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Entry version 145 (31 Jul 2019)
Sequence version 1 (01 Mar 2001)
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Protein

IQ domain-containing protein N

Gene

IQCN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
IQ domain-containing protein NImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IQCNImported
Synonyms:KIAA1683
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:29350 IQCN

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q9H0B3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000130518

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134952902

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
KIAA1683

Domain mapping of disease mutations (DMDM)

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DMDMi
73920083

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000508011 – 1180IQ domain-containing protein NAdd BLAST1180

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9H0B3

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9H0B3

PeptideAtlas

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PeptideAtlasi
Q9H0B3

PRoteomics IDEntifications database

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PRIDEi
Q9H0B3

ProteomicsDB human proteome resource

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ProteomicsDBi
19643
20458
80240 [Q9H0B3-1]
80241 [Q9H0B3-2]
80242 [Q9H0B3-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9H0B3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9H0B3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000130518 Expressed in 106 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9H0B3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H0B3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042409

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
123276, 67 interactors

Protein interaction database and analysis system

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IntActi
Q9H0B3, 12 interactors

Molecular INTeraction database

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MINTi
Q9H0B3

STRING: functional protein association networks

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STRINGi
9606.ENSP00000376213

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini103 – 132IQ 1PROSITE-ProRule annotationAdd BLAST30
Domaini926 – 955IQ 2PROSITE-ProRule annotationAdd BLAST30
Domaini949 – 978IQ 3PROSITE-ProRule annotationAdd BLAST30
Domaini972 – 1001IQ 4PROSITE-ProRule annotationAdd BLAST30
Domaini1113 – 1142IQ 5PROSITE-ProRule annotationAdd BLAST30
Domaini1136 – 1165IQ 6PROSITE-ProRule annotationAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi336 – 424Thr-richAdd BLAST89

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IEXS Eukaryota
ENOG41118PW LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156018

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000113175

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9H0B3

Identification of Orthologs from Complete Genome Data

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OMAi
SQALCQG

Database of Orthologous Groups

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OrthoDBi
203720at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9H0B3

TreeFam database of animal gene trees

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TreeFami
TF337595

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR040124 IQCN
IPR027417 P-loop_NTPase

The PANTHER Classification System

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PANTHERi
PTHR22590:SF2 PTHR22590:SF2, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00612 IQ, 6 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00015 IQ, 6 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50096 IQ, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H0B3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTLQGRADLS GNQGNAAGRL ATVHEPVVTQ WAVHPPAPAH PSLLDKMEKA
60 70 80 90 100
PPQPQHEGLK SKEHLPQQPA EGKTASRRVP RLRAVVESQA FKNILVDEMD
110 120 130 140 150
MMHARAATLI QANWRGYWLR QKLISQMMAA KAIQEAWRRF NKRHILHSSK
160 170 180 190 200
SLVKKTRAEE GDIPYHAPQQ VRFQHPEENR LLSPPIMVNK ETQFPSCDNL
210 220 230 240 250
VLCRPQSSPL LQPPAAQGTP EPCVQGPHAA RVRGLAFLPH QTVTIRFPCP
260 270 280 290 300
VSLDAKCQPC LLTRTIRSTC LVHIEGDSVK TKRVSARTNK ARAPETPLSR
310 320 330 340 350
RYDQAVTRPS RAQTQGPVKA ETPKAPFQIC PGPMITKTLL QTYPVVSVTL
360 370 380 390 400
PQTYPASTMT TTPPKTSPVP KVTIIKTPAQ MYPGPTVTKT APHTCPMPTM
410 420 430 440 450
TKIQVHPTAS RTGTPRQTCP ATITAKNRPQ VSLLASIMKS LPQVCPGPAM
460 470 480 490 500
AKTPPQMHPV TTPAKNPLQT CLSATMSKTS SQRSPVGVTK PSPQTRLPAM
510 520 530 540 550
ITKTPAQLRS VATILKTLCL ASPTVANVKA PPQVAVAAGT PNTSGSIHEN
560 570 580 590 600
PPKAKATVNV KQAAKVVKAS SPSYLAEGKI RCLAQPHPGT GVPRAAAELP
610 620 630 640 650
LEAEKIKTGT QKQAKTDMAF KTSVAVEMAG APSWTKVAEE GDKPPHVYVP
660 670 680 690 700
VDMAVTLPRG QLAAPLTNAS SQRHPPCLSQ RPLAAPLTKA SSQGHLPTEL
710 720 730 740 750
TKTPSLAHLD TCLSKMHSQT HLATGAVKVQ SQAPLATCLT KTQSRGQPIT
760 770 780 790 800
DITTCLIPAH QAADLSSNTH SQVLLTGSKV SNHACQRLGG LSAPPWAKPE
810 820 830 840 850
DRQTQPQPHG HVPGKTTQGG PCPAACEVQG MLVPPMAPTG HSTCNVESWG
860 870 880 890 900
DNGATRAQPS MPGQAVPCQE DTGPADAGVV GGQSWNRAWE PARGAASWDT
910 920 930 940 950
WRNKAVVPPR RSGEPMVSMQ AAEEIRILAV ITIQAGVRGY LARRRIRLWH
960 970 980 990 1000
RGAMVIQATW RGYRVRRNLA HLCRATTTIQ SAWRGYSTRR DQARHWQMLH
1010 1020 1030 1040 1050
PVTWVELGSR AGVMSDRSWF QDGRARTVSD HRCFQSCQAH ACSVCHSLSS
1060 1070 1080 1090 1100
RIGSPPSVVM LVGSSPRTCH TCGRTQPTRV VQGMGQGTEG PGAVSWASAY
1110 1120 1130 1140 1150
QLAALSPRQP HRQDKAATAI QSAWRGFKIR QQMRQQQMAA KIVQATWRGH
1160 1170 1180
HTRSCLKNTE ALLGPADPSA SSRHMHWPGI
Length:1,180
Mass (Da):127,693
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA81A2824C2794AC3
GO
Isoform 2 (identifier: Q9H0B3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     440-1053: Missing.
     1148-1180: RGHHTRSCLKNTEALLGPADPSASSRHMHWPGI → HLGPWLPAVGTSWEALMALWV

