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Entry version 159 (16 Oct 2019)
Sequence version 1 (01 Mar 2001)
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Protein

Protein Wnt-10a

Gene

WNT10A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays a role in normal ectoderm development (PubMed:17847007, PubMed:28589954). Required for normal tooth development (PubMed:17847007, PubMed:29178643, PubMed:28589954). Required for normal postnatal development and maintenance of tongue papillae and sweat ducts (PubMed:28589954). Required for normal proliferation of basal cells in tongue filiform papillae, plantar epithelium and sweat ducts. Required for normal expression of keratins in tongue papillae (By similarity). Required for normal expression of KRT9 in foot plant epithelium (PubMed:28589954). Required for normal hair follicle function (PubMed:28589954).By similarityCurated3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3238698 WNT ligand biogenesis and trafficking
R-HSA-373080 Class B/2 (Secretin family receptors)

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9GZT5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein Wnt-10a
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WNT10A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:13829 WNT10A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606268 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9GZT5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Odonto-onycho-dermal dysplasia (OODD)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare autosomal recessive ectodermal dysplasia characterized by dry hair, severe hypodontia, smooth tongue with marked reduction of fungiform and filiform papillae, onychodysplasia, keratoderma and hyperhidrosis of palms and soles, and hyperkeratosis of the skin.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_062510128R → Q in OODD and STHAG4. 2 PublicationsCorresponds to variant dbSNP:rs121908121EnsemblClinVar.1
Natural variantiVAR_077448131A → V in OODD. 1 Publication1
Natural variantiVAR_077450213G → S in STHAG4 and OODD; unknown pathological significance. 6 PublicationsCorresponds to variant dbSNP:rs147680216EnsemblClinVar.1
Natural variantiVAR_062511228F → I in OODD and STHAG4; also found in patients with an unclassified form of ectodermal dysplasia. 4 PublicationsCorresponds to variant dbSNP:rs121908120EnsemblClinVar.1
Natural variantiVAR_077453356G → C in OODD; unknown pathological significance. 1 Publication1
Schopf-Schulz-Passarge syndrome (SSPS)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare ectodermal dysplasia, characterized chiefly by cysts of the eyelid margins, palmoplantar keratoderma, hypodontia, hypotrichosis and nail dystrophy. Multiple eyelid apocrine hidrocystomas are the hallmark of this condition, although they usually appear in adulthood. The concomitant presence of eccrine syringofibroadenoma in most patients and of other adnexal skin tumors in some affected subjects indicates that Schopf-Schulz-Passarge syndrome is a genodermatosis with skin appendage neoplasms.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_077447131A → T in SSPS. 1 PublicationCorresponds to variant dbSNP:rs372993798EnsemblClinVar.1
Natural variantiVAR_077451266G → C in SSPS. 1 Publication1
Tooth agenesis, selective, 4 (STHAG4)8 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth). In STHAG4, the upper lateral incisors are absent or peg-shaped. Some STHAG4 patients manifest mild features of ectodermal dysplasia, including sparse hair, sparse eyebrows, short eyelashes, abnormalities of the nails, sweating anomalies and dry skin. STHAG4 inheritance is autosomal dominant or autosomal recessive.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07941870R → W in STHAG4; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs146460077EnsemblClinVar.1
Natural variantiVAR_06917195E → K in STHAG4. 1 PublicationCorresponds to variant dbSNP:rs318240759EnsemblClinVar.1
Natural variantiVAR_079419107 – 417Missing in STHAG4. 1 PublicationAdd BLAST311
Natural variantiVAR_079420113R → C in STHAG4; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs141074983EnsemblClinVar.1
Natural variantiVAR_077446126G → S in STHAG4; unknown pathological significance. 1 Publication1
Natural variantiVAR_062510128R → Q in OODD and STHAG4. 2 PublicationsCorresponds to variant dbSNP:rs121908121EnsemblClinVar.1
Natural variantiVAR_064837143H → Y in STHAG4; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs202024965Ensembl.1
Natural variantiVAR_064838145V → M in STHAG4; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs543063101EnsemblClinVar.1
Natural variantiVAR_069172163R → W in STHAG4; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs368280129EnsemblClinVar.1
Natural variantiVAR_077449171R → C in STHAG4; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs116998555EnsemblClinVar.1
Natural variantiVAR_077450213G → S in STHAG4 and OODD; unknown pathological significance. 6 PublicationsCorresponds to variant dbSNP:rs147680216EnsemblClinVar.1
Natural variantiVAR_069173217D → N in STHAG4; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs146902156EnsemblClinVar.1
Natural variantiVAR_079421223R → C in STHAG4; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs149245953EnsemblClinVar.1
Natural variantiVAR_062511228F → I in OODD and STHAG4; also found in patients with an unclassified form of ectodermal dysplasia. 4 PublicationsCorresponds to variant dbSNP:rs121908120EnsemblClinVar.1
Natural variantiVAR_077452266G → S in STHAG4; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs778752861Ensembl.1
Natural variantiVAR_069174277W → C in STHAG4. 1 PublicationCorresponds to variant dbSNP:rs1234227647EnsemblClinVar.1
Natural variantiVAR_069175306N → K in STHAG4; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs745513263EnsemblClinVar.1
Natural variantiVAR_077454357T → I in STHAG4; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs750190755Ensembl.1
Natural variantiVAR_077455379R → C in STHAG4; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1347556761Ensembl.1

