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Entry version 162 (03 Jul 2019)
Sequence version 2 (24 May 2004)
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Protein

Natural killer cell receptor 2B4

Gene

CD244

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Acts as activating natural killer (NK) cell receptor (PubMed:10359122, PubMed:8376943, PubMed:11714776). Activating function implicates association with SH2D1A and FYN (PubMed:15713798). Downstreaming signaling involves predominantly VAV1, and, to a lesser degree, INPP5D/SHIP1 and CBL. Signal attenuation in the absence of SH2D1A is proposed to be dependent on INPP5D and to a lesser extent PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:10934222, PubMed:15713798). Stimulates NK cell cytotoxicity, production of IFN-gamma and granule exocytosis (PubMed:8376943, PubMed:11714776). Optimal expansion and activation of NK cells seems to be dependent on the engagement of CD244 with CD48 expressed on neighboring NK cells (By similarity). Acts as costimulator in NK activation by enhancing signals by other NK receptors such as NCR3 and NCR1 (PubMed:10741393). At early stages of NK cell differentiation may function as an inhibitory receptor possibly ensuring the self-tolerance of developing NK cells (PubMed:11917118). Involved in the regulation of CD8+ T-cell proliferation; expression on activated T-cells and binding to CD488 provides costimulatory-like function for neighboring T-cells (By similarity). Inhibits inflammatory responses in dendritic cells (DCs) (By similarity).By similarity1 Publication6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • MHC class I protein binding Source: UniProtKB
  • signaling receptor activity Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processAdaptive immunity, Immunity, Innate immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-202733 Cell surface interactions at the vascular wall

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q9BZW8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Natural killer cell receptor 2B4
Alternative name(s):
NK cell activation-inducing ligand
Short name:
NAIL
NK cell type I receptor protein 2B4
Short name:
NKR2B4
Short name:
h2B4
SLAM family member 4
Short name:
SLAMF4
Signaling lymphocytic activation molecule 4
CD_antigen: CD244
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CD244
Synonyms:2B4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:18171 CD244

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605554 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9BZW8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 229ExtracellularSequence analysisAdd BLAST208
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei230 – 250HelicalSequence analysisAdd BLAST21
Topological domaini251 – 370CytoplasmicSequence analysisAdd BLAST120

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi68K → A: Disrupts interaction with CD48; when associated with A-70. 1 Publication1
Mutagenesisi70E → A: Disrupts interaction with CD48; when associated with A-68. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
51744

MalaCards human disease database

More...
MalaCardsi
CD244

Open Targets

More...
OpenTargetsi
ENSG00000122223

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134905192

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CD244

Domain mapping of disease mutations (DMDM)

More...
DMDMi
47605541

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 212 PublicationsAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001466822 – 370Natural killer cell receptor 2B4Add BLAST349

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi71N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi77N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi89N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi157 ↔ 199PROSITE-ProRule annotation
Glycosylationi164N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi181N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi200N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi213N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei271Phosphotyrosine3 Publications1
Modified residuei297Phosphotyrosine; by FYN3 Publications1
Modified residuei317Phosphotyrosine2 Publications1
Modified residuei342Phosphotyrosine; by FYN2 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-linked glycosylation is essential for the binding to its ligand CD48. Also O-glycosylated, in contrast, O-linked sialylation has a negative impact on ligand binding.1 Publication
Phosphorylated by FYN and CSK on tyrosine residues following activation. Coligation with inhibitory receptors such as KIR2DL1 inhibits phosphorylation upon contact of NK cells with sensitive target cells.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9BZW8

PeptideAtlas

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PeptideAtlasi
Q9BZW8

PRoteomics IDEntifications database

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PRIDEi
Q9BZW8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
79913
79914 [Q9BZW8-2]
79915 [Q9BZW8-3]
79916 [Q9BZW8-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9BZW8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9BZW8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in spleen, PBL, followed by lung, liver, testis and small intestine. Expressed in all natural killer (NK) cells, monocytes and basophils, TCR-gamma/delta+ T-cells, monocytes, basophils, and on a subset of CD8+ T-cells.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000122223 Expressed in 96 organ(s), highest expression level in leukocyte

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9BZW8 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CD48 (PubMed:9841922).

