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Entry version 145 (16 Oct 2019)
Sequence version 1 (01 Mar 2001)
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Protein

Sodium-coupled neutral amino acid transporter 1

Gene

SLC38A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of glutamine and sodium ions with a stoichiometry of 1:1. May also transport small zwitterionic and aliphatic amino acids with a lower affinity. May supply glutamatergic and GABAergic neurons with glutamine which is required for the synthesis of the neurotransmitters glutamate and GABA.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by potassium, choline ions and 2-methylamino-isobutyric acid (MeAIB) (By similarity). Inhibited by lithium and N-methyl-D-glucamine.By similarity1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=890 µM for 2-methylamino-isobutyric acid (MeAIB) (at pH 8.5)1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Biological processAmino-acid transport, Ion transport, Sodium transport, Symport, Transport
    LigandSodium

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-210455 Astrocytic Glutamate-Glutamine Uptake And Metabolism
    R-HSA-352230 Amino acid transport across the plasma membrane

    Protein family/group databases

    Transport Classification Database

    More...
    TCDBi
    2.A.18.6.14 the amino acid/auxin permease (aaap) family

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Sodium-coupled neutral amino acid transporter 1
    Alternative name(s):
    Amino acid transporter A1
    N-system amino acid transporter 2
    Solute carrier family 38 member 1
    System A amino acid transporter 1
    System N amino acid transporter 1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:SLC38A1
    Synonyms:ATA1, NAT2, SAT1, SNAT1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:13447 SLC38A1

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    608490 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q9H2H9

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 74CytoplasmicSequence analysisAdd BLAST74
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei75 – 97HelicalSequence analysisAdd BLAST23
    Topological domaini98 – 112ExtracellularSequence analysisAdd BLAST15
    Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
    Topological domaini134 – 147CytoplasmicSequence analysisAdd BLAST14
    Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
    Topological domaini169 – 188ExtracellularSequence analysisAdd BLAST20
    Transmembranei189 – 211HelicalSequence analysisAdd BLAST23
    Topological domaini212 – 216CytoplasmicSequence analysis5
    Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
    Topological domaini238 – 275ExtracellularSequence analysisAdd BLAST38
    Transmembranei276 – 296HelicalSequence analysisAdd BLAST21
    Topological domaini297 – 312CytoplasmicSequence analysisAdd BLAST16
    Transmembranei313 – 333HelicalSequence analysisAdd BLAST21
    Topological domaini334 – 350ExtracellularSequence analysisAdd BLAST17
    Transmembranei351 – 371HelicalSequence analysisAdd BLAST21
    Topological domaini372 – 393CytoplasmicSequence analysisAdd BLAST22
    Transmembranei394 – 414HelicalSequence analysisAdd BLAST21
    Topological domaini415 – 416ExtracellularSequence analysis2
    Transmembranei417 – 437HelicalSequence analysisAdd BLAST21
    Topological domaini438 – 452CytoplasmicSequence analysisAdd BLAST15
    Transmembranei453 – 473HelicalSequence analysisAdd BLAST21
    Topological domaini474 – 487ExtracellularSequence analysisAdd BLAST14

    Keywords - Cellular componenti

    Cell membrane, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    81539

    Open Targets

    More...
    OpenTargetsi
    ENSG00000111371

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA37772

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q9H2H9

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    SLC38A1

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    74733561

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003104751 – 487Sodium-coupled neutral amino acid transporter 1Add BLAST487

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei6PhosphoserineBy similarity1
    Modified residuei11PhosphothreonineBy similarity1
    Modified residuei25PhosphoserineCombined sources1
    Modified residuei28PhosphoserineCombined sources1
    Modified residuei49PhosphoserineCombined sources1
    Modified residuei52PhosphoserineCombined sources1
    Modified residuei54PhosphothreonineCombined sources1
    Modified residuei56PhosphoserineCombined sources1
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi245 ↔ 264PROSITE-ProRule annotation
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi251N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi257N-linked (GlcNAc...) asparagineSequence analysis1

