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Entry version 141 (18 Sep 2019)
Sequence version 1 (01 Oct 2000)
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Protein

Nuclear receptor coactivator 6

Gene

Ncoa6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. Involved in placental, cardiac, hepatic and embryonic development.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear receptor coactivator 6
Alternative name(s):
Activating signal cointegrator 2
Short name:
ASC-2
Amplified in breast cancer protein 3
Cancer-amplified transcriptional coactivator ASC-2
Nuclear receptor coactivator RAP250
Short name:
NRC
Nuclear receptor-activating protein, 250 kDa
Peroxisome proliferator-activated receptor-interacting protein
Short name:
PPAR-interacting protein
Thyroid hormone receptor-binding protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ncoa6
Synonyms:Aib3, Prip, Rap250, Trbp
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1929915 Ncoa6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi891 – 894LVNL → AVNA: Abolishes interaction with nuclear receptors. 1 Publication4

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000944141 – 2067Nuclear receptor coactivator 6Add BLAST2067

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei95Asymmetric dimethylarginineCombined sources1
Modified residuei888PhosphoserineBy similarity1
Modified residuei1050Asymmetric dimethylarginineCombined sources1
Modified residuei1061Asymmetric dimethylarginineCombined sources1
Modified residuei1099Asymmetric dimethylarginineCombined sources1
Modified residuei1822N6-acetyllysineCombined sources1
Modified residuei1825N6-acetyllysineCombined sources1
Modified residuei2022PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9JL19

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9JL19

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9JL19

PeptideAtlas

More...
PeptideAtlasi
Q9JL19

PRoteomics IDEntifications database

More...
PRIDEi
Q9JL19

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9JL19

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9JL19

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. High expression in testis and weak expression in small intestine.

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed at 9 dpc in placenta and at weaker level in uterus. High expression in neural tube and in CNS throughout development. High expression in sensory ganglia and retina from 11 dpc. In the alimentary tract and olfactory epithelium expression was seen from 13 dpc. Strong expression present in liver and kidney, from 11 dpc and 13 dpc respectively, and then expression decreased at later stages of development. Moderate expression in lung from 13 dpc, while it decreases during postnatal life. Strong expression in thymus from 15 dpc onwards, and in spleen from 17 dpc and during early postnatal life, then, the expression decreases.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer and homodimer.

Interacts in vitro with the basal transcription factors GTF2A and TBP, suggesting an autonomous transactivation function.

Interacts with NCOA1, CRSP3, RBM14, the histone acetyltransferase proteins EP300 and CREBBP, and with methyltransferase proteins NCOA6IP and PRMT2 (By similarity).

Interacts with RBM39.

Component of the MLL2/3 complex (also named ASCOM complex), at least composed of KMT2D/MLL2 or KMT2C/MLL3, ASH2L, RBBP5, WDR5, NCOA6, DPY30, KDM6A, PAXIP1/PTIP, PAGR1 and alpha- and beta-tubulin (By similarity).

Interacts with ZNF335; may enhance ligand-dependent transcriptional activation by nuclear hormone receptors (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-61283N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q9JL19

Protein interaction database and analysis system

More...
IntActi
Q9JL19, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000105295

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 1314NCOA1-binding regionBy similarityAdd BLAST1314
Regioni1 – 1060CREBBP-binding regionBy similarityAdd BLAST1060
Regioni1 – 932TBP/GTF2A-binding regionBy similarityAdd BLAST932
Regioni777 – 931NCOA6IP-binding regionBy similarityAdd BLAST155
Regioni1644 – 2067EP300/CRSP3-binding regionBy similarityAdd BLAST424

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi891 – 895LXXLL motif 15
Motifi1495 – 1499LXXLL motif 25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi227 – 1044Gln-richAdd BLAST818
Compositional biasi376 – 381Poly-Pro6
Compositional biasi917 – 922Poly-Lys6
Compositional biasi1543 – 1592Ser-richAdd BLAST50

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains two Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. Only motif 1 is essential for the association with nuclear receptors.

