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Entry version 154 (08 May 2019)
Sequence version 1 (01 Mar 2001)
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Protein

Ribokinase

Gene

RBKS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.UniRule annotation1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+UniRule annotationNote: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity (By similarity). Competitively inhibited by phosphonoacetic acid, etidronate, 2-carboxethylphosphonic acid, N-(phosphonomethyl)glycine, N-(phosphonomethyl)iminodiacetic acid and clodronate (PubMed:17585908).UniRule annotation1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=2.17 mM for ribose (in the presence of 10 mM inorganic phosphate)1 Publication
  2. KM=3.39 mM for ribose (in the presence of 5 mM inorganic phosphate)1 Publication
  3. KM=6.62 mM for ribose (in the presence of 2 mM inorganic phosphate)1 Publication
  4. KM=30.43 mM for ribose (in the presence of 1 mM inorganic phosphate)1 Publication
  5. KM=0.07 mM for ATP (in the presence of 5 mM inorganic phosphate)1 Publication
  6. KM=0.08 mM for ATP (in the presence of 2 mM inorganic phosphate)1 Publication
  7. KM=0.10 mM for ATP (in the presence of 1 mM inorganic phosphate)1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: D-ribose degradation

    This protein is involved in step 2 of the subpathway that synthesizes D-ribose 5-phosphate from beta-D-ribopyranose.UniRule annotation
    Proteins known to be involved in the 2 steps of the subpathway in this organism are:
    1. no protein annotated in this organism
    2. Ribokinase (RBKS)
    This subpathway is part of the pathway D-ribose degradation, which is itself part of Carbohydrate metabolism.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribose 5-phosphate from beta-D-ribopyranose, the pathway D-ribose degradation and in Carbohydrate metabolism.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei154SubstrateUniRule annotationBy similarity1
    Binding sitei199ATPUniRule annotation1 Publication1
    Binding sitei256ATPUniRule annotation1 Publication1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi263PotassiumUniRule annotation1 Publication1
    Metal bindingi265Potassium; via carbonyl oxygenUniRule annotationBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei269Proton acceptorUniRule annotationBy similarity1
    Binding sitei269SubstrateUniRule annotationBy similarity1
    Binding sitei295ATPUniRule annotation1 Publication1
    Metal bindingi301Potassium; via carbonyl oxygenUniRule annotation1 Publication1
    Metal bindingi304Potassium; via carbonyl oxygenUniRule annotation1 Publication1
    Metal bindingi306Potassium; via carbonyl oxygenUniRule annotationBy similarity1
    Metal bindingi310PotassiumUniRule annotation1 Publication1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi235 – 240ATPUniRule annotation1 Publication6
    Nucleotide bindingi268 – 269ATPUniRule annotation1 Publication2

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionKinase, Transferase
    Biological processCarbohydrate metabolism
    LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-71336 Pentose phosphate pathway

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00916;UER00889

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Ribokinase1 PublicationUniRule annotation (EC:2.7.1.15UniRule annotation1 Publication)
    Short name:
    RK1 PublicationUniRule annotation
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:RBKSUniRule annotation
    Synonyms:RBSK
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:30325 RBKS

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    611132 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q9H477

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    64080

    Open Targets

    More...
    OpenTargetsi
    ENSG00000171174

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA134951602

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    RBKS

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    20139730

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000800921 – 322RibokinaseAdd BLAST322

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q9H477

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q9H477

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q9H477

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9H477

    PeptideAtlas

    More...
    PeptideAtlasi
    Q9H477

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9H477

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    80790

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9H477

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q9H477

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000171174 Expressed in 187 organ(s), highest expression level in jejunal mucosa

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9H477 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9H477 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA019725
    HPA028285

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer.