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q9H2H9

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q9H2H9

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q9H2H9

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q9H2H9

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9H2H9

    PeptideAtlas

    More...
    PeptideAtlasi
    Q9H2H9

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9H2H9

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    80552

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9H2H9

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q9H2H9

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    Q9H2H9

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed in the cerebral cortex by pyramidal and GABAergic neurons, astrocytes and other non-neuronal cells (at protein level). Expressed in placenta, heart, lung, skeletal muscle, spleen, stomach and testis.4 Publications

    <p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Down-regulated by bacterial lipopolysaccharides (LPS) in glial cells. Down-regulated upon hypoxia.2 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000111371 Expressed in 225 organ(s), highest expression level in placenta

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9H2H9 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9H2H9 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA039460
    HPA052272

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    123509, 15 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q9H2H9, 87 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000449756

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1305 Eukaryota
    COG0814 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000160716

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000013088

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9H2H9

    KEGG Orthology (KO)

    More...
    KOi
    K14990

    Database of Orthologous Groups

    More...
    OrthoDBi
    697331at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9H2H9

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF328787

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR013057 AA_transpt_TM

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01490 Aa_trans, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

    Q9H2H9-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MMHFKSGLEL TELQNMTVPE DDNISNDSND FTEVENGQIN SKFISDRESR
    60 70 80 90 100
    RSLTNSHLEK KKCDEYIPGT TSLGMSVFNL SNAIMGSGIL GLAFALANTG
    110 120 130 140 150
    ILLFLVLLTS VTLLSIYSIN LLLICSKETG CMVYEKLGEQ VFGTTGKFVI
    160 170 180 190 200
    FGATSLQNTG AMLSYLFIVK NELPSAIKFL MGKEETFSAW YVDGRVLVVI
    210 220 230 240 250
    VTFGIILPLC LLKNLGYLGY TSGFSLSCMV FFLIVVIYKK FQIPCIVPEL
    260 270 280 290 300
    NSTISANSTN ADTCTPKYVT FNSKTVYALP TIAFAFVCHP SVLPIYSELK
    310 320 330 340 350
    DRSQKKMQMV SNISFFAMFV MYFLTAIFGY LTFYDNVQSD LLHKYQSKDD
    360 370 380 390 400
    ILILTVRLAV IVAVILTVPV LFFTVRSSLF ELAKKTKFNL CRHTVVTCIL
    410 420 430 440 450
    LVVINLLVIF IPSMKDIFGV VGVTSANMLI FILPSSLYLK ITDQDGDKGT
    460 470 480
    QRIWAALFLG LGVLFSLVSI PLVIYDWACS SSSDEGH
    Length:487
    Mass (Da):54,048
    Last modified:March 1, 2001 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5CBC96880D7BDE03
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    F8VX04F8VX04_HUMAN
    Sodium-coupled neutral amino acid t...
    SLC38A1
    503Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    F8VX12F8VX12_HUMAN
    Sodium-coupled neutral amino acid t...
    SLC38A1
    78Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAG44546 differs from that shown. Reason: Frameshift.Curated
    The sequence BAC11186 differs from that shown. Reason: Erroneous initiation.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti107L → P in BAB55394 (PubMed:14702039).Curated1
    Sequence conflicti203F → V in BAC11310 (PubMed:16303743).Curated1
    Sequence conflicti375V → D in AAG44546 (Ref. 2) Curated1
    Sequence conflicti483 – 484SD → NG in AAG44546 (Ref. 2) Curated2

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF271070 mRNA Translation: AAG39354.1
    AF247166 mRNA Translation: AAG44546.1 Frameshift.
    AK027825 mRNA Translation: BAB55394.1
    AK074758 mRNA Translation: BAC11186.1 Different initiation.
    AK074949 mRNA Translation: BAC11310.1
    CH471111 Genomic DNA Translation: EAW57895.1
    BC010620 mRNA Translation: AAH10620.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS41774.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    JC7328