Keywords - Diseasei

Disease mutation, Ectodermal dysplasia, Hypotrichosis, Palmoplantar keratoderma

Organism-specific databases

DisGeNET

More...
DisGeNETi
80326

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
WNT10A

MalaCards human disease database

More...
MalaCardsi
WNT10A
MIMi150400 phenotype
224750 phenotype
257980 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000135925

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
248 Autosomal recessive hypohidrotic ectodermal dysplasia
2227 NON RARE IN EUROPE: Hypodontia
2721 Odonto-onycho-dermal dysplasia
99798 Oligodontia
50944 Schoepf-Schulz-Passarge syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37817

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9GZT5

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
WNT10A

Domain mapping of disease mutations (DMDM)

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DMDMi
14424011

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 35Sequence analysisAdd BLAST35
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004146036 – 417Protein Wnt-10aAdd BLAST382

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei59PhosphothreonineBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi96 ↔ 107By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi149 ↔ 157By similarity
Disulfide bondi159 ↔ 214By similarity
Disulfide bondi262 ↔ 276By similarity
Disulfide bondi264 ↔ 271By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi268O-palmitoleoyl serine; by PORCNBy similarity1
Disulfide bondi346 ↔ 377By similarity
Disulfide bondi362 ↔ 372By similarity
Glycosylationi363N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi376 ↔ 416By similarity
Disulfide bondi392 ↔ 407By similarity
Disulfide bondi394 ↔ 404By similarity
Disulfide bondi399 ↔ 400By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9GZT5

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9GZT5

PeptideAtlas

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PeptideAtlasi
Q9GZT5

PRoteomics IDEntifications database

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PRIDEi
Q9GZT5

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
80132

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9GZT5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000135925 Expressed in 78 organ(s), highest expression level in ectocervix

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9GZT5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9GZT5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA013898

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity (PubMed:26902720). The complex with AFM may represent the physiological form in body fluids (PubMed:26902720).

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
123238, 1 interactor

Protein interaction database and analysis system

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IntActi
Q9GZT5, 1 interactor

STRING: functional protein association networks

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STRINGi
9606.ENSP00000258411

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Wnt family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3913 Eukaryota
ENOG410XQZ1 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160299

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000039528

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9GZT5

KEGG Orthology (KO)

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KOi
K01357

Identification of Orthologs from Complete Genome Data

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OMAi
SERCNCK

Database of Orthologous Groups

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OrthoDBi
468249at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9GZT5

TreeFam database of animal gene trees

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TreeFami
TF105310

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR005817 Wnt
IPR013302 Wnt10
IPR018161 Wnt_CS

