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Entry version 140 (13 Nov 2019)
Sequence version 3 (14 Oct 2008)
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Protein

Eukaryotic translation initiation factor 2A

Gene

EIF2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.1 Publication

Caution

Was initially thought to constitute the ortholog of prokaryotic IF-2 (infB) protein.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis, Translation regulation

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9BY44

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Eukaryotic translation initiation factor 2A
Short name:
eIF-2A
Alternative name(s):
65 kDa eukaryotic translation initiation factor 2A
Cleaved into the following chain:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EIF2A
ORF Names:CDA02, MSTP004, MSTP089
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3254 EIF2A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609234 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BY44

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
83939

Open Targets

More...
OpenTargetsi
ENSG00000144895

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485453

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9BY44

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EIF2A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
209572747

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004244661 – 585Eukaryotic translation initiation factor 2AAdd BLAST585
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved; alternate1 Publication
ChainiPRO_00002860762 – 585Eukaryotic translation initiation factor 2A, N-terminally processedAdd BLAST584

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei2N-acetylalanine; in Eukaryotic translation initiation factor 2A, N-terminally processed1 Publication1
Modified residuei5PhosphothreonineCombined sources1
Modified residuei503PhosphoserineCombined sources1
Modified residuei506PhosphoserineCombined sources1
Modified residuei517PhosphoserineCombined sources1
Modified residuei518PhosphothreonineCombined sources1
Modified residuei526PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9BY44

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9BY44

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9BY44

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9BY44

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BY44

PeptideAtlas

More...
PeptideAtlasi
Q9BY44

PRoteomics IDEntifications database

More...
PRIDEi
Q9BY44

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
4015
4834
79581 [Q9BY44-1]
79582 [Q9BY44-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BY44

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BY44

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9BY44

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Expressed at higher level in pancreas, heart, brain and placenta.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000144895 Expressed in 200 organ(s), highest expression level in secondary oocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9BY44 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9BY44 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036256

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123822, 60 interactors

Database of interacting proteins

More...
DIPi
DIP-40272N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q9BY44

Protein interaction database and analysis system

More...
IntActi
Q9BY44, 25 interactors

Molecular INTeraction database

More...
MINTi
Q9BY44

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000417229

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BY44

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati56 – 100WD 1Add BLAST45
Repeati101 – 159WD 2Add BLAST59
Repeati160 – 210WD 3Add BLAST51
Repeati211 – 264WD 4Add BLAST54
Repeati265 – 306WD 5Add BLAST42
Repeati307 – 348WD 6Add BLAST42
Repeati349 – 391WD 7Add BLAST43

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili531 – 582Sequence analysisAdd BLAST52

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat EIF2A family.Curated

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2315 Eukaryota
COG5354 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111053

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000193775

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BY44

KEGG Orthology (KO)

More...
KOi
K15026

Identification of Orthologs from Complete Genome Data

More...
OMAi
TYLSTWE

Database of Orthologous Groups

More...
OrthoDBi
464990at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BY44

TreeFam database of animal gene trees

More...
TreeFami
TF105866

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011387 TIF2A
IPR013979 TIF_beta_prop-like
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR13227 PTHR13227, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08662 eIF2A, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF017222 eIF2A, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BY44-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPSTPLLTV RGSEGLYMVN GPPHFTESTV FPRESGKNCK VCIFSKDGTL
60 70 80 90 100
FAWGNGEKVN IISVTNKGLL HSFDLLKAVC LEFSPKNTVL ATWQPYTTSK
110 120 130 140 150
DGTAGIPNLQ LYDVKTGTCL KSFIQKKMQN WCPSWSEDET LCARNVNNEV
160 170 180 190 200
HFFENNNFNT IANKLHLQKI NDFVLSPGPQ PYKVAVYVPG SKGAPSFVRL
210 220 230 240 250
YQYPNFAGPH AALANKSFFK ADKVTMLWNK KATAVLVIAS TDVDKTGASY
260 270 280 290 300
YGEQTLHYIA TNGESAVVQL PKNGPIYDVV WNSSSTEFCA VYGFMPAKAT
310 320 330 340 350
IFNLKCDPVF DFGTGPRNAA YYSPHGHILV LAGFGNLRGQ MEVWDVKNYK
360 370 380 390 400
LISKPVASDS TYFAWCPDGE HILTATCAPR LRVNNGYKIW HYTGSILHKY
410 420 430 440 450
DVPSNAELWQ VSWQPFLDGI FPAKTITYQA VPSEVPNEEP KVATAYRPPA
460 470 480 490 500
LRNKPITNSK LHEEEPPQNM KPQSGNDKPL SKTALKNQRK HEAKKAAKQE
510 520 530 540 550
ARSDKSPDLA PTPAPQSTPR NTVSQSISGD PEIDKKIKNL KKKLKAIEQL
560 570 580
KEQAATGKQL EKNQLEKIQK ETALLQELED LELGI
Length:585
Mass (Da):64,990
Last modified:October 14, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i63D63C0676F232C9
GO
Isoform 2 (identifier: Q9BY44-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-213: Missing.
     214-219: ANKSFF → MFQEV

