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Entry version 117 (18 Sep 2019)
Sequence version 1 (01 Mar 2001)
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Protein

Phosphoinositide 3-kinase adapter protein 1

Gene

Pik3ap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL.7 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1257604 PIP3 activates AKT signaling
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-MMU-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphoinositide 3-kinase adapter protein 1
Alternative name(s):
B-cell adapter for phosphoinositide 3-kinase
B-cell phosphoinositide 3-kinase adapter protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pik3ap1
Synonyms:Bcap
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:1933177 Pik3ap1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice lacking Pik3ap1 display altered B-cell maturation and impaired immune function. Pik3ap1 depletion has an opposite effect in NK cells by promoting their maturation. Mice lacking Pik3ap1 and Cd19 have severe defects in generation of immature and mature B-cells. Moreover, mice lacking Pik3ap1 display increased IL-10, Il-12 and TNF proinflammatory cytokine secretion upon activation of the Toll-like receptors TLR4, TLR7 and TLR9.4 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi264Y → F: Fails to bind PIK3R1 in a BCR-signaling dependent manner; when associated with Y-420; Y-445 and Y-460. Loss of regulatory function in Toll-like receptor signaling probably due to loss of interaction with PIK3R1; when associated with Y-420; Y-445 and Y-460. Impairs mature B-cell generation; when associated with Y-420; Y-445 and Y-460. 1 Publication1
Mutagenesisi420Y → F: Fails to bind PIK3R1 in a BCR-signaling dependent manner; when associated with Y-264; Y-445 and Y-460. Loss of regulatory function in Toll-like receptor signaling probably due to loss of interaction with PIK3R1; when associated with Y-264; Y-445 and Y-460. Impairs mature B-cell generation; when associated with Y-264; Y-445 and Y-460. 1 Publication1
Mutagenesisi445Y → F: Fails to bind PIK3R1 in a BCR-signaling dependent manner; when associated with Y-264; Y-420 and Y-460. Loss of regulatory function in Toll-like receptor signaling probably due to loss of interaction with PIK3R1; when associated with Y-264; Y-420 and Y-460. Impairs mature B-cell generation; when associated with Y-264; Y-420 and Y-460. 1 Publication1
Mutagenesisi460Y → F: Fails to bind PIK3R1 in a BCR-signaling dependent manner; when associated with Y-264; Y-420 and Y-445. Loss of regulatory function in Toll-like receptor signaling probably due to loss of interaction with PIK3R1; when associated with Y-264; Y-420 and Y-445. Impairs mature B-cell generation; when associated with Y-264; Y-420 and Y-445. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003412741 – 811Phosphoinositide 3-kinase adapter protein 1Add BLAST811

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei264Phosphotyrosine2 Publications1
Modified residuei420Phosphotyrosine; by SYK3 Publications1
Modified residuei445Phosphotyrosine; by SYK3 Publications1
Modified residuei460Phosphotyrosine; by SYK3 Publications1
Modified residuei513Phosphotyrosine; by ABL1By similarity1
Modified residuei553Phosphotyrosine; by ABL1By similarity1
Modified residuei570Phosphotyrosine; by ABL1By similarity1
Modified residuei594Phosphotyrosine; by ABL1By similarity1
Modified residuei642PhosphoserineBy similarity1
Modified residuei694Phosphotyrosine; by ABL1By similarity1
Modified residuei718PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Constitutively phosphorylated. Phosphorylated on tyrosine residues in C-terminal region by ABL1 (By similarity). Phosphorylated on tyrosine residues within the YXXM motifs by BTK and SYK. Isoform 1 and isoform 2 are phosphorylated on tyrosine residues, most likely within the YXXM motifs, via CD19 activation. Toll-like receptor activation induces appearance of a phosphorylated form associated with membranes.By similarity5 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9EQ32

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9EQ32

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9EQ32

PeptideAtlas

More...
PeptideAtlasi
Q9EQ32

PRoteomics IDEntifications database

More...
PRIDEi
Q9EQ32

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9EQ32

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9EQ32

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9EQ32

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in spleen (at protein level). Expressed at lower levels in thymus, liver and lung. Expressed in B-cells, macrophages and natural killer (NK) cells.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSMUSG00000025017 Expressed in 37 organ(s), highest expression level in bone marrow macrophage

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9EQ32 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer (Probable).

Interacts (phosphorylated on tyrosine residues within YXXM motifs) with PIK3R1 (via SH2 domain); required for BCR- and TLR-mediated activation of phosphoinositide 3-kinase.

Interacts (via polyproline C-terminal region) with ABI1 (via SH3 domain); the interaction promotes phosphorylation of PIK3AP1 by ABL1 (By similarity). May interact with MYD88 and TIRAP.