The PANTHER Classification System

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PANTHERi
PTHR12027 PTHR12027, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00110 wnt, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01893 WNT10PROTEIN
PR01349 WNTPROTEIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00097 WNT1, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00246 WNT1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9GZT5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSAHPRPWL RLRPQPQPRP ALWVLLFFLL LLAAAMPRSA PNDILDLRLP
60 70 80 90 100
PEPVLNANTV CLTLPGLSRR QMEVCVRHPD VAASAIQGIQ IAIHECQHQF
110 120 130 140 150
RDQRWNCSSL ETRNKIPYES PIFSRGFRES AFAYAIAAAG VVHAVSNACA
160 170 180 190 200
LGKLKACGCD ASRRGDEEAF RRKLHRLQLD ALQRGKGLSH GVPEHPALPT
210 220 230 240 250
ASPGLQDSWE WGGCSPDMGF GERFSKDFLD SREPHRDIHA RMRLHNNRVG
260 270 280 290 300
RQAVMENMRR KCKCHGTSGS CQLKTCWQVT PEFRTVGALL RSRFHRATLI
310 320 330 340 350
RPHNRNGGQL EPGPAGAPSP APGAPGPRRR ASPADLVYFE KSPDFCEREP
360 370 380 390 400
RLDSAGTVGR LCNKSSAGSD GCGSMCCGRG HNILRQTRSE RCHCRFHWCC
410
FVVCEECRIT EWVSVCK
Length:417
Mass (Da):46,444
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i868DF5146A895319
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BZB8H7BZB8_HUMAN
Protein Wnt
WNT10A
212Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti52E → G in BAB55602 (PubMed:11350055).Curated1
Sequence conflicti52E → G in BAB14898 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07941870R → W in STHAG4; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs146460077EnsemblClinVar.1
Natural variantiVAR_06917195E → K in STHAG4. 1 PublicationCorresponds to variant dbSNP:rs318240759EnsemblClinVar.1
Natural variantiVAR_079419107 – 417Missing in STHAG4. 1 PublicationAdd BLAST311
Natural variantiVAR_079420113R → C in STHAG4; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs141074983EnsemblClinVar.1
Natural variantiVAR_077446126G → S in STHAG4; unknown pathological significance. 1 Publication1
Natural variantiVAR_062510128R → Q in OODD and STHAG4. 2 PublicationsCorresponds to variant dbSNP:rs121908121EnsemblClinVar.1
Natural variantiVAR_077447131A → T in SSPS. 1 PublicationCorresponds to variant dbSNP:rs372993798EnsemblClinVar.1
Natural variantiVAR_077448131A → V in OODD. 1 Publication1
Natural variantiVAR_064837143H → Y in STHAG4; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs202024965Ensembl.1
Natural variantiVAR_064838145V → M in STHAG4; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs543063101EnsemblClinVar.1
Natural variantiVAR_069172163R → W in STHAG4; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs368280129EnsemblClinVar.1
Natural variantiVAR_077449171R → C in STHAG4; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs116998555EnsemblClinVar.1
Natural variantiVAR_077450213G → S in STHAG4 and OODD; unknown pathological significance. 6 PublicationsCorresponds to variant dbSNP:rs147680216EnsemblClinVar.1
Natural variantiVAR_069173217D → N in STHAG4; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs146902156EnsemblClinVar.1
Natural variantiVAR_079421223R → C in STHAG4; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs149245953EnsemblClinVar.1
Natural variantiVAR_062511228F → I in OODD and STHAG4; also found in patients with an unclassified form of ectodermal dysplasia. 4 PublicationsCorresponds to variant dbSNP:rs121908120EnsemblClinVar.1
Natural variantiVAR_077451266G → C in SSPS. 1 Publication1
Natural variantiVAR_077452266G → S in STHAG4; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs778752861Ensembl.1
Natural variantiVAR_069174277W → C in STHAG4. 1 PublicationCorresponds to variant dbSNP:rs1234227647EnsemblClinVar.1
Natural variantiVAR_013239302P → T. Corresponds to variant dbSNP:rs1057306Ensembl.1
Natural variantiVAR_069175306N → K in STHAG4; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs745513263EnsemblClinVar.1
Natural variantiVAR_077453356G → C in OODD; unknown pathological significance. 1 Publication1
Natural variantiVAR_077454357T → I in STHAG4; unknown pathological significance. 2 PublicationsCorresponds to variant dbSNP:rs750190755Ensembl.1
Natural variantiVAR_064839360R → C Probable disease-associated mutation found in patients with an unclassified form of ectodermal dysplasia. 1 Publication1
Natural variantiVAR_077455379R → C in STHAG4; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1347556761Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY009400 mRNA Translation: AAG38660.1
AF315943 Genomic DNA Translation: AAG45153.1
AB059569 mRNA Translation: BAB55602.1
AK024363 mRNA Translation: BAB14898.1
AK315081 mRNA Translation: BAG37548.1
AC073128 Genomic DNA Translation: AAY24175.1
CH471063 Genomic DNA Translation: EAW70659.1
BC052234 mRNA Translation: AAH52234.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS2426.1