Interacts (via phosphorylated ITSM 1-4) with SH2D1A (via SH2 domain); SH2D1A probably mediates association with FYN.

Interacts (via phosphorylated ITSM 3) with PTPN11/SHP-2, INPP5D/SHIP1, PTPN6/SHP-1 and CSK; binding of SH2D1A/SAP prevents association with PTPN11, PTPN6 and CSK; conflictingly a similar association has been described for phosphorylated ITSM 1 also including GRB2 and PLCG1.

Interacts weakly (via phosphorylated ITSM 2) with PTPN11/SHP-2 and CSK (PubMed:10358138, PubMed:10934222, PubMed:12458214, PubMed:24642916, PubMed:26221972, PubMed:15713798).

Interacts with SH2D1B (PubMed:12458214, PubMed:24642916).

Interacts with PIK3R1; PI3K recruits SH2D1A (PubMed:11815622).

Interacts with MHC class I proteins; the interaction is proposed to prevent self-killing of NK cells.

By similarity12 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119709, 25 interactors

Database of interacting proteins

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DIPi
DIP-40331N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q9BZW8

Protein interaction database and analysis system

More...
IntActi
Q9BZW8, 16 interactors

Molecular INTeraction database

More...
MINTi
Q9BZW8

STRING: functional protein association networks

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STRINGi
9606.ENSP00000357012

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9BZW8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 127Ig-like 1Add BLAST106
Domaini131 – 215Ig-like 2Add BLAST85

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi269 – 274ITSM 1By similarity6
Motifi295 – 300ITSM 2By similarity6
Motifi315 – 320ITSM 3By similarity6
Motifi340 – 345ITSM 4By similarity6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The ITSMs (immunoreceptor tyrosine-based switch motifs) with the consensus sequence T-X-Y-X-X-[VI] present in SLAM family receptors have overlapping specificity for activating and inhibitory SH2 domain-containing binding partners. Especially they mediate the interaction with the SH2 domain of SH2D1A and SH2D1B. A 'three-pronged' mechanism is proposed involving threonine (position -2), phosphorylated tyrosine (position 0) and valine/isoleucine (position +3).By similarity2 Publications

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IKYZ Eukaryota
ENOG410Y74Q LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000182746

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9BZW8

KEGG Orthology (KO)

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KOi
K06582

Identification of Orthologs from Complete Genome Data

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OMAi
QDCQNAH

Database of Orthologous Groups

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OrthoDBi
1532935at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9BZW8

TreeFam database of animal gene trees

More...
TreeFami
TF334964

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR024304 NK_rcpt_2B4
IPR024303 NK_rcpt_2B4_Ig_dom

The PANTHER Classification System

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PANTHERi
PTHR12080:SF56 PTHR12080:SF56, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF13895 Ig_2, 1 hit
PF11465 Receptor_2B4, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48726 SSF48726, 2 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9BZW8-1) [UniParc]FASTAAdd to basket
Also known as: H2B4-B

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLGQVVTLIL LLLLKVYQGK GCQGSADHVV SISGVPLQLQ PNSIQTKVDS
60 70 80 90 100
IAWKKLLPSQ NGFHHILKWE NGSLPSNTSN DRFSFIVKNL SLLIKAAQQQ
110 120 130 140 150
DSGLYCLEVT SISGKVQTAT FQVFVFESLL PDKVEKPRLQ GQGKILDRGR
160 170 180 190 200
CQVALSCLVS RDGNVSYAWY RGSKLIQTAG NLTYLDEEVD INGTHTYTCN
210 220 230 240 250
VSNPVSWESH TLNLTQDCQN AHQEFRFWPF LVIIVILSAL FLGTLACFCV
260 270 280 290 300
WRRKRKEKQS ETSPKEFLTI YEDVKDLKTR RNHEQEQTFP GGGSTIYSMI
310 320 330 340 350
QSQSSAPTSQ EPAYTLYSLI QPSRKSGSRK RNHSPSFNST IYEVIGKSQP
360 370
KAQNPARLSR KELENFDVYS
Length:370
Mass (Da):41,616
Last modified:May 24, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i959FF8DBB0BACC87
GO
Isoform 2 (identifier: Q9BZW8-2) [UniParc]FASTAAdd to basket
Also known as: H2B4-A

