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Entry version 167 (18 Sep 2019)
Sequence version 2 (22 Aug 2003)
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Protein

Interleukin-1 receptor accessory protein

Gene

IL1RAP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable).By similarity2 Publications2 Publications
Isoform 2: Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (PubMed:12530978). Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling (By similarity).By similarity1 Publication
Isoform 4: Unable to mediate canonical IL-1 signaling (PubMed:19481478). Required for Src phosphorylation by IL1B. May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processImmunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-388844 Receptor-type tyrosine-protein phosphatases
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-9014826 Interleukin-36 pathway
R-HSA-9014843 Interleukin-33 signaling
R-HSA-9020702 Interleukin-1 signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q9NPH3

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9NPH3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-1 receptor accessory protein
Short name:
IL-1 receptor accessory protein
Short name:
IL-1RAcP
Alternative name(s):
Interleukin-1 receptor 3
Short name:
IL-1R-3
Short name:
IL-1R3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IL1RAP
Synonyms:C3orf13, IL1R3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5995 IL1RAP

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602626 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NPH3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini21 – 367ExtracellularSequence analysisAdd BLAST347
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei368 – 388HelicalSequence analysisAdd BLAST21
Topological domaini389 – 570CytoplasmicSequence analysisAdd BLAST182

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3556

Open Targets

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OpenTargetsi
ENSG00000196083

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29811

Chemistry databases

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1897

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IL1RAP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
34222652

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001545021 – 570Interleukin-1 receptor accessory proteinAdd BLAST550

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi24 ↔ 122PROSITE-ProRule annotation1 Publication
Disulfide bondi47 ↔ 114PROSITE-ProRule annotation1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi107N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi111N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi118N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi137 ↔ 181PROSITE-ProRule annotation1 Publication
Disulfide bondi160 ↔ 212PROSITE-ProRule annotation1 Publication
Glycosylationi196N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi209N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi266 ↔ 332PROSITE-ProRule annotation1 Publication
Glycosylationi299N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei557PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-2221

Encyclopedia of Proteome Dynamics

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EPDi
Q9NPH3

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9NPH3

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9NPH3

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9NPH3

PeptideAtlas

More...
PeptideAtlasi
Q9NPH3

PRoteomics IDEntifications database

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PRIDEi
Q9NPH3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
81999 [Q9NPH3-1]
82000 [Q9NPH3-2]
82001 [Q9NPH3-3]
82002 [Q9NPH3-5]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1425

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9NPH3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NPH3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in liver, skin, placenta, thymus and lung. Isoform 4 is predominantly expressed in brain. Overexpressed on candidate chronic myeloid leukemia (CML) stem cells, hematopoietic stem cells and mononuclear cells of patients with acute myeloid leukemia (AML). Overexpressed in patients with chronic obstructive pulmonary disease (COPD). Expressed in T-helper 1 (Th1) and T-helper 2 (Th2) cell subsets (PubMed:10653850).7 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Isoform 1 is down-regulated by phorbol ester treatment. Isoform 2 is induced by phorbol ester treatment.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000196083 Expressed in 175 organ(s), highest expression level in liver

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9NPH3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9NPH3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA035293

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The interleukin-36 receptor complex is a heterodimer of IL1RL2 and IL1RAP; the association is inhibited by IL36RN (By similarity). The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Associates with IL1R2 to form a non-signaling interleukin-1 receptor complex.

Isoform 4 interacts with IL1R1 in an interleukin-1-dependent manner.

Interacts with IL-33-bound IL1RL1 to form the minimal interleukin-33 signaling complex with a 1:1:1 stoichiometry.

Interacts with KIT (independently of stimulation with KITLG/SCF). A mast cell-specific KITLG/SCF-induced interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88 (By similarity).

Interacts (via the first immunoglobilin domain) with PTPRD (via the third immunoglobilin domain); induces pre- and postsynaptic differentiation of neurons (By similarity).

By similarity1 Publication4 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109771, 23 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9NPH3

Database of interacting proteins

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DIPi
DIP-33487N

Protein interaction database and analysis system

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IntActi
Q9NPH3, 16 interactors

Molecular INTeraction database

More...
MINTi
Q9NPH3

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1570
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NPH3

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9NPH3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 128Ig-like C2-type 1Add BLAST108
Domaini141 – 230Ig-like C2-type 2Add BLAST90
Domaini242 – 348Ig-like C2-type 3Add BLAST107
Domaini403 – 549TIRPROSITE-ProRule annotationAdd BLAST147

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni69 – 85Essential for interaction with PTPRDBy similarityAdd BLAST17

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree

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GeneTreei
ENSGT00960000186586

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000092977

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9NPH3

KEGG Orthology (KO)

