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Entry version 157 (31 Jul 2019)
Sequence version 2 (18 May 2010)
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Protein

Ceramide synthase 4

Gene

CERS4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward long and very-long chains (C18:0-C22:0) as acyl donor.4 Publications

Caution

Some prediction bioinformatics tools predict the presence of a homeobox domain (By similarity). However, the domain is degenerate and residues that are important for DNA-binding are absent (By similarity).Sequence analysis

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1.8 µM for sphinganine (with octadecanoyl-CoA as substrate)1 Publication
  2. KM=1.8 µM for sphinganine (with eicosanoyl-CoA as substrate)1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: sphingolipid metabolism

    This protein is involved in the pathway sphingolipid metabolism, which is part of Lipid metabolism.4 Publications
    View all proteins of this organism that are known to be involved in the pathway sphingolipid metabolism and in Lipid metabolism.

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionTransferase
    Biological processLipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-1660661 Sphingolipid de novo biosynthesis

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00222

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...
    SwissLipidsi
    SLP:000000699

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Ceramide synthase 41 Publication (EC:2.3.1.-4 Publications)
    Short name:
    CerS41 Publication
    Alternative name(s):
    LAG1 longevity assurance homolog 4By similarity
    Sphingosine N-acyltransferase CERS4Curated (EC:2.3.1.24By similarity)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:CERS41 PublicationImported
    Synonyms:LASS4By similarity
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:23747 CERS4

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    615334 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q9HA82

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 31Lumenal1 PublicationAdd BLAST31
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei32 – 52HelicalSequence analysisAdd BLAST21
    Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
    Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
    Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
    Transmembranei260 – 280HelicalSequence analysisAdd BLAST21
    Transmembranei304 – 324HelicalSequence analysisAdd BLAST21
    Topological domaini325 – 394Cytoplasmic1 PublicationAdd BLAST70

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi291 – 298ESISNRGP → YPLELYPA: Altered specificity toward acyl donor; generates C24 ceramides instead of C18-C22-ceramides. 1 Publication8
    Mutagenesisi342 – 350SDVEESDSS → ADVEEADAA: Decreased phosphorylation. 1 Publication9

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    79603

    Open Targets

    More...
    OpenTargetsi
    ENSG00000090661

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA134915173

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    CERS4

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    296434561

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001855121 – 394Ceramide synthase 4Add BLAST394

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi19N-linked (GlcNAc...) asparagineSequence analysis1
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei342PhosphoserineBy similarity1
    Modified residuei349PhosphoserineBy similarity1
    Modified residuei350PhosphoserineBy similarity1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Phosphorylated at the C-terminus by CK2.1 Publication
    N-glycosylated.2 Publications

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q9HA82

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q9HA82

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q9HA82

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9HA82

    PeptideAtlas

    More...
    PeptideAtlasi
    Q9HA82

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9HA82

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    81384

    PTM databases

    GlyConnect protein glycosylation platform

    More...
    GlyConnecti
    1106

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9HA82

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q9HA82

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000090661 Expressed in 154 organ(s), highest expression level in lower esophagus mucosa

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9HA82 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9HA82 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    CAB033734
    HPA054729

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    122740, 2 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q9HA82, 34 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000251363

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q9HA82

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini131 – 332TLCPROSITE-ProRule annotationAdd BLAST202

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni67 – 128Homeobox-likeCuratedAdd BLAST62

    Motif

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi291 – 301Last loop motif1 PublicationAdd BLAST11

    <p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    The last loop motif confers selectivity toward stearoyl-CoA (octadecanoyl-CoA; C18:0-CoA) to behenoyl-CoA (docosanoyl-CoA; C22:0-CoA) as acyl donors.1 Publication

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1607 Eukaryota
    COG5058 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00950000182700

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000231977

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9HA82

    KEGG Orthology (KO)

    More...
    KOi
    K04710

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    EACKMFN

    Database of Orthologous Groups

    More...
    OrthoDBi
    987268at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9HA82

