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Entry version 134 (18 Sep 2019)
Sequence version 2 (23 Apr 2003)
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Protein

GDNF family receptor alpha-4

Gene

GFRA4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-419037 NCAM1 interactions
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-8853659 RET signaling

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9GZZ7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GDNF family receptor alpha-4
Short name:
GDNF receptor alpha-4
Short name:
GDNFR-alpha-4
Short name:
GFR-alpha-4
Alternative name(s):
Persephin receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GFRA4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13821 GFRA4

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9GZZ7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
64096

Open Targets

More...
OpenTargetsi
ENSG00000125861

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28656

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GFRA4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
30173123

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001079321 – 278GDNF family receptor alpha-4Add BLAST258
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000010794279 – 299Removed in mature formSequence analysisAdd BLAST21

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi208N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi278GPI-anchor amidated glycineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9GZZ7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9GZZ7

PeptideAtlas

More...
PeptideAtlasi
Q9GZZ7

PRoteomics IDEntifications database

More...
PRIDEi
Q9GZZ7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
80185 [Q9GZZ7-1]
80186 [Q9GZZ7-2]
80187 [Q9GZZ7-3]

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000125861 Expressed in 19 organ(s), highest expression level in right lobe of thyroid gland

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9GZZ7 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SORL1.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122057, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000313423

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GDNFR family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J23G Eukaryota
ENOG4111972 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160491

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231728

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9GZZ7

Identification of Orthologs from Complete Genome Data

More...
OMAi
TFVPACA

Database of Orthologous Groups

More...
OrthoDBi
1007489at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9GZZ7

TreeFam database of animal gene trees

More...
TreeFami
TF331647

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016017 GDNF/GAS1
IPR037193 GDNF_alpha
IPR003438 GDNF_rcpt

The PANTHER Classification System

More...
PANTHERi
PTHR10269 PTHR10269, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02351 GDNF, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01316 GDNFRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00907 GDNF, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF110035 SSF110035, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.
Isoform GFRalpha4b (identifier: Q9GZZ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVRCLGPALL LLLLLGSASS VGGNRCVDAA EACTADARCQ RLRSEYVAQC
60 70 80 90 100
LGRAAQGGCP RARCRRALRR FFARGPPALT HALLFCPCAG PACAERRRQT
110 120 130 140 150
FVPSCAFSGP GPAPPSCLEP LNFCERSRVC RCARAAAGPW RGWGRGLSPA
160 170 180 190 200
HRPPAAQASP PGLSGLVHPS AQRPRRLPAG PGRPLPARLR GPRGVPAGTA
210 220 230 240 250
VTPNYVDNVS ARVAPWCDCG ASGNRREDCE AFRGLFTRNR CLDGAIQAFA
260 270 280 290
SGWPPVLLDQ LNPQGDPEHS LLQVSSTGRA LERRSLLSIL PVLALPALL
Length:299
Mass (Da):31,670
Last modified:April 23, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8443B8342FF10801
GO
Isoform GFRalpha4a (identifier: Q9GZZ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     132-197: CARAAAGPWR...RLRGPRGVPA → PRLLAFQVSC...RCLRAYAGLV

Show »
Length:269
Mass (Da):28,650
Checksum:i09E1DE67073974D1
GO
Isoform GFRalpha4c (identifier: Q9GZZ7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     132-182: CARAAAGPWR...RPRRLPAGPG → PRLLAFQVSC...PPSPLTTWTT
     183-299: Missing.

Show »
Length:182
Mass (Da):19,216
Checksum:iDB837797C0688D5D
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_007223132 – 197CARAA…RGVPA → PRLLAFQVSCTPAPSAPDGC LLDQGARCLRAYAGLV in isoform GFRalpha4a. 1 PublicationAdd BLAST66
Alternative sequenceiVSP_007224132 – 182CARAA…PAGPG → PRLLAFQVSCTPAPSAPDGC LLDQGARCLRAYAGLVGSPQ APPSPLTTWTT in isoform GFRalpha4c. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_007225183 – 299Missing in isoform GFRalpha4c. 1 PublicationAdd BLAST117

