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Entry version 168 (16 Oct 2019)
Sequence version 2 (13 Nov 2007)
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Protein

NIF3-like protein 1

Gene

NIF3L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NIF3-like protein 11 Publication
Alternative name(s):
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 1 protein1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NIF3L1Imported
Synonyms:ALS2CR11 Publication
ORF Names:MDS015, My018
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:13390 NIF3L1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
605778 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q9GZT8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
60491

Open Targets

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OpenTargetsi
ENSG00000196290

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA31629

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9GZT8

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NIF3L1

Domain mapping of disease mutations (DMDM)

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DMDMi
160112850

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001473531 – 377NIF3-like protein 1Add BLAST377

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei109N6-acetyllysineCombined sources1
Modified residuei255PhosphothreonineBy similarity1
Modified residuei259PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9GZT8

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9GZT8

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9GZT8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9GZT8

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9GZT8

PeptideAtlas

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PeptideAtlasi
Q9GZT8

PRoteomics IDEntifications database

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PRIDEi
Q9GZT8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
80135 [Q9GZT8-1]
80136 [Q9GZT8-2]
80137 [Q9GZT8-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9GZT8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9GZT8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000196290 Expressed in 224 organ(s), highest expression level in secondary oocyte

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9GZT8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9GZT8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036335
HPA036336
HPA061466

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:12951069).

Interacts with COPS2 (By similarity).

Interacts with THOC7 (PubMed:12951069).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
121922, 136 interactors

Protein interaction database and analysis system

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IntActi
Q9GZT8, 109 interactors

Molecular INTeraction database

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MINTi
Q9GZT8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000386394

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9GZT8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni244 – 377Mediates interaction with COPS2By similarityAdd BLAST134

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4131 Eukaryota
COG0327 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000003590

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000014260

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9GZT8

Identification of Orthologs from Complete Genome Data

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OMAi
HWATEWP

Database of Orthologous Groups

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OrthoDBi
1293706at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9GZT8

TreeFam database of animal gene trees

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TreeFami
TF324125

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002678 GTP_cyclohydrolase_I/Nif3
IPR036069 GTP_cyclohydrolase_I/Nif3_sf
IPR017222 NIF3L1_animal

The PANTHER Classification System

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PANTHERi
PTHR13799 PTHR13799, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01784 NIF3, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF037490 UCP037490_NIF3_euk, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF102705 SSF102705, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00486 YbgI_SA1388, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9GZT8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLSSCVRPVP TTVRFVDSLI CNSSRSFMDL KALLSSLNDF ASLSFAESWD
60 70 80 90 100
NVGLLVEPSP PHTVNTLFLT NDLTEEVMEE VLQKKADLIL SYHPPIFRPM
110 120 130 140 150
KRITWNTWKE RLVIRALENR VGIYSPHTAY DAAPQGVNNW LAKGLGACTS
160 170 180 190 200
RPIHPSKAPN YPTEGNHRVE FNVNYTQDLD KVMSAVKGID GVSVTSFSAR
210 220 230 240 250
TGNEEQTRIN LNCTQKALMQ VVDFLSRNKQ LYQKTEILSL EKPLLLHTGM
260 270 280 290 300
GRLCTLDESV SLATMIDRIK RHLKLSHIRL ALGVGRTLES QVKVVALCAG
310 320 330 340 350
SGSSVLQGVE ADLYLTGEMS HHDTLDAASQ GINVILCEHS NTERGFLSDL
360 370
RDMLDSHLEN KINIILSETD RDPLQVV
Length:377
Mass (Da):41,968
Last modified:November 13, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i41BDCADDD81CA0D8
GO
Isoform 2 (identifier: Q9GZT8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: Missing.

Show »
Length:350
Mass (Da):38,984
Checksum:i81F1A5AD35B25ED7
GO
Isoform 3 (identifier: Q9GZT8-3) [UniParc]FASTAAdd to basket
Also known as: beta

The sequence of this isoform differs from the canonical sequence as follows:
     243-377: PLLLHTGMGR...ETDRDPLQVV → SLKSKSWPCV...MILWMLLPKE

Show »
Length:285
Mass (Da):32,164
Checksum:i5084AD8C6E9700EC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6X734Q6X734_HUMAN
NIF3-like protein 1
NIF3L1
252Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B8ZZI0B8ZZI0_HUMAN
NIF3-like protein 1
NIF3L1
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EXA3E7EXA3_HUMAN
NIF3-like protein 1
NIF3L1
209Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JN42C9JN42_HUMAN
NIF3-like protein 1
NIF3L1
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1A8H7C1A8_HUMAN
NIF3-like protein 1
NIF3L1
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG14952 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti109K → E in AAG14952 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_037084324T → I. Corresponds to variant dbSNP:rs7917Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0293281 – 27Missing in isoform 2. 4 PublicationsAdd BLAST27
Alternative sequenceiVSP_043248243 – 377PLLLH…PLQVV → SLKSKSWPCVLVLGAAFCRV LRLTFTSQVRCPIMILWMLL PKE in isoform 3. 1 PublicationAdd BLAST135