Note: No experimental confirmation available.
Show »
Length:371
Mass (Da):41,339
Checksum:i0D4454F18732DBD2
GO
Isoform 3 (identifier: Q9BY44-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-58: Missing.

Note: No experimental confirmation available.
Show »
Length:560
Mass (Da):62,289
Checksum:iAE5E408990B0CC21
GO
Isoform 4 (identifier: Q9BY44-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     98-158: Missing.

Note: No experimental confirmation available.
Show »
Length:524
Mass (Da):57,994
Checksum:iE6F35813714656EF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WAE5F8WAE5_HUMAN
Eukaryotic translation initiation f...
EIF2A
580Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5R5H7C5R5_HUMAN
Eukaryotic translation initiation f...
EIF2A
316Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5Q3H7C5Q3_HUMAN
Eukaryotic translation initiation f...
EIF2A
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9IZE1C9IZE1_HUMAN
Eukaryotic translation initiation f...
EIF2A
236Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WAT3F8WAT3_HUMAN
Eukaryotic translation initiation f...
EIF2A
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WF18F8WF18_HUMAN
Eukaryotic translation initiation f...
EIF2A
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5Q4H7C5Q4_HUMAN
Eukaryotic translation initiation f...
EIF2A
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK14926 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAM83402 differs from that shown. Reason: Frameshift.Curated
The sequence AAQ13506 differs from that shown. Reason: Frameshift.Curated
The sequence AAQ13612 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti7L → F in AAQ13612 (Ref. 4) Curated1
Sequence conflicti14 – 16EGL → LRT in AAQ13612 (Ref. 4) Curated3
Sequence conflicti54G → A in AAM83402 (PubMed:12133843).Curated1
Sequence conflicti55N → I in AAM83402 (PubMed:12133843).Curated1
Sequence conflicti84S → P in BAB55058 (PubMed:14702039).Curated1
Sequence conflicti150V → A in AAQ13612 (Ref. 4) Curated1
Sequence conflicti173F → S in AAQ13612 (Ref. 4) Curated1
Sequence conflicti261T → P in AAM83402 (PubMed:12133843).Curated1
Sequence conflicti263G → F in AAM83402 (PubMed:12133843).Curated1
Sequence conflicti268V → L in AAM83402 (PubMed:12133843).Curated1
Sequence conflicti292Y → S in AAM83402 (PubMed:12133843).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03206697T → S5 PublicationsCorresponds to variant dbSNP:rs1132979Ensembl.1
Natural variantiVAR_032067582E → K1 PublicationCorresponds to variant dbSNP:rs17850813Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0249751 – 213Missing in isoform 2. 1 PublicationAdd BLAST213
Alternative sequenceiVSP_05604734 – 58Missing in isoform 3. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_05604898 – 158Missing in isoform 4. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_024976214 – 219ANKSFF → MFQEV in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF497978 mRNA Translation: AAM83402.1 Frameshift.
AK027356 mRNA Translation: BAB55058.1
AK298586 mRNA Translation: BAG60776.1
AK293993 mRNA Translation: BAG57357.1
AF212241 mRNA Translation: AAK14926.1 Different initiation.
AF109358 mRNA Translation: AAQ13506.1 Frameshift.
AF172818 mRNA Translation: AAQ13612.1 Different initiation.
AC107426 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78830.1
CH471052 Genomic DNA Translation: EAW78831.1
BC011885 mRNA Translation: AAH11885.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS46935.1 [Q9BY44-1]
CCDS82859.1 [Q9BY44-4]
CCDS82861.1 [Q9BY44-3]