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ291673 mRNA Translation: CAC19690.1
AJ291674 mRNA Translation: CAC19691.1
AJ291675 mRNA Translation: CAC19692.1
AF253318 mRNA Translation: AAG25925.1
AL356755 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13055.1 [Q9GZZ7-2]
CCDS13056.1 [Q9GZZ7-1]

NCBI Reference Sequences

More...
RefSeqi
NP_071422.1, NM_022139.3 [Q9GZZ7-2]
NP_665705.1, NM_145762.2 [Q9GZZ7-1]
XP_005260850.1, XM_005260793.2 [Q9GZZ7-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000290417; ENSP00000290417; ENSG00000125861 [Q9GZZ7-2]
ENST00000319242; ENSP00000313423; ENSG00000125861 [Q9GZZ7-1]
ENST00000477160; ENSP00000435801; ENSG00000125861 [Q9GZZ7-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
64096

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:64096

UCSC genome browser

More...
UCSCi
uc002win.3 human [Q9GZZ7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ291673 mRNA Translation: CAC19690.1
AJ291674 mRNA Translation: CAC19691.1
AJ291675 mRNA Translation: CAC19692.1
AF253318 mRNA Translation: AAG25925.1
AL356755 Genomic DNA No translation available.
CCDSiCCDS13055.1 [Q9GZZ7-2]
CCDS13056.1 [Q9GZZ7-1]
RefSeqiNP_071422.1, NM_022139.3 [Q9GZZ7-2]
NP_665705.1, NM_145762.2 [Q9GZZ7-1]
XP_005260850.1, XM_005260793.2 [Q9GZZ7-3]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi122057, 1 interactor
STRINGi9606.ENSP00000313423

Polymorphism and mutation databases

BioMutaiGFRA4
DMDMi30173123

Proteomic databases

MassIVEiQ9GZZ7
PaxDbiQ9GZZ7
PeptideAtlasiQ9GZZ7
PRIDEiQ9GZZ7
ProteomicsDBi80185 [Q9GZZ7-1]
80186 [Q9GZZ7-2]
80187 [Q9GZZ7-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
64096
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290417; ENSP00000290417; ENSG00000125861 [Q9GZZ7-2]
ENST00000319242; ENSP00000313423; ENSG00000125861 [Q9GZZ7-1]
ENST00000477160; ENSP00000435801; ENSG00000125861 [Q9GZZ7-3]
GeneIDi64096
KEGGihsa:64096
UCSCiuc002win.3 human [Q9GZZ7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64096
DisGeNETi64096

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GFRA4
HGNCiHGNC:13821 GFRA4
neXtProtiNX_Q9GZZ7
OpenTargetsiENSG00000125861
PharmGKBiPA28656

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J23G Eukaryota
ENOG4111972 LUCA
GeneTreeiENSGT00940000160491
HOGENOMiHOG000231728
InParanoidiQ9GZZ7
OMAiTFVPACA
OrthoDBi1007489at2759
PhylomeDBiQ9GZZ7
TreeFamiTF331647

Enzyme and pathway databases

ReactomeiR-HSA-419037 NCAM1 interactions
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-8853659 RET signaling
SIGNORiQ9GZZ7

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
64096

Pharos

More...
Pharosi
Q9GZZ7

Protein Ontology

More...
PROi
PR:Q9GZZ7

Gene expression databases

BgeeiENSG00000125861 Expressed in 19 organ(s), highest expression level in right lobe of thyroid gland
GenevisibleiQ9GZZ7 HS

Family and domain databases

InterProiView protein in InterPro
IPR016017 GDNF/GAS1
IPR037193 GDNF_alpha
IPR003438 GDNF_rcpt
PANTHERiPTHR10269 PTHR10269, 1 hit
PfamiView protein in Pfam
PF02351 GDNF, 2 hits
PRINTSiPR01316 GDNFRECEPTOR
SMARTiView protein in SMART
SM00907 GDNF, 2 hits
SUPFAMiSSF110035 SSF110035, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGFRA4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9GZZ7
Secondary accession number(s): Q5JT74, Q9H191, Q9H192
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: April 23, 2003
Last modified: September 18, 2019
This is version 134 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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