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Entry version 160 (18 Sep 2019)
Sequence version 1 (01 Mar 2001)
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Protein

N-alpha-acetyltransferase 50

Gene

NAA50

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine (PubMed:19744929, PubMed:22311970, PubMed:21900231, PubMed:27484799). Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position (PubMed:27484799). Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins (PubMed:19744929). Autoacetylates in vivo (PubMed:19744929). The relevance of N-epsilon-acetyltransferase activity is however unclear: able to acetylate H4 in vitro, but this result has not been confirmed in vivo (PubMed:19744929). Component of a N-alpha-acetyltransferase complex containing NAA10 and NAA15, but NAA50 does not influence the acetyltransferase activity of NAA10: this multiprotein complex probably constitutes the major contributor for N-terminal acetylation at the ribosome exit tunnel, with NAA10 acetylating all amino termini that are devoid of methionine and NAA50 acetylating other peptides (PubMed:16507339, PubMed:27484799). Required for sister chromatid cohesion during mitosis by promoting binding of CDCA5/sororin to cohesin: may act by counteracting the function of NAA10 (PubMed:17502424, PubMed:27422821).7 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 7.2 min(-1) with M-L-G-P-E peptide. kcat is 7.2 min(-1) with M-L-D-P-E peptide. kcat is 10.9 min(-1) with M-I-G-P-E peptide. kcat is 6.8 min(-1) with M-L-A-L-I peptide. kcat is 2.3 min(-1) with M-L-G-T-G peptide. kcat is 5.6 min(-1) with M-L-G-T-E peptide.1 Publication
  1. KM=132.6 µM for M-A-A-A peptide1 Publication
  2. KM=126.1 µM for L-A-A-A peptide1 Publication
  3. KM=5 µM for Acetyl-CoA1 Publication
  4. KM=79 µM for M-L-G-P-E peptide1 Publication
  5. KM=91 µM for M-L-D-P-E peptide1 Publication
  6. KM=185 µM for M-I-G-P-E peptide1 Publication
  7. KM=190 µM for M-L-A-L-I peptide1 Publication
  8. KM=320 µM for M-L-G-T-G peptide1 Publication
  9. KM=416 µM for M-L-G-T-E peptide1 Publication
  10. KM=460 µM for M-L-R-P-E peptide1 Publication
  11. KM=478 µM for M-L-L-P-E peptide1 Publication
  12. KM=3734 µM for M-F-G-P-E peptide1 Publication

    pH dependencei

    Optimum pH is 7.5-8.0.1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei31SubstrateCombined sources2 Publications1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei731 Publication1
    Binding sitei75SubstrateCombined sources2 Publications1
    Active sitei1121 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionAcyltransferase, Transferase

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:ENSG00000121579-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.3.1.88 2681

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    N-alpha-acetyltransferase 50Curated (EC:2.3.1.2584 Publications)
    Short name:
    hNaa50p2 Publications
    Alternative name(s):
    N-acetyltransferase 13
    N-acetyltransferase 51 Publication
    Short name:
    hNAT51 Publication
    N-acetyltransferase san homolog1 Publication
    Short name:
    hSAN1 Publication
    N-epsilon-acetyltransferase 50Curated (EC:2.3.1.-1 Publication)
    NatE catalytic subunit
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:NAA50Imported
    Synonyms:MAK31 Publication, NAT13, NAT51 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:29533 NAA50

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    610834 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q9GZZ1

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi27F → A: Abolishes N-alpha-acetyltransferase activity. 2 Publications1
    Mutagenesisi28P → A: Strongly decreased N-alpha-acetyltransferase activity. 1 Publication1
    Mutagenesisi29V → A: Strongly decreased N-alpha-acetyltransferase activity. 1 Publication1
    Mutagenesisi31Y → A: Abolishes N-alpha-acetyltransferase activity. 1 Publication1
    Mutagenesisi34 – 37KFYK → AFYA: Decreased acetylation; when associated with A-140. 1 Publication4
    Mutagenesisi35F → A: Abolishes N-alpha-acetyltransferase activity. 1 Publication1
    Mutagenesisi73Y → A or F: Abolishes N-alpha-acetyltransferase activity. 1 Publication1
    Mutagenesisi84R → A: Strongly decreased N-alpha-acetyltransferase activity. 1 Publication1
    Mutagenesisi112H → A or F: Abolishes N-alpha-acetyltransferase activity. 1 Publication1
    Mutagenesisi124Y → F: Strongly decreased N-alpha-acetyltransferase activity. Impaired sister chromatid cohesion during mitosis. 3 Publications1
    Mutagenesisi139Y → A: Abolishes N-alpha-acetyltransferase activity. 1 Publication1
    Mutagenesisi140K → A: Decreased acetylation; when associated with 34-A-A-37. 1 Publication1
    Mutagenesisi142I → A: Decreased N-alpha-acetyltransferase activity. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    80218