By similarityCurated3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
219934, 1 interactor

Protein interaction database and analysis system

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IntActi
Q9EQ32, 8 interactors

Molecular INTeraction database

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MINTi
Q9EQ32

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000052777

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9EQ32

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini182 – 318DBBPROSITE-ProRule annotationAdd BLAST137

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni10 – 145Necessary and sufficient to mediate inhibition of NF-kappa-B downstream of activated TLRs; may mediate interaction with MYD88 and TIRAP1 PublicationAdd BLAST136

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi760 – 808Pro-richAdd BLAST49

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DBB domain is required for dimerization.

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IKKC Eukaryota
ENOG4110NCP LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000008787

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9EQ32

KEGG Orthology (KO)

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KOi
K12230

Identification of Orthologs from Complete Genome Data

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OMAi
YVETADM

Database of Orthologous Groups

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OrthoDBi
280243at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9EQ32

TreeFam database of animal gene trees

More...
TreeFami
TF328570

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.50.10140, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR017893 DBB_domain
IPR041340 PIK3AP1_TIR
IPR035897 Toll_tir_struct_dom_sf

Pfam protein domain database

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Pfami
View protein in Pfam
PF14545 DBB, 1 hit
PF18567 TIR_3, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01282 DBB, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51376 DBB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9EQ32-1) [UniParc]FASTAAdd to basket
Also known as: BCAP-L

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAASGWGRGC DILIFYSPDA EEWCQYLQDL FVSCRQVRSQ KTQTYRLVPD
60 70 80 90 100
ASFSAQDLWV FRDARCVLVL LSAGLVGCFG QPGLLPMLQR ACHPPQRVVR
110 120 130 140 150
LLCGVQPGDE DFQAFFPDWA HWQEMTCDDE PETYLAAVRK AISEDSGCDS
160 170 180 190 200
VTDTEPEDER ELPFSKQTNL PPEISPGNLM VVQPDRIRCG AETTVYIIVR
210 220 230 240 250
CKLDEKVSTE AEFSPEDSPS IRVEGTLENE YTVSVKAPDL SSGNVSLKVY
260 270 280 290 300
SGDLVVCETT VSYYTDMEEI GNLLSSAANP VEFMCQAFKI VPYNTETLDK
310 320 330 340 350
LLTESLKNNI PASGLHLFGI NQLEEDDMMT NQRDEELPTL LHFAAKYGLK
360 370 380 390 400
NLTALLLTCP GALQAYSVAN KHGHYPNTIA EKHGFRDLRQ FIDEYVETVD
410 420 430 440 450
MLKTHIKEEL MQGEEADDVY ESMAHLSTDL LMKCSLNPGC DDELYESMAA
460 470 480 490 500
FAPAATEDLY VEMLQASAGN PVSGESFSRP TKDSMIRKFL EGNSVKPASW
510 520 530 540 550
EREQHHPYGE ELYHIVDEDE TFSVDLANRP PVPVPRPEAS APGPPPPPDN
560 570 580 590 600
EPYISKVFAE KSQERLGNFY VSSESIRKEP LVRPWRDRPP SSIYDPFAGM
610 620 630 640 650
KTPGQRQLIT LQEQVKLGIV NVDEAVLHFK EWQLNQKKRS ESFRFQQENL
660 670 680 690 700
KRLRESITRR RKEKPKSGKH TDLEITVPIR HSQHLPEKVE FGVYESGPRK
710 720 730 740 750
SVLPARTELR RGDWKTDSMS STASSTSNRS STRSLLSVSS GMEGDNEDNE
760 770 780 790 800
IPEITRSRGP GPTQVDGAPV VTGTPVGTLE RPPRVPPRAA SQRPLTRESF
810
HPPPPVPPRG R
Length:811
Mass (Da):90,928
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3268E89B5C73F218
GO
Isoform 2 (identifier: Q9EQ32-2) [UniParc]FASTAAdd to basket
Also known as: BCAP-S

The sequence of this isoform differs from the canonical sequence as follows:
     1-179: Missing.

Show »
Length:632
Mass (Da):70,809
Checksum:i4F0FE6801E34684A
GO
Isoform 3 (identifier: Q9EQ32-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     493-517: NSVKPASWEREQHHPYGEELYHIVD → KLSLIREAETLVFKGQVATDMACDD
     518-811: Missing.