Protein sequence database of the Protein Information Resource

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PIRi
JC7693

NCBI Reference Sequences

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RefSeqi
NP_079492.2, NM_025216.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000258411; ENSP00000258411; ENSG00000135925

Database of genes from NCBI RefSeq genomes

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GeneIDi
80326

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:80326

UCSC genome browser

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UCSCi
uc002vjd.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY009400 mRNA Translation: AAG38660.1
AF315943 Genomic DNA Translation: AAG45153.1
AB059569 mRNA Translation: BAB55602.1
AK024363 mRNA Translation: BAB14898.1
AK315081 mRNA Translation: BAG37548.1
AC073128 Genomic DNA Translation: AAY24175.1
CH471063 Genomic DNA Translation: EAW70659.1
BC052234 mRNA Translation: AAH52234.1
CCDSiCCDS2426.1
PIRiJC7693
RefSeqiNP_079492.2, NM_025216.2

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi123238, 1 interactor
IntActiQ9GZT5, 1 interactor
STRINGi9606.ENSP00000258411

PTM databases

PhosphoSitePlusiQ9GZT5

Polymorphism and mutation databases

BioMutaiWNT10A
DMDMi14424011

Proteomic databases

MassIVEiQ9GZT5
PaxDbiQ9GZT5
PeptideAtlasiQ9GZT5
PRIDEiQ9GZT5
ProteomicsDBi80132

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
80326

Genome annotation databases

EnsembliENST00000258411; ENSP00000258411; ENSG00000135925
GeneIDi80326
KEGGihsa:80326
UCSCiuc002vjd.2 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
80326
DisGeNETi80326

GeneCards: human genes, protein and diseases

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GeneCardsi
WNT10A
GeneReviewsiWNT10A
HGNCiHGNC:13829 WNT10A
HPAiHPA013898
MalaCardsiWNT10A
MIMi150400 phenotype
224750 phenotype
257980 phenotype
606268 gene
neXtProtiNX_Q9GZT5
OpenTargetsiENSG00000135925
Orphaneti248 Autosomal recessive hypohidrotic ectodermal dysplasia
2227 NON RARE IN EUROPE: Hypodontia
2721 Odonto-onycho-dermal dysplasia
99798 Oligodontia
50944 Schoepf-Schulz-Passarge syndrome
PharmGKBiPA37817

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3913 Eukaryota
ENOG410XQZ1 LUCA
GeneTreeiENSGT00940000160299
HOGENOMiHOG000039528
InParanoidiQ9GZT5
KOiK01357
OMAiSERCNCK
OrthoDBi468249at2759
PhylomeDBiQ9GZT5
TreeFamiTF105310

Enzyme and pathway databases

ReactomeiR-HSA-3238698 WNT ligand biogenesis and trafficking
R-HSA-373080 Class B/2 (Secretin family receptors)
SIGNORiQ9GZT5

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
WNT10A human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
WNT10A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
80326
PharosiQ9GZT5

Protein Ontology

More...
PROi
PR:Q9GZT5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000135925 Expressed in 78 organ(s), highest expression level in ectocervix
ExpressionAtlasiQ9GZT5 baseline and differential
GenevisibleiQ9GZT5 HS

Family and domain databases

InterProiView protein in InterPro
IPR005817 Wnt
IPR013302 Wnt10
IPR018161 Wnt_CS
PANTHERiPTHR12027 PTHR12027, 1 hit
PfamiView protein in Pfam
PF00110 wnt, 1 hit
PRINTSiPR01893 WNT10PROTEIN
PR01349 WNTPROTEIN
SMARTiView protein in SMART
SM00097 WNT1, 1 hit
PROSITEiView protein in PROSITE
PS00246 WNT1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWN10A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9GZT5
Secondary accession number(s): Q53S44, Q96TA7, Q9H7S8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 1, 2001
Last modified: October 16, 2019
This is version 159 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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