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Entry version 150 (18 Sep 2019)
Sequence version 1 (01 Oct 2000)
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Protein

Intraflagellar transport protein 57 homolog

Gene

IFT57

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processApoptosis, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5610787 Hedgehog 'off' state
R-HSA-5620924 Intraflagellar transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Intraflagellar transport protein 57 homolog
Alternative name(s):
Dermal papilla-derived protein 8
Estrogen-related receptor beta-like protein 1
HIP1-interacting protein
MHS4R2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IFT57
Synonyms:DERP8, ESRRBL1, HIPPI
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17367 IFT57

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606621 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NWB7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Orofaciodigital syndrome 18 (OFD18)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of orofaciodigital syndrome, a group of heterogeneous disorders characterized by malformations of the oral cavity, face and digits, and associated phenotypic abnormalities that lead to the delineation of various subtypes. OFD18 is an autosomal recessive form characterized by short stature, brachymesophalangy, pre- and postaxial polysyndactyly, and stocky femoral necks, as well as oral anomalies and dysmorphic facial features.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi409K → D: Impairs the interaction with HIP1. 1 Publication1

Keywords - Diseasei

Ciliopathy

Organism-specific databases

DisGeNET

More...
DisGeNETi
55081

MalaCards human disease database

More...
MalaCardsi
IFT57
MIMi617927 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000114446

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
508501 Oral-facial-digital syndrome with short stature and brachymesophalangy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27890

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IFT57

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74734638

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003288841 – 429Intraflagellar transport protein 57 homologAdd BLAST429

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NWB7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NWB7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NWB7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NWB7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NWB7

PeptideAtlas

More...
PeptideAtlasi
Q9NWB7

PRoteomics IDEntifications database

More...
PRIDEi
Q9NWB7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
82925

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NWB7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NWB7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Present in many tissues such as brain, thymus, lymph node, lung, liver, skin and kidney (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000114446 Expressed in 220 organ(s), highest expression level in bronchial epithelial cell

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NWB7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NWB7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA035514
HPA035515

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88.

Interacts with IFT20 and IFT88.

Interacts with BLOC1S2 and RYBP.

Interacts with HOMER1, possibly preventing pro-apoptotic effects of IFT57 (By similarity).

Interacts with HIP1. In normal conditions, it poorly interacts with HIP1, HIP1 being strongly associated with HTT. However, in mutant HTT proteins with a long poly-Gln region, interaction between HTT and HIP1 is inhibited, promoting the interaction between HIP1 and IFT57, leading to apoptosis.

Interacts with BFAR.

Interacts with chicken anemia virus protein apoptin.

Interacts with TTC25 (PubMed:25860617).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120396, 65 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9NWB7

Protein interaction database and analysis system

More...
IntActi
Q9NWB7, 60 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000264538

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NWB7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni335 – 426pDEDAdd BLAST92

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili304 – 369Sequence analysisAdd BLAST66

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The pseudo DED region (pDED) meadiates the interaction with HIP1.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IFT57 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0972 Eukaryota
ENOG410XT77 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006307

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007186

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NWB7

KEGG Orthology (KO)

More...
KOi
K04638

Identification of Orthologs from Complete Genome Data

More...
OMAi
VHAHDQD

Database of Orthologous Groups

More...
OrthoDBi
839892at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NWB7

TreeFam database of animal gene trees

More...
TreeFami
TF106156

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019530 Intra-flagellar_transport_57