Show »
Length:517
Mass (Da):57,643
Checksum:i38B3FFBB3B556AC5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti206K → N in BAE42191 (PubMed:16141072).Curated1
Sequence conflicti414E → G in BAE41584 (PubMed:16141072).Curated1
Sequence conflicti414E → G in BAE42118 (PubMed:16141072).Curated1
Sequence conflicti509G → GE in AAI13142 (PubMed:15489334).Curated1
Sequence conflicti768A → AP in BAC40962 (PubMed:16141072).Curated1
Sequence conflicti768A → AP in BAE42191 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0342411 – 179Missing in isoform 2. 1 PublicationAdd BLAST179
Alternative sequenceiVSP_034242493 – 517NSVKP…YHIVD → KLSLIREAETLVFKGQVATD MACDD in isoform 3. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_034243518 – 811Missing in isoform 3. 1 PublicationAdd BLAST294

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF293806 mRNA Translation: AAG48584.1
AK087722 mRNA Translation: BAC39980.1
AK089785 mRNA Translation: BAC40962.1
AK150114 mRNA Translation: BAE29318.1
AK153548 mRNA Translation: BAE32085.1
AK170130 mRNA Translation: BAE41584.1
AK170925 mRNA Translation: BAE42118.1
AK171021 mRNA Translation: BAE42191.1
BC113141 mRNA Translation: AAI13142.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS37987.1 [Q9EQ32-1]

NCBI Reference Sequences

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RefSeqi
NP_113553.1, NM_031376.3 [Q9EQ32-1]
XP_006527535.1, XM_006527472.3 [Q9EQ32-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000059672; ENSMUSP00000052777; ENSMUSG00000025017 [Q9EQ32-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
83490

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:83490

UCSC genome browser

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UCSCi
uc008hlu.1 mouse [Q9EQ32-1]
uc008hlv.1 mouse [Q9EQ32-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF293806 mRNA Translation: AAG48584.1
AK087722 mRNA Translation: BAC39980.1
AK089785 mRNA Translation: BAC40962.1
AK150114 mRNA Translation: BAE29318.1
AK153548 mRNA Translation: BAE32085.1
AK170130 mRNA Translation: BAE41584.1
AK170925 mRNA Translation: BAE42118.1
AK171021 mRNA Translation: BAE42191.1
BC113141 mRNA Translation: AAI13142.1
CCDSiCCDS37987.1 [Q9EQ32-1]
RefSeqiNP_113553.1, NM_031376.3 [Q9EQ32-1]
XP_006527535.1, XM_006527472.3 [Q9EQ32-2]

3D structure databases

SMRiQ9EQ32
ModBaseiSearch...

Protein-protein interaction databases

BioGridi219934, 1 interactor
IntActiQ9EQ32, 8 interactors
MINTiQ9EQ32
STRINGi10090.ENSMUSP00000052777

PTM databases

iPTMnetiQ9EQ32
PhosphoSitePlusiQ9EQ32
SwissPalmiQ9EQ32

Proteomic databases

EPDiQ9EQ32
jPOSTiQ9EQ32
PaxDbiQ9EQ32
PeptideAtlasiQ9EQ32
PRIDEiQ9EQ32

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059672; ENSMUSP00000052777; ENSMUSG00000025017 [Q9EQ32-1]
GeneIDi83490
KEGGimmu:83490
UCSCiuc008hlu.1 mouse [Q9EQ32-1]
uc008hlv.1 mouse [Q9EQ32-3]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
118788
MGIiMGI:1933177 Pik3ap1

Phylogenomic databases

eggNOGiENOG410IKKC Eukaryota
ENOG4110NCP LUCA
GeneTreeiENSGT00390000008787
InParanoidiQ9EQ32
KOiK12230
OMAiYVETADM
OrthoDBi280243at2759
PhylomeDBiQ9EQ32
TreeFamiTF328570

Enzyme and pathway databases

ReactomeiR-MMU-1257604 PIP3 activates AKT signaling
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-MMU-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Miscellaneous databases

Protein Ontology

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PROi
PR:Q9EQ32

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000025017 Expressed in 37 organ(s), highest expression level in bone marrow macrophage
GenevisibleiQ9EQ32 MM

Family and domain databases

Gene3Di3.40.50.10140, 1 hit
InterProiView protein in InterPro
IPR017893 DBB_domain
IPR041340 PIK3AP1_TIR
IPR035897 Toll_tir_struct_dom_sf
PfamiView protein in Pfam
PF14545 DBB, 1 hit
PF18567 TIR_3, 1 hit
SMARTiView protein in SMART
SM01282 DBB, 1 hit
PROSITEiView protein in PROSITE
PS51376 DBB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBCAP_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9EQ32
Secondary accession number(s): Q2KHL6
, Q3TBW6, Q3TC39, Q3U5J3, Q8BN25, Q8C2Y4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: March 1, 2001
Last modified: September 18, 2019
This is version 117 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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