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Entry version 141 (03 Jul 2019)
Sequence version 2 (20 Dec 2005)
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Protein

Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

Gene

PAG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-180292 GAB1 signalosome
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9NWQ8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1
Alternative name(s):
Csk-binding protein
Transmembrane adapter protein PAG
Transmembrane phosphoprotein Cbp
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PAG1
Synonyms:CBP, PAG
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30043 PAG1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605767 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NