Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
1 to 12 of 12  Show
  1. 12
    "RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling."
    Zhang Y., Liu S., Mickanin C., Feng Y., Charlat O., Michaud G.A., Schirle M., Shi X., Hild M., Bauer A., Myer V.E., Finan P.M., Porter J.A., Huang S.M., Cong F.
    Nat. Cell Biol. 13:623-629(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PATHWAY, DOMAIN WWE, UBIQUITINATION, INTERACTION WITH AXIN1; AXIN2; CASC3 AND BLZF1, MUTAGENESIS OF ARG-163.
    Category: Function, Pathology & Biotech, PTM / Processing, Interaction, Family & Domains.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 6 and mapped to 60 other entries.

  2. 13
    "Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death."
    Andrabi S.A., Kang H.C., Haince J.F., Lee Y.I., Zhang J., Chi Z., West A.B., Koehler R.C., Poirier G.G., Dawson T.M., Dawson V.L.
    Nat. Med. 17:692-699(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN NEUROPROTECTION.
    Category: Function.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 1 other entry.

  3. 14
    Cited for: FUNCTION IN WNT SIGNALING, INTERACTION WITH AXIN1; DDB1; DHX15; IQGAP1; LRPPRC; PARP1; PARP2; PRKDC; RUVBL2; TNKS1 AND TNKS2, UBIQUITINATION, SUBCELLULAR LOCATION, MUTAGENESIS OF HIS-54 AND TRP-106.
    Category: Function, Subcellular Location, Pathology & Biotech, PTM / Processing, Interaction.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 4 and mapped to 65 other entries.

  4. 15
    "Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage."
    Kang H.C., Lee Y.I., Shin J.H., Andrabi S.A., Chi Z., Gagne J.P., Lee Y., Ko H.S., Lee B.D., Poirier G.G., Dawson V.L., Dawson T.M.
    Proc. Natl. Acad. Sci. U.S.A. 108:14103-14108(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN DNA DAMAGE RESPONSE, HOMOOLIGOMERIZATION, INTERACTION WITH H1-2; IPO7; LIG3; NCL; PARP1; XRCC1; XRCC5 AND XRCC6, SUBCELLULAR LOCATION, AUTOUBIQUITINATION AT LYS-85; LYS-95; LYS-131 AND LYS-176.
    Category: Function, Subcellular Location, PTM / Processing, Interaction.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 1 and mapped to 3 other entries.

  5. 17
    "Recognition of the iso-ADP-ribose moiety in poly(ADP-ribose) by WWE domains suggests a general mechanism for poly(ADP-ribosyl)ation-dependent ubiquitination."
    Wang Z., Michaud G.A., Cheng Z., Zhang Y., Hinds T.R., Fan E., Cong F., Xu W.
    Genes Dev. 26:235-240(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 100-184 IN COMPLEX WITH ISO-ADP-RIBOSE, FUNCTION, MUTAGENESIS OF TYR-108; ARG-111; TRP-115; TYR-145; GLN-154; ARG-164 AND LYS-176.
    Category: Function, Pathology & Biotech, Interaction, Structure.
    Source: UniProtKB/Swiss-Prot (reviewed).
  6. 21
    Category: Function.
    Annotation: Pathway.
    Source: Reactome:R-HSA-3640827.

    This publication is cited by 3 and mapped to 72 other entries.

  7. 22
    "The Ubiquitin specific protease USP34 regulates Axin stability and Wnt/beta-catenin signaling."
    Lui T.T., Lacroix C., Ahmed S.M., Goldenberg S.J., Leach C.A., Daulat A.M., Angers S.
    Mol. Cell. Biol. 31:2053-2065(2011) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Pathway.
    Source: Reactome:R-HSA-3640827.

    This publication is cited by 2 and mapped to 18 other entries.

  8. 24
    "Ring finger protein 146/Iduna is a poly(ADP-ribose) polymer binding and PARsylation dependent E3 ubiquitin ligase."
    Zhou Z.D., Chan C.H., Xiao Z.C., Tan E.K.
    Cell Adh Migr 5:463-471(2011) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Subcellular Location, Interaction.
    Annotation: RNF146/Iduna has been found to be implicated in neurodegenerative disease and cancer development. (review).
    Source: GeneRIF:81847.
  9. 28
    "Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth."
    Li N., Zhang Y., Han X., Liang K., Wang J., Feng L., Wang W., Songyang Z., Lin C., Yang L., Yu Y., Chen J.
    Genes Dev. 29:157-170(2015) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Pathway.
    Source: Reactome:R-HSA-3640827.

    This publication is mapped to 52 other entries.

  10. 29
    "Neuroprotectin D1 upregulates Iduna expression and provides protection in cellular uncompensated oxidative stress and in experimental ischemic stroke."
    Belayev L., Mukherjee P.K., Balaszczuk V., Calandria J.M., Obenaus A., Khoutorova L., Hong S.H., Bazan N.G.
    Cell Death Differ. 24:1091-1099(2017) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Iduna expression under disruptive neurohomeostasis (e.g. uncompensated oxidative stress or ischemic stroke after MCAo) is upregulated by neuroprotectin D1 and thus serves as a key regulator of cell survival halting neural cell death.
    Source: GeneRIF:81847.
  11. 31
    "The E3 ubiquitin ligase RNF146 promotes colorectal cancer by activating the Wnt/beta-catenin pathway via ubiquitination of Axin1."
    Shen J., Yu Z., Li N.
    Biochem. Biophys. Res. Commun. 503:991-997(2018) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Expression.
    Annotation: RNF146 exerted oncogenic role through ubiquitination of Axin1 to activate beta-catenin signaling.
    Source: GeneRIF:81847.
  12. 32
    "Rhododendrin-Induced RNF146 Expression via Estrogen Receptor beta Activation is Cytoprotective Against 6-OHDA-Induced Oxidative Stress."
    Kim H., Park J., Leem H., Cho M., Yoon J.H., Maeng H.J., Lee Y.
    Int J Mol Sci 20:0-0(2019) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Expression.
    Annotation: Rhododendrin is cytoprotective against 6-hydroxydopamine (6-OHDA)-induced cell death which is largely dependent on ERbeta activity and RNF146 expression.
    Source: GeneRIF:81847.

    This publication is mapped to 7 other entries.

1 to 12 of 12  Show
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again