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1 to 25 of 118  Show
  1. 1
    "The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas."
    Feng S.-L.Y., Guo Y., Factor V.M., Thorgeirsson S.S., Bell D.W., Testa J.R., Peifley K.A., Winkles J.A.
    Am. J. Pathol. 156:1253-1261(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Category: Sequences.
    Tissue: Placenta.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is mapped to 3 other entries.

  2. 2
    "Human homologue of Fn14."
    Tanaka S., Sugimachi K.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Category: Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).
  3. 3
    Category: Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).
  4. 4
    "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Category: Sequences.
    Tissue: Uterus.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 50448 other entries.

  5. 5
    "A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis."
    Wiley S.R., Cassiano L., Lofton T., Davis-Smith T., Winkles J.A., Lindner V., Liu H., Daniel T.O., Smith C.A., Fanslow W.C.
    Immunity 15:837-846(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Category: Function.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is mapped to 4 other entries.

  6. 6
    "Solution structure of the STN_TNFRSF12A_TNFR domain of tumor necrosis factor receptor superfamily member 12A precursor."
    RIKEN structural genomics initiative (RSGI)
    Submitted (APR-2008) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 26-70.
    Category: Structure.
    Source: UniProtKB/Swiss-Prot (reviewed).
  7. 7
    "Solution structure of the cysteine-rich domain in Fn14, a member of the tumor necrosis factor receptor superfamily."
    He F., Dang W., Saito K., Watanabe S., Kobayashi N., Guntert P., Kigawa T., Tanaka A., Muto Y., Yokoyama S.
    Protein Sci. 18:650-656(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 26-70, DISULFIDE BONDS.
    Category: PTM / Processing, Structure.
    Source: UniProtKB/Swiss-Prot (reviewed).
  8. 8
    "TWEAK induces angiogenesis and proliferation of endothelial cells."
    Lynch C.N., Wang Y.C., Lund J.K., Chen Y.-W., Leal J.A., Wiley S.R.
    J. Biol. Chem. 274:8455-8459(1999) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Pathway.
    Source: Reactome:R-HSA-5675666.
  9. 9
    "Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli."
    Yang Y., Fang S., Jensen J.P., Weissman A.M., Ashwell J.D.
    Science 288:874-877(2000) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Pathway.
    Source: Reactome:R-HSA-5675666.

    This publication is mapped to 67 other entries.

  10. 10
    "Pro-inflammatory effect of TWEAK/Fn14 interaction on human umbilical vein endothelial cells."
    Harada N., Nakayama M., Nakano H., Fukuchi Y., Yagita H., Okumura K.
    Biochem. Biophys. Res. Commun. 299:488-493(2002) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: These results indicated that TWEAK could induce pro-inflammatory reactions via fibroblast growth factor-inducible 14 (Fn14)on human umbilical vein endothelial cells.
    Source: GeneRIF:51330.

    This publication is mapped to 4 other entries.

  11. 11
    "Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death."
    Nakayama M., Ishidoh K., Kojima Y., Harada N., Kominami E., Okumura K., Yagita H.
    J. Immunol. 170:341-348(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: FN14 is the sole mediator of the multiple pathways of TWEAK-induced cell death in all TWEAK-sensitive tumor cell lines.
    Source: GeneRIF:51330.

    This publication is mapped to 4 other entries.

  12. 12
    "The Fn14 cytoplasmic tail binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation."
    Brown S.A., Richards C.M., Hanscom H.N., Feng S.L., Winkles J.A.
    Biochem. J. 371:395-403(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Pathway.
    Source: Reactome:R-HSA-5675666.

    This publication is mapped to 26 other entries.

  13. 13
    "The human Fn14 receptor gene is up-regulated in migrating glioma cells in vitro and overexpressed in advanced glial tumors."
    Tran N.L., McDonough W.S., Donohue P.J., Winkles J.A., Berens T.J., Ross K.R., Hoelzinger D.B., Beaudry C., Coons S.W., Berens M.E.
    Am. J. Pathol. 162:1313-1321(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Expression.
    Annotation: up-regulated in migrating glioma cells in vitro and overexpressed in advanced glial tumors.
    Source: GeneRIF:51330.
  14. 14
    "TWEAK, a member of the TNF superfamily, is a multifunctional cytokine that binds the TweakR/Fn14 receptor."
    Wiley S.R., Winkles J.A.
    Cytokine Growth Factor Rev. 14:241-249(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Pathway.
    Source: Reactome:R-HSA-5675666.
  15. 15
    "Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation."
    Liao G., Zhang M., Harhaj E.W., Sun S.C.
    J. Biol. Chem. 279:26243-26250(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Pathway.
    Source: Reactome:R-HSA-5675666.

    This publication is cited by 1 and mapped to 68 other entries.

  16. 16
    Category: Function, Interaction.
    Annotation: TWEAK acts on human keratinocytes as an inducer of RANTES via Fn14.
    Source: GeneRIF:51330.

    This publication is mapped to 9 other entries.

  17. 17
    "The role of TWEAK/Fn14 in the pathogenesis of inflammation and systemic autoimmunity."
    Campbell S., Michaelson J., Burkly L., Putterman C.
    Front. Biosci. 9:2273-2284(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: TWEAK/TWEAK receptor interactions have roles in the pathogenesis of inflammatory and systemic autoimmune diseases (review).
    Source: GeneRIF:51330.

