioMutaiGGTLC1
DMDMi34395714

Proteomic databases

jPOSTiQ9BX51
MassIVEiQ9BX51
MaxQBiQ9BX51
PaxDbiQ9BX51
PeptideAtlasiQ9BX51
PRIDEiQ9BX51
ProteomicsDBi79349

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
92086
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278765; ENSP00000278765; ENSG00000149435
ENST00000286890; ENSP00000286890; ENSG00000149435
ENST00000335694; ENSP00000337587; ENSG00000149435
GeneIDi92086
KEGGihsa:92086
UCSCiuc002wts.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
92086
DisGeNETi92086

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GGTLC1
HGNCiHGNC:16437 GGTLC1
HPAiHPA045635
HPA047534
MIMi612338 gene
neXtProtiNX_Q9BX51
OpenTargetsiENSG00000149435
PharmGKBiPA28671

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2410 Eukaryota
COG0405 LUCA
GeneTreeiENSGT00940000154601
HOGENOMiHOG000074069
InParanoidiQ9BX51
OMAiRERNHNT
OrthoDBi1419292at2759
PhylomeDBiQ9BX51

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
92086

Pharos

More...
Pharosi
Q9BX51

Protein Ontology

More...
PROi
PR:Q9BX51

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000149435 Expressed in 90 organ(s), highest expression level in right lung
GenevisibleiQ9BX51 HS

Family and domain databases

InterProiView protein in InterPro
IPR000101 GGT_peptidase
IPR029055 Ntn_hydrolases_N
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00462 G_GLU_TRANSPEPTIDASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGGTL1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BX51
Secondary accession number(s): D3DW43, Q08246
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: August 29, 2003
Last modified: September 18, 2019
This is version 122 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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