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Entry version 159 (18 Sep 2019)
Sequence version 1 (01 Oct 2000)
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Protein

Gap junction beta-4 protein

Gene

GJB4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Structural component of gap junctions (By similarity). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-190861 Gap junction assembly

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Gap junction beta-4 protein
Alternative name(s):
Connexin-30.3
Short name:
Cx30.3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GJB4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4286 GJB4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605425 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NTQ9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei2 – 13By similarityAdd BLAST12
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini14 – 20CytoplasmicCurated7
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei21 – 40HelicalBy similarityAdd BLAST20
Topological domaini41 – 73ExtracellularCuratedAdd BLAST33
Transmembranei74 – 94HelicalBy similarityAdd BLAST21
Topological domaini95 – 130CytoplasmicCuratedAdd BLAST36
Transmembranei131 – 151HelicalBy similarityAdd BLAST21
Topological domaini152 – 184ExtracellularCuratedAdd BLAST33
Transmembranei185 – 205HelicalBy similarityAdd BLAST21
Topological domaini206 – 266CytoplasmicCuratedAdd BLAST61

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Erythrokeratodermia variabilis et progressiva 2 (EKVP2)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of erythrokeratodermia variabilis et progressiva, a genodermatosis characterized by the coexistence of two independent skin lesions: transient erythema and hyperkeratosis that is usually localized but occasionally occurs in its generalized form. Clinical presentation varies significantly within a family and from one family to another. Palmoplantar keratoderma is present in around 50% of cases.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07919412G → D in EKVP2. 2 PublicationsCorresponds to variant dbSNP:rs80358211EnsemblClinVar.1
Natural variantiVAR_07919522R → H in EKVP2. 1 PublicationCorresponds to variant dbSNP:rs80358212EnsemblClinVar.1
Natural variantiVAR_07919685T → P in EKVP2. 1 PublicationCorresponds to variant dbSNP:rs80358210EnsemblClinVar.1
Natural variantiVAR_010206137F → L in EKVP2. 2 PublicationsCorresponds to variant dbSNP:rs80358206EnsemblClinVar.1
Natural variantiVAR_079197189F → Y in EKVP2. 1 PublicationCorresponds to variant dbSNP:rs80358213EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Palmoplantar keratoderma

Organism-specific databases

DisGeNET

More...
DisGeNETi
127534

MalaCards human disease database

More...
MalaCardsi
GJB4
MIMi617524 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000189433

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
317 Erythrokeratodermia variabilis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28697

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GJB4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
12229761

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000578651 – 266Gap junction beta-4 proteinAdd BLAST266

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi53 ↔ 175By similarity
Disulfide bondi60 ↔ 169By similarity
Disulfide bondi64 ↔ 164By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NTQ9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NTQ9

PeptideAtlas

More...
PeptideAtlasi
Q9NTQ9

PRoteomics IDEntifications database

More...
PRIDEi
Q9NTQ9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
82630

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NTQ9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NTQ9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000189433 Expressed in 27 organ(s), highest expression level in skin of leg

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NTQ9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA055112

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

A hemichannel or connexon is composed of a hexamer of connexins. A functional gap junction is formed by the apposition of two hemichannels (By similarity). Forms heteromeric channels with GJB2 (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
126063, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q9NTQ9, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000345868

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IE21 Eukaryota
ENOG410Y9C2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182704

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231127

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NTQ9

KEGG Orthology (KO)

More...
KOi
K07623

Identification of Orthologs from Complete Genome Data

More...
OMAi
HTVDCYI

Database of Orthologous Groups

More...
OrthoDBi
955506at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NTQ9

TreeFam database of animal gene trees

More...
TreeFami
TF329606

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1440.80, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000500 Connexin
IPR002270 Connexin311
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11984 PTHR11984, 1 hit
PTHR11984:SF30 PTHR11984:SF30, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00029 Connexin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00206 CONNEXIN
PR01142 CONNEXINB5

