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Entry version 180 (31 Jul 2019)
Sequence version 2 (07 Dec 2004)
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Protein

E3 ubiquitin-protein ligase TRIM39

Gene

TRIM39

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri29 – 70RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri102 – 143B box-typePROSITE-ProRule annotationAdd BLAST42

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processApoptosis, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase TRIM39 (EC:2.3.2.27)
Alternative name(s):
RING finger protein 23
RING-type E3 ubiquitin transferase TRIM39Curated
Testis-abundant finger protein
Tripartite motif-containing protein 39
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRIM39
Synonyms:RNF23, TFP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10065 TRIM39

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605700 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9HCM9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
56658

Open Targets

More...
OpenTargetsi
ENSG00000204599

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35535

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRIM39

Domain mapping of disease mutations (DMDM)

More...
DMDMi
56405385

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000562571 – 518E3 ubiquitin-protein ligase TRIM39Add BLAST518

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autoubiquitinated.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9HCM9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9HCM9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9HCM9

PeptideAtlas

More...
PeptideAtlasi
Q9HCM9

PRoteomics IDEntifications database

More...
PRIDEi
Q9HCM9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
81768 [Q9HCM9-1]
81769 [Q9HCM9-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9HCM9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9HCM9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous; highly expressed in brain, heart, kidney, liver, skeletal muscle, spleen and testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000204599 Expressed in 190 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9HCM9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9HCM9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA051120
HPA059496

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MOAP1.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121170, 95 interactors

Protein interaction database and analysis system

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IntActi
Q9HCM9, 57 interactors

Molecular INTeraction database

More...
MINTi
Q9HCM9

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000365844

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1518
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9HCM9

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9HCM9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini319 – 514B30.2/SPRYPROSITE-ProRule annotationAdd BLAST196

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili181 – 250Sequence analysisAdd BLAST70

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri29 – 70RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri102 – 143B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410ITFV Eukaryota
ENOG410YDPJ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154126

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234133

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9HCM9

KEGG Orthology (KO)

More...
KOi
K12015

Identification of Orthologs from Complete Genome Data

More...
OMAi
WAVGVCQ

Database of Orthologous Groups

More...
OrthoDBi
423686at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9HCM9

TreeFam database of animal gene trees

More...
TreeFami
TF342569

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00021 BBOX, 1 hit
cd13745 SPRY_PRY_TRIM39, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR035033 PRY/SPRY_TRIM39
IPR003877 SPRY_dom
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01407 BUTYPHLNCDUF

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00336 BBOX, 1 hit
SM00589 PRY, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9HCM9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAETSLLEAG ASAASTAAAL ENLQVEASCS VCLEYLKEPV IIECGHNFCK
60 70 80 90 100
ACITRWWEDL ERDFPCPVCR KTSRYRSLRP NRQLGSMVEI AKQLQAVKRK
110 120 130 140 150
IRDESLCPQH HEALSLFCYE DQEAVCLICA ISHTHRAHTV VPLDDATQEY
160 170 180 190 200
KEKLQKCLEP LEQKLQEITR CKSSEEKKPG ELKRLVESRR QQILREFEEL
210 220 230 240 250
HRRLDEEQQV LLSRLEEEEQ DILQRLRENA AHLGDKRRDL AHLAAEVEGK
260 270 280 290 300
CLQSGFEMLK DVKSTLEKNI PRKFGGSLST ICPRDHKALL GLVKEINRCE
310 320 330 340 350
KVKTMEVTSV SIELEKNFSN FPRQYFALRK ILKQLIADVT LDPETAHPNL
360 370 380 390 400
VLSEDRKSVK FVETRLRDLP DTPRRFTFYP CVLATEGFTS GRHYWEVEVG
410 420 430 440 450
DKTHWAVGVC RDSVSRKGEL TPLPETGYWR VRLWNGDKYA ATTTPFTPLH
460 470 480 490 500
IKVKPKRVGI FLDYEAGTLS FYNVTDRSHI YTFTDTFTEK LWPLFYPGIR
510
AGRKNAAPLT IRPPTDWE
Length:518
Mass (Da):59,690
Last modified:December 7, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2F946F518B217153
GO
Isoform 2 (identifier: Q9HCM9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     269-298: Missing.

