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Entry version 95 (16 Oct 2019)
Sequence version 1 (01 Oct 2000)
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Protein

Protein TSSC4

Gene

Tssc4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein TSSC4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tssc4
ORF Names:MNCb-3063
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1861712 Tssc4

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000763611 – 317Protein TSSC4Add BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei57PhosphoserineCombined sources1
Modified residuei64PhosphoserineCombined sources1
Modified residuei83PhosphoserineBy similarity1
Modified residuei92PhosphoserineCombined sources1
Modified residuei124PhosphothreonineCombined sources1
Modified residuei214N6-acetyllysineBy similarity1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9JHE7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9JHE7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9JHE7

PeptideAtlas

More...
PeptideAtlasi
Q9JHE7

PRoteomics IDEntifications database

More...
PRIDEi
Q9JHE7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9JHE7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9JHE7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in placenta. Widely expressed in embryo and newborn.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in embryo at 12.5 dpc and 16.5 dpc.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000045752 Expressed in 274 organ(s), highest expression level in ear vesicle

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9JHE7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9JHE7 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
208191, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000056582

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TSSC4 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IIC0 Eukaryota
ENOG41120VA LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000011846

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154697

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9JHE7

Identification of Orthologs from Complete Genome Data

More...
OMAi
PEAEEWS

Database of Orthologous Groups

More...
OrthoDBi
1538986at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9JHE7

TreeFam database of animal gene trees

More...
TreeFami
TF335741

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029338 TSSC4

The PANTHER Classification System

More...
PANTHERi
PTHR13445 PTHR13445, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15264 TSSC4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9JHE7-1) [UniParc]FASTAAdd to basket
Also known as: Tssc4-1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAETEAGLEA DEPTEDDTLP SDTVSLSDSD SDLSLPSGVE VQVLSPERLS
60 70 80 90 100
EEGQEDSGPE DPPSPPTGTL TTAVQPFHLR GMSSTFSQRS HSIFDCLESA
110 120 130 140 150
ARQAPCSAPQ TSVSDNGSFR RPVTPPSQTP ARGLSRVHGN TGPTRVLPVP
160 170 180 190 200
DYVSHPERWT KYSLEDVSEA SEQSNRDAAL AFLSSRSQVS HTDYVPSFNQ
210 220 230 240 250
DPSSCGEGRV VFTKPVRDSE ARAERKRVLK KGVGSGAGGE AAVELAHLAG
260 270 280 290 300
PEAEEWSGHQ GQPEVVVPSE AAHPESSSGP IGVKAVGFHG SKKRSRDHFR
310
NRDGNPGGPG SERGPSV
Length:317
Mass (Da):33,569
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF0BC4EAEA7709342
GO
Isoform 2 (identifier: Q9JHE7-2) [UniParc]FASTAAdd to basket
Also known as: Tssc4-2

The sequence of this isoform differs from the canonical sequence as follows:
     113-114: VS → AP
     115-317: Missing.

Show »
Length:114
Mass (Da):11,947
Checksum:iEDE73978F0362346
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YZR1D3YZR1_MOUSE
Protein TSSC4
Tssc4
217Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YYU6D3YYU6_MOUSE
Protein TSSC4
Tssc4
265Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z6S3D3Z6S3_MOUSE
Protein TSSC4
Tssc4
196Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_016562113 – 114VS → AP in isoform 2. 1 Publication2
Alternative sequenceiVSP_016563115 – 317Missing in isoform 2. 1 PublicationAdd BLAST203

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB038011 mRNA Translation: BAA96876.1
AJ251835 Genomic DNA Translation: CAB94775.1
AJ279796 mRNA Translation: CAB94724.1
AB041597 mRNA Translation: BAA95080.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS40195.1 [Q9JHE7-1]
CCDS40196.1 [Q9JHE7-2]

NCBI Reference Sequences

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RefSeqi
NP_001108557.1, NM_001115085.1 [Q9JHE7-1]
NP_064681.1, NM_020285.2 [Q9JHE7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000060433; ENSMUSP00000056582; ENSMUSG00000045752 [Q9JHE7-1]
ENSMUST00000105920; ENSMUSP00000101540; ENSMUSG00000045752 [Q9JHE7-2]
ENSMUST00000177841; ENSMUSP00000137399; ENSMUSG00000045752 [Q9JHE7-1]
ENSMUST00000208779; ENSMUSP00000146914; ENSMUSG00000045752 [Q9JHE7-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
56844

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:56844

UCSC genome browser

More...
UCSCi
uc009kow.1 mouse [Q9JHE7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038011 mRNA Translation: BAA96876.1
AJ251835 Genomic DNA Translation: CAB94775.1
AJ279796 mRNA Translation: CAB94724.1
AB041597 mRNA Translation: BAA95080.1
CCDSiCCDS40195.1 [Q9JHE7-1]
CCDS40196.1 [Q9JHE7-2]
RefSeqiNP_001108557.1, NM_001115085.1 [Q9JHE7-1]
NP_064681.1, NM_020285.2 [Q9JHE7-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi208191, 1 interactor
STRINGi10090.ENSMUSP00000056582

PTM databases

iPTMnetiQ9JHE7
PhosphoSitePlusiQ9JHE7

Proteomic databases

EPDiQ9JHE7
jPOSTiQ9JHE7
PaxDbiQ9JHE7
PeptideAtlasiQ9JHE7
PRIDEiQ9JHE7

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
56844

Genome annotation databases

EnsembliENSMUST00000060433; ENSMUSP00000056582; ENSMUSG00000045752 [Q9JHE7-1]
ENSMUST00000105920; ENSMUSP00000101540; ENSMUSG00000045752 [Q9JHE7-2]
ENSMUST00000177841; ENSMUSP00000137399; ENSMUSG00000045752 [Q9JHE7-1]
ENSMUST00000208779; ENSMUSP00000146914; ENSMUSG00000045752 [Q9JHE7-2]
GeneIDi56844
KEGGimmu:56844
UCSCiuc009kow.1 mouse [Q9JHE7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10078
MGIiMGI:1861712 Tssc4

Phylogenomic databases

eggNOGiENOG410IIC0 Eukaryota
ENOG41120VA LUCA
GeneTreeiENSGT00390000011846
HOGENOMiHOG000154697
InParanoidiQ9JHE7
OMAiPEAEEWS
OrthoDBi1538986at2759
PhylomeDBiQ9JHE7
TreeFamiTF335741

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Tssc4 mouse

Protein Ontology

More...
PROi
PR:Q9JHE7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000045752 Expressed in 274 organ(s), highest expression level in ear vesicle
ExpressionAtlasiQ9JHE7 baseline and differential
GenevisibleiQ9JHE7 MM

Family and domain databases

InterProiView protein in InterPro
IPR029338 TSSC4
PANTHERiPTHR13445 PTHR13445, 1 hit
PfamiView protein in Pfam
PF15264 TSSC4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTSSC4_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9JHE7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 1, 2000
Last modified: October 16, 2019
This is version 95 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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