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Entry version 163 (31 Jul 2019)
Sequence version 2 (27 Sep 2005)
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Protein

Zinc finger protein 341

Gene

ZNF341

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional activator of STAT3 involved in the regulation of immune homeostasis. Also able to activate STAT1 transcription.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri53 – 76C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST24
Zinc fingeri322 – 344C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri350 – 372C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri445 – 467C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri473 – 497C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri503 – 525C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri540 – 564C2H2-type 7PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri566 – 588C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri594 – 616C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri622 – 644C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri650 – 677C2H2-type 11PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri683 – 705C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 341
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF341
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15992 ZNF341

Online Mendelian Inheritance in Man (OMIM)

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MIMi
618269 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BYN7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hyper-IgE recurrent infection syndrome 3, autosomal recessive (HIES3)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn immunologic disorder characterized by skin bacterial infections in particular with Staphylococcus aureus, susceptibility to fungal infections such as chronic mucocutaneous candidiasis, atopic dermatitis, recurrent respiratory infections, bronchiectasis, and increased serum IgE and IgG. Immunologic work-up shows impaired differentiation of CD4+ T cells into T-helper 17 cells, decreased memory B cells, and often decreased NK cells. Some patients manifest extrahemapoietic features, including facial dysmorphism, abnormal dentition, alopecia, joint hypermobility and bone fractures. Disease onset is in early childhood.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_081880195 – 854Missing in HIES3; does not localize to the nucleus. 1 PublicationAdd BLAST660
Natural variantiVAR_081881302 – 854Missing in HIES3; absence of the full-length protein in patient cells; loss of function in transcriptional STAT3 activation; loss of DNA binding; does not localize to the nucleus. 2 PublicationsAdd BLAST553
Natural variantiVAR_081882386 – 854Missing in HIES3; decreased function in transcriptional STAT3 activation; severly reduced DNA binding in vitro; does not affect nuclear localization. 1 PublicationAdd BLAST469
Natural variantiVAR_081883549 – 854Missing in HIES3; absence of the full-length protein in patient cells; results in weak DNA binding in vitro; does not affect localization to the nucleus. 1 PublicationAdd BLAST306

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
84905
MIMi618282 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000131061

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA38076

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
ZNF341

Domain mapping of disease mutations (DMDM)

More...
DMDMi
76803837

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000475411 – 854Zinc finger protein 341Add BLAST854

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9BYN7

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9BYN7

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9BYN7

PeptideAtlas

More...
PeptideAtlasi
Q9BYN7

PRoteomics IDEntifications database

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PRIDEi
Q9BYN7

ProteomicsDB human proteome resource

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ProteomicsDBi
79671 [Q9BYN7-1]
79672 [Q9BYN7-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BYN7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BYN7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000131061 Expressed in 119 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9BYN7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9BYN7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA023240
HPA024607
HPA067108

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds DNA and to the STAT3 promoter.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
124344, 8 interactors

Protein interaction database and analysis system

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IntActi
Q9BYN7, 16 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000364346

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9BYN7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi143 – 186Pro-richAdd BLAST44

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri53 – 76C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST24
Zinc fingeri322 – 344C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri350 – 372C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri445 – 467C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri473 – 497C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri503 – 525C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri540 – 564C2H2-type 7PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri566 – 588C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri594 – 616C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri622 – 644C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri650 – 677C2H2-type 11PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri683 – 705C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000000546

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000232006

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9BYN7

Identification of Orthologs from Complete Genome Data

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OMAi
CPFSSHT

Database of Orthologous Groups

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OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9BYN7

TreeFam database of animal gene trees

More...
TreeFami
TF333164

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096 zf-C2H2, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 12 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF57667 SSF57667, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9BYN7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQAIFEALE GMDNQTVLAV QSLLDGQGAV PDPTGQSVNA PPAIQPLDDE
60 70 80 90 100
DVFLCGKCKK QFNSLPAFMT HKREQCQGNA PALATVSLAT NSIYPPSAAP
110 120 130 140 150
TAVQQAPTPA NRQISTYITV PPSPLIQTLV QGNILVSDDV LMSAMSAFTS
160 170 180 190 200
LDQPMPQGPP PVQSSLNMHS VPSYLTQPPP PPPPPPPLPP PPPPQPPPPP
210 220 230 240 250
PQSLGPPGRP NPGGNGVVEV YSAAAPLAGS GTVEIQALGM QPYPPLEVPN
260 270 280 290 300
QCVEPPVYPT PTVYSPGKQG FKPKGPNPAA PMTSATGGTV ATFDSPATLK
310 320 330 340 350
TRRAKGARGL PEAAGKPKAQ KLKCSYCDKS FTKNFDLQQH IRSHTGEKPF
360 370 380 390 400
QCIACGRAFA QKSNVKKHMQ THKVWPPGHS GGTVSRNSVT VQVMALNPSR
410 420 430 440 450
QEDEESTGLG QPLPGAPQPQ ALSTAGEEEG DKPESKQVVL IDSSYLCQFC
460 470 480 490 500
PSKFSTYFQL KSHMTQHKNE QVYKCVVKSC AQTFPKLDTF LEHIKSHQEE
510 520 530 540 550
LSYRCHLCGK DFPSLYDLGV HQYSHSLLPQ HSPKKDNAVY KCVKCVNKYS
560 570 580 590 600
TPEALEHHLQ TATHNFPCPH CQKVFPCERY LRRHLPTHGS GGRFKCQVCK
610 620 630 640 650
KFFRREHYLK LHAHIHSGEK PYKCSVCESA FNRKDKLKRH MLIHEPFKKY
660 670 680 690 700
KCPFSTHTGC SKEFNRPDKL KAHILSHSGM KLHKCALCSK SFSRRAHLAE
710 720 730 740 750
HQRAHTGNYK FRCAGCAKGF SRHKYLKDHR CRLGPQKDKD LQTRRPPQRR
760 770 780 790 800
AAPRSCGSGG RKVLTPLPDP LGLEELKDTG AGLVPEAVPG KPPFAEPDAV
810 820 830 840 850
LSIVVGGAVG AETELVVPGH AEGLGSNLAL AELQAGAEGP CAMLAVPVYI