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IK20 Eukaryota
ENOG410XW4F LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9JL19

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026638 NCOA6
IPR032715 NCOA6_nucleic_acid-bd

The PANTHER Classification System

More...
PANTHERi
PTHR15690 PTHR15690, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13820 Nucleic_acid_bd, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9JL19-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVLDDLPNFE DIYTSLCSST MGDSEVEFDS GLEDDDTKGD SILEDSTIFV
60 70 80 90 100
AFKGNIDDKD FKWKLDAILK NVPNLLHMES SKLKVQKVEP WNSVRVTFNI
110 120 130 140 150
PREAAERLWI LAQSNNQQLR DLGILSVQIE GEGAINLALG QNRSQDVRMN
160 170 180 190 200
GPVASGNSVR MEAGFPMASG PGLIRMTSPA AVMTPQGGNM SSSMMAPGPN
210 220 230 240 250
PELQPRTPRP ASQSDAMDPL LSGLHIQQQS HPSGSLPPAH HSMQPVPVNR
260 270 280 290 300
QMNPANFPQL QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ LQTRPLQQHQ
310 320 330 340 350
QQPQGIRPQF TAPTQVPVPP GWNQLPSGAL QPPPAQGSLG TMTTNQGWKK
360 370 380 390 400
APLPSPMQAQ LQARPSLATV QTPSHPPPPY PFGSQQASQA HTNFPQMSNP
410 420 430 440 450
GQFTAPQMKG LQGGPSRVPT PLQQPHLTNK SPASSPSSFQ QGSPASSPTV
460 470 480 490 500
NQTQQQMGPR PPQNNPLSQG FQQPVSSPGR NPMVQQGNVP PNFMVMQQQP
510 520 530 540 550
PNQGPQSLHP GLGGMPKRLP PGFSAGQANP NFMQGQVPST TAATPGNSGA
560 570 580 590 600
LQLQANQNVQ HAGGQGAGPP QNQMQVSHGP PNMMQPSLMG IHGNINNQQA
610 620 630 640 650
GSSGVPQVTL GNMQGQPQQG PPSQLMGMHQ QIVPSQGQMA QQQGTLNPQN
660 670 680 690 700
PMILSRAQLM PQGQMMVNAQ NQNLGPSPQR MTPPKQMLPQ QGPQMMAPHN
710 720 730 740 750
QMMGPQGQVL LQQNPMIEQI MTNQMQGNKA QFNSQNQSNV MPGPAQIMRG
760 770 780 790 800
PTPNMQGNMV QFTGQMSGQM LPQQGPVNNS PSQVMGIQGQ VLRPPGPSPH
810 820 830 840 850
MAQQHTDPVT TANNDVNLSQ MMPDVSMQQA SMVPPHVQSM QGNSASGSHF
860 870 880 890 900
SGHGVSFNAP FGGAPNGSQM SCGQNPGFPV NKDVTLTSPL LVNLLQSDIS
910 920 930 940 950
AGHFGVNNKQ NNTNANKPKK KKPPRKKKNC HQDLNTPDNR PTGLEEVDQQ
960 970 980 990 1000
SLPGEQGINL DTTGPKLPDF SNRPPGYPTQ PVEQRPLPQM PPQLMQHVAP
1010 1020 1030 1040 1050
PPQPPQQQPQ PQLPQQQQPP PPSQPQSQQQ QQQQQMMMML MMQQDPKSIR
1060 1070 1080 1090 1100
LPVSQNVHPP RGPLNPDSQR MPVQQSGNVP VMVGLQGPAS VPPSPDKQRM
1110 1120 1130 1140 1150
PMSVNTPMGS NSRKMVYQEN PQNSSSSPLG EMSSLPEASG SEVPSVAGGP
1160 1170 1180 1190 1200
NNMPSHLVVS QNQLMMTGPK PGPSPLSATQ GATPQQPPVN SLPSSHGHHF
1210 1220 1230 1240 1250
PNVAAPTQTS RPKTPNRASP RPYYPQTPNN RPPSTEPSEI SLSPERLNAS
1260 1270 1280 1290 1300
IAGLFPPQIN IPLPPRPNLN RGFDQQGLNP TTLKAIGQAP SNLTITNPPN
1310 1320 1330 1340 1350
FAAPQAHKLD SVVVNSGKQS NPGTTKRASP SNSRRSSPGS SRKTTPSPGR
1360 1370 1380 1390 1400
QNSKAPKLTL ASQTSTTMLQ NMELPRNVLV GPTPLANPPL PGSFPNNTGL
1410 1420 1430 1440 1450
NPQNPTVPVP AMGTVLEDNK ESVNIPQDSD CQNAQGRKEQ VNTELKVVPT
1460 1470 1480 1490 1500
QEAKMAVPED QSKKDGQPLD PNKLPSVEEN KNLMSPAMRE APTSLSQLLD
1510 1520 1530 1540 1550
NSGAPNVTIK PPGLTDLEVT PPVVSGEDLR KASVIPTLQD PPSKEPSTSL
1560 1570 1580 1590 1600
SSPHSSEPCS TLARSELSEV SSNAAPSIPP VMSRPVSSSS ISTPLPPNQI
1610 1620 1630 1640 1650
TVFVTSNPIT TSSNTSAALP THLQSALMST VVTMPNVGNK VMVSEGQSAA
1660 1670 1680 1690 1700
QSNARPQFIT PVFINSSSII QVMKGSQPST IPATPLTTNS GLMPPSVAVV
1710 1720 1730 1740 1750
GPLHIPQNIK FSSAPVTPNV PSSSPAPNIQ TGRPLVLSSR ATPVQLPSPP
1760 1770 1780 1790 1800
CTSSPVVAPN PSVQQVKELN PDEASPQTNT SADQSTLPPS QPTTVVSSLL
1810 1820 1830 1840 1850
TNSPGSSANR RSPVSSSKGK GKVDKIGQIL LTKACKKVTG SLEKGEEQYG
1860 1870 1880 1890 1900
ADGETEGPGL EITTPGLMGT EQCSTELDSK TPTPSAPTLL KMTSSPMAPS
1910 1920 1930 1940 1950
STSTGPILPG GALPTSVRSI VTTLVPSELI STAPTTKGNH GGVTSEPLAG
1960 1970 1980 1990 2000
GLVEEKVGSH PELLPSIAPS QNLAPKETPA TALQGSVARP ELEANAAIAS
2010 2020 2030 2040 2050
GQSCEPKEIV EKSKTLTSRR NSRTEEPTMA SESVENGHRK RSSRPASASS
2060
STKDITGAVQ SKRRKSK
Length:2,067
Mass (Da):219,663
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC855F8777167AD48
GO
Isoform 2 (identifier: Q9JL19-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     458-2067: Missing.