The sequence of this isoform differs from the canonical sequence as follows:
     127-131: Missing.

Note: Binds to CD48 with a sronger affinity than isoform 1, and interactions induces greater cytotoxicity and intracellular calcium release.
Show »
Length:365
Mass (Da):41,077
Checksum:i7DEDD0EBF2E19322
GO
Isoform 3 (identifier: Q9BZW8-3) [UniParc]FASTAAdd to basket
Also known as: H2B4

The sequence of this isoform differs from the canonical sequence as follows:
     127-131: Missing.
     326-334: SGSRKRNHS → GDRFYSFSG
     335-370: Missing.

Note: No experimental confirmation available.
Show »
Length:329
Mass (Da):36,987
Checksum:i639FE10EA76F074E
GO
Isoform 4 (identifier: Q9BZW8-4) [UniParc]FASTAAdd to basket
Also known as: H2B4b

The sequence of this isoform differs from the canonical sequence as follows:
     128-224: Missing.

Note: No experimental confirmation available.
Show »
Length:273
Mass (Da):30,784
Checksum:i036514F046E2099C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti127 – 133ESLLPDK → GMAMCPM in AAK50015 (PubMed:15489334).Curated7

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05603689N → D. Corresponds to variant dbSNP:rs34846692Ensembl.1
Natural variantiVAR_056037323S → F. Corresponds to variant dbSNP:rs12064925Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_010397127 – 131Missing in isoform 2 and isoform 3. 7 Publications5
Alternative sequenceiVSP_010398128 – 224Missing in isoform 4. 1 PublicationAdd BLAST97
Alternative sequenceiVSP_010399326 – 334SGSRKRNHS → GDRFYSFSG in isoform 3. 1 Publication9
Alternative sequenceiVSP_010400335 – 370Missing in isoform 3. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF105261 mRNA Translation: AAD32538.1
AF117711 mRNA Translation: AAF28833.1
AF145782 mRNA Translation: AAD38951.1
AF107761 mRNA Translation: AAD37838.1
AF242540 mRNA Translation: AAK00233.1
AJ245376 mRNA Translation: CAC00648.1
AJ245377 mRNA Translation: CAC00649.1
AJ245375 mRNA Translation: CAC00647.1
AL354714 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52691.1
CH471121 Genomic DNA Translation: EAW52692.1
CH471121 Genomic DNA Translation: EAW52693.1
BC028073 mRNA Translation: AAH28073.1
BC053985 mRNA Translation: AAH53985.1
AF363452 mRNA Translation: AAK50015.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS1210.1 [Q9BZW8-2]
CCDS53398.1 [Q9BZW8-4]
CCDS53399.1 [Q9BZW8-1]

NCBI Reference Sequences

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RefSeqi
NP_001160135.1, NM_001166663.1 [Q9BZW8-1]
NP_001160136.1, NM_001166664.1 [Q9BZW8-4]
NP_057466.1, NM_016382.3 [Q9BZW8-2]
XP_011507924.1, XM_011509622.2 [Q9BZW8-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000322302; ENSP00000313619; ENSG00000122223 [Q9BZW8-4]
ENST00000368033; ENSP00000357012; ENSG00000122223 [Q9BZW8-1]
ENST00000368034; ENSP00000357013; ENSG00000122223 [Q9BZW8-2]
ENST00000492063; ENSP00000432636; ENSG00000122223 [Q9BZW8-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
51744