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KOi
K04723

Identification of Orthologs from Complete Genome Data

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OMAi
HRLYIEY

Database of Orthologous Groups

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OrthoDBi
985064at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9NPH3

TreeFam database of animal gene trees

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TreeFami
TF325519

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 3 hits
3.40.50.10140, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR041416 Ig_6
IPR003599 Ig_sub
IPR015621 IL-1_rcpt_fam
IPR004074 IL-1_rcpt_I/II-typ
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR11890 PTHR11890, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF18452 Ig_6, 1 hit
PF01582 TIR, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01536 INTRLKN1R12F

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00409 IG, 3 hits
SM00255 TIR, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48726 SSF48726, 3 hits
SSF52200 SSF52200, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 2 hits
PS50104 TIR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NPH3-1) [UniParc]FASTAAdd to basket
Also known as: Membrane-bound IL-1RAcP, mIL-1RAcP

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTLLWCVVSL YFYGILQSDA SERCDDWGLD TMRQIQVFED EPARIKCPLF
60 70 80 90 100
EHFLKFNYST AHSAGLTLIW YWTRQDRDLE EPINFRLPEN RISKEKDVLW
110 120 130 140 150
FRPTLLNDTG NYTCMLRNTT YCSKVAFPLE VVQKDSCFNS PMKLPVHKLY
160 170 180 190 200
IEYGIQRITC PNVDGYFPSS VKPTITWYMG CYKIQNFNNV IPEGMNLSFL
210 220 230 240 250
IALISNNGNY TCVVTYPENG RTFHLTRTLT VKVVGSPKNA VPPVIHSPND
260 270 280 290 300
HVVYEKEPGE ELLIPCTVYF SFLMDSRNEV WWTIDGKKPD DITIDVTINE
310 320 330 340 350
SISHSRTEDE TRTQILSIKK VTSEDLKRSY VCHARSAKGE VAKAAKVKQK
360 370 380 390 400
VPAPRYTVEL ACGFGATVLL VVILIVVYHV YWLEMVLFYR AHFGTDETIL
410 420 430 440 450
DGKEYDIYVS YARNAEEEEF VLLTLRGVLE NEFGYKLCIF DRDSLPGGIV
460 470 480 490 500
TDETLSFIQK SRRLLVVLSP NYVLQGTQAL LELKAGLENM ASRGNINVIL
510 520 530 540 550
VQYKAVKETK VKELKRAKTV LTVIKWKGEK SKYPQGRFWK QLQVAMPVKK
560 570
SPRRSSSDEQ GLSYSSLKNV
Length:570
Mass (Da):65,418
Last modified:August 22, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5F47F8D0ECA98B8A
GO
Isoform 2 (identifier: Q9NPH3-2) [UniParc]FASTAAdd to basket
Also known as: Soluble IL-1RAcP, sIL-1RAcP

The sequence of this isoform differs from the canonical sequence as follows:
     351-356: VPAPRY → GNRCGQ
     357-570: Missing.

Show »
Length:356
Mass (Da):41,019
Checksum:i39B72452C458A1C3
GO
Isoform 3 (identifier: Q9NPH3-3) [UniParc]FASTAAdd to basket
Also known as: Soluble IL-1RAcP-beta, sIL-1RAcP-beta

The sequence of this isoform differs from the canonical sequence as follows:
     302-570: ISHSRTEDET...GLSYSSLKNV → ASSKIHSGTG...PILPGSFWNR

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:346
Mass (Da):39,743
Checksum:i6F13B34E6763E062
GO
Isoform 4 (identifier: Q9NPH3-5) [UniParc]FASTAAdd to basket
Also known as: AcPb, mIL-1RAcP687

The sequence of this isoform differs from the canonical sequence as follows:
     449-570: IVTDETLSFI...GLSYSSLKNV → NTVEAVFDFI...LSNNNDFYIL

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Length:687
Mass (Da):78,603
Checksum:i5489237C18503D4C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J1D9C9J1D9_HUMAN
Interleukin-1 receptor accessory pr...
IL1RAP
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JT28C9JT28_HUMAN
Interleukin-1 receptor accessory pr...
IL1RAP
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J9W1C9J9W1_HUMAN
Interleukin-1 receptor accessory pr...
IL1RAP
215Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3W4H7C3W4_HUMAN
Interleukin-1 receptor accessory pr...
IL1RAP
193Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053383473V → M. Corresponds to variant dbSNP:rs34661910Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_008052302 – 570ISHSR…SLKNV → ASSKIHSGTGLWFWSHSPAS GDSHCCLPCLLARDGPILPG SFWNR in isoform 3. 1 PublicationAdd BLAST269
Alternative sequenceiVSP_008050351 – 356VPAPRY → GNRCGQ in isoform 2. 3 Publications6
Alternative sequenceiVSP_008051357 – 570Missing in isoform 2. 3 PublicationsAdd BLAST214
Alternative sequenceiVSP_041256449 – 570IVTDE…SLKNV → NTVEAVFDFIQRSRRMIVVL SPDYVTEKSISMLEFKLGVM CQNSIATKLIVVEYRPLEHP HPGILQLKESVSFVSWKGEK SKHSGSKFWKALRLALPLRS LSASSGWNESCSSQSDISLD HVQRRRSRLKEPPELQSSER AAGSPPAPGTMSKHRGKSSA TCRCCVTYCEGENHLRNKSR AEIHNQPQWETHLCKPVPQE SETQWIQNGTRLEPPAPQIS ALALHHFTDLSNNNDFYIL in isoform 4. 2 PublicationsAdd BLAST122

