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Entry version 160 (13 Nov 2019)
Sequence version 2 (24 Oct 2003)
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Protein

Tyrosyl-DNA phosphodiesterase 1

Gene

TDP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate.5 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 7 sec(-1) with single-stranded 5'-tyrosyl DNA as substrate.
  1. KM=0.08 µM for 14-mer single-stranded oligo with a 3'-phosphotyrosine1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei263Nucleophile2 Publications1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei265Substrate1 Publication1
    Active sitei493Proton donor/acceptor2 Publications1
    Binding sitei495Substrate1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionExonuclease, Hydrolase, Nuclease
    Biological processDNA damage, DNA repair

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-5693571 Nonhomologous End-Joining (NHEJ)

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    Q9NUW8

    SIGNOR Signaling Network Open Resource

    More...
    SIGNORi
    Q9NUW8

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Tyrosyl-DNA phosphodiesterase 1 (EC:3.1.4.-3 Publications)
    Short name:
    Tyr-DNA phosphodiesterase 1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:TDP1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:18884 TDP1

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    607198 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q9NUW8

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 1 (SCAN1)5 Publications
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionA form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAN1 is an autosomal recessive cerebellar ataxia (ARCA) associated with peripheral axonal motor and sensory neuropathy, distal muscular atrophy, pes cavus and steppage gait as seen in Charcot-Marie-Tooth neuropathy. All affected individuals have normal intelligence.
    Related information in OMIM
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_017144493H → R in SCAN1; reduces enzyme activity and leads to the accumulation of covalent complexes between TDP1 and DNA. 5 PublicationsCorresponds to variant dbSNP:rs119467003EnsemblClinVar.1

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi263H → A: Loss of activity. 2 Publications1
    Mutagenesisi265K → A: Abolishes hydrolysis of the covalent intermediate between the active site nucleophile and DNA. 2 Publications1
    Mutagenesisi265K → S: Reduces the activity to nearly undetectable levels. 2 Publications1
    Mutagenesisi283N → A: No effect. 1 Publication1
    Mutagenesisi294Q → A: Slightly reduced hydrolysis of the covalent intermediate between the active site nucleophile and DNA. 1 Publication1
    Mutagenesisi493H → A: 3000-fold reduction in activity; abolishes hydrolysis of the covalent intermediate between the active site nucleophile and DNA. 2 Publications1
    Mutagenesisi493H → N: 15000-fold reduction in activity. 2 Publications1
    Mutagenesisi495K → A: Abolishes hydrolysis of the covalent intermediate between the active site nucleophile and DNA. 2 Publications1
    Mutagenesisi495K → S: 125-fold reduction in activity. 2 Publications1
    Mutagenesisi516N → A: Reduced hydrolysis of the covalent intermediate between the active site nucleophile and DNA. 1 Publication1
    Mutagenesisi538E → A: Abolishes hydrolysis of the covalent intermediate between the active site nucleophile and DNA. 1 Publication1

    Keywords - Diseasei

    Disease mutation, Neurodegeneration

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    55775

    GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

    More...
    GeneReviewsi
    TDP1

    MalaCards human disease database

    More...
    MalaCardsi
    TDP1
    MIMi607250 phenotype

    Open Targets

    More...
    OpenTargetsi
    ENSG00000042088

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    94124 Spinocerebellar ataxia with axonal neuropathy type 1

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA421

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q9NUW8

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL1075138

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    TDP1

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    37999797

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002124861 – 608Tyrosyl-DNA phosphodiesterase 1Add BLAST608

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei61PhosphoserineCombined sources1
    Modified residuei147PhosphothreonineCombined sources1
    Modified residuei148PhosphoserineCombined sources1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Phosphorylated on serine and/or threonine residues, but not on tyrosine residues.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q9NUW8

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q9NUW8

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q9NUW8

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q9NUW8

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9NUW8

    PeptideAtlas

    More...
    PeptideAtlasi
    Q9NUW8

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9NUW8

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    69739
    82725 [Q9NUW8-1]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9NUW8

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q9NUW8

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Ubiquitously expressed. Similar expression throughout the central nervous system (whole brain, amygdala, caudate nucleus, cerebellum, cerebral cortex, frontal lobe, hippocampus, medulla oblongata, occipital lobe, putamen, substantia nigra, temporal lobe, thalamus, nucleus accumbens and spinal cord) and increased expression in testis and thymus.2 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000042088 Expressed in 170 organ(s), highest expression level in oocyte

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9NUW8 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9NUW8 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA071317

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Monomer.