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF314319

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd00086 homeodomain, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR009057 Homeobox-like_sf
    IPR001356 Homeobox_dom
    IPR016439 Lag1/Lac1-like
    IPR006634 TLC-dom

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR12560 PTHR12560, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00046 Homeodomain, 1 hit
    PF03798 TRAM_LAG1_CLN8, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF005225 LAG1_LAC1, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00724 TLC, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF46689 SSF46689, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50922 TLC, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

    Q9HA82-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MLSSFNEWFW QDRFWLPPNV TWTELEDRDG RVYPHPQDLL AALPLALVLL
    60 70 80 90 100
    AMRLAFERFI GLPLSRWLGV RDQTRRQVKP NATLEKHFLT EGHRPKEPQL
    110 120 130 140 150
    SLLAAQCGLT LQQTQRWFRR RRNQDRPQLT KKFCEASWRF LFYLSSFVGG
    160 170 180 190 200
    LSVLYHESWL WAPVMCWDRY PNQTLKPSLY WWYLLELGFY LSLLIRLPFD
    210 220 230 240 250
    VKRKDFKEQV IHHFVAVILM TFSYSANLLR IGSLVLLLHD SSDYLLEACK
    260 270 280 290 300
    MVNYMQYQQV CDALFLIFSF VFFYTRLVLF PTQILYTTYY ESISNRGPFF
    310 320 330 340 350
    GYYFFNGLLM LLQLLHVFWS CLILRMLYSF MKKGQMEKDI RSDVEESDSS
    360 370 380 390
    EEAAAAQEPL QLKNGAAGGP RPAPTDGPRS RVAGRLTNRH TTAT
    Length:394
    Mass (Da):46,399
    Last modified:May 18, 2010 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDAA12AA386ED2802
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    H0YN04H0YN04_HUMAN
    Ceramide synthase 4
    CERS4
    306Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0YKC9H0YKC9_HUMAN
    Ceramide synthase 4
    CERS4
    343Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0YNR6H0YNR6_HUMAN
    Ceramide synthase 4
    CERS4
    192Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0YKR4H0YKR4_HUMAN
    Ceramide synthase 4
    CERS4
    136Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0YMY6H0YMY6_HUMAN
    Ceramide synthase 4
    CERS4
    92Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0YLY3H0YLY3_HUMAN
    Ceramide synthase 4
    CERS4
    113Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0YKS3H0YKS3_HUMAN
    Ceramide synthase 4
    CERS4
    31Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034065119R → Q. Corresponds to variant dbSNP:rs17159388Ensembl.1
    Natural variantiVAR_019556301G → S. Corresponds to variant dbSNP:rs2288413Ensembl.1
    Natural variantiVAR_060263353A → V2 PublicationsCorresponds to variant dbSNP:rs17160348Ensembl.1
    Natural variantiVAR_019557366A → T1 PublicationCorresponds to variant dbSNP:rs36259Ensembl.1
    Natural variantiVAR_060264379R → Q2 PublicationsCorresponds to variant dbSNP:rs17160349Ensembl.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AK022151 mRNA Translation: BAB13972.1
    AC022146 Genomic DNA No translation available.
    CH471139 Genomic DNA Translation: EAW68940.1
    CH471139 Genomic DNA Translation: EAW68941.1
    CH471139 Genomic DNA Translation: EAW68942.1
    CH471139 Genomic DNA Translation: EAW68945.1
    BC009828 mRNA Translation: AAH09828.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS12197.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_078828.2, NM_024552.2
    XP_011526592.1, XM_011528290.2
    XP_011526593.1, XM_011528291.2
    XP_011526594.1, XM_011528292.2
    XP_011526595.1, XM_011528293.2
    XP_011526596.1, XM_011528294.2
    XP_011526597.1, XM_011528295.2
    XP_016882792.1, XM_017027303.1
    XP_016882793.1, XM_017027304.1
    XP_016882794.1, XM_017027305.1

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000251363; ENSP00000251363; ENSG00000090661
    ENST00000559450; ENSP00000453509; ENSG00000090661

