UniProtKB - Q9JJL3 (SO1B2_MOUSE)
Protein
Solute carrier organic anion transporter family member 1B2
Gene
Slco1b2
Organism
Mus musculus (Mouse)
Status
Functioni
Mediates the Na+-independent uptake of organic anions such as taurochlate, bromosulfophthalein and steroid conjugates such as estrone-3-sulfate, 17-beta-glucuronosyl estradiol, dehydroepiandrosterone sulfate and prostaglandin E2.By similarity
GO - Molecular functioni
- bile acid transmembrane transporter activity Source: MGI
- oligopeptide transmembrane transporter activity Source: MGI
- organic anion transmembrane transporter activity Source: MGI
- sodium-independent organic anion transmembrane transporter activity Source: GO_Central
GO - Biological processi
- bile acid and bile salt transport Source: MGI
- drug transport Source: MGI
- liver development Source: Ensembl
- oligopeptide transport Source: MGI
- response to antibiotic Source: Ensembl
- response to cytokine Source: Ensembl
- response to glucocorticoid Source: Ensembl
- response to lipopolysaccharide Source: Ensembl
- response to peptide hormone Source: Ensembl
- sodium-independent organic anion transport Source: GO_Central
Keywordsi
Biological process | Ion transport, Transport |
Enzyme and pathway databases
Reactomei | R-MMU-159418 Recycling of bile acids and salts R-MMU-879518 Transport of organic anions |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier organic anion transporter family member 1B2Alternative name(s): Liver-specific organic anion transporter 1 Short name: LST-1 SLC21A6 Solute carrier family 21 member 10 |
Gene namesi | Name:Slco1b2 Synonyms:Oatp1b2, Slc21a10 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1351899 Slco1b2 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- basolateral plasma membrane Source: MGI
- integral component of plasma membrane Source: MGI
- plasma membrane Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 26 | CytoplasmicSequence analysisAdd BLAST | 26 | |
Transmembranei | 27 – 46 | Helical; Name=1Sequence analysisAdd BLAST | 20 | |
Topological domaini | 47 – 65 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 66 – 86 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 87 – 92 | CytoplasmicSequence analysis | 6 | |
Transmembranei | 93 – 117 | Helical; Name=3Sequence analysisAdd BLAST | 25 | |
Topological domaini | 118 – 163 | ExtracellularSequence analysisAdd BLAST | 46 | |
Transmembranei | 164 – 192 | Helical; Name=4Sequence analysisAdd BLAST | 29 | |
Topological domaini | 193 – 211 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 212 – 232 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 233 – 250 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 251 – 275 | Helical; Name=6Sequence analysisAdd BLAST | 25 | |
Topological domaini | 276 – 326 | CytoplasmicSequence analysisAdd BLAST | 51 | |
Transmembranei | 327 – 348 | Helical; Name=7Sequence analysisAdd BLAST | 22 | |
Topological domaini | 349 – 368 | ExtracellularSequence analysisAdd BLAST | 20 | |
Transmembranei | 369 – 392 | Helical; Name=8Sequence analysisAdd BLAST | 24 | |
Topological domaini | 393 – 396 | CytoplasmicSequence analysis | 4 | |
Transmembranei | 397 – 420 | Helical; Name=9Sequence analysisAdd BLAST | 24 | |
Topological domaini | 421 – 533 | ExtracellularSequence analysisAdd BLAST | 113 | |
Transmembranei | 534 – 556 | Helical; Name=10Sequence analysisAdd BLAST | 23 | |
Topological domaini | 557 – 565 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 566 – 591 | Helical; Name=11Sequence analysisAdd BLAST | 26 | |
Topological domaini | 592 – 625 | ExtracellularSequence analysisAdd BLAST | 34 | |
Transmembranei | 626 – 643 | Helical; Name=12Sequence analysisAdd BLAST | 18 | |
Topological domaini | 644 – 689 | CytoplasmicSequence analysisAdd BLAST | 46 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000191051 | 1 – 689 | Solute carrier organic anion transporter family member 1B2Add BLAST | 689 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 132 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 140 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 288 | PhosphoserineCombined sources | 1 | |
Modified residuei | 290 | PhosphoserineCombined sources | 1 | |
Disulfide bondi | 454 ↔ 480 | PROSITE-ProRule annotation | ||
Disulfide bondi | 458 ↔ 469 | PROSITE-ProRule annotation | ||
Disulfide bondi | 460 ↔ 484 | PROSITE-ProRule annotation | ||
Glycosylationi | 513 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 662 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 680 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
jPOSTi | Q9JJL3 |
PaxDbi | Q9JJL3 |
PeptideAtlasi | Q9JJL3 |
PRIDEi | Q9JJL3 |
PTM databases
iPTMneti | Q9JJL3 |
PhosphoSitePlusi | Q9JJL3 |
SwissPalmi | Q9JJL3 |
Expressioni
Tissue specificityi
Liver specific.