Show »
Length:488
Mass (Da):56,374
Checksum:i102AA8E5C8786A3E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AAZ6A2AAZ6_HUMAN
E3 ubiquitin-protein ligase TRIM39
TRIM39
260Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y735H0Y735_HUMAN
E3 ubiquitin-protein ligase TRIM39
TRIM39
227Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AAZ5A2AAZ5_HUMAN
E3 ubiquitin-protein ligase TRIM39
TRIM39
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AAZ4A2AAZ4_HUMAN
E3 ubiquitin-protein ligase TRIM39
TRIM39
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AAZ3A2AAZ3_HUMAN
E3 ubiquitin-protein ligase TRIM39
TRIM39
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AAZ2A2AAZ2_HUMAN
E3 ubiquitin-protein ligase TRIM39
TRIM39
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti137A → P in BAB16374 (PubMed:11006080).Curated1
Sequence conflicti419E → K in BAD13703 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_005755269 – 298Missing in isoform 2. 2 PublicationsAdd BLAST30

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB046381 mRNA Translation: BAB16374.1
BT007370 mRNA Translation: AAP36034.1
AB110937 Genomic DNA Translation: BAD13703.1
AK292512 mRNA Translation: BAF85201.1
AB110938 Genomic DNA Translation: BAD13704.1
AB202089 Genomic DNA Translation: BAE78608.1
AL662832 Genomic DNA No translation available.
AL662795 Genomic DNA No translation available.
AL773535 Genomic DNA No translation available.
BX248580 Genomic DNA No translation available.
CR759928 Genomic DNA No translation available.
BX927214 Genomic DNA No translation available.
CR759281 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03283.1
CH471081 Genomic DNA Translation: EAX03284.1
BC007661 mRNA Translation: AAH07661.1
BC034985 mRNA Translation: AAH34985.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34377.1 [Q9HCM9-1]
CCDS34378.1 [Q9HCM9-2]

Protein sequence database of the Protein Information Resource

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PIRi
JC7387

NCBI Reference Sequences

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RefSeqi
NP_067076.2, NM_021253.3 [Q9HCM9-1]
NP_742013.1, NM_172016.2 [Q9HCM9-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000376656; ENSP00000365844; ENSG00000204599 [Q9HCM9-1]
ENST00000376659; ENSP00000365847; ENSG00000204599 [Q9HCM9-2]
ENST00000383601; ENSP00000373095; ENSG00000206495 [Q9HCM9-2]
ENST00000383602; ENSP00000373096; ENSG00000206495 [Q9HCM9-1]
ENST00000383603; ENSP00000373097; ENSG00000206495 [Q9HCM9-2]
ENST00000396547; ENSP00000379796; ENSG00000204599 [Q9HCM9-1]
ENST00000396548; ENSP00000379797; ENSG00000204599 [Q9HCM9-2]
ENST00000396551; ENSP00000379800; ENSG00000204599 [Q9HCM9-2]
ENST00000400644; ENSP00000383486; ENSG00000206495 [Q9HCM9-2]
ENST00000413715; ENSP00000411949; ENSG00000224994 [Q9HCM9-1]
ENST00000414015; ENSP00000401071; ENSG00000224994 [Q9HCM9-2]
ENST00000419790; ENSP00000401184; ENSG00000229929 [Q9HCM9-2]
ENST00000424575; ENSP00000409902; ENSG00000230308 [Q9HCM9-1]
ENST00000426469; ENSP00000397043; ENSG00000229929 [Q9HCM9-1]
ENST00000430502; ENSP00000398956; ENSG00000232839 [Q9HCM9-2]
ENST00000431272; ENSP00000396986; ENSG00000230308 [Q9HCM9-2]
ENST00000433900; ENSP00000389852; ENSG00000232839 [Q9HCM9-2]
ENST00000438076; ENSP00000389198; ENSG00000232839 [Q9HCM9-2]
ENST00000438859; ENSP00000411582; ENSG00000226437 [Q9HCM9-2]
ENST00000440117; ENSP00000392130; ENSG00000224994 [Q9HCM9-2]
ENST00000443109; ENSP00000414525; ENSG00000229929 [Q9HCM9-2]
ENST00000445206; ENSP00000391917; ENSG00000226437 [Q9HCM9-1]
ENST00000446397; ENSP00000412743; ENSG00000230308 [Q9HCM9-2]
ENST00000449318; ENSP00000404904; ENSG00000224994 [Q9HCM9-2]
ENST00000450778; ENSP00000387445; ENSG00000226437 [Q9HCM9-2]
ENST00000451132; ENSP00000394353; ENSG00000226437 [Q9HCM9-2]
ENST00000451715; ENSP00000398355; ENSG00000232839 [Q9HCM9-1]
ENST00000452705; ENSP00000415259; ENSG00000229929 [Q9HCM9-2]
ENST00000458607; ENSP00000404340; ENSG00000230308 [Q9HCM9-2]
ENST00000547030; ENSP00000449847; ENSG00000224994 [Q9HCM9-1]
ENST00000548002; ENSP00000447835; ENSG00000232839 [Q9HCM9-1]
ENST00000549841; ENSP00000448572; ENSG00000230308 [Q9HCM9-1]
ENST00000550282; ENSP00000449272; ENSG00000206495 [Q9HCM9-1]
ENST00000552337; ENSP00000450288; ENSG00000226437 [Q9HCM9-1]
ENST00000552520; ENSP00000448462; ENSG00000229929 [Q9HCM9-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
56658