QASE
Note: No experimental confirmation available.
Length:854
Mass (Da):92,728
Last modified:September 27, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1198203F2C7ECF07
GO
Isoform 2 (identifier: Q9BYN7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     306-312: Missing.

Note: Gene prediction based on EST data.
Show »
Length:847
Mass (Da):92,047
Checksum:iF386C0D71EDB6936
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PN62E9PN62_HUMAN
Zinc finger protein 341
ZNF341
604Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQQ0E9PQQ0_HUMAN
Zinc finger protein 341
ZNF341
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB55193 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti659G → D in BAB55193 (PubMed:14702039).Curated1
Sequence conflicti706T → M in BAB55193 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_081880195 – 854Missing in HIES3; does not localize to the nucleus. 1 PublicationAdd BLAST660
Natural variantiVAR_081881302 – 854Missing in HIES3; absence of the full-length protein in patient cells; loss of function in transcriptional STAT3 activation; loss of DNA binding; does not localize to the nucleus. 2 PublicationsAdd BLAST553
Natural variantiVAR_081882386 – 854Missing in HIES3; decreased function in transcriptional STAT3 activation; severly reduced DNA binding in vitro; does not affect nuclear localization. 1 PublicationAdd BLAST469
Natural variantiVAR_081883549 – 854Missing in HIES3; absence of the full-length protein in patient cells; results in weak DNA binding in vitro; does not affect localization to the nucleus. 1 PublicationAdd BLAST306

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_027218306 – 312Missing in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL050349 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76295.1
BC132873 mRNA Translation: AAI32874.1
BC144188 mRNA Translation: AAI44189.1
BC146811 mRNA Translation: AAI46812.1
BC157823 mRNA Translation: AAI57824.1
AK027550 mRNA Translation: BAB55193.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS13227.1 [Q9BYN7-2]
CCDS74719.1 [Q9BYN7-1]

NCBI Reference Sequences

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RefSeqi
NP_001269862.1, NM_001282933.1 [Q9BYN7-1]
NP_001269864.1, NM_001282935.1
NP_116208.3, NM_032819.4 [Q9BYN7-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000342427; ENSP00000344308; ENSG00000131061 [Q9BYN7-2]
ENST00000375200; ENSP00000364346; ENSG00000131061 [Q9BYN7-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
84905

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:84905

UCSC genome browser

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UCSCi
uc002wzx.5 human [Q9BYN7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL050349 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76295.1
BC132873 mRNA Translation: AAI32874.1
BC144188 mRNA Translation: AAI44189.1
BC146811 mRNA Translation: AAI46812.1
BC157823 mRNA Translation: AAI57824.1
AK027550 mRNA Translation: BAB55193.1 Different initiation.
CCDSiCCDS13227.1 [Q9BYN7-2]
CCDS74719.1 [Q9BYN7-1]
RefSeqiNP_001269862.1, NM_001282933.1 [Q9BYN7-1]
NP_001269864.1, NM_001282935.1
NP_116208.3, NM_032819.4 [Q9BYN7-2]

3D structure databases

SMRiQ9BYN7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi124344, 8 interactors
IntActiQ9BYN7, 16 interactors
STRINGi9606.ENSP00000364346

PTM databases

iPTMnetiQ9BYN7
PhosphoSitePlusiQ9BYN7

Polymorphism and mutation databases

BioMutaiZNF341
DMDMi76803837

Proteomic databases

jPOSTiQ9BYN7
MaxQBiQ9BYN7
PaxDbiQ9BYN7
PeptideAtlasiQ9BYN7
PRIDEiQ9BYN7
ProteomicsDBi79671 [Q9BYN7-1]
79672 [Q9BYN7-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
84905
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342427; ENSP00000344308; ENSG00000131061 [Q9BYN7-2]
ENST00000375200; ENSP00000364346; ENSG00000131061 [Q9BYN7-1]
GeneIDi84905
KEGGihsa:84905
UCSCiuc002wzx.5 human [Q9BYN7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84905
DisGeNETi84905

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF341
HGNCiHGNC:15992 ZNF341
HPAiHPA023240
HPA024607
HPA067108
MIMi618269 gene
618282 phenotype
neXtProtiNX_Q9BYN7
OpenTargetsiENSG00000131061
PharmGKBiPA38076

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00390000000546
HOGENOMiHOG000232006
InParanoidiQ9BYN7
OMAiCPFSSHT
OrthoDBi1318335at2759
PhylomeDBiQ9BYN7
TreeFamiTF333164

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF341 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84905

Protein Ontology

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PROi
PR:Q9BYN7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000131061 Expressed in 119 organ(s), highest expression level in blood
ExpressionAtlasiQ9BYN7 baseline and differential
GenevisibleiQ9BYN7 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN341_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BYN7
Secondary accession number(s): A2RUF4
, B2RXE5, B7ZM09, Q5JXM8, Q96ST5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: September 27, 2005
Last modified: July 31, 2019
This is version 163 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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