    1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei518Interaction with DNA1 Publication1

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    120890, 12 interactors

    CORUM comprehensive resource of mammalian protein complexes

    More...
    CORUMi
    Q9NUW8

    Protein interaction database and analysis system

    More...
    IntActi
    Q9NUW8, 10 interactors

    Molecular INTeraction database

    More...
    MINTi
    Q9NUW8

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000337353

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    Q9NUW8

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1608
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q9NUW8

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    Q9NUW8

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni400 – 403Interaction with DNA1 Publication4

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG2031 Eukaryota
    ENOG410XQPZ LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000002211

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000067775

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9NUW8

    KEGG Orthology (KO)

    More...
    KOi
    K10862

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    NIKKWGH

    Database of Orthologous Groups

    More...
    OrthoDBi
    1295967at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9NUW8

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF105989

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.30.870.20, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR010347 Tdp1
    IPR027415 TDP_C

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR12415 PTHR12415, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF06087 Tyr-DNA_phospho, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q9NUW8-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MSQEGDYGRW TISSSDESEE EKPKPDKPST SSLLCARQGA ANEPRYTCSE
    60 70 80 90 100
    AQKAAHKRKI SPVKFSNTDS VLPPKRQKSG SQEDLGWCLS SSDDELQPEM
    110 120 130 140 150
    PQKQAEKVVI KKEKDISAPN DGTAQRTENH GAPACHRLKE EEDEYETSGE
    160 170 180 190 200
    GQDIWDMLDK GNPFQFYLTR VSGVKPKYNS GALHIKDILS PLFGTLVSSA
    210 220 230 240 250
    QFNYCFDVDW LVKQYPPEFR KKPILLVHGD KREAKAHLHA QAKPYENISL
    260 270 280 290 300
    CQAKLDIAFG THHTKMMLLL YEEGLRVVIH TSNLIHADWH QKTQGIWLSP
    310 320 330 340 350
    LYPRIADGTH KSGESPTHFK ADLISYLMAY NAPSLKEWID VIHKHDLSET
    360 370 380 390 400
    NVYLIGSTPG RFQGSQKDNW GHFRLKKLLK DHASSMPNAE SWPVVGQFSS
    410 420 430 440 450
    VGSLGADESK WLCSEFKESM LTLGKESKTP GKSSVPLYLI YPSVENVRTS
    460 470 480 490 500
    LEGYPAGGSL PYSIQTAEKQ NWLHSYFHKW SAETSGRSNA MPHIKTYMRP
    510 520 530 540 550
    SPDFSKIAWF LVTSANLSKA AWGALEKNGT QLMIRSYELG VLFLPSAFGL
    560 570 580 590 600
    DSFKVKQKFF AGSQEPMATF PVPYDLPPEL YGSKDRPWIW NIPYVKAPDT

    HGNMWVPS
    Length:608
    Mass (Da):68,420
    Last modified:October 24, 2003 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF30202BD8329E5CE
    GO
    Isoform 2 (identifier: Q9NUW8-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-25: MSQEGDYGRWTISSSDESEEEKPKP → MVISERLRLTSMPRPSLTRTSLSAR
         26-264: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:369
    Mass (Da):41,630
    Checksum:i8674BAEED98FA149
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    G3V2F4G3V2F4_HUMAN
    Tyrosyl-DNA phosphodiesterase 1
    TDP1
    578Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E7EPD8E7EPD8_HUMAN
    Tyrosyl-DNA phosphodiesterase 1
    TDP1
    589Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    G3V2U6G3V2U6_HUMAN
    Tyrosyl-DNA phosphodiesterase 1
    TDP1
    279Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    G3V3Q0G3V3Q0_HUMAN
    Tyrosyl-DNA phosphodiesterase 1
    TDP1
    146Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    G3V554G3V554_HUMAN
    Tyrosyl-DNA phosphodiesterase 1
    TDP1
    161Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    G3V5B8G3V5B8_HUMAN
    Tyrosyl-DNA phosphodiesterase 1
    TDP1
    151Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    G3V5F9G3V5F9_HUMAN
    Tyrosyl-DNA phosphodiesterase 1
    TDP1
    147Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    G3V2J6G3V2J6_HUMAN
    Tyrosyl-DNA phosphodiesterase 1
    TDP1
    219Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    G3V4W8G3V4W8_HUMAN
    Tyrosyl-DNA phosphodiesterase 1
    TDP1
    191Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    G3V5H9G3V5H9_HUMAN
    Tyrosyl-DNA phosphodiesterase 1
    TDP1
    259Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    There are more potential isoformsShow all