Show »
Length:554
Mass (Da):60,963
Checksum:i40386EC8A196A156
GO
Isoform 3 (identifier: Q9H0B3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-736: Missing.
     737-872: TCLTKTQSRG...GQAVPCQEDT → MAPSSRWDAM...KASLNSTILQ

Show »
Length:444
Mass (Da):49,193
Checksum:i1F32C281B6FCEEEB
GO
Isoform 4 (identifier: Q9H0B3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     872-872: T → TVGSLLASLC...LGPVRPQTSK

Note: No experimental confirmation available.
Show »
Length:1,367
Mass (Da):147,266
Checksum:iDA1B0ADE754F8578
GO
Isoform 5 (identifier: Q9H0B3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.

Note: No experimental confirmation available.
Show »
Length:1,134
Mass (Da):122,901
Checksum:i9DD6A52B63131CD9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GY12V9GY12_HUMAN
IQ domain-containing protein N
IQCN
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KQN7U3KQN7_HUMAN
IQ domain-containing protein N
IQCN
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WXN0A0A087WXN0_HUMAN
IQ domain-containing protein N
IQCN
794Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KQG6U3KQG6_HUMAN
IQ domain-containing protein N
IQCN
22Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JLK5A0A0G2JLK5_HUMAN
IQ domain-containing protein N
IQCN
7Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB21774 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti381M → V in BAB71500 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02341844L → P2 PublicationsCorresponds to variant dbSNP:rs1469023Ensembl.1
Natural variantiVAR_04952050A → V. Corresponds to variant dbSNP:rs3810431Ensembl.1
Natural variantiVAR_049521197C → R1 PublicationCorresponds to variant dbSNP:rs12609001Ensembl.1
Natural variantiVAR_023419235L → V2 PublicationsCorresponds to variant dbSNP:rs8103906Ensembl.1
Natural variantiVAR_023420285S → T2 PublicationsCorresponds to variant dbSNP:rs8104533Ensembl.1
Natural variantiVAR_023421359M → T2 PublicationsCorresponds to variant dbSNP:rs3746186Ensembl.1
Natural variantiVAR_049522524T → A. Corresponds to variant dbSNP:rs12462974Ensembl.1
Natural variantiVAR_049523610T → P2 PublicationsCorresponds to variant dbSNP:rs2277922Ensembl.1
Natural variantiVAR_049524614A → V. Corresponds to variant dbSNP:rs16982285Ensembl.1
Natural variantiVAR_034042648Y → F2 PublicationsCorresponds to variant dbSNP:rs8110972Ensembl.1
Natural variantiVAR_034043823P → R1 PublicationCorresponds to variant dbSNP:rs12608777Ensembl.1
Natural variantiVAR_049525835P → L1 PublicationCorresponds to variant dbSNP:rs2277921Ensembl.1
Natural variantiVAR_023422908P → H3 PublicationsCorresponds to variant dbSNP:rs999813Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0154731 – 736Missing in isoform 3. 1 PublicationAdd BLAST736
Alternative sequenceiVSP_0457131 – 46Missing in isoform 5. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_015474440 – 1053Missing in isoform 2. 1 PublicationAdd BLAST614
Alternative sequenceiVSP_015475737 – 872TCLTK…CQEDT → MAPSSRWDAMGPKNSYRSVH GRIVPELLESSVARVRPLQY VQRQPSQASARSGANPTHRP SAEVRPVIRTGEMTHSSVIP PLAPGVRRVSLGYESSPSGS LPPLFNQESPWRRQDSYSPQ NPAVSHKASLNSTILQ in isoform 3. 1 PublicationAdd BLAST136
Alternative sequenceiVSP_045714872T → TVGSLLASLCAEVAGVLASQ EDLRTLLAKALSQGEVWAAL NQALSKEVLGATVTKALPQS MLSMALVKALSWSELRLTLS RALSRGELRAELTKVMQGKL AEVLSKALTEEEWVALSQAL CQGELGALLSQSWCRVALRT GTILPKAASKSTGSGVTKTP ALVKVACRRSPSAAWGPSLG PVRPQTSK in isoform 4. 1 Publication1
Alternative sequenceiVSP_0154761148 – 1180RGHHT…HWPGI → HLGPWLPAVGTSWEALMALW V in isoform 2. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL136867 mRNA Translation: CAB66801.1
AK057466 mRNA Translation: BAB71500.1
AK302431 mRNA Translation: BAG63734.1
AC008397 Genomic DNA No translation available.
BC034327 mRNA Translation: AAH34327.1
BC112932 mRNA Translation: AAI12933.1
AB051470 mRNA Translation: BAB21774.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32958.1 [Q9H0B3-1]
CCDS46017.1 [Q9H0B3-4]
CCDS46018.1 [Q9H0B3-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001138776.1, NM_001145304.1 [Q9H0B3-4]
NP_001138777.1, NM_001145305.1 [Q9H0B3-5]
NP_079525.1, NM_025249.3 [Q9H0B3-1]
XP_005260141.1, XM_005260084.1 [Q9H0B3-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000392413; ENSP00000376213; ENSG00000130518 [Q9H0B3-4]
ENST00000600328; ENSP00000470780; ENSG00000130518 [Q9H0B3-1]
ENST00000600359; ENSP00000472912; ENSG00000130518 [Q9H0B3-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
80726

