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Entry version 129 (18 Sep 2019)
Sequence version 4 (12 Sep 2018)
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Protein

Rho guanine nucleotide exchange factor 10-like protein

Gene

ARHGEF10L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-193648 NRAGE signals death through JNK
R-HSA-194840 Rho GTPase cycle
R-HSA-416482 G alpha (12/13) signalling events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 10-like protein
Alternative name(s):
GrinchGEF
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARHGEF10L
Synonyms:GRINCHGEF, KIAA1626
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25540 ARHGEF10L

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612494 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9HCE6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55160

Open Targets

More...
OpenTargetsi
ENSG00000074964

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672586

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ARHGEF10L

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373481

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003423611 – 1279Rho guanine nucleotide exchange factor 10-like proteinAdd BLAST1279

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei40PhosphoserineCombined sources1
Modified residuei131PhosphotyrosineBy similarity1
Modified residuei152PhosphotyrosineBy similarity1
Modified residuei281PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9HCE6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9HCE6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9HCE6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9HCE6

PeptideAtlas

More...
PeptideAtlasi
Q9HCE6

PRoteomics IDEntifications database

More...
PRIDEi
Q9HCE6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
81688 [Q9HCE6-1]
81689 [Q9HCE6-2]
81690 [Q9HCE6-3]
81691 [Q9HCE6-4]
81692 [Q9HCE6-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9HCE6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9HCE6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in heart, liver, skeletal muscle, kidney and pancreas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000074964 Expressed in 227 organ(s), highest expression level in right lobe of liver

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9HCE6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9HCE6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA026426
HPA026440
HPA028115

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RHOA, RHOB and RHOC.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9HCE6, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000355060

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini316 – 503DHPROSITE-ProRule annotationAdd BLAST188

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3522 Eukaryota
KOG3524 Eukaryota
ENOG410ZJK1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153798

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9HCE6

KEGG Orthology (KO)

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KOi
K16727

Identification of Orthologs from Complete Genome Data

More...
OMAi
RVNISYH

Database of Orthologous Groups

More...
OrthoDBi
67600at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9HCE6

TreeFam database of animal gene trees

More...
TreeFami
TF331430

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00160 RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 1 hit
2.130.10.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039919 ARHGEF10/ARHGEF17
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR011993 PH-like_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12877 PTHR12877, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00621 RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00325 RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065 SSF48065, 1 hit
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50010 DH_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9HCE6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASSNPPPQP AIGDQLVPGV PGPSSEAEDD PGEAFEFDDS DDEEDTSAAL
60 70 80 90 100
GVPSLAPERD TDPPLIHLDS IPVTDPDPAA APPGTGVPAW VSNGDAADAA
110 120 130 140 150
FSGARHSSWK RKSSRRIDRF TFPALEEDVI YDDVPCESPD AHQPGAERNL
160 170 180 190 200
LYEDAHRAGA PRQAEDLGWS SSEFESYSED SGEEAKPEVE VEPAKHRVSF
210 220 230 240 250
QPKLSPDLTR LKERYARTKR DILALRVGGR DMQELKHKYD CKMTQLMKAA
260 270 280 290 300
KSGTKDGLEK TRMAVMRKVS FLHRKDVLGD SEEEDMGLLE VSVSDIKPPA
310 320 330 340 350
PELGPMPEGL SPQQVVRRHI LGSIVQSEGS YVESLKRILQ DYRNPLMEME
360 370 380 390 400
PKALSARKCQ VVFFRVKEIL HCHSMFQIAL SSRVAEWDST EKIGDLFVAS
410 420 430 440 450
FSKSMVLDVY SDYVNNFTSA MSIIKKACLT KPAFLEFLKR RQVCSPDRVT
460 470 480 490 500
LYGLMVKPIQ RFPQFILLLQ DMLKNTPRGH PDRLSLQLAL TELETLAEKL
510 520 530 540 550
NEQKRLADQV AEIQQLTKSV SDRSSLNKLL TSGQRQLLLC ETLTETVYGD
560 570 580 590 600
RGQLIKSKER RVFLLNDMLV CANINFKPAN HRGQLEISSL VPLGPKYVVK
610 620 630 640 650
WNTALPQVQV VEVGQDGGTY DKDNVLIQHS GAKKASASGQ AQNKVYLGPP
660 670 680 690 700
RLFQELQDLQ KDLAVVEQIT LLISTLHGTY QNLNMTVAQD WCLALQRLMR
710 720 730 740 750
VKEEEIHSAN KCRLRLLLPG KPDKSGRPIS FMVVFITPNP LSKISWVNRL
760 770 780 790 800
HLAKIGLREE NQPGWLCPDE DKKSKAPFWC PILACCIPAF SSRALSLQLG
810 820 830 840 850
ALVHSPVNCP LLGFSAVSTS LPQGYLWVGG GQEGAGGQVE IFSLNRPSPR
860 870 880 890 900
TVKSFPLAAP VLCMEYIPEL EEEAESRDES PTVADPSATV HPTICLGLQD
910 920 930 940 950
GSILLYSSVD TGTQCLVSCR SPGLQPVLCL RHSPFHLLAG LQDGTLAAYP
960 970 980 990 1000
RTSGGVLWDL ESPPVCLTVG PGPVRTLLSL EDAVWASCGP RVTVLEATTL
1010 1020 1030 1040 1050
QPQQSFEAHQ DEAVSVTHMV KAGSGVWMAF SSGTSIRLFH TETLEHLQEI
1060 1070 1080 1090 1100
NIATRTTFLL PGQKHLCVTS LLICQGLLWV GTDQGVIVLL PVPRLEGIPK
1110 1120 1130 1140 1150
ITGKGMVSLN GHCGPVAFLA VATSILAPDI LRSDQEEAEG PRAEEDKPDG
1160 1170 1180 1190 1200
QAHEPMPDSH VGRELTRKKG ILLQYRLRST AHLPGPLLSM REPAPADGAA
1210 1220 1230 1240 1250
LEHSEEDGSI YEMADDPDIW VRSRPCARDA HRKEICSVAI ISGGQGYRNF
1260 1270
GSALGSSGRQ APCGETDSTL LIWQVPLML
Length:1,279
Mass (Da):140,379
Last modified:September 12, 2018 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1ED000F0C8864CD7
GO
Isoform 2 (identifier: Q9HCE6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     203-241: Missing.