    Database of genes from NCBI RefSeq genomes

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    GeneIDi
    79603

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:79603

    UCSC genome browser

    More...
    UCSCi
    uc002mjg.4 human

    Keywords - Coding sequence diversityi

    Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AK022151 mRNA Translation: BAB13972.1
    AC022146 Genomic DNA No translation available.
    CH471139 Genomic DNA Translation: EAW68940.1
    CH471139 Genomic DNA Translation: EAW68941.1
    CH471139 Genomic DNA Translation: EAW68942.1
    CH471139 Genomic DNA Translation: EAW68945.1
    BC009828 mRNA Translation: AAH09828.1
    CCDSiCCDS12197.1
    RefSeqiNP_078828.2, NM_024552.2
    XP_011526592.1, XM_011528290.2
    XP_011526593.1, XM_011528291.2
    XP_011526594.1, XM_011528292.2
    XP_011526595.1, XM_011528293.2
    XP_011526596.1, XM_011528294.2
    XP_011526597.1, XM_011528295.2
    XP_016882792.1, XM_017027303.1
    XP_016882793.1, XM_017027304.1
    XP_016882794.1, XM_017027305.1

    3D structure databases

    SMRiQ9HA82
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGridi122740, 2 interactors
    IntActiQ9HA82, 34 interactors
    STRINGi9606.ENSP00000251363

    Chemistry databases

    SwissLipidsiSLP:000000699

    PTM databases

    GlyConnecti1106
    iPTMnetiQ9HA82
    PhosphoSitePlusiQ9HA82

    Polymorphism and mutation databases

    BioMutaiCERS4
    DMDMi296434561

    Proteomic databases

    EPDiQ9HA82
    jPOSTiQ9HA82
    MaxQBiQ9HA82
    PaxDbiQ9HA82
    PeptideAtlasiQ9HA82
    PRIDEiQ9HA82
    ProteomicsDBi81384

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    79603
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000251363; ENSP00000251363; ENSG00000090661
    ENST00000559450; ENSP00000453509; ENSG00000090661
    GeneIDi79603
    KEGGihsa:79603
    UCSCiuc002mjg.4 human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    79603
    DisGeNETi79603

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    CERS4
    HGNCiHGNC:23747 CERS4
    HPAiCAB033734
    HPA054729
    MIMi615334 gene
    neXtProtiNX_Q9HA82
    OpenTargetsiENSG00000090661
    PharmGKBiPA134915173

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1607 Eukaryota
    COG5058 LUCA
    GeneTreeiENSGT00950000182700
    HOGENOMiHOG000231977
    InParanoidiQ9HA82
    KOiK04710
    OMAiEACKMFN
    OrthoDBi987268at2759
    PhylomeDBiQ9HA82
    TreeFamiTF314319

    Enzyme and pathway databases

    UniPathwayiUPA00222
    ReactomeiR-HSA-1660661 Sphingolipid de novo biosynthesis

    Miscellaneous databases

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    79603

    Protein Ontology

    More...
    PROi
    PR:Q9HA82

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000090661 Expressed in 154 organ(s), highest expression level in lower esophagus mucosa
    ExpressionAtlasiQ9HA82 baseline and differential
    GenevisibleiQ9HA82 HS

    Family and domain databases

    CDDicd00086 homeodomain, 1 hit
    InterProiView protein in InterPro
    IPR009057 Homeobox-like_sf
    IPR001356 Homeobox_dom
    IPR016439 Lag1/Lac1-like
    IPR006634 TLC-dom
    PANTHERiPTHR12560 PTHR12560, 1 hit
    PfamiView protein in Pfam
    PF00046 Homeodomain, 1 hit
    PF03798 TRAM_LAG1_CLN8, 1 hit
    PIRSFiPIRSF005225 LAG1_LAC1, 1 hit
    SMARTiView protein in SMART
    SM00724 TLC, 1 hit
    SUPFAMiSSF46689 SSF46689, 1 hit
    PROSITEiView protein in PROSITE
    PS50922 TLC, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCERS4_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HA82
    Secondary accession number(s): D6W665
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: May 18, 2010
    Last modified: July 31, 2019
    This is version 157 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    UniProt is an ELIXIR core data resource
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