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9NTQ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNWAFLQGLL SGVNKYSTVL SRIWLSVVFI FRVLVYVVAA EEVWDDEQKD
60 70 80 90 100
FVCNTKQPGC PNVCYDEFFP VSHVRLWALQ LILVTCPSLL VVMHVAYREE
110 120 130 140 150
RERKHHLKHG PNAPSLYDNL SKKRGGLWWT YLLSLIFKAA VDAGFLYIFH
160 170 180 190 200
RLYKDYDMPR VVACSVEPCP HTVDCYISRP TEKKVFTYFM VTTAAICILL
210 220 230 240 250
NLSEVFYLVG KRCMEIFGPR HRRPRCRECL PDTCPPYVLS QGGHPEDGNS
260
VLMKAGSAPV DAGGYP
Length:266
Mass (Da):30,419
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF136B3706AA14648
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07919412G → D in EKVP2. 2 PublicationsCorresponds to variant dbSNP:rs80358211EnsemblClinVar.1
Natural variantiVAR_07919522R → H in EKVP2. 1 PublicationCorresponds to variant dbSNP:rs80358212EnsemblClinVar.1
Natural variantiVAR_07919685T → P in EKVP2. 1 PublicationCorresponds to variant dbSNP:rs80358210EnsemblClinVar.1
Natural variantiVAR_015088103R → C1 PublicationCorresponds to variant dbSNP:rs9426009Ensembl.1
Natural variantiVAR_015089124R → Q2 PublicationsCorresponds to variant dbSNP:rs140996335Ensembl.1
Natural variantiVAR_010206137F → L in EKVP2. 2 PublicationsCorresponds to variant dbSNP:rs80358206EnsemblClinVar.1
Natural variantiVAR_015090160R → C1 PublicationCorresponds to variant dbSNP:rs148710003Ensembl.1
Natural variantiVAR_015091169C → W2 PublicationsCorresponds to variant dbSNP:rs79193415EnsemblClinVar.1
Natural variantiVAR_079197189F → Y in EKVP2. 1 PublicationCorresponds to variant dbSNP:rs80358213EnsemblClinVar.1
Natural variantiVAR_015092204E → A2 PublicationsCorresponds to variant dbSNP:rs3738346EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK057628 mRNA Translation: BAG51944.1
AL121988 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07443.1
BC034709 mRNA Translation: AAH34709.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS383.1

NCBI Reference Sequences

More...
RefSeqi
NP_694944.1, NM_153212.2
XP_011538981.1, XM_011540679.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000339480; ENSP00000345868; ENSG00000189433

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
127534

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:127534

UCSC genome browser

More...
UCSCi
uc001bxv.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057628 mRNA Translation: BAG51944.1
AL121988 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07443.1
BC034709 mRNA Translation: AAH34709.1
CCDSiCCDS383.1
RefSeqiNP_694944.1, NM_153212.2
XP_011538981.1, XM_011540679.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi126063, 1 interactor
IntActiQ9NTQ9, 7 interactors
STRINGi9606.ENSP00000345868

PTM databases

iPTMnetiQ9NTQ9
PhosphoSitePlusiQ9NTQ9

Polymorphism and mutation databases

BioMutaiGJB4
DMDMi12229761

Proteomic databases

jPOSTiQ9NTQ9
PaxDbiQ9NTQ9
PeptideAtlasiQ9NTQ9
PRIDEiQ9NTQ9
ProteomicsDBi82630

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
127534
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339480; ENSP00000345868; ENSG00000189433
GeneIDi127534
KEGGihsa:127534
UCSCiuc001bxv.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
127534
DisGeNETi127534

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GJB4
HGNCiHGNC:4286 GJB4
HPAiHPA055112
MalaCardsiGJB4
MIMi605425 gene
617524 phenotype
neXtProtiNX_Q9NTQ9
OpenTargetsiENSG00000189433
Orphaneti317 Erythrokeratodermia variabilis
PharmGKBiPA28697

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IE21 Eukaryota
ENOG410Y9C2 LUCA
GeneTreeiENSGT00950000182704
HOGENOMiHOG000231127
InParanoidiQ9NTQ9
KOiK07623
OMAiHTVDCYI
OrthoDBi955506at2759
PhylomeDBiQ9NTQ9
TreeFamiTF329606

Enzyme and pathway databases

ReactomeiR-HSA-190861 Gap junction assembly

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
GJB4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
127534

Pharos

More...
Pharosi
Q9NTQ9

Protein Ontology

More...
PROi
PR:Q9NTQ9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000189433 Expressed in 27 organ(s), highest expression level in skin of leg
GenevisibleiQ9NTQ9 HS

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR002270 Connexin311
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PTHR11984:SF30 PTHR11984:SF30, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PRINTSiPR00206 CONNEXIN
PR01142 CONNEXINB5
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCXB4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NTQ9
Secondary accession number(s): B3KQ82
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: September 18, 2019
This is version 159 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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