    Open Targets

    More...
    OpenTargetsi
    ENSG00000121579

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA165697846

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    NAA50

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    74733509

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002849021 – 169N-alpha-acetyltransferase 50Add BLAST169

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei12PhosphothreonineCombined sources1
    Modified residuei34N6-acetyllysine; by autocatalysisCombined sources1 Publication1
    Modified residuei37N6-acetyllysine; by autocatalysisCombined sources1 Publication1
    Modified residuei110PhosphotyrosineCombined sources1
    Modified residuei140N6-acetyllysine; by autocatalysis1 Publication1
    Isoform 2 (identifier: Q9GZZ1-2)
    Modified residuei34N6-acetyllysineCombined sources1

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q9GZZ1

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q9GZZ1

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q9GZZ1

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q9GZZ1

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9GZZ1

    PeptideAtlas

    More...
    PeptideAtlasi
    Q9GZZ1

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9GZZ1

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    80182 [Q9GZZ1-1]
    80183 [Q9GZZ1-2]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9GZZ1

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q9GZZ1

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    Q9GZZ1

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000121579 Expressed in 233 organ(s), highest expression level in skeletal muscle tissue of rectus abdominis

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9GZZ1 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9GZZ1 HS

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Component of a complex composed of NAA50, NAA15 and NAA10 (PubMed:16507339).

    Interacts with NAA35 (By similarity).

    By similarity1 Publication

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    123185, 53 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q9GZZ1, 25 interactors

    Molecular INTeraction database

    More...
    MINTi
    Q9GZZ1

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000240922

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1169
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q9GZZ1

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    Q9GZZ1

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 155N-acetyltransferasePROSITE-ProRule annotationAdd BLAST150

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni77 – 90Acetyl-CoA bindingCombined sources3 PublicationsAdd BLAST14
    Regioni117 – 126Coenzyme A bindingCombined sources3 Publications10
    Regioni138 – 141SubstrateCombined sources2 Publications4

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG3138 Eukaryota
    COG0456 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000009110

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000238056

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9GZZ1

    KEGG Orthology (KO)

    More...
    KOi
    K20793

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    IVETKEH

    Database of Orthologous Groups

    More...
    OrthoDBi
    1536763at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9GZZ1

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF314841

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR016181 Acyl_CoA_acyltransferase
    IPR000182 GNAT_dom

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00583 Acetyltransf_1, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF55729 SSF55729, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51186 GNAT, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q9GZZ1-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MKGSRIELGD VTPHNIKQLK RLNQVIFPVS YNDKFYKDVL EVGELAKLAY
    60 70 80 90 100
    FNDIAVGAVC CRVDHSQNQK RLYIMTLGCL APYRRLGIGT KMLNHVLNIC
    110 120 130 140 150
    EKDGTFDNIY LHVQISNESA IDFYRKFGFE IIETKKNYYK RIEPADAHVL
    160
    QKNLKVPSGQ NADVQKTDN
    Length:169
    Mass (Da):19,398
    Last modified:March 1, 2001 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i153A8021B74655CC
    GO
    Isoform 2 (identifier: Q9GZZ1-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         35-122: Missing.

    Note: No experimental confirmation available.Combined sources
    Show »
    Length:81
    Mass (Da):9,465
    Checksum:i72B366F6387B4FC5
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    E7EQ69E7EQ69_HUMAN
    N-alpha-acetyltransferase 50
    NAA50
    168Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    B0AZT5B0AZT5_HUMAN
    N-alpha-acetyltransferase 50
    NAA50
    95Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    C9J5D1C9J5D1_HUMAN
    N-alpha-acetyltransferase 50
    NAA50
    129Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    C9J5J3C9J5J3_HUMAN
    N-alpha-acetyltransferase 50
    NAA50
    58Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    F8WCK0F8WCK0_HUMAN
    N-alpha-acetyltransferase 50
    NAA50
    48Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A087WWJ2A0A087WWJ2_HUMAN
    N-alpha-acetyltransferase 50
    NAA50
    81Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    C9JZU6C9JZU6_HUMAN
    N-alpha-acetyltransferase 50
    NAA50
    57Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A0D9SF32A0A0D9SF32_HUMAN
    N-alpha-acetyltransferase 50
    NAA50
    58Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02474735 – 122Missing in isoform 2. 1 PublicationAdd BLAST88