The PANTHER Classification System

More...
PANTHERi
PTHR16011 PTHR16011, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10498 IFT57, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9NWB7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTAALAVVTT SGLEDGVPRS RGEGTGEVVL ERGPGAAYHM FVVMEDLVEK
60 70 80 90 100
LKLLRYEEEF LRKSNLKAPS RHYFALPTNP GEQFYMFCTL AAWLINKAGR
110 120 130 140 150
PFEQPQEYDD PNATISNILS ELRSFGRTAD FPPSKLKSGY GEHVCYVLDC
160 170 180 190 200
FAEEALKYIG FTWKRPIYPV EELEEESVAE DDAELTLNKV DEEFVEEETD
210 220 230 240 250
NEENFIDLNV LKAQTYHLDM NETAKQEDIL ESTTDAAEWS LEVERVLPQL
260 270 280 290 300
KVTIRTDNKD WRIHVDQMHQ HRSGIESALK ETKGFLDKLH NEITRTLEKI
310 320 330 340 350
SSREKYINNQ LENLVQEYRA AQAQLSEAKE RYQQGNGGVT ERTRLLSEVM
360 370 380 390 400
EELEKVKQEM EEKGSSMTDG APLVKIKQSL TKLKQETVEM DIRIGIVEHT
410 420
LLQSKLKEKS NMTRNMHATV IPEPATGFY
Length:429
Mass (Da):49,108
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD80200D957AE5AC4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JB84C9JB84_HUMAN
Intraflagellar transport protein 57...
IFT57
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WBM2F8WBM2_HUMAN
Intraflagellar transport protein 57...
IFT57
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti293I → V in AAH09690 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF245220 mRNA Translation: AAK28373.1
AF139576 mRNA Translation: AAK13588.1
AB014762 mRNA Translation: BAB87803.1
AK001009 mRNA Translation: BAA91466.1
CR457251 mRNA Translation: CAG33532.1
CH471052 Genomic DNA Translation: EAW79730.1
BC009690 mRNA Translation: AAH09690.2
BC011899 mRNA Translation: AAH11899.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2951.1

NCBI Reference Sequences

More...
RefSeqi
NP_060480.1, NM_018010.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000264538; ENSP00000264538; ENSG00000114446

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55081

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55081

UCSC genome browser

More...
UCSCi
uc003dwx.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF245220 mRNA Translation: AAK28373.1
AF139576 mRNA Translation: AAK13588.1
AB014762 mRNA Translation: BAB87803.1
AK001009 mRNA Translation: BAA91466.1
CR457251 mRNA Translation: CAG33532.1
CH471052 Genomic DNA Translation: EAW79730.1
BC009690 mRNA Translation: AAH09690.2
BC011899 mRNA Translation: AAH11899.1
CCDSiCCDS2951.1
RefSeqiNP_060480.1, NM_018010.3

3D structure databases

SMRiQ9NWB7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi120396, 65 interactors
CORUMiQ9NWB7
IntActiQ9NWB7, 60 interactors
STRINGi9606.ENSP00000264538

PTM databases

iPTMnetiQ9NWB7
PhosphoSitePlusiQ9NWB7

Polymorphism and mutation databases

BioMutaiIFT57
DMDMi74734638

Proteomic databases

EPDiQ9NWB7
jPOSTiQ9NWB7
MassIVEiQ9NWB7
MaxQBiQ9NWB7
PaxDbiQ9NWB7
PeptideAtlasiQ9NWB7
PRIDEiQ9NWB7
ProteomicsDBi82925

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
55081
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264538; ENSP00000264538; ENSG00000114446
GeneIDi55081
KEGGihsa:55081
UCSCiuc003dwx.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55081
DisGeNETi55081

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IFT57
HGNCiHGNC:17367 IFT57
HPAiHPA035514
HPA035515
MalaCardsiIFT57
MIMi606621 gene
617927 phenotype
neXtProtiNX_Q9NWB7
OpenTargetsiENSG00000114446
Orphaneti508501 Oral-facial-digital syndrome with short stature and brachymesophalangy
PharmGKBiPA27890

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0972 Eukaryota
ENOG410XT77 LUCA
GeneTreeiENSGT00390000006307
HOGENOMiHOG000007186
InParanoidiQ9NWB7
KOiK04638
OMAiVHAHDQD
OrthoDBi839892at2759
PhylomeDBiQ9NWB7
TreeFamiTF106156

Enzyme and pathway databases

ReactomeiR-HSA-5610787 Hedgehog 'off' state
R-HSA-5620924 Intraflagellar transport

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
IFT57 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
IFT57

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55081

Pharos

More...
Pharosi
Q9NWB7

Protein Ontology

More...
PROi
PR:Q9NWB7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000114446 Expressed in 220 organ(s), highest expression level in bronchial epithelial cell
ExpressionAtlasiQ9NWB7 baseline and differential
GenevisibleiQ9NWB7 HS

Family and domain databases

InterProiView protein in InterPro
IPR019530 Intra-flagellar_transport_57
PANTHERiPTHR16011 PTHR16011, 1 hit
PfamiView protein in Pfam
PF10498 IFT57, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIFT57_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NWB7
Secondary accession number(s): Q96DA9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: October 1, 2000
Last modified: September 18, 2019
This is version 150 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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