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Entry version 120 (18 Sep 2019)
Sequence version 1 (01 Oct 2000)
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Protein

RNA-dependent RNA polymerase 1

Gene

RDR1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-dependent direct polymerase involved in antiviral silencing. Required for the production of some small RNAs (mainly 21 and some 22 nucleotides) derived from the crucifer-infecting tobamovirus (TMV-cg). Required for turnip mosaic virus (TuMV) silencing and accumulation of viral siRNAs. Involved in cucumber mosaic virus (CMV) silencing. Required for the biogenesis of viral secondary siRNAs, process that follows the production of primary siRNAs derived from viral RNA replication. Specifically targets the positive-strand of the 3 RNA genomes of CMV and preferentially amplifies the 5'-terminal siRNAs of each viral genomic RNA. Not involved in the production of siRNAs derived from a single-stranded 336-nucleotide satellite RNA of CMV.4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, RNA-directed RNA polymerase, Transferase
Biological processPlant defense, RNA-mediated gene silencing

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.7.48 399

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-dependent RNA polymerase 1 (EC:2.7.7.48)
Short name:
AtRDRP1
Alternative name(s):
RNA-directed RNA polymerase 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RDR1
Synonyms:RDRP1
Ordered Locus Names:At1g14790
ORF Names:F10B6.19
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G14790

The Arabidopsis Information Resource

More...
TAIRi
locus:2006822 AT1G14790

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Upon viral infection, increased levels of TMV-cg, tobacco rattle virus (TRV) and CMV genomic viral RNAs. Reduced levels of TMV-cg-derived small RNAs and CMV-derived siRNAs.3 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004046721 – 1107RNA-dependent RNA polymerase 1Add BLAST1107

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9LQV2

PRoteomics IDEntifications database

More...
PRIDEi
Q9LQV2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By salicylic acid (SA) and infection by a crucifer-infecting tobamovirus (TMV-cg).

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9LQV2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9LQV2 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT1G14790.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9LQV2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RdRP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0988 Eukaryota
ENOG410XQMQ LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000239464

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9LQV2

KEGG Orthology (KO)

More...
KOi
K11699

Identification of Orthologs from Complete Genome Data

More...
OMAi
HTPHIKH

Database of Orthologous Groups

More...
OrthoDBi
63910at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9LQV2

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035979 RBD_domain_sf
IPR007855 RNA-dep_RNA_pol_euk-typ

The PANTHER Classification System

More...
PANTHERi
PTHR23079 PTHR23079, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05183 RdRP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928 SSF54928, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9LQV2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKTIQVFGF PNGVSAEEVK KFLERLTGSG TVYAIKVRQP KKGGPRVYAI
60 70 80 90 100
VQFTSERHTR LIITAAAERL YYGRSYLKAF EVEQDIVPKP RASLHTISGL
110 120 130 140 150
KMFFGCQVST KKFLTLWSAQ DVCVSFGIGM RKLHFSFSWY QKDYRLELSY
160 170 180 190 200
ENIWQIDLHS PQGRSSKFLV IQVIGAPKIF EKEDQPINLL FGIMDFYSDG
210 220 230 240 250
SDEQWIRTTD FTSSSCIGQS TAFCLELPVH LNVPDFRENF ANYAEHRASS
260 270 280 290 300
FLIESGSSYS SNANTLVPVV DPPPGFSLPF EILFKLNTLV QNACLSGPAL
310 320 330 340 350
DLDFYRLLNQ KKYDRALIDH CLEKLFHLGE CCYEPAHWLR DEYKKWISKG
360 370 380 390 400
KLPLSPTISL DDGLVYMYRV QVTPARVYFS GPEVNVSNRV LRHYSKYINN
410 420 430 440 450
FLRVSFVDED LEKVRSMDLS PRSSTQRRTK LYDRIYSVLR DGIVIGDKKF
460 470 480 490 500
EFLAFSSSQL RENSAWMFAP IDRITAAHIR AWMGDFDHIR NVAKYAARLG
510 520 530 540 550
QSFSSSRETL NVRSDEIEVI PDVEIISLGT RYVFSDGIGK ISAEFARKVA
560 570 580 590 600
RKCGLTEFSP SAFQIRYGGY KGVVAVDPNS SKKLSLRKSM SKFESENTKL
610 620 630 640 650
DVLAWSKYQP CYMNRQLITL LSTLGVTDSV FEKKQREVVD RLDAILTHPL
660 670 680 690 700
EAHEALGLMA PGENTNILKA LILCGYKPDA EPFLSMMLQN FRASKLLELR
710 720 730 740 750
TKTRIFISGG RSMMGCLDET RTLEYGQVVV QYSDPMRPGR RFIITGPVVV
760 770 780 790 800
AKNPCLHPGD VRVLQAVNVP ALNHMVDCVV FPQKGLRPHP NECSGSDLDG
810 820 830 840 850
DIYFVCWDQE LVPPRTSEPM DYTPEPTQIL DHDVTIEEVE EYFANYIVND
860 870 880 890 900
SLGIIANAHT AFADKEPLKA FSDPCIELAK KFSTAVDFPK TGVAAVIPQH
910 920 930 940 950
LYVKEYPDFM EKPDKPTYES KNVIGKLFRE VKERAPPLIS IKSFTLDVAS
960 970 980 990 1000
KSYDKDMEVD GFEEYVDEAF YQKANYDFKL GNLMDYYGIK TEAEILSGGI
1010 1020 1030 1040 1050
MRMSKSFTKR RDAESIGRAV RALRKETLSL FNASEEEENE SAKASAWYHV
1060 1070 1080 1090 1100
TYHSSYWGLY NEGLNRDHFL SFAWCVYDKL VRIKKTNLGR RQRQETLERL