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:51744

UCSC genome browser

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UCSCi
uc001fxa.4 human [Q9BZW8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF105261 mRNA Translation: AAD32538.1
AF117711 mRNA Translation: AAF28833.1
AF145782 mRNA Translation: AAD38951.1
AF107761 mRNA Translation: AAD37838.1
AF242540 mRNA Translation: AAK00233.1
AJ245376 mRNA Translation: CAC00648.1
AJ245377 mRNA Translation: CAC00649.1
AJ245375 mRNA Translation: CAC00647.1
AL354714 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52691.1
CH471121 Genomic DNA Translation: EAW52692.1
CH471121 Genomic DNA Translation: EAW52693.1
BC028073 mRNA Translation: AAH28073.1
BC053985 mRNA Translation: AAH53985.1
AF363452 mRNA Translation: AAK50015.1
CCDSiCCDS1210.1 [Q9BZW8-2]
CCDS53398.1 [Q9BZW8-4]
CCDS53399.1 [Q9BZW8-1]
RefSeqiNP_001160135.1, NM_001166663.1 [Q9BZW8-1]
NP_001160136.1, NM_001166664.1 [Q9BZW8-4]
NP_057466.1, NM_016382.3 [Q9BZW8-2]
XP_011507924.1, XM_011509622.2 [Q9BZW8-3]

3D structure databases

SMRiQ9BZW8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi119709, 25 interactors
DIPiDIP-40331N
ELMiQ9BZW8
IntActiQ9BZW8, 16 interactors
MINTiQ9BZW8
STRINGi9606.ENSP00000357012

PTM databases

iPTMnetiQ9BZW8
PhosphoSitePlusiQ9BZW8

Polymorphism and mutation databases

BioMutaiCD244
DMDMi47605541

Proteomic databases

PaxDbiQ9BZW8
PeptideAtlasiQ9BZW8
PRIDEiQ9BZW8
ProteomicsDBi79913
79914 [Q9BZW8-2]
79915 [Q9BZW8-3]
79916 [Q9BZW8-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
51744
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322302; ENSP00000313619; ENSG00000122223 [Q9BZW8-4]
ENST00000368033; ENSP00000357012; ENSG00000122223 [Q9BZW8-1]
ENST00000368034; ENSP00000357013; ENSG00000122223 [Q9BZW8-2]
ENST00000492063; ENSP00000432636; ENSG00000122223 [Q9BZW8-3]
GeneIDi51744
KEGGihsa:51744
UCSCiuc001fxa.4 human [Q9BZW8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51744
DisGeNETi51744

GeneCards: human genes, protein and diseases

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GeneCardsi
CD244
HGNCiHGNC:18171 CD244
MalaCardsiCD244
MIMi605554 gene
neXtProtiNX_Q9BZW8
OpenTargetsiENSG00000122223
PharmGKBiPA134905192

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IKYZ Eukaryota
ENOG410Y74Q LUCA
GeneTreeiENSGT00950000182746
InParanoidiQ9BZW8
KOiK06582
OMAiQDCQNAH
OrthoDBi1532935at2759
PhylomeDBiQ9BZW8
TreeFamiTF334964

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall
SignaLinkiQ9BZW8

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CD244 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CD244

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
51744

Protein Ontology

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PROi
PR:Q9BZW8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000122223 Expressed in 96 organ(s), highest expression level in leukocyte
GenevisibleiQ9BZW8 HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR024304 NK_rcpt_2B4
IPR024303 NK_rcpt_2B4_Ig_dom
PANTHERiPTHR12080:SF56 PTHR12080:SF56, 1 hit
PfamiView protein in Pfam
PF13895 Ig_2, 1 hit
PF11465 Receptor_2B4, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCD244_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9BZW8
Secondary accession number(s): Q5VYI2
, Q5VYI6, Q5VYI7, Q96T47, Q9NQD2, Q9NQD3, Q9Y288
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: July 3, 2019
This is version 162 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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