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Entry version 164 (03 Jul 2019)
Sequence version 4 (23 Jan 2007)
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Protein

Exocyst complex component 1

Gene

EXOC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
(Microbial infection) Has an antiviral effect against flaviviruses by affecting viral RNA transcription and translation through the sequestration of elongation factor 1-alpha (EEF1A1). This results in decreased viral RNA synthesis and decreased viral protein translation.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiviral defense, Exocytosis, Host-virus interaction, Protein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-264876 Insulin processing
R-HSA-5620916 VxPx cargo-targeting to cilium

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.F.2.1.2 the octameric exocyst (exocyst) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Exocyst complex component 1
Alternative name(s):
Exocyst complex component Sec3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EXOC1
Synonyms:SEC3, SEC3L1
ORF Names:BM-012
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30380 EXOC1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607879 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NV70

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55763

Open Targets

More...
OpenTargetsi
ENSG00000090989

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134891660

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EXOC1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
24418677

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001189132 – 894Exocyst complex component 1Add BLAST893

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei470PhosphoserineCombined sources1
Modified residuei471PhosphothreonineCombined sources1
Modified residuei473PhosphoserineCombined sources1
Modified residuei487PhosphoserineCombined sources1
Modified residuei501PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NV70

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NV70

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NV70

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NV70

PeptideAtlas

More...
PeptideAtlasi
Q9NV70

PRoteomics IDEntifications database

More...
PRIDEi
Q9NV70

ProteomicsDB human proteome resource

More...
ProteomicsDBi
82754
82755 [Q9NV70-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NV70

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NV70

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000090989 Expressed in 222 organ(s), highest expression level in gingival epithelium

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NV70 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NV70 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA037706
HPA044873

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8.

Interacts with EEF1A1 (PubMed:19889084).

1 Publication

(Microbial infection)

Interacts with West Nile virus and Dengue virus capsid protein C; this interaction results in EXOC1 degradation through the proteasome degradation pathway.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120881, 108 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9NV70

Database of interacting proteins

More...
DIPi
DIP-37579N

Protein interaction database and analysis system

More...
IntActi
Q9NV70, 93 interactors

Molecular INTeraction database

More...
MINTi
Q9NV70

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000370695

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NV70

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili152 – 174Sequence analysisAdd BLAST23
Coiled coili205 – 259Sequence analysisAdd BLAST55

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SEC3 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2148 Eukaryota
ENOG410XQEE LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158640

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000247048

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NV70

KEGG Orthology (KO)

More...
KOi
K19983

Identification of Orthologs from Complete Genome Data

More...
OMAi
SFYSLYV

Database of Orthologous Groups

More...
OrthoDBi
201698at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NV70

TreeFam database of animal gene trees

More...
TreeFami
TF314195

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028258 Sec3-PIP2_bind
IPR019160 Sec3_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15277 Sec3-PIP2_bind, 1 hit
PF09763 Sec3_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01313 Sec3-PIP2_bind, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9NV70-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTAIKHALQR DIFTPNDERL LSIVNVCKAG KKKKNCFLCA TVTTERPVQV
60 70 80 90 100
KVVKVKKSDK GDFYKRQIAW ALRDLAVVDA KDAIKENPEF DLHFEKIYKW
110 120 130 140 150
VASSTAEKNA FISCIWKLNQ RYLRKKIDFV NVSSQLLEES VPSGENQSVT
160 170 180 190 200
GGDEEVVDEY QELNAREEQD IEIMMEGCEY AISNAEAFAE KLSRELQVLD
210 220 230 240 250
GANIQSIMAS EKQVNILMKL LDEALKEVDQ IELKLSSYEE MLQSVKEQMD
260 270 280 290 300
QISESNHLIH LSNTNNVKLL SEIEFLVNHM DLAKGHIKAL QEGDLASSRG
310 320 330 340 350
IEACTNAADA LLQCMNVALR PGHDLLLAVK QQQQRFSDLR ELFARRLASH
360 370 380 390 400
LNNVFVQQGH DQSSTLAQHS VELTLPNHHP FHRDLLRYAK LMEWLKSTDY
410 420 430 440 450
GKYEGLTKNY MDYLSRLYER EIKDFFEVAK IKMTGTTKES KKFATLPRKE
460 470 480 490 500
SAVKQETESL HGSSGKLTGS TSSLNKLSVQ SSGNRRSQSS SLLDMGNMSA
510 520 530 540 550
SDLDVADRTK FDKIFEQVLS ELEPLCLAEQ DFISKFFKLQ QHQSMPGTMA
560 570 580 590 600
EAEDLDGGTL SRQHNCGTPL PVSSEKDMIR QMMIKIFRCI EPELNNLIAL
610 620 630 640 650
GDKIDSFNSL YMLVKMSHHV WTAQNVDPAS FLSTTLGNVL VTVKRNFDKC
660 670 680 690 700
ISNQIRQMEE VKISKKSKVG ILPFVAEFEE FAGLAESIFK NAERRGDLDK
710 720 730 740 750
AYTKLIRGVF VNVEKVANES QKTPRDVVMM ENFHHIFATL SRLKISCLEA
760 770 780 790 800
EKKEAKQKYT DHLQSYVIYS LGQPLEKLNH FFEGVEARVA QGIREEEVSY
810 820 830 840 850
QLAFNKQELR KVIKEYPGKE VKKGLDNLYK KVDKHLCEEE NLLQVVWHSM
860 870 880 890
QDEFIRQYKH FEGLIARCYP GSGVTMEFTI QDILDYCSSI AQSH
Length:894
Mass (Da):101,982
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF63C88E3A7F611BD
GO
Isoform 2 (identifier: Q9NV70-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     444-459: ATLPRKESAVKQETES → G