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AK023090 mRNA Translation: BAB14397.1
    AK023256 mRNA Translation: BAB14490.1
    CR749314 mRNA Translation: CAH18169.1
    CH471052 Genomic DNA Translation: EAW79629.1
    CH471052 Genomic DNA Translation: EAW79630.1
    BC012731 mRNA Translation: AAH12731.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS2975.1 [Q9GZZ1-1]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_079422.1, NM_025146.3 [Q9GZZ1-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000240922; ENSP00000240922; ENSG00000121579 [Q9GZZ1-1]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    80218

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:80218

    UCSC genome browser

    More...
    UCSCi
    uc003ean.3 human [Q9GZZ1-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AK023090 mRNA Translation: BAB14397.1
    AK023256 mRNA Translation: BAB14490.1
    CR749314 mRNA Translation: CAH18169.1
    CH471052 Genomic DNA Translation: EAW79629.1
    CH471052 Genomic DNA Translation: EAW79630.1
    BC012731 mRNA Translation: AAH12731.1
    CCDSiCCDS2975.1 [Q9GZZ1-1]
    RefSeqiNP_079422.1, NM_025146.3 [Q9GZZ1-1]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2OB0X-ray1.80A/B/C2-169[»]
    2PSWX-ray2.10A/B/C2-169[»]
    3TFYX-ray2.75A/B/C1-169[»]
    4X5KX-ray2.49A1-169[»]
    SMRiQ9GZZ1
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGridi123185, 53 interactors
    IntActiQ9GZZ1, 25 interactors
    MINTiQ9GZZ1
    STRINGi9606.ENSP00000240922

    PTM databases

    iPTMnetiQ9GZZ1
    PhosphoSitePlusiQ9GZZ1
    SwissPalmiQ9GZZ1

    Polymorphism and mutation databases

    BioMutaiNAA50
    DMDMi74733509

    Proteomic databases

    EPDiQ9GZZ1
    jPOSTiQ9GZZ1
    MassIVEiQ9GZZ1
    MaxQBiQ9GZZ1
    PaxDbiQ9GZZ1
    PeptideAtlasiQ9GZZ1
    PRIDEiQ9GZZ1
    ProteomicsDBi80182 [Q9GZZ1-1]
    80183 [Q9GZZ1-2]

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    80218
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000240922; ENSP00000240922; ENSG00000121579 [Q9GZZ1-1]
    GeneIDi80218
    KEGGihsa:80218
    UCSCiuc003ean.3 human [Q9GZZ1-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    80218
    DisGeNETi80218

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    NAA50
    HGNCiHGNC:29533 NAA50
    MIMi610834 gene
    neXtProtiNX_Q9GZZ1
    OpenTargetsiENSG00000121579
    PharmGKBiPA165697846

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG3138 Eukaryota
    COG0456 LUCA
    GeneTreeiENSGT00390000009110
    HOGENOMiHOG000238056
    InParanoidiQ9GZZ1
    KOiK20793
    OMAiIVETKEH
    OrthoDBi1536763at2759
    PhylomeDBiQ9GZZ1
    TreeFamiTF314841

    Enzyme and pathway databases

    BioCyciMetaCyc:ENSG00000121579-MONOMER
    BRENDAi2.3.1.88 2681

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    NAA50 human
    EvolutionaryTraceiQ9GZZ1

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    80218

    Pharos

    More...
    Pharosi
    Q9GZZ1

    Protein Ontology

    More...
    PROi
    PR:Q9GZZ1

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000121579 Expressed in 233 organ(s), highest expression level in skeletal muscle tissue of rectus abdominis
    ExpressionAtlasiQ9GZZ1 baseline and differential
    GenevisibleiQ9GZZ1 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR016181 Acyl_CoA_acyltransferase
    IPR000182 GNAT_dom
    PfamiView protein in Pfam
    PF00583 Acetyltransf_1, 1 hit
    SUPFAMiSSF55729 SSF55729, 1 hit
    PROSITEiView protein in PROSITE
    PS51186 GNAT, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNAA50_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9GZZ1
    Secondary accession number(s): D3DN74, Q68DQ1
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: March 1, 2001
    Last modified: September 18, 2019
    This is version 160 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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