Show »
Length:1,240
Mass (Da):135,723
Checksum:i4595B923D7040F1C
GO
Isoform 3 (identifier: Q9HCE6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     203-241: Missing.
     578-582: Missing.

Show »
Length:1,235
Mass (Da):135,147
Checksum:i85A6ACCF22F85D9E
GO
Isoform 4 (identifier: Q9HCE6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-221: Missing.
     222-278: ILALRVGGRD...VSFLHRKDVL → MLPSSSWGKR...SSSSSSVSCS
     401-470: Missing.
     578-582: Missing.

Show »
Length:982
Mass (Da):107,436
Checksum:iC8A874DDF02C751B
GO
Isoform 5 (identifier: Q9HCE6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     578-582: Missing.
     1062-1072: GQKHLCVTSLL → DRSLIKCSPRA
     1073-1279: Missing.

Note: No experimental confirmation available.
Show »
Length:1,067
Mass (Da):117,621
Checksum:i290DE8650304BBC2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5VXI4Q5VXI4_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF10L
1,052Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A384DVK7A0A384DVK7_HUMAN
Rho guanine nucleotide exchange fac...
ARHGEF10L
611Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91663 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB13452 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC03792 differs from that shown. Reason: Erroneous termination at position 931. Translated as Arg.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti24S → P in AAZ73162 (PubMed:16112081).Curated1
Sequence conflicti924L → P in BAA91663 (PubMed:14702039).Curated1
Sequence conflicti1006F → S in BAA91663 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06179447S → N. Corresponds to variant dbSNP:rs34417109Ensembl.1
Natural variantiVAR_04418369D → N. Corresponds to variant dbSNP:rs35497285Ensembl.1
Natural variantiVAR_04418496A → V in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1421731181Ensembl.1
Natural variantiVAR_044185991R → W. Corresponds to variant dbSNP:rs6695710Ensembl.1
Natural variantiVAR_0441861219I → V3 PublicationsCorresponds to variant dbSNP:rs2270976Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0344201 – 221Missing in isoform 4. 1 PublicationAdd BLAST221
Alternative sequenceiVSP_034421203 – 241Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST39
Alternative sequenceiVSP_034422222 – 278ILALR…RKDVL → MLPSSSWGKRKLRGRLGWVR SDARGVMWARQEGLHHPHPH AVIRCPSSSSSSVSCS in isoform 4. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_034423401 – 470Missing in isoform 4. 1 PublicationAdd BLAST70
Alternative sequenceiVSP_034424578 – 582Missing in isoform 3, isoform 4 and isoform 5. 3 Publications5
Alternative sequenceiVSP_0344251062 – 1072GQKHLCVTSLL → DRSLIKCSPRA in isoform 5. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_0344261073 – 1279Missing in isoform 5. 1 PublicationAdd BLAST207