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti389A → P in BAA91997 (PubMed:14702039).Curated1
    Sequence conflicti511L → R in AAF65624 (PubMed:10521354).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_02581795E → D1 PublicationCorresponds to variant dbSNP:rs35114462EnsemblClinVar.1
    Natural variantiVAR_025818101P → L1 PublicationCorresponds to variant dbSNP:rs35455108EnsemblClinVar.1
    Natural variantiVAR_025819134A → T1 PublicationCorresponds to variant dbSNP:rs28365054EnsemblClinVar.1
    Natural variantiVAR_025820187D → G1 PublicationCorresponds to variant dbSNP:rs35271143Ensembl.1
    Natural variantiVAR_025821304R → Q1 PublicationCorresponds to variant dbSNP:rs34452707EnsemblClinVar.1
    Natural variantiVAR_017144493H → R in SCAN1; reduces enzyme activity and leads to the accumulation of covalent complexes between TDP1 and DNA. 5 PublicationsCorresponds to variant dbSNP:rs119467003EnsemblClinVar.1
    Natural variantiVAR_017145566P → L in autosomal recessive or sporadic spinocerebellar ataxia affected Japanese individuals. 1 PublicationCorresponds to variant dbSNP:rs767298655Ensembl.1
    Natural variantiVAR_025822569T → A1 PublicationCorresponds to variant dbSNP:rs35973343EnsemblClinVar.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0557651 – 25MSQEG…EKPKP → MVISERLRLTSMPRPSLTRT SLSAR in isoform 2. 1 PublicationAdd BLAST25
    Alternative sequenceiVSP_05576626 – 264Missing in isoform 2. 1 PublicationAdd BLAST239

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    BX161451 mRNA Translation: CAD61915.1
    AK001952 mRNA Translation: BAA91997.1
    DQ367843 Genomic DNA Translation: ABC79301.1
    AL137128 Genomic DNA No translation available.
    BC015474 mRNA Translation: AAH15474.1
    AF182002 mRNA Translation: AAF65623.1
    AF182003 mRNA Translation: AAF65624.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS9888.1 [Q9NUW8-1]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001008744.1, NM_001008744.1 [Q9NUW8-1]
    NP_060789.2, NM_018319.3 [Q9NUW8-1]
    XP_005267904.1, XM_005267847.2
    XP_005267905.1, XM_005267848.2 [Q9NUW8-1]
    XP_006720260.1, XM_006720197.3 [Q9NUW8-1]
    XP_006720261.1, XM_006720198.3
    XP_011535244.1, XM_011536942.2 [Q9NUW8-1]
    XP_011535245.1, XM_011536943.2
    XP_016876928.1, XM_017021439.1 [Q9NUW8-1]
    XP_016876931.1, XM_017021442.1
    XP_016876932.1, XM_017021443.1
    XP_016876933.1, XM_017021444.1

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000335725; ENSP00000337353; ENSG00000042088 [Q9NUW8-1]
    ENST00000393454; ENSP00000377099; ENSG00000042088 [Q9NUW8-1]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    55775

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:55775

    UCSC genome browser

    More...
    UCSCi
    uc001xxy.4 human [Q9NUW8-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    BX161451 mRNA Translation: CAD61915.1
    AK001952 mRNA Translation: BAA91997.1
    DQ367843 Genomic DNA Translation: ABC79301.1
    AL137128 Genomic DNA No translation available.
    BC015474 mRNA Translation: AAH15474.1
    AF182002 mRNA Translation: AAF65623.1
    AF182003 mRNA Translation: AAF65624.1
    CCDSiCCDS9888.1 [Q9NUW8-1]
    RefSeqiNP_001008744.1, NM_001008744.1 [Q9NUW8-1]
    NP_060789.2, NM_018319.3 [Q9NUW8-1]
    XP_005267904.1, XM_005267847.2
    XP_005267905.1, XM_005267848.2 [Q9NUW8-1]
    XP_006720260.1, XM_006720197.3 [Q9NUW8-1]
    XP_006720261.1, XM_006720198.3
    XP_011535244.1, XM_011536942.2 [Q9NUW8-1]
    XP_011535245.1, XM_011536943.2
    XP_016876928.1, XM_017021439.1 [Q9NUW8-1]
    XP_016876931.1, XM_017021442.1
    XP_016876932.1, XM_017021443.1
    XP_016876933.1, XM_017021444.1