Gene expression databases
Bgeei | ENSMUSG00000030236 Expressed in 37 organ(s), highest expression level in liver |
ExpressionAtlasi | Q9JJL3 baseline and differential |
Genevisiblei | Q9JJL3 MM |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 448 – 505 | Kazal-likePROSITE-ProRule annotationAdd BLAST | 58 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3626 Eukaryota ENOG410XRSF LUCA |
GeneTreei | ENSGT00970000193398 |
HOGENOMi | HOG000231269 |
InParanoidi | Q9JJL3 |
KOi | K05043 |
OMAi | TNTTLMC |
OrthoDBi | 1029129at2759 |
PhylomeDBi | Q9JJL3 |
TreeFami | TF317540 |
Family and domain databases
InterProi | View protein in InterPro IPR002350 Kazal_dom IPR036058 Kazal_dom_sf IPR020846 MFS_dom IPR036259 MFS_trans_sf IPR004156 OATP |
PANTHERi | PTHR11388 PTHR11388, 1 hit |
Pfami | View protein in Pfam PF07648 Kazal_2, 1 hit PF03137 OATP, 1 hit |
SMARTi | View protein in SMART SM00280 KAZAL, 1 hit |
SUPFAMi | SSF100895 SSF100895, 1 hit SSF103473 SSF103473, 1 hit |
TIGRFAMsi | TIGR00805 oat, 1 hit |
PROSITEi | View protein in PROSITE PS51465 KAZAL_2, 1 hit PS50850 MFS, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9JJL3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDQTQHPSKA AQPLRSEKTR HCDGFRIFLA ALSFSYICKA LGGVIMKSSI
60 70 80 90 100
TQIERRFDIP SSISGLIDGG FEIGNLLVIV FVSYFGSKLH RPKLIGTGCF
110 120 130 140 150
IMGIGSILTA LPHFFMGYYR YATENDISSL HNSTLTCLVN QTTSLTGTSP
160 170 180 190 200
EIMEKGCEKG SNSYTWIYVL MGNMLRGIGE TPIVPLGVSY IDDFAKEGNS
210 220 230 240 250
SMYLGTLHTI AMIGPILGFI MSSVFAKLYV DVGYVDLRSV RITPQDARWV
260 270 280 290 300
GAWWLGFIVN GLLCIICSIP FFFLPKIPKR SQKERKNSAS LHVLKTDEDK
310 320 330 340 350
NPVTNPTTQE KQAPANLTGF LWSLRSILTN EQYVIFLILT LLQISSFIGS
360 370 380 390 400
FTYLFKFIEQ QFGQTASQAN FLLGVITIPT MASGMFLGGY LIKRLKLTLL
410 420 430 440 450
GITKFVFFTT TMAYVFYLSY FLLICENKAF AGLTLTYDGM NPVDSHIDVP
460 470 480 490 500
LSYCNSDCIC DKNQWEPVCG ENGVTYISPC LAGCKSFRGD KKLMNIEFYD
510 520 530 540 550
CSCVSGSGFQ KGNHSARLGE CPRDKCKTKY YFYITFQVII SFFTALGSTS
560 570 580 590 600
LMLILIRSVQ PELKSLGMGF HSLVVRTLGG ILAPVYYGAL IDRTCMKWSV
610 620 630 640 650
TSCGARGACR LYNSRLFGMI YVGLSIALKT PILLLYVALI YVMKRKMKRN
660 670 680
DNKILENGRK FTDEGNPEPV NNNGYSCVPS DEKNSETPL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0N4SUN2 | A0A0N4SUN2_MOUSE | Solute carrier organic anion transp... | Slco1b2 | 654 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 455 | N → H in AAF74719 (Ref. 2) Curated | 1 | |
Sequence conflicti | 481 | L → R in AAF74719 (Ref. 2) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006149 | 398 | T → TAKLYVDVGYVDLRSVRITP in isoform 2. Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB031959 mRNA Translation: BAB03272.1 AB037202 Genomic DNA Translation: BAA98050.1 Sequence problems. AF250912 mRNA Translation: AAF74719.1 |