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:56658

UCSC genome browser

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UCSCi
uc003nqb.4 human [Q9HCM9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046381 mRNA Translation: BAB16374.1
BT007370 mRNA Translation: AAP36034.1
AB110937 Genomic DNA Translation: BAD13703.1
AK292512 mRNA Translation: BAF85201.1
AB110938 Genomic DNA Translation: BAD13704.1
AB202089 Genomic DNA Translation: BAE78608.1
AL662832 Genomic DNA No translation available.
AL662795 Genomic DNA No translation available.
AL773535 Genomic DNA No translation available.
BX248580 Genomic DNA No translation available.
CR759928 Genomic DNA No translation available.
BX927214 Genomic DNA No translation available.
CR759281 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03283.1
CH471081 Genomic DNA Translation: EAX03284.1
BC007661 mRNA Translation: AAH07661.1
BC034985 mRNA Translation: AAH34985.1
CCDSiCCDS34377.1 [Q9HCM9-1]
CCDS34378.1 [Q9HCM9-2]
PIRiJC7387
RefSeqiNP_067076.2, NM_021253.3 [Q9HCM9-1]
NP_742013.1, NM_172016.2 [Q9HCM9-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DIDNMR-A104-143[»]
2DIFNMR-A104-143[»]
2ECJNMR-A19-69[»]
SMRiQ9HCM9
ModBaseiSearch...

Protein-protein interaction databases

BioGridi121170, 95 interactors
IntActiQ9HCM9, 57 interactors
MINTiQ9HCM9
STRINGi9606.ENSP00000365844