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF029213 mRNA Translation: AAB84059.1
AB006537 mRNA Translation: BAA25421.1
AF167343 mRNA Translation: AAF71687.1
AF167340
, AF167335, AF167336, AF167337, AF167338, AF167339 Genomic DNA Translation: AAF71688.1
AF167342
, AF167335, AF167336, AF167337, AF167338, AF167339, AF167340, AF167341 Genomic DNA Translation: AAF71689.1
AF538730 mRNA Translation: AAQ01755.1
AF538731 mRNA Translation: AAQ01756.1
AF538732 mRNA Translation: AAQ01757.1
AF538733 mRNA Translation: AAQ01758.1
AF538734 mRNA Translation: AAQ01759.1
AF487335 mRNA Translation: AAO49451.1
EF591790 mRNA Translation: ABU90811.1
FJ998418 mRNA Translation: ACR82488.1
AC008249 Genomic DNA No translation available.
AC108747 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78100.1
CH471052 Genomic DNA Translation: EAW78102.1
BC053621 mRNA Translation: AAH53621.1
AF016261 Genomic DNA Translation: AAC39609.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS3298.1 [Q9NPH3-1]
CCDS46982.1 [Q9NPH3-2]
CCDS54696.1 [Q9NPH3-5]

NCBI Reference Sequences

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RefSeqi
NP_001161400.1, NM_001167928.1 [Q9NPH3-1]
NP_001161401.1, NM_001167929.1 [Q9NPH3-1]
NP_001161402.1, NM_001167930.1 [Q9NPH3-2]
NP_001161403.1, NM_001167931.1 [Q9NPH3-5]
NP_002173.1, NM_002182.3 [Q9NPH3-1]
NP_608273.1, NM_134470.3 [Q9NPH3-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000072516; ENSP00000072516; ENSG00000196083 [Q9NPH3-1]
ENST00000317757; ENSP00000314807; ENSG00000196083 [Q9NPH3-5]
ENST00000342550; ENSP00000345829; ENSG00000196083 [Q9NPH3-3]
ENST00000412504; ENSP00000412053; ENSG00000196083 [Q9NPH3-1]
ENST00000413869; ENSP00000416296; ENSG00000196083 [Q9NPH3-3]
ENST00000422485; ENSP00000409352; ENSG00000196083 [Q9NPH3-2]
ENST00000422940; ENSP00000387371; ENSG00000196083 [Q9NPH3-2]
ENST00000439062; ENSP00000401132; ENSG00000196083 [Q9NPH3-1]
ENST00000443369; ENSP00000408893; ENSG00000196083 [Q9NPH3-5]
ENST00000447382; ENSP00000390541; ENSG00000196083 [Q9NPH3-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
3556

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3556

UCSC genome browser

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UCSCi
uc003fsk.4 human [Q9NPH3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029213 mRNA Translation: AAB84059.1
AB006537 mRNA Translation: BAA25421.1
AF167343 mRNA Translation: AAF71687.1
AF167340
, AF167335, AF167336, AF167337, AF167338, AF167339 Genomic DNA Translation: AAF71688.1
AF167342
, AF167335, AF167336, AF167337, AF167338, AF167339, AF167340, AF167341 Genomic DNA Translation: AAF71689.1
AF538730 mRNA Translation: AAQ01755.1
AF538731 mRNA Translation: AAQ01756.1
AF538732 mRNA Translation: AAQ01757.1
AF538733 mRNA Translation: AAQ01758.1
AF538734 mRNA Translation: AAQ01759.1
AF487335 mRNA Translation: AAO49451.1
EF591790 mRNA Translation: ABU90811.1
FJ998418 mRNA Translation: ACR82488.1
AC008249 Genomic DNA No translation available.
AC108747 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78100.1
CH471052 Genomic DNA Translation: EAW78102.1
BC053621 mRNA Translation: AAH53621.1
AF016261 Genomic DNA Translation: AAC39609.1
CCDSiCCDS3298.1 [Q9NPH3-1]
CCDS46982.1 [Q9NPH3-2]
CCDS54696.1 [Q9NPH3-5]
RefSeqiNP_001161400.1, NM_001167928.1 [Q9NPH3-1]
NP_001161401.1, NM_001167929.1 [Q9NPH3-1]
NP_001161402.1, NM_001167930.1 [Q9NPH3-2]
NP_001161403.1, NM_001167931.1 [Q9NPH3-5]
NP_002173.1, NM_002182.3 [Q9NPH3-1]
NP_608273.1, NM_134470.3 [Q9NPH3-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3O4OX-ray3.30B21-350[»]
4DEPX-ray3.10C/F21-367[»]
SMRiQ9NPH3
ModBaseiSearch...