CCDSi | CCDS20678.1 [Q9JJL3-1] |
PIRi | JC7286 |
RefSeqi | NP_065241.1, NM_020495.1 [Q9JJL3-1] XP_006507026.1, XM_006506963.2 [Q9JJL3-1] XP_017177100.1, XM_017321611.1 [Q9JJL3-1] |
Genome annotation databases
Ensembli | ENSMUST00000042812; ENSMUSP00000044326; ENSMUSG00000030236 [Q9JJL3-1] |
GeneIDi | 28253 |
KEGGi | mmu:28253 |
UCSCi | uc009eoq.1 mouse [Q9JJL3-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB031959 mRNA Translation: BAB03272.1 AB037202 Genomic DNA Translation: BAA98050.1 Sequence problems. AF250912 mRNA Translation: AAF74719.1 |
CCDSi | CCDS20678.1 [Q9JJL3-1] |
PIRi | JC7286 |
RefSeqi | NP_065241.1, NM_020495.1 [Q9JJL3-1] XP_006507026.1, XM_006506963.2 [Q9JJL3-1] XP_017177100.1, XM_017321611.1 [Q9JJL3-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000044326 |
PTM databases
iPTMneti | Q9JJL3 |
PhosphoSitePlusi | Q9JJL3 |
SwissPalmi | Q9JJL3 |
Proteomic databases
jPOSTi | Q9JJL3 |
PaxDbi | Q9JJL3 |
PeptideAtlasi | Q9JJL3 |
PRIDEi | Q9JJL3 |
Genome annotation databases
Ensembli | ENSMUST00000042812; ENSMUSP00000044326; ENSMUSG00000030236 [Q9JJL3-1] |
GeneIDi | 28253 |
KEGGi | mmu:28253 |
UCSCi | uc009eoq.1 mouse [Q9JJL3-1] |
Organism-specific databases
CTDi | 28253 |
MGIi | MGI:1351899 Slco1b2 |
Phylogenomic databases
eggNOGi | KOG3626 Eukaryota ENOG410XRSF LUCA |
GeneTreei | ENSGT00970000193398 |
HOGENOMi | HOG000231269 |
InParanoidi | Q9JJL3 |
KOi | K05043 |
OMAi | TNTTLMC |
OrthoDBi | 1029129at2759 |
PhylomeDBi | Q9JJL3 |
TreeFami | TF317540 |
Enzyme and pathway databases
Reactomei | R-MMU-159418 Recycling of bile acids and salts R-MMU-879518 Transport of organic anions |
Miscellaneous databases
PROi | PR:Q9JJL3 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000030236 Expressed in 37 organ(s), highest expression level in liver |
ExpressionAtlasi | Q9JJL3 baseline and differential |
Genevisiblei | Q9JJL3 MM |
Family and domain databases
InterProi | View protein in InterPro IPR002350 Kazal_dom IPR036058 Kazal_dom_sf IPR020846 MFS_dom IPR036259 MFS_trans_sf IPR004156 OATP |
PANTHERi | PTHR11388 PTHR11388, 1 hit |
Pfami | View protein in Pfam PF07648 Kazal_2, 1 hit PF03137 OATP, 1 hit |
SMARTi | View protein in SMART SM00280 KAZAL, 1 hit |
SUPFAMi | SSF100895 SSF100895, 1 hit SSF103473 SSF103473, 1 hit |
TIGRFAMsi | TIGR00805 oat, 1 hit |
PROSITEi | View protein in PROSITE PS51465 KAZAL_2, 1 hit PS50850 MFS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SO1B2_MOUSE | |
Accessioni | Q9JJL3Primary (citable) accession number: Q9JJL3 Secondary accession number(s): Q9JI79, Q9JJJ1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 10, 2003 |
Last sequence update: | October 1, 2000 | |
Last modified: | October 16, 2019 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot