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Entry version 102 (18 Sep 2019)
Sequence version 2 (13 Nov 2007)
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Protein

Uncharacterized protein CCDC198

Gene

CCDC198

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein CCDC198Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC198Imported
Synonyms:C14orf105
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20189 CCDC198

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NVL8

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000100557

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134868494

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NVL8

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCDC198

Domain mapping of disease mutations (DMDM)

More...
DMDMi
160332322

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000899131 – 296Uncharacterized protein CCDC198Add BLAST296

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NVL8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NVL8

PeptideAtlas

More...
PeptideAtlasi
Q9NVL8

PRoteomics IDEntifications database

More...
PRIDEi
Q9NVL8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
82824

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NVL8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NVL8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000100557 Expressed in 80 organ(s), highest expression level in kidney

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NVL8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NVL8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA029202

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120492, 22 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NVL8, 19 interactors

Molecular INTeraction database

More...
MINTi
Q9NVL8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IE4S Eukaryota
ENOG410YY0W LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001071

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000024829

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NVL8

Database of Orthologous Groups

More...
OrthoDBi
1196221at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NVL8

TreeFam database of animal gene trees

More...
TreeFami
TF336148

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029235 DUF4619

The PANTHER Classification System

More...
PANTHERi
PTHR16065 PTHR16065, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15398 DUF4619, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q9NVL8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLSHSKTHL RVIKVAPLQN KEVETPSAGR VDFAFNQNLE EKTSYSLARL
60 70 80 90 100
QDQNKALEGQ LPPLQENWYG RYSTASRDMY FDIPLEHRET SIIKRHPPQR
110 120 130 140 150
LQKLEPIDLP RVITSGRLLS QREARTMHKA KQVLEKKMQT PMYTSENRQY
160 170 180 190 200
LHKMQVLEMI RKRQEAQMEL KKSLHGEARI NKQSPRDHKA KKTLQSTPRN
210 220 230 240 250
DDHDLLTMLP DEILNRGPGN SKNTEFLKHQ AVNNYCPWKI GKMETWLHEQ
260 270 280 290
EAQGQLLWDS SSSDSDEQGK DEKKPRALVR TRTERIPLFD EFFDQE
Length:296
Mass (Da):34,690
Last modified:November 13, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6718547F055B1C49
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PSE9E9PSE9_HUMAN
Uncharacterized protein CCDC198
CCDC198
295Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GWJ3F5GWJ3_HUMAN
Uncharacterized protein CCDC198
CCDC198
336Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q05C89Q05C89_HUMAN
C14orf105 protein
CCDC198 C14orf105
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PI50E9PI50_HUMAN
Uncharacterized protein CCDC198
CCDC198
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YES7H0YES7_HUMAN
Uncharacterized protein CCDC198
CCDC198
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti132Missing in AAI17406 (PubMed:15489334).Curated1
Sequence conflicti132Missing in AAI43567 (PubMed:15489334).Curated1
Sequence conflicti132Missing in EAW80707 (Ref. 4) Curated1
Sequence conflicti223N → D in BAA91732 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_024310235Y → C4 PublicationsCorresponds to variant dbSNP:rs1152530Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK001512 mRNA Translation: BAA91732.1
AK223127 mRNA Translation: BAD96847.1
AL161804 Genomic DNA No translation available.
AL355834 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW80707.1
BC117405 mRNA Translation: AAI17406.1
BC143566 mRNA Translation: AAI43567.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9730.1

NCBI Reference Sequences

More...
RefSeqi
NP_001269985.1, NM_001283056.1
NP_001269986.1, NM_001283057.1
NP_001269987.1, NM_001283058.1
NP_001269988.1, NM_001283059.1
NP_060638.2, NM_018168.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000216445; ENSP00000216445; ENSG00000100557

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55195

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55195

UCSC genome browser

More...
UCSCi
uc001xcy.4 human

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001512 mRNA Translation: BAA91732.1
AK223127 mRNA Translation: BAD96847.1
AL161804 Genomic DNA No translation available.
AL355834 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW80707.1
BC117405 mRNA Translation: AAI17406.1
BC143566 mRNA Translation: AAI43567.1
CCDSiCCDS9730.1
RefSeqiNP_001269985.1, NM_001283056.1
NP_001269986.1, NM_001283057.1
NP_001269987.1, NM_001283058.1
NP_001269988.1, NM_001283059.1
NP_060638.2, NM_018168.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi120492, 22 interactors
IntActiQ9NVL8, 19 interactors
MINTiQ9NVL8

PTM databases

iPTMnetiQ9NVL8
PhosphoSitePlusiQ9NVL8

Polymorphism and mutation databases

BioMutaiCCDC198
DMDMi160332322

Proteomic databases

MassIVEiQ9NVL8
PaxDbiQ9NVL8
PeptideAtlasiQ9NVL8
PRIDEiQ9NVL8
ProteomicsDBi82824

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
55195

Genome annotation databases

EnsembliENST00000216445; ENSP00000216445; ENSG00000100557
GeneIDi55195
KEGGihsa:55195
UCSCiuc001xcy.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55195

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCDC198
HGNCiHGNC:20189 CCDC198
HPAiHPA029202
neXtProtiNX_Q9NVL8
OpenTargetsiENSG00000100557
PharmGKBiPA134868494

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IE4S Eukaryota
ENOG410YY0W LUCA
GeneTreeiENSGT00390000001071
HOGENOMiHOG000024829
InParanoidiQ9NVL8
OrthoDBi1196221at2759
PhylomeDBiQ9NVL8
TreeFamiTF336148

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55195
PharosiQ9NVL8

Protein Ontology

More...
PROi
PR:Q9NVL8

Gene expression databases

BgeeiENSG00000100557 Expressed in 80 organ(s), highest expression level in kidney
ExpressionAtlasiQ9NVL8 baseline and differential
GenevisibleiQ9NVL8 HS

Family and domain databases

InterProiView protein in InterPro
IPR029235 DUF4619
PANTHERiPTHR16065 PTHR16065, 1 hit
PfamiView protein in Pfam
PF15398 DUF4619, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCC198_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NVL8
Secondary accession number(s): Q17R99, Q53G04
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: November 13, 2007
Last modified: September 18, 2019
This is version 102 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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