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ139833 mRNA Translation: AAZ73162.1
AB046846 mRNA Translation: BAB13452.1 Different initiation.
AK001383 mRNA Translation: BAA91663.1 Different initiation.
AK092020 mRNA Translation: BAC03792.1 Sequence problems.
AL139250 Genomic DNA No translation available.
AL358593 Genomic DNA No translation available.
BC065561 mRNA Translation: AAH65561.1
BC080596 mRNA Translation: AAH80596.1
BC117171 mRNA Translation: AAI17172.1
BC143347 mRNA Translation: AAI43348.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS182.1 [Q9HCE6-1]
CCDS30617.1 [Q9HCE6-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001011722.2, NM_001011722.2 [Q9HCE6-2]
NP_001306766.1, NM_001319837.1 [Q9HCE6-3]
NP_001306767.1, NM_001319838.1 [Q9HCE6-4]
NP_001315053.1, NM_001328124.1
NP_060595.3, NM_018125.3 [Q9HCE6-1]
XP_005245982.2, XM_005245925.2 [Q9HCE6-2]
XP_016857106.1, XM_017001617.1 [Q9HCE6-3]
XP_016857110.1, XM_017001621.1 [Q9HCE6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000361221; ENSP00000355060; ENSG00000074964 [Q9HCE6-1]
ENST00000375415; ENSP00000364564; ENSG00000074964 [Q9HCE6-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55160

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55160

UCSC genome browser

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UCSCi
uc001ban.4 human [Q9HCE6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ139833 mRNA Translation: AAZ73162.1
AB046846 mRNA Translation: BAB13452.1 Different initiation.
AK001383 mRNA Translation: BAA91663.1 Different initiation.
AK092020 mRNA Translation: BAC03792.1 Sequence problems.
AL139250 Genomic DNA No translation available.
AL358593 Genomic DNA No translation available.
BC065561 mRNA Translation: AAH65561.1
BC080596 mRNA Translation: AAH80596.1
BC117171 mRNA Translation: AAI17172.1
BC143347 mRNA Translation: AAI43348.1
CCDSiCCDS182.1 [Q9HCE6-1]
CCDS30617.1 [Q9HCE6-2]
RefSeqiNP_001011722.2, NM_001011722.2 [Q9HCE6-2]
NP_001306766.1, NM_001319837.1 [Q9HCE6-3]
NP_001306767.1, NM_001319838.1 [Q9HCE6-4]
NP_001315053.1, NM_001328124.1
NP_060595.3, NM_018125.3 [Q9HCE6-1]
XP_005245982.2, XM_005245925.2 [Q9HCE6-2]
XP_016857106.1, XM_017001617.1 [Q9HCE6-3]
XP_016857110.1, XM_017001621.1 [Q9HCE6-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ9HCE6, 5 interactors
STRINGi9606.ENSP00000355060

PTM databases

iPTMnetiQ9HCE6
PhosphoSitePlusiQ9HCE6

Polymorphism and mutation databases

BioMutaiARHGEF10L
DMDMi317373481

Proteomic databases

EPDiQ9HCE6
jPOSTiQ9HCE6
MassIVEiQ9HCE6
PaxDbiQ9HCE6
PeptideAtlasiQ9HCE6
PRIDEiQ9HCE6
ProteomicsDBi81688 [Q9HCE6-1]
81689 [Q9HCE6-2]
81690 [Q9HCE6-3]
81691 [Q9HCE6-4]
81692 [Q9HCE6-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361221; ENSP00000355060; ENSG00000074964 [Q9HCE6-1]
ENST00000375415; ENSP00000364564; ENSG00000074964 [Q9HCE6-2]
GeneIDi55160
KEGGihsa:55160
UCSCiuc001ban.4 human [Q9HCE6-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55160
DisGeNETi55160

GeneCards: human genes, protein and diseases

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GeneCardsi
ARHGEF10L
HGNCiHGNC:25540 ARHGEF10L
HPAiHPA026426
HPA026440
HPA028115
MIMi612494 gene
neXtProtiNX_Q9HCE6
OpenTargetsiENSG00000074964
PharmGKBiPA142672586

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3522 Eukaryota
KOG3524 Eukaryota
ENOG410ZJK1 LUCA
GeneTreeiENSGT00940000153798
InParanoidiQ9HCE6
KOiK16727
OMAiRVNISYH
OrthoDBi67600at2759
PhylomeDBiQ9HCE6
TreeFamiTF331430

Enzyme and pathway databases

ReactomeiR-HSA-193648 NRAGE signals death through JNK
R-HSA-194840 Rho GTPase cycle
R-HSA-416482 G alpha (12/13) signalling events

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ARHGEF10L human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55160

Pharos

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Pharosi
Q9HCE6

Protein Ontology

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PROi
PR:Q9HCE6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000074964 Expressed in 227 organ(s), highest expression level in right lobe of liver
ExpressionAtlasiQ9HCE6 baseline and differential
GenevisibleiQ9HCE6 HS

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.130.10.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR039919 ARHGEF10/ARHGEF17
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR011993 PH-like_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR12877 PTHR12877, 1 hit
PfamiView protein in Pfam
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00325 RhoGEF, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARGAL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HCE6
Secondary accession number(s): B7ZKS1
, Q17RW1, Q3YFJ4, Q5VXI5, Q5VXI6, Q66K51, Q6P0L7, Q8NAV5, Q9NVT3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: September 12, 2018
Last modified: September 18, 2019
This is version 129 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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