    UniRule annotationBy similarity

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    WithEntry#Exp.IntActNotes
    ACDQ96AP02EBI-10982959,EBI-717666

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    122046, 11 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q9H477, 7 interactors

    Molecular INTeraction database

    More...
    MINTi
    Q9H477

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000306817

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1322
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q9H477

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    Q9H477

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni25 – 27Substrate bindingUniRule annotationBy similarity3
    Regioni53 – 57Substrate bindingUniRule annotationBy similarity5

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.UniRule annotation

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG2855 Eukaryota
    COG0524 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000005743

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000235950

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9H477

    KEGG Orthology (KO)

    More...
    KOi
    K00852

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    DIVLIQQ

    Database of Orthologous Groups

    More...
    OrthoDBi
    918144at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9H477

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF105770

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd01174 ribokinase, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.40.1190.20, 1 hit

    HAMAP database of protein families

    More...
    HAMAPi
    MF_01987 Ribokinase, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR002173 Carboh/pur_kinase_PfkB_CS
    IPR011877 D_ribokin
    IPR011611 PfkB_dom
    IPR002139 Ribo/fructo_kinase
    IPR029056 Ribokinase-like

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00294 PfkB, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00990 RIBOKINASE

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF53613 SSF53613, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR02152 D_ribokin_bact, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00584 PFKB_KINASES_2, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q9H477-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MAASGEPQRQ WQEEVAAVVV VGSCMTDLVS LTSRLPKTGE TIHGHKFFIG
    60 70 80 90 100
    FGGKGANQCV QAARLGAMTS MVCKVGKDSF GNDYIENLKQ NDISTEFTYQ
    110 120 130 140 150
    TKDAATGTAS IIVNNEGQNI IVIVAGANLL LNTEDLRAAA NVISRAKVMV
    160 170 180 190 200
    CQLEITPATS LEALTMARRS GVKTLFNPAP AIADLDPQFY TLSDVFCCNE
    210 220 230 240 250
    SEAEILTGLT VGSAADAGEA ALVLLKRGCQ VVIITLGAEG CVVLSQTEPE
    260 270 280 290 300
    PKHIPTEKVK AVDTTGAGDS FVGALAFYLA YYPNLSLEDM LNRSNFIAAV
    310 320
    SVQAAGTQSS YPYKKDLPLT LF
    Length:322
    Mass (Da):34,143
    Last modified:March 1, 2001 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i50D0E7161F33E94B
    GO
    Isoform 2 (identifier: Q9H477-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         266-322: GAGDSFVGAL...YKKDLPLTLF → CRPGSRPKSEAASVKKQKHYK

    Note: No experimental confirmation available.
    Show »
    Length:286
    Mass (Da):30,361
    Checksum:i020866FD563F058F
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    H7C091H7C091_HUMAN
    Ribokinase
    RBKS
    147Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E7EQ18E7EQ18_HUMAN
    Ribokinase
    RBKS
    63Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PBU0E9PBU0_HUMAN
    Ribokinase
    RBKS
    36Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti101T → A in AAT64917 (Ref. 2) Curated1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054380266 – 322GAGDS…PLTLF → CRPGSRPKSEAASVKKQKHY K in isoform 2. 1 PublicationAdd BLAST57

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AJ404857 mRNA Translation: CAC12877.1
    AY643715 mRNA Translation: AAT64917.1
    AK300989 mRNA Translation: BAG62608.1
    AC021171 Genomic DNA No translation available.
    AC110084 Genomic DNA No translation available.
    BC017425 mRNA Translation: AAH17425.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS1762.1 [Q9H477-1]

    NCBI Reference Sequences

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    RefSeqi
    NP_001274509.1, NM_001287580.1
    NP_071411.1, NM_022128.2 [Q9H477-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000302188; ENSP00000306817; ENSG00000171174 [Q9H477-1]

    Database of genes from NCBI RefSeq genomes

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    GeneIDi
    64080

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:64080

    UCSC genome browser

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    UCSCi
    uc002rlo.3 human [Q9H477-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AJ404857 mRNA Translation: CAC12877.1
    AY643715 mRNA Translation: AAT64917.1
    AK300989 mRNA Translation: BAG62608.1
    AC021171 Genomic DNA No translation available.
    AC110084 Genomic DNA No translation available.
    BC017425 mRNA Translation: AAH17425.1
    CCDSiCCDS1762.1 [Q9H477-1]
    RefSeqiNP_001274509.1, NM_001287580.1
    NP_071411.1, NM_022128.2 [Q9H477-1]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