    This publication is mapped to 4 other entries.

  18. 18
    "The tumor necrosis factor-like weak inducer of apoptosis (TWEAK)-fibroblast growth factor-inducible 14 (Fn14) signaling system regulates glioma cell survival via NFkappaB pathway activation and BCL-XL/BCL-W expression."
    Tran N.L., McDonough W.S., Savitch B.A., Sawyer T.F., Winkles J.A., Berens M.E.
    J. Biol. Chem. 280:3483-3492(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Fn14 protein functions in part through the NFkappaB signaling pathway to up-regulate BCL-XL and BCL-W expression to foster malignant glioblastoma cell survival.
    Source: GeneRIF:51330.

    This publication is mapped to 4 other entries.

  19. 19
    "Expression of TWEAK and its receptor Fn14 in human subcutaneous adipose tissue. Relationship with other inflammatory cytokines in obesity."
    Chacon M.R., Richart C., Gomez J.M., Megia A., Vilarrasa N., Fernandez-Real J.M., Garcia-Espana A., Miranda M., Masdevall C., Ricard W., Caubet E., Soler J., Vendrell J.
    Cytokine 33:129-137(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Expression.
    Annotation: Expression of Fn14 in subcutaneous adipose tissue from obese patients.
    Source: GeneRIF:51330.

    This publication is mapped to 4 other entries.

  20. 20
    "TWEAK binding to the Fn14 cysteine-rich domain depends on charged residues located in both the A1 and D2 modules."
    Brown S.A., Hanscom H.N., Vu H., Brew S.A., Winkles J.A.
    Biochem. J. 397:297-304(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Structure.
    Annotation: the TWEAK-Fn14 interaction is highly dependent on multiple Fn14 residues located in both CRD modules.
    Source: GeneRIF:51330.

    This publication is mapped to 12 other entries.

  21. 21
    "Fn14 is upregulated in cytokine-stimulated vascular smooth muscle cells and is expressed in human carotid atherosclerotic plaques: modulation by atorvastatin."
    Munoz-Garcia B., Martin-Ventura J.L., Martinez E., Sanchez S., Hernandez G., Ortega L., Ortiz A., Egido J., Blanco-Colio L.M.
    Stroke 37:2044-2053(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Expression.
    Annotation: TWEAK and Fn14 are expressed in atherosclerotic plaques and could be novel mediators of atherosclerosis.
    Source: GeneRIF:51330.
  22. 22
    "Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-kappaB and correlate with poor patient outcome."
    Tran N.L., McDonough W.S., Savitch B.A., Fortin S.P., Winkles J.A., Symons M., Nakada M., Cunliffe H.E., Hostetter G., Hoelzinger D.B., Rennert J.L., Michaelson J.S., Burkly L.C., Lipinski C.A., Loftus J.C., Mariani L., Berens M.E.
    Cancer Res. 66:9535-9542(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: The Fn14 promoter has NF-kappaB binding sites mediating positive feedback causing sustained overexpression of Fn14 & enduring glioma cell invasion. The Fn14 cascade operates as a positive feedback mechanism for elevated & sustained Fn14 expression.
    Source: GeneRIF:51330.

    This publication is mapped to 4 other entries.

  23. 23
    "TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration."
    Girgenrath M., Weng S., Kostek C.A., Browning B., Wang M., Brown S.A., Winkles J.A., Michaelson J.S., Allaire N., Schneider P., Scott M.L., Hsu Y.M., Yagita H., Flavell R.A., Miller J.B., Burkly L.C., Zheng T.S.
    EMBO J. 25:5826-5839(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: These results indicate that the TWEAK/Fn14 pathway is a novel regulator of skeletal muscle precursor cells and illustrate an important mechanism by which inflammatory cytokines influence tissue regeneration and repair.
    Source: GeneRIF:51330.

    This publication is mapped to 12 other entries.

  24. 24
    "Fibroblast growth factor inducible 14 (Fn14) is required for the expression of myogenic regulatory factors and differentiation of myoblasts into myotubes. Evidence for TWEAK-independent functions of Fn14 during myogenesis."
    Dogra C., Hall S.L., Wedhas N., Linkhart T.A., Kumar A.
    J. Biol. Chem. 282:15000-15010(2007) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Expression.
    Annotation: Fn14 receptor is required for the expression of myogenic regulatory factors and differentiation of myoblasts into myotubes.
    Source: GeneRIF:51330.

    This publication is mapped to 12 other entries.

  25. 25
    "Identification of Fn14/TWEAK receptor as a potential therapeutic target in esophageal adenocarcinoma."
    Watts G.S., Tran N.L., Berens M.E., Bhattacharyya A.K., Nelson M.A., Montgomery E.A., Sampliner R.E.
    Int. J. Cancer 121:2132-2139(2007) [PubMed] [Europe PMC] [Abstract]
    Category: Expression.
    Annotation: Fn14 protein expression increased with disease progression in esophageal adenocarcinoma.
    Source: GeneRIF:51330.
1 to 25 of 118  Show
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