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF283538 mRNA Translation: AAG44846.1
AB038949 mRNA Translation: BAB32499.1
AY251943 mRNA Translation: AAP84063.1
AF060513 mRNA Translation: AAG43131.1
AF182416 mRNA Translation: AAG14952.1 Frameshift.
AK023378 mRNA Translation: BAB14551.1
AC005037 Genomic DNA Translation: AAY14724.1
CH471063 Genomic DNA Translation: EAW70224.1
BC007654 mRNA Translation: AAH07654.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42797.1 [Q9GZT8-2]
CCDS46485.1 [Q9GZT8-1]
CCDS46486.1 [Q9GZT8-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001129511.1, NM_001136039.2 [Q9GZT8-1]
NP_001135827.1, NM_001142355.1 [Q9GZT8-2]
NP_001135828.1, NM_001142356.1 [Q9GZT8-3]
NP_068596.2, NM_021824.3 [Q9GZT8-2]
XP_005246799.1, XM_005246742.3
XP_011509884.1, XM_011511582.1
XP_011509885.1, XM_011511583.1
XP_011509886.1, XM_011511584.1
XP_011509887.1, XM_011511585.1
XP_016860119.1, XM_017004630.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000359683; ENSP00000352711; ENSG00000196290 [Q9GZT8-2]
ENST00000409020; ENSP00000386394; ENSG00000196290 [Q9GZT8-1]
ENST00000409357; ENSP00000387315; ENSG00000196290 [Q9GZT8-1]
ENST00000409588; ENSP00000387021; ENSG00000196290 [Q9GZT8-3]
ENST00000651500; ENSP00000498853; ENSG00000196290 [Q9GZT8-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
60491

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:60491

UCSC genome browser

More...
UCSCi
uc002uwn.3 human [Q9GZT8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF283538 mRNA Translation: AAG44846.1
AB038949 mRNA Translation: BAB32499.1
AY251943 mRNA Translation: AAP84063.1
AF060513 mRNA Translation: AAG43131.1
AF182416 mRNA Translation: AAG14952.1 Frameshift.
AK023378 mRNA Translation: BAB14551.1
AC005037 Genomic DNA Translation: AAY14724.1
CH471063 Genomic DNA Translation: EAW70224.1
BC007654 mRNA Translation: AAH07654.1
CCDSiCCDS42797.1 [Q9GZT8-2]
CCDS46485.1 [Q9GZT8-1]
CCDS46486.1 [Q9GZT8-3]
RefSeqiNP_001129511.1, NM_001136039.2 [Q9GZT8-1]
NP_001135827.1, NM_001142355.1 [Q9GZT8-2]
NP_001135828.1, NM_001142356.1 [Q9GZT8-3]
NP_068596.2, NM_021824.3 [Q9GZT8-2]
XP_005246799.1, XM_005246742.3
XP_011509884.1, XM_011511582.1
XP_011509885.1, XM_011511583.1
XP_011509886.1, XM_011511584.1
XP_011509887.1, XM_011511585.1
XP_016860119.1, XM_017004630.1

3D structure databases

SMRiQ9GZT8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi121922, 136 interactors
IntActiQ9GZT8, 109 interactors
MINTiQ9GZT8
STRINGi9606.ENSP00000386394

PTM databases

iPTMnetiQ9GZT8
PhosphoSitePlusiQ9GZT8

Polymorphism and mutation databases

BioMutaiNIF3L1
DMDMi160112850

Proteomic databases

EPDiQ9GZT8
jPOSTiQ9GZT8
MassIVEiQ9GZT8
MaxQBiQ9GZT8
PaxDbiQ9GZT8
PeptideAtlasiQ9GZT8
PRIDEiQ9GZT8
ProteomicsDBi80135 [Q9GZT8-1]
80136 [Q9GZT8-2]
80137 [Q9GZT8-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
60491

Genome annotation databases

EnsembliENST00000359683; ENSP00000352711; ENSG00000196290 [Q9GZT8-2]
ENST00000409020; ENSP00000386394; ENSG00000196290 [Q9GZT8-1]
ENST00000409357; ENSP00000387315; ENSG00000196290 [Q9GZT8-1]
ENST00000409588; ENSP00000387021; ENSG00000196290 [Q9GZT8-3]
ENST00000651500; ENSP00000498853; ENSG00000196290 [Q9GZT8-1]
GeneIDi60491
KEGGihsa:60491
UCSCiuc002uwn.3 human [Q9GZT8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
60491
DisGeNETi60491

GeneCards: human genes, protein and diseases

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GeneCardsi
NIF3L1
HGNCiHGNC:13390 NIF3L1
HPAiHPA036335
HPA036336
HPA061466
MIMi605778 gene
neXtProtiNX_Q9GZT8
OpenTargetsiENSG00000196290
PharmGKBiPA31629

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4131 Eukaryota
COG0327 LUCA
GeneTreeiENSGT00390000003590
HOGENOMiHOG000014260
InParanoidiQ9GZT8
OMAiHWATEWP
OrthoDBi1293706at2759
PhylomeDBiQ9GZT8
TreeFamiTF324125

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
NIF3L1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
60491
PharosiQ9GZT8

Protein Ontology

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PROi
PR:Q9GZT8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000196290 Expressed in 224 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ9GZT8 baseline and differential
GenevisibleiQ9GZT8 HS

Family and domain databases

InterProiView protein in InterPro
IPR002678 GTP_cyclohydrolase_I/Nif3
IPR036069 GTP_cyclohydrolase_I/Nif3_sf
IPR017222 NIF3L1_animal
PANTHERiPTHR13799 PTHR13799, 1 hit
PfamiView protein in Pfam
PF01784 NIF3, 1 hit
PIRSFiPIRSF037490 UCP037490_NIF3_euk, 1 hit
SUPFAMiSSF102705 SSF102705, 1 hit
TIGRFAMsiTIGR00486 YbgI_SA1388, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNIF3L_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9GZT8
Secondary accession number(s): Q53TX4
, Q6X735, Q9H2D2, Q9HC18
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: November 13, 2007
Last modified: October 16, 2019
This is version 168 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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