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:80726

UCSC genome browser

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UCSCi
uc002nin.3 human [Q9H0B3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136867 mRNA Translation: CAB66801.1
AK057466 mRNA Translation: BAB71500.1
AK302431 mRNA Translation: BAG63734.1
AC008397 Genomic DNA No translation available.
BC034327 mRNA Translation: AAH34327.1
BC112932 mRNA Translation: AAI12933.1
AB051470 mRNA Translation: BAB21774.1 Sequence problems.
CCDSiCCDS32958.1 [Q9H0B3-1]
CCDS46017.1 [Q9H0B3-4]
CCDS46018.1 [Q9H0B3-5]
RefSeqiNP_001138776.1, NM_001145304.1 [Q9H0B3-4]
NP_001138777.1, NM_001145305.1 [Q9H0B3-5]
NP_079525.1, NM_025249.3 [Q9H0B3-1]
XP_005260141.1, XM_005260084.1 [Q9H0B3-4]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
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Protein-protein interaction databases

BioGridi123276, 67 interactors
IntActiQ9H0B3, 12 interactors
MINTiQ9H0B3
STRINGi9606.ENSP00000376213

PTM databases

iPTMnetiQ9H0B3
PhosphoSitePlusiQ9H0B3

Polymorphism and mutation databases

BioMutaiKIAA1683
DMDMi73920083

Proteomic databases

jPOSTiQ9H0B3
PaxDbiQ9H0B3
PeptideAtlasiQ9H0B3
PRIDEiQ9H0B3
ProteomicsDBi19643
20458
80240 [Q9H0B3-1]
80241 [Q9H0B3-2]
80242 [Q9H0B3-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
80726
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392413; ENSP00000376213; ENSG00000130518 [Q9H0B3-4]
ENST00000600328; ENSP00000470780; ENSG00000130518 [Q9H0B3-1]
ENST00000600359; ENSP00000472912; ENSG00000130518 [Q9H0B3-5]
GeneIDi80726
KEGGihsa:80726
UCSCiuc002nin.3 human [Q9H0B3-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
80726

GeneCards: human genes, protein and diseases

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GeneCardsi
IQCN
HGNCiHGNC:29350 IQCN
HPAiHPA042409
neXtProtiNX_Q9H0B3
OpenTargetsiENSG00000130518
PharmGKBiPA134952902

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IEXS Eukaryota
ENOG41118PW LUCA
GeneTreeiENSGT00940000156018
HOGENOMiHOG000113175
InParanoidiQ9H0B3
OMAiSQALCQG
OrthoDBi203720at2759
PhylomeDBiQ9H0B3
TreeFamiTF337595

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
KIAA1683

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
80726

Protein Ontology

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PROi
PR:Q9H0B3

Gene expression databases

BgeeiENSG00000130518 Expressed in 106 organ(s), highest expression level in testis
ExpressionAtlasiQ9H0B3 baseline and differential
GenevisibleiQ9H0B3 HS

Family and domain databases

InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR040124 IQCN
IPR027417 P-loop_NTPase
PANTHERiPTHR22590:SF2 PTHR22590:SF2, 3 hits
PfamiView protein in Pfam
PF00612 IQ, 6 hits
SMARTiView protein in SMART
SM00015 IQ, 6 hits
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS50096 IQ, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIQCN_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H0B3
Secondary accession number(s): B4DYH2
, E9PDE0, E9PH54, Q2KHR5, Q8N4G8, Q96M14, Q9C0I0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2001
Last modified: July 31, 2019
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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