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1JY1X-ray1.69A149-608[»]
    1MU7X-ray2.00A/B149-608[»]
    1MU9X-ray2.05A/B149-608[»]
    1NOPX-ray2.30A/B149-608[»]
    1QZQX-ray2.40A/B149-608[»]
    1RFFX-ray1.70A/B149-608[»]
    1RFIX-ray2.20A/B149-608[»]
    1RG1X-ray2.10A/B149-608[»]
    1RG2X-ray2.10A/B149-608[»]
    1RGTX-ray2.00A/B149-608[»]
    1RGUX-ray2.22A/B149-608[»]
    1RH0X-ray2.30A/B149-608[»]
    5NW9X-ray2.04A/B149-608[»]
    5NWAX-ray3.20A/B149-608[»]
    6DHUX-ray1.63A/B148-608[»]
    6DIEX-ray1.78A/B148-608[»]
    6DIHX-ray1.78A/B148-608[»]
    6DIMX-ray1.81A/B148-608[»]
    6DJDX-ray1.78A/B148-608[»]
    6DJEX-ray1.71A/B148-608[»]
    6DJFX-ray1.67A/B148-608[»]
    6DJGX-ray1.88A/B148-608[»]
    6DJHX-ray1.92A/B148-608[»]
    6DJIX-ray1.75A/B148-608[»]
    6DJJX-ray1.74A/B148-608[»]
    6MJ5X-ray1.85A/B149-608[»]
    6N17X-ray1.64A/B148-608[»]
    6N19X-ray1.50A/B148-608[»]
    SMRiQ9NUW8
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGridi120890, 12 interactors
    CORUMiQ9NUW8
    IntActiQ9NUW8, 10 interactors
    MINTiQ9NUW8
    STRINGi9606.ENSP00000337353

    Chemistry databases

    BindingDBiQ9NUW8
    ChEMBLiCHEMBL1075138

    PTM databases

    iPTMnetiQ9NUW8
    PhosphoSitePlusiQ9NUW8

    Polymorphism and mutation databases

    BioMutaiTDP1
    DMDMi37999797

    Proteomic databases

    EPDiQ9NUW8
    jPOSTiQ9NUW8
    MassIVEiQ9NUW8
    MaxQBiQ9NUW8
    PaxDbiQ9NUW8
    PeptideAtlasiQ9NUW8
    PRIDEiQ9NUW8
    ProteomicsDBi69739
    82725 [Q9NUW8-1]

    Genome annotation databases

    EnsembliENST00000335725; ENSP00000337353; ENSG00000042088 [Q9NUW8-1]
    ENST00000393454; ENSP00000377099; ENSG00000042088 [Q9NUW8-1]
    GeneIDi55775
    KEGGihsa:55775
    UCSCiuc001xxy.4 human [Q9NUW8-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    55775
    DisGeNETi55775

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    TDP1
    GeneReviewsiTDP1
    HGNCiHGNC:18884 TDP1
    HPAiHPA071317
    MalaCardsiTDP1
    MIMi607198 gene
    607250 phenotype
    neXtProtiNX_Q9NUW8
    OpenTargetsiENSG00000042088
    Orphaneti94124 Spinocerebellar ataxia with axonal neuropathy type 1
    PharmGKBiPA421

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG2031 Eukaryota
    ENOG410XQPZ LUCA
    GeneTreeiENSGT00390000002211
    HOGENOMiHOG000067775
    InParanoidiQ9NUW8
    KOiK10862
    OMAiNIKKWGH
    OrthoDBi1295967at2759
    PhylomeDBiQ9NUW8
    TreeFamiTF105989

    Enzyme and pathway databases

    ReactomeiR-HSA-5693571 Nonhomologous End-Joining (NHEJ)
    SABIO-RKiQ9NUW8
    SIGNORiQ9NUW8

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    TDP1 human
    EvolutionaryTraceiQ9NUW8

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    TDP1

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    55775
    PharosiQ9NUW8

    Protein Ontology

    More...
    PROi
    PR:Q9NUW8

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000042088 Expressed in 170 organ(s), highest expression level in oocyte
    ExpressionAtlasiQ9NUW8 baseline and differential
    GenevisibleiQ9NUW8 HS

    Family and domain databases

    Gene3Di3.30.870.20, 1 hit
    InterProiView protein in InterPro
    IPR010347 Tdp1
    IPR027415 TDP_C
    PANTHERiPTHR12415 PTHR12415, 1 hit
    PfamiView protein in Pfam
    PF06087 Tyr-DNA_phospho, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTYDP1_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NUW8
    Secondary accession number(s): Q2HXX4
    , Q86TV8, Q96BK7, Q9NZM7, Q9NZM8
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
    Last sequence update: October 24, 2003
    Last modified: November 13, 2019
    This is version 160 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. SIMILARITY comments
      Index of protein domains and families
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
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