Protein-protein interaction databases

BioGridi109771, 23 interactors
CORUMiQ9NPH3
DIPiDIP-33487N
IntActiQ9NPH3, 16 interactors
MINTiQ9NPH3

Chemistry databases

DrugCentral

More...
DrugCentrali
Q9NPH3
GuidetoPHARMACOLOGYi1897

PTM databases

GlyConnecti1425
iPTMnetiQ9NPH3
PhosphoSitePlusiQ9NPH3

Polymorphism and mutation databases

BioMutaiIL1RAP
DMDMi34222652

Proteomic databases

CPTACiCPTAC-2221
EPDiQ9NPH3
jPOSTiQ9NPH3
MassIVEiQ9NPH3
MaxQBiQ9NPH3
PeptideAtlasiQ9NPH3
PRIDEiQ9NPH3
ProteomicsDBi81999 [Q9NPH3-1]
82000 [Q9NPH3-2]
82001 [Q9NPH3-3]
82002 [Q9NPH3-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3556
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000072516; ENSP00000072516; ENSG00000196083 [Q9NPH3-1]
ENST00000317757; ENSP00000314807; ENSG00000196083 [Q9NPH3-5]
ENST00000342550; ENSP00000345829; ENSG00000196083 [Q9NPH3-3]
ENST00000412504; ENSP00000412053; ENSG00000196083 [Q9NPH3-1]
ENST00000413869; ENSP00000416296; ENSG00000196083 [Q9NPH3-3]
ENST00000422485; ENSP00000409352; ENSG00000196083 [Q9NPH3-2]
ENST00000422940; ENSP00000387371; ENSG00000196083 [Q9NPH3-2]
ENST00000439062; ENSP00000401132; ENSG00000196083 [Q9NPH3-1]
ENST00000443369; ENSP00000408893; ENSG00000196083 [Q9NPH3-5]
ENST00000447382; ENSP00000390541; ENSG00000196083 [Q9NPH3-1]
GeneIDi3556
KEGGihsa:3556
UCSCiuc003fsk.4 human [Q9NPH3-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3556
DisGeNETi3556

GeneCards: human genes, protein and diseases

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GeneCardsi
IL1RAP
HGNCiHGNC:5995 IL1RAP
HPAiHPA035293
MIMi602626 gene
neXtProtiNX_Q9NPH3
OpenTargetsiENSG00000196083
PharmGKBiPA29811

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00960000186586
HOGENOMiHOG000092977
InParanoidiQ9NPH3
KOiK04723
OMAiHRLYIEY
OrthoDBi985064at2759
PhylomeDBiQ9NPH3
TreeFamiTF325519

Enzyme and pathway databases

ReactomeiR-HSA-1257604 PIP3 activates AKT signaling
R-HSA-388844 Receptor-type tyrosine-protein phosphatases
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-9014826 Interleukin-36 pathway
R-HSA-9014843 Interleukin-33 signaling
R-HSA-9020702 Interleukin-1 signaling
SignaLinkiQ9NPH3
SIGNORiQ9NPH3

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
IL1RAP human
EvolutionaryTraceiQ9NPH3

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
IL1RAP

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3556

Pharos

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Pharosi
Q9NPH3

Protein Ontology

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PROi
PR:Q9NPH3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000196083 Expressed in 175 organ(s), highest expression level in liver
ExpressionAtlasiQ9NPH3 baseline and differential
GenevisibleiQ9NPH3 HS

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.40.50.10140, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR041416 Ig_6
IPR003599 Ig_sub
IPR015621 IL-1_rcpt_fam
IPR004074 IL-1_rcpt_I/II-typ
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR11890 PTHR11890, 1 hit
PfamiView protein in Pfam
PF18452 Ig_6, 1 hit
PF01582 TIR, 1 hit
PRINTSiPR01536 INTRLKN1R12F
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00255 TIR, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
PS50104 TIR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIL1AP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NPH3
Secondary accession number(s): B1NLD0
, D3DNW0, O14915, Q86WJ7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: August 22, 2003
Last modified: September 18, 2019
This is version 167 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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