Note: No experimental confirmation available.
Show »
Length:879
Mass (Da):100,283
Checksum:i6EA94986B9AC8AD5
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF64268 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti74D → G in BAB55095 (PubMed:14702039).Curated1
Sequence conflicti275F → L in BAA91886 (PubMed:14702039).Curated1
Sequence conflicti801Q → R in BAA91886 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_001481444 – 459ATLPR…QETES → G in isoform 2. 3 PublicationsAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK001755 mRNA Translation: BAA91886.1
AK027413 mRNA Translation: BAB55095.1
BC020650 mRNA Translation: AAH20650.1
BC094751 mRNA Translation: AAH94751.1
AF208854 mRNA Translation: AAF64268.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3502.1 [Q9NV70-1]
CCDS3503.1 [Q9NV70-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001020095.1, NM_001024924.1 [Q9NV70-1]
NP_060731.2, NM_018261.3 [Q9NV70-1]
NP_839955.1, NM_178237.2 [Q9NV70-2]
XP_016863898.1, XM_017008409.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000346134; ENSP00000326514; ENSG00000090989 [Q9NV70-1]
ENST00000349598; ENSP00000334431; ENSG00000090989 [Q9NV70-2]
ENST00000381295; ENSP00000370695; ENSG00000090989 [Q9NV70-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55763

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55763

UCSC genome browser

More...
UCSCi
uc003hbe.2 human [Q9NV70-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001755 mRNA Translation: BAA91886.1
AK027413 mRNA Translation: BAB55095.1
BC020650 mRNA Translation: AAH20650.1
BC094751 mRNA Translation: AAH94751.1
AF208854 mRNA Translation: AAF64268.1 Different initiation.
CCDSiCCDS3502.1 [Q9NV70-1]
CCDS3503.1 [Q9NV70-2]
RefSeqiNP_001020095.1, NM_001024924.1 [Q9NV70-1]
NP_060731.2, NM_018261.3 [Q9NV70-1]
NP_839955.1, NM_178237.2 [Q9NV70-2]
XP_016863898.1, XM_017008409.1

3D structure databases

SMRiQ9NV70
ModBaseiSearch...

Protein-protein interaction databases

BioGridi120881, 108 interactors
CORUMiQ9NV70
DIPiDIP-37579N
IntActiQ9NV70, 93 interactors
MINTiQ9NV70
STRINGi9606.ENSP00000370695

Protein family/group databases

TCDBi1.F.2.1.2 the octameric exocyst (exocyst) family

PTM databases

iPTMnetiQ9NV70
PhosphoSitePlusiQ9NV70

Polymorphism and mutation databases

BioMutaiEXOC1
DMDMi24418677

Proteomic databases

EPDiQ9NV70
jPOSTiQ9NV70
MaxQBiQ9NV70
PaxDbiQ9NV70
PeptideAtlasiQ9NV70
PRIDEiQ9NV70
ProteomicsDBi82754
82755 [Q9NV70-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
55763
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000346134; ENSP00000326514; ENSG00000090989 [Q9NV70-1]
ENST00000349598; ENSP00000334431; ENSG00000090989 [Q9NV70-2]
ENST00000381295; ENSP00000370695; ENSG00000090989 [Q9NV70-1]
GeneIDi55763
KEGGihsa:55763
UCSCiuc003hbe.2 human [Q9NV70-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55763
DisGeNETi55763

GeneCards: human genes, protein and diseases

More...
GeneCardsi
EXOC1
HGNCiHGNC:30380 EXOC1
HPAiHPA037706
HPA044873
MIMi607879 gene
neXtProtiNX_Q9NV70
OpenTargetsiENSG00000090989
PharmGKBiPA134891660

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2148 Eukaryota
ENOG410XQEE LUCA
GeneTreeiENSGT00940000158640
HOGENOMiHOG000247048
InParanoidiQ9NV70
KOiK19983
OMAiSFYSLYV
OrthoDBi201698at2759
PhylomeDBiQ9NV70
TreeFamiTF314195

Enzyme and pathway databases

ReactomeiR-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-264876 Insulin processing
R-HSA-5620916 VxPx cargo-targeting to cilium

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
EXOC1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55763

Protein Ontology

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PROi
PR:Q9NV70

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000090989 Expressed in 222 organ(s), highest expression level in gingival epithelium
ExpressionAtlasiQ9NV70 baseline and differential
GenevisibleiQ9NV70 HS

Family and domain databases

InterProiView protein in InterPro
IPR028258 Sec3-PIP2_bind
IPR019160 Sec3_C
PfamiView protein in Pfam
PF15277 Sec3-PIP2_bind, 1 hit
PF09763 Sec3_C, 1 hit
SMARTiView protein in SMART
SM01313 Sec3-PIP2_bind, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEXOC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NV70
Secondary accession number(s): Q504V4
, Q8WUE7, Q96T15, Q9NZE4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: January 23, 2007
Last modified: July 3, 2019
This is version 164 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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