NCBI Reference Sequences

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RefSeqi
NP_001305972.1, NM_001319043.1 [Q9BY44-3]
NP_001305973.1, NM_001319044.1 [Q9BY44-4]
NP_001305974.1, NM_001319045.1
NP_001305975.1, NM_001319046.1 [Q9BY44-2]
NP_114414.2, NM_032025.4 [Q9BY44-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000406576; ENSP00000385292; ENSG00000144895 [Q9BY44-4]
ENST00000460851; ENSP00000417229; ENSG00000144895 [Q9BY44-1]
ENST00000487799; ENSP00000420537; ENSG00000144895 [Q9BY44-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
83939

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:83939

UCSC genome browser

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UCSCi
uc003eya.4 human [Q9BY44-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF497978 mRNA Translation: AAM83402.1 Frameshift.
AK027356 mRNA Translation: BAB55058.1
AK298586 mRNA Translation: BAG60776.1
AK293993 mRNA Translation: BAG57357.1
AF212241 mRNA Translation: AAK14926.1 Different initiation.
AF109358 mRNA Translation: AAQ13506.1 Frameshift.
AF172818 mRNA Translation: AAQ13612.1 Different initiation.
AC107426 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78830.1
CH471052 Genomic DNA Translation: EAW78831.1
BC011885 mRNA Translation: AAH11885.1
CCDSiCCDS46935.1 [Q9BY44-1]
CCDS82859.1 [Q9BY44-4]
CCDS82861.1 [Q9BY44-3]
RefSeqiNP_001305972.1, NM_001319043.1 [Q9BY44-3]
NP_001305973.1, NM_001319044.1 [Q9BY44-4]
NP_001305974.1, NM_001319045.1
NP_001305975.1, NM_001319046.1 [Q9BY44-2]
NP_114414.2, NM_032025.4 [Q9BY44-1]

3D structure databases

SMRiQ9BY44
ModBaseiSearch...

Protein-protein interaction databases

BioGridi123822, 60 interactors
DIPiDIP-40272N
ELMiQ9BY44
IntActiQ9BY44, 25 interactors
MINTiQ9BY44
STRINGi9606.ENSP00000417229

PTM databases

iPTMnetiQ9BY44
PhosphoSitePlusiQ9BY44
SwissPalmiQ9BY44

Polymorphism and mutation databases

BioMutaiEIF2A
DMDMi209572747

Proteomic databases

EPDiQ9BY44
jPOSTiQ9BY44
MassIVEiQ9BY44
MaxQBiQ9BY44
PaxDbiQ9BY44
PeptideAtlasiQ9BY44
PRIDEiQ9BY44
ProteomicsDBi4015
4834
79581 [Q9BY44-1]
79582 [Q9BY44-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
83939

Genome annotation databases

EnsembliENST00000406576; ENSP00000385292; ENSG00000144895 [Q9BY44-4]
ENST00000460851; ENSP00000417229; ENSG00000144895 [Q9BY44-1]
ENST00000487799; ENSP00000420537; ENSG00000144895 [Q9BY44-3]
GeneIDi83939
KEGGihsa:83939
UCSCiuc003eya.4 human [Q9BY44-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
83939
DisGeNETi83939

GeneCards: human genes, protein and diseases

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GeneCardsi
EIF2A
HGNCiHGNC:3254 EIF2A
HPAiHPA036256
MIMi609234 gene
neXtProtiNX_Q9BY44
OpenTargetsiENSG00000144895
PharmGKBiPA143485453

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2315 Eukaryota
COG5354 LUCA
GeneTreeiENSGT00730000111053
HOGENOMiHOG000193775
InParanoidiQ9BY44
KOiK15026
OMAiTYLSTWE
OrthoDBi464990at2759
PhylomeDBiQ9BY44
TreeFamiTF105866

Enzyme and pathway databases

SIGNORiQ9BY44

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
EIF2A human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
EIF2A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
83939
PharosiQ9BY44

Protein Ontology

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PROi
PR:Q9BY44

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000144895 Expressed in 200 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ9BY44 baseline and differential
GenevisibleiQ9BY44 HS

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR011387 TIF2A
IPR013979 TIF_beta_prop-like
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR13227 PTHR13227, 1 hit
PfamiView protein in Pfam
PF08662 eIF2A, 1 hit
PIRSFiPIRSF017222 eIF2A, 1 hit
SUPFAMiSSF50978 SSF50978, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEIF2A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BY44
Secondary accession number(s): A8MPS6
, B4DF96, B4DQ14, D3DNI9, Q5QTR2, Q7Z4E9, Q8NFM1, Q96EW9, Q96K81
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 14, 2008
Last modified: November 13, 2019
This is version 140 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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