Note: Acts as a dominant negative repressor.
Show »
Length:457
Mass (Da):49,981
Checksum:i36DA08FFC583D250
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5XJV5Q5XJV5_MOUSE
Nuclear receptor coactivator 6
Ncoa6 mCG_21081
2,069Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AQN0A2AQN0_MOUSE
Nuclear receptor coactivator 6
Ncoa6
519Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AQM9A2AQM9_MOUSE
Nuclear receptor coactivator 6
Ncoa6
1,516Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti39G → S in AAH31113 (PubMed:15489334).Curated1
Sequence conflicti109W → R in AAH31113 (PubMed:15489334).Curated1
Sequence conflicti194M → I in AAH31113 (PubMed:15489334).Curated1
Sequence conflicti290Q → QQ in AAH31113 (PubMed:15489334).Curated1
Sequence conflicti1014P → L in AAF35973 (PubMed:10681503).Curated1
Sequence conflicti1141 – 1142SE → RS in AAF35973 (PubMed:10681503).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_003410458 – 2067Missing in isoform 2. 2 PublicationsAdd BLAST1610

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF216186 mRNA Translation: AAF35860.1
BC031113 mRNA Translation: AAH31113.1
AF135169 mRNA Translation: AAF35973.1

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF216186 mRNA Translation: AAF35860.1
BC031113 mRNA Translation: AAH31113.1
AF135169 mRNA Translation: AAF35973.1

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

DIPiDIP-61283N
ELMiQ9JL19
IntActiQ9JL19, 2 interactors
STRINGi10090.ENSMUSP00000105295

PTM databases

iPTMnetiQ9JL19
PhosphoSitePlusiQ9JL19

Proteomic databases

EPDiQ9JL19
jPOSTiQ9JL19
PaxDbiQ9JL19
PeptideAtlasiQ9JL19
PRIDEiQ9JL19

Organism-specific databases

MGIiMGI:1929915 Ncoa6

Phylogenomic databases

eggNOGiENOG410IK20 Eukaryota
ENOG410XW4F LUCA
InParanoidiQ9JL19

Enzyme and pathway databases

ReactomeiR-MMU-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Ncoa6 mouse

Protein Ontology

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PROi
PR:Q9JL19

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Family and domain databases

InterProiView protein in InterPro
IPR026638 NCOA6
IPR032715 NCOA6_nucleic_acid-bd
PANTHERiPTHR15690 PTHR15690, 2 hits
PfamiView protein in Pfam
PF13820 Nucleic_acid_bd, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNCOA6_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9JL19
Secondary accession number(s): Q9JLT9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: October 1, 2000
Last modified: September 18, 2019
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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