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Entry version 139 (18 Sep 2019)
Sequence version 1 (01 Oct 2000)
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Protein

Centromere protein M

Gene

CENPM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-68877 Mitotic Prometaphase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Centromere protein M
Short name:
CENP-M
Alternative name(s):
Interphase centromere complex protein 39
Proliferation-associated nuclear element protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CENPM
Synonyms:C22orf18, ICEN39, PANE1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:18352 CENPM

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610152 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NSP4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Kinetochore, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
79019

Open Targets

More...
OpenTargetsi
ENSG00000100162

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25885

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CENPM

Domain mapping of disease mutations (DMDM)

More...
DMDMi
47117330

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000582241 – 180Centromere protein MAdd BLAST180

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NSP4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NSP4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NSP4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NSP4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NSP4

PeptideAtlas

More...
PeptideAtlasi
Q9NSP4

PRoteomics IDEntifications database

More...
PRIDEi
Q9NSP4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
2973
82572 [Q9NSP4-1]
82573 [Q9NSP4-2]
82574 [Q9NSP4-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NSP4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NSP4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 3 is highly expressed in spleen, and intermediately in heart, prostate and ovary. Isoform 3 is highly expressed in resting CD19 B-cells and B-lineage chronic lymphocytic leukemia (B-CLL) cells and weakly expressed in activated B-cells. Isoform 1 is selectively expressed in activated CD19 cells and weakly in resting CD19 B-cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000100162 Expressed in 123 organ(s), highest expression level in mucosa of transverse colon

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NSP4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NSP4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042404
HPA056500

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122488, 54 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9NSP4

Protein interaction database and analysis system

More...
IntActi
Q9NSP4, 9 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000215980

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9NSP4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IZ5U Eukaryota
ENOG4111PTI LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017504

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000048739

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NSP4

KEGG Orthology (KO)

More...
KOi
K11505

Identification of Orthologs from Complete Genome Data

More...
OMAi
HCSVHRN

Database of Orthologous Groups

More...
OrthoDBi
1551430at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NSP4

TreeFam database of animal gene trees

More...
TreeFami
TF328778

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR020987 Centromere_Cenp-M

The PANTHER Classification System

More...
PANTHERi
PTHR34436 PTHR34436, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11111 CENP-M, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NSP4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVLRPLDKL PGLNTATILL VGTEDALLQQ LADSMLKEDC ASELKVHLAK
60 70 80 90 100
SLPLPSSVNR PRIDLIVFVV NLHSKYSLQN TEESLRHVDA SFFLGKVCFL
110 120 130 140 150
ATGAGRESHC SIHRHTVVKL AHTYQSPLLY CDLEVEGFRA TMAQRLVRVL
160 170 180
QICAGHVPGV SALNLLSLLR SSEGPSLEDL
Length:180
Mass (Da):19,737
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i37DB044092BF63F4
GO
Isoform 2 (identifier: Q9NSP4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     104-132: AGRESHCSIHRHTVVKLAHTYQSPLLYCD → GKYVPRLLLPTPSQGKAGAAVGFLLRHPG
     133-180: Missing.

Note: Due to intron retention. No experimental confirmation available.
Show »
Length:132
Mass (Da):14,287
Checksum:i3A8E77D553024B38
GO
Isoform 3 (identifier: Q9NSP4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-122: Missing.
     123-134: TYQSPLLYCDLE → MGRVWDLPGVLK

Show »
Length:58
Mass (Da):6,257
Checksum:iD5B353502075D069
GO
Isoform 4 (identifier: Q9NSP4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     104-179: AGRESHCSIH...RSSEGPSLED → GGR

Note: No experimental confirmation available.
Show »
Length:107
Mass (Da):11,687
Checksum:i4FBAB92E26A66A1F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AHQ6B1AHQ6_HUMAN
Centromere protein M
CENPM
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AHQ7B1AHQ7_HUMAN
Centromere protein M
CENPM
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AHQ8B1AHQ8_HUMAN
Centromere protein M
CENPM
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0177261 – 122Missing in isoform 3. 1 PublicationAdd BLAST122
Alternative sequenceiVSP_046189104 – 179AGRES…PSLED → GGR in isoform 4. 1 PublicationAdd BLAST76
Alternative sequenceiVSP_010259104 – 132AGRES…LLYCD → GKYVPRLLLPTPSQGKAGAA VGFLLRHPG in isoform 2. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_017725123 – 134TYQSP…YCDLE → MGRVWDLPGVLK in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_010260133 – 180Missing in isoform 2. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EU035297 mRNA Translation: ABS84666.1
AL160131 mRNA Translation: CAB77147.1
AK123479 mRNA Translation: BAC85624.1
CR456399 mRNA Translation: CAG30285.1
CR457392 mRNA Translation: CAG33673.1
Z99716 Genomic DNA No translation available.
BC000705 mRNA Translation: AAH00705.1
BC007495 mRNA Translation: AAH07495.1
BU194618 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14025.1 [Q9NSP4-1]
CCDS46719.1 [Q9NSP4-3]
CCDS46720.1 [Q9NSP4-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001002876.1, NM_001002876.2 [Q9NSP4-4]
NP_001103685.1, NM_001110215.2 [Q9NSP4-3]
NP_001291299.1, NM_001304370.1
NP_001291300.1, NM_001304371.1 [Q9NSP4-2]
NP_001291301.1, NM_001304372.1
NP_001291302.1, NM_001304373.1
NP_076958.1, NM_024053.4 [Q9NSP4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000215980; ENSP00000215980; ENSG00000100162 [Q9NSP4-1]
ENST00000407253; ENSP00000384743; ENSG00000100162 [Q9NSP4-4]
ENST00000472374; ENSP00000430624; ENSG00000100162 [Q9NSP4-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
79019