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001070952.1, NM_001077484.1
    NP_001265316.1, NM_001278387.1
    NP_001265317.1, NM_001278388.1
    NP_001265318.1, NM_001278389.1
    NP_109599.3, NM_030674.3

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000398637; ENSP00000381634; ENSG00000111371
    ENST00000439706; ENSP00000398142; ENSG00000111371
    ENST00000546893; ENSP00000447853; ENSG00000111371
    ENST00000549049; ENSP00000449607; ENSG00000111371

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    81539

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:81539

    UCSC genome browser

    More...
    UCSCi
    uc001rpb.5 human

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF271070 mRNA Translation: AAG39354.1
    AF247166 mRNA Translation: AAG44546.1 Frameshift.
    AK027825 mRNA Translation: BAB55394.1
    AK074758 mRNA Translation: BAC11186.1 Different initiation.
    AK074949 mRNA Translation: BAC11310.1
    CH471111 Genomic DNA Translation: EAW57895.1
    BC010620 mRNA Translation: AAH10620.1
    CCDSiCCDS41774.1
    PIRiJC7328
    RefSeqiNP_001070952.1, NM_001077484.1
    NP_001265316.1, NM_001278387.1
    NP_001265317.1, NM_001278388.1
    NP_001265318.1, NM_001278389.1
    NP_109599.3, NM_030674.3

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    BioGridi123509, 15 interactors
    IntActiQ9H2H9, 87 interactors
    STRINGi9606.ENSP00000449756

    Protein family/group databases

    TCDBi2.A.18.6.14 the amino acid/auxin permease (aaap) family

    PTM databases

    iPTMnetiQ9H2H9
    PhosphoSitePlusiQ9H2H9
    SwissPalmiQ9H2H9

    Polymorphism and mutation databases

    BioMutaiSLC38A1
    DMDMi74733561

    Proteomic databases

    EPDiQ9H2H9
    jPOSTiQ9H2H9
    MassIVEiQ9H2H9
    MaxQBiQ9H2H9
    PaxDbiQ9H2H9
    PeptideAtlasiQ9H2H9
    PRIDEiQ9H2H9
    ProteomicsDBi80552

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    81539

    Genome annotation databases

    EnsembliENST00000398637; ENSP00000381634; ENSG00000111371
    ENST00000439706; ENSP00000398142; ENSG00000111371
    ENST00000546893; ENSP00000447853; ENSG00000111371
    ENST00000549049; ENSP00000449607; ENSG00000111371
    GeneIDi81539
    KEGGihsa:81539
    UCSCiuc001rpb.5 human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    81539
    DisGeNETi81539

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    SLC38A1
    HGNCiHGNC:13447 SLC38A1
    HPAiHPA039460
    HPA052272
    MIMi608490 gene
    neXtProtiNX_Q9H2H9
    OpenTargetsiENSG00000111371
    PharmGKBiPA37772

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1305 Eukaryota
    COG0814 LUCA
    GeneTreeiENSGT00940000160716
    HOGENOMiHOG000013088
    InParanoidiQ9H2H9
    KOiK14990
    OrthoDBi697331at2759
    PhylomeDBiQ9H2H9
    TreeFamiTF328787

    Enzyme and pathway databases

    ReactomeiR-HSA-210455 Astrocytic Glutamate-Glutamine Uptake And Metabolism
    R-HSA-352230 Amino acid transport across the plasma membrane

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    SLC38A1 human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    SLC38A1

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    81539
    PharosiQ9H2H9

    Protein Ontology

    More...
    PROi
    PR:Q9H2H9

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000111371 Expressed in 225 organ(s), highest expression level in placenta
    ExpressionAtlasiQ9H2H9 baseline and differential
    GenevisibleiQ9H2H9 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR013057 AA_transpt_TM
    PfamiView protein in Pfam
    PF01490 Aa_trans, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS38A1_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H2H9
    Secondary accession number(s): Q8NC61
    , Q8NCF8, Q96JX2, Q9H2Q2
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: March 1, 2001
    Last modified: October 16, 2019
    This is version 145 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    UniProt is an ELIXIR core data resource
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