PTM databases

iPTMnetiQ9HCM9
PhosphoSitePlusiQ9HCM9

Polymorphism and mutation databases

BioMutaiTRIM39
DMDMi56405385

Proteomic databases

jPOSTiQ9HCM9
MaxQBiQ9HCM9
PaxDbiQ9HCM9
PeptideAtlasiQ9HCM9
PRIDEiQ9HCM9
ProteomicsDBi81768 [Q9HCM9-1]
81769 [Q9HCM9-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
56658
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376656; ENSP00000365844; ENSG00000204599 [Q9HCM9-1]
ENST00000376659; ENSP00000365847; ENSG00000204599 [Q9HCM9-2]
ENST00000383601; ENSP00000373095; ENSG00000206495 [Q9HCM9-2]
ENST00000383602; ENSP00000373096; ENSG00000206495 [Q9HCM9-1]
ENST00000383603; ENSP00000373097; ENSG00000206495 [Q9HCM9-2]
ENST00000396547; ENSP00000379796; ENSG00000204599 [Q9HCM9-1]
ENST00000396548; ENSP00000379797; ENSG00000204599 [Q9HCM9-2]
ENST00000396551; ENSP00000379800; ENSG00000204599 [Q9HCM9-2]
ENST00000400644; ENSP00000383486; ENSG00000206495 [Q9HCM9-2]
ENST00000413715; ENSP00000411949; ENSG00000224994 [Q9HCM9-1]
ENST00000414015; ENSP00000401071; ENSG00000224994 [Q9HCM9-2]
ENST00000419790; ENSP00000401184; ENSG00000229929 [Q9HCM9-2]
ENST00000424575; ENSP00000409902; ENSG00000230308 [Q9HCM9-1]
ENST00000426469; ENSP00000397043; ENSG00000229929 [Q9HCM9-1]
ENST00000430502; ENSP00000398956; ENSG00000232839 [Q9HCM9-2]
ENST00000431272; ENSP00000396986; ENSG00000230308 [Q9HCM9-2]
ENST00000433900; ENSP00000389852; ENSG00000232839 [Q9HCM9-2]
ENST00000438076; ENSP00000389198; ENSG00000232839 [Q9HCM9-2]
ENST00000438859; ENSP00000411582; ENSG00000226437 [Q9HCM9-2]
ENST00000440117; ENSP00000392130; ENSG00000224994 [Q9HCM9-2]
ENST00000443109; ENSP00000414525; ENSG00000229929 [Q9HCM9-2]
ENST00000445206; ENSP00000391917; ENSG00000226437 [Q9HCM9-1]
ENST00000446397; ENSP00000412743; ENSG00000230308 [Q9HCM9-2]
ENST00000449318; ENSP00000404904; ENSG00000224994 [Q9HCM9-2]
ENST00000450778; ENSP00000387445; ENSG00000226437 [Q9HCM9-2]
ENST00000451132; ENSP00000394353; ENSG00000226437 [Q9HCM9-2]
ENST00000451715; ENSP00000398355; ENSG00000232839 [Q9HCM9-1]
ENST00000452705; ENSP00000415259; ENSG00000229929 [Q9HCM9-2]
ENST00000458607; ENSP00000404340; ENSG00000230308 [Q9HCM9-2]
ENST00000547030; ENSP00000449847; ENSG00000224994 [Q9HCM9-1]
ENST00000548002; ENSP00000447835; ENSG00000232839 [Q9HCM9-1]
ENST00000549841; ENSP00000448572; ENSG00000230308 [Q9HCM9-1]
ENST00000550282; ENSP00000449272; ENSG00000206495 [Q9HCM9-1]
ENST00000552337; ENSP00000450288; ENSG00000226437 [Q9HCM9-1]
ENST00000552520; ENSP00000448462; ENSG00000229929 [Q9HCM9-1]
GeneIDi56658
KEGGihsa:56658
UCSCiuc003nqb.4 human [Q9HCM9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
56658
DisGeNETi56658

GeneCards: human genes, protein and diseases

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GeneCardsi
TRIM39
HGNCiHGNC:10065 TRIM39
HPAiHPA051120
HPA059496
MIMi605700 gene
neXtProtiNX_Q9HCM9
OpenTargetsiENSG00000204599
PharmGKBiPA35535

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410ITFV Eukaryota
ENOG410YDPJ LUCA
GeneTreeiENSGT00940000154126
HOGENOMiHOG000234133
InParanoidiQ9HCM9
KOiK12015
OMAiWAVGVCQ
OrthoDBi423686at2759
PhylomeDBiQ9HCM9
TreeFamiTF342569

Enzyme and pathway databases

UniPathwayiUPA00143
ReactomeiR-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TRIM39 human
EvolutionaryTraceiQ9HCM9

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
56658

Protein Ontology

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PROi
PR:Q9HCM9

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000204599 Expressed in 190 organ(s), highest expression level in testis
ExpressionAtlasiQ9HCM9 baseline and differential
GenevisibleiQ9HCM9 HS

Family and domain databases

CDDicd00021 BBOX, 1 hit
cd13745 SPRY_PRY_TRIM39, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR006574 PRY
IPR035033 PRY/SPRY_TRIM39
IPR003877 SPRY_dom
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF00643 zf-B_box, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
SM00589 PRY, 1 hit
SM00184 RING, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRI39_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9HCM9
Secondary accession number(s): Q5STG3
, Q5STG4, Q76BL3, Q8IYT9, Q96IB6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: December 7, 2004
Last modified: July 31, 2019
This is version 180 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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