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    PDBei

    Protein Data Bank RCSB

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    RCSB PDBi

    Protein Data Bank Japan

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    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2FV7X-ray2.10A/B11-322[»]
    5BYCX-ray1.95A/B1-322[»]
    5BYDX-ray2.10A/B1-322[»]
    5BYEX-ray1.75A/B1-322[»]
    5BYFX-ray2.00A/B1-322[»]
    5C3YX-ray2.60A/B/C/D/E/F/G/H/I/J/K/L1-322[»]
    5C3ZX-ray1.90A/B1-322[»]
    5C40X-ray1.50A/B1-322[»]
    5C41X-ray1.95A/B/C/D1-322[»]
    SMRiQ9H477
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGridi122046, 11 interactors
    IntActiQ9H477, 7 interactors
    MINTiQ9H477
    STRINGi9606.ENSP00000306817

    PTM databases

    iPTMnetiQ9H477
    PhosphoSitePlusiQ9H477

    Polymorphism and mutation databases

    BioMutaiRBKS
    DMDMi20139730

    Proteomic databases

    EPDiQ9H477
    jPOSTiQ9H477
    MaxQBiQ9H477
    PaxDbiQ9H477
    PeptideAtlasiQ9H477
    PRIDEiQ9H477
    ProteomicsDBi80790

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    64080
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000302188; ENSP00000306817; ENSG00000171174 [Q9H477-1]
    GeneIDi64080
    KEGGihsa:64080
    UCSCiuc002rlo.3 human [Q9H477-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    64080
    DisGeNETi64080

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    RBKS
    HGNCiHGNC:30325 RBKS
    HPAiHPA019725
    HPA028285
    MIMi611132 gene
    neXtProtiNX_Q9H477
    OpenTargetsiENSG00000171174
    PharmGKBiPA134951602

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG2855 Eukaryota
    COG0524 LUCA
    GeneTreeiENSGT00390000005743
    HOGENOMiHOG000235950
    InParanoidiQ9H477
    KOiK00852
    OMAiDIVLIQQ
    OrthoDBi918144at2759
    PhylomeDBiQ9H477
    TreeFamiTF105770

    Enzyme and pathway databases

    UniPathwayiUPA00916;UER00889
    ReactomeiR-HSA-71336 Pentose phosphate pathway

    Miscellaneous databases

    EvolutionaryTraceiQ9H477

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    64080

    Protein Ontology

    More...
    PROi
    PR:Q9H477

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000171174 Expressed in 187 organ(s), highest expression level in jejunal mucosa
    ExpressionAtlasiQ9H477 baseline and differential
    GenevisibleiQ9H477 HS

    Family and domain databases

    CDDicd01174 ribokinase, 1 hit
    Gene3Di3.40.1190.20, 1 hit
    HAMAPiMF_01987 Ribokinase, 1 hit
    InterProiView protein in InterPro
    IPR002173 Carboh/pur_kinase_PfkB_CS
    IPR011877 D_ribokin
    IPR011611 PfkB_dom
    IPR002139 Ribo/fructo_kinase
    IPR029056 Ribokinase-like
    PfamiView protein in Pfam
    PF00294 PfkB, 1 hit
    PRINTSiPR00990 RIBOKINASE
    SUPFAMiSSF53613 SSF53613, 1 hit
    TIGRFAMsiTIGR02152 D_ribokin_bact, 1 hit
    PROSITEiView protein in PROSITE
    PS00584 PFKB_KINASES_2, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRBSK_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H477
    Secondary accession number(s): A9UK04, B4DV96
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: March 1, 2001
    Last modified: May 8, 2019
    This is version 154 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families
    4. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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