DHVLRFG
Length:1,107
Mass (Da):126,214
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF8FF97691FF82187
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti758P → S in AAN64409 (PubMed:12650452).Curated1
Sequence conflicti758P → S in CAA09894 (PubMed:9836747).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY148431 mRNA Translation: AAN64409.1
AC006917 Genomic DNA Translation: AAF79241.1
CP002684 Genomic DNA Translation: AEE29226.1
AK228731 mRNA Translation: BAF00633.1
AJ011977 Genomic DNA Translation: CAA09894.1

NCBI Reference Sequences

More...
RefSeqi
NP_172932.1, NM_101348.4

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G14790.1; AT1G14790.1; AT1G14790

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
838044

Gramene; a comparative resource for plants

More...
Gramenei
AT1G14790.1; AT1G14790.1; AT1G14790

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT1G14790

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY148431 mRNA Translation: AAN64409.1
AC006917 Genomic DNA Translation: AAF79241.1
CP002684 Genomic DNA Translation: AEE29226.1
AK228731 mRNA Translation: BAF00633.1
AJ011977 Genomic DNA Translation: CAA09894.1
RefSeqiNP_172932.1, NM_101348.4

3D structure databases

SMRiQ9LQV2
ModBaseiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G14790.1

Proteomic databases

PaxDbiQ9LQV2
PRIDEiQ9LQV2

Genome annotation databases

EnsemblPlantsiAT1G14790.1; AT1G14790.1; AT1G14790
GeneIDi838044
GrameneiAT1G14790.1; AT1G14790.1; AT1G14790
KEGGiath:AT1G14790

Organism-specific databases

AraportiAT1G14790
TAIRilocus:2006822 AT1G14790

Phylogenomic databases

eggNOGiKOG0988 Eukaryota
ENOG410XQMQ LUCA
HOGENOMiHOG000239464
InParanoidiQ9LQV2
KOiK11699
OMAiHTPHIKH
OrthoDBi63910at2759
PhylomeDBiQ9LQV2

Enzyme and pathway databases

BRENDAi2.7.7.48 399

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9LQV2

Gene expression databases

ExpressionAtlasiQ9LQV2 baseline and differential
GenevisibleiQ9LQV2 AT

Family and domain databases

InterProiView protein in InterPro
IPR035979 RBD_domain_sf
IPR007855 RNA-dep_RNA_pol_euk-typ
PANTHERiPTHR23079 PTHR23079, 1 hit
PfamiView protein in Pfam
PF05183 RdRP, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRDR1_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9LQV2
Secondary accession number(s): Q8H1K9, Q9ZRX5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: October 1, 2000
Last modified: September 18, 2019
This is version 120 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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