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79019

UCSC genome browser

More...
UCSCi
uc003bbn.4 human [Q9NSP4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU035297 mRNA Translation: ABS84666.1
AL160131 mRNA Translation: CAB77147.1
AK123479 mRNA Translation: BAC85624.1
CR456399 mRNA Translation: CAG30285.1
CR457392 mRNA Translation: CAG33673.1
Z99716 Genomic DNA No translation available.
BC000705 mRNA Translation: AAH00705.1
BC007495 mRNA Translation: AAH07495.1
BU194618 mRNA No translation available.
CCDSiCCDS14025.1 [Q9NSP4-1]
CCDS46719.1 [Q9NSP4-3]
CCDS46720.1 [Q9NSP4-4]
RefSeqiNP_001002876.1, NM_001002876.2 [Q9NSP4-4]
NP_001103685.1, NM_001110215.2 [Q9NSP4-3]
NP_001291299.1, NM_001304370.1
NP_001291300.1, NM_001304371.1 [Q9NSP4-2]
NP_001291301.1, NM_001304372.1
NP_001291302.1, NM_001304373.1
NP_076958.1, NM_024053.4 [Q9NSP4-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4P0TX-ray1.49A/B1-171[»]
4WAUX-ray2.20A/B1-171[»]
SMRiQ9NSP4
ModBaseiSearch...

Protein-protein interaction databases

BioGridi122488, 54 interactors
CORUMiQ9NSP4
IntActiQ9NSP4, 9 interactors
STRINGi9606.ENSP00000215980

PTM databases

iPTMnetiQ9NSP4
PhosphoSitePlusiQ9NSP4

Polymorphism and mutation databases

BioMutaiCENPM
DMDMi47117330

Proteomic databases

EPDiQ9NSP4
jPOSTiQ9NSP4
MassIVEiQ9NSP4
MaxQBiQ9NSP4
PaxDbiQ9NSP4
PeptideAtlasiQ9NSP4
PRIDEiQ9NSP4
ProteomicsDBi2973
82572 [Q9NSP4-1]
82573 [Q9NSP4-2]
82574 [Q9NSP4-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
79019
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000215980; ENSP00000215980; ENSG00000100162 [Q9NSP4-1]
ENST00000407253; ENSP00000384743; ENSG00000100162 [Q9NSP4-4]
ENST00000472374; ENSP00000430624; ENSG00000100162 [Q9NSP4-3]
GeneIDi79019
KEGGihsa:79019
UCSCiuc003bbn.4 human [Q9NSP4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79019
DisGeNETi79019

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CENPM
HGNCiHGNC:18352 CENPM
HPAiHPA042404
HPA056500
MIMi610152 gene
neXtProtiNX_Q9NSP4
OpenTargetsiENSG00000100162
PharmGKBiPA25885

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IZ5U Eukaryota
ENOG4111PTI LUCA
GeneTreeiENSGT00390000017504
HOGENOMiHOG000048739
InParanoidiQ9NSP4
KOiK11505
OMAiHCSVHRN
OrthoDBi1551430at2759
PhylomeDBiQ9NSP4
TreeFamiTF328778

Enzyme and pathway databases

ReactomeiR-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-68877 Mitotic Prometaphase

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CENPM human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CENPM

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79019

Pharos

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Pharosi
Q9NSP4

Protein Ontology

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PROi
PR:Q9NSP4

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000100162 Expressed in 123 organ(s), highest expression level in mucosa of transverse colon
ExpressionAtlasiQ9NSP4 baseline and differential
GenevisibleiQ9NSP4 HS

Family and domain databases

InterProiView protein in InterPro
IPR020987 Centromere_Cenp-M
PANTHERiPTHR34436 PTHR34436, 1 hit
PfamiView protein in Pfam
PF11111 CENP-M, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCENPM_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NSP4
Secondary accession number(s): A7LM22, B1AHQ9, Q6I9W3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2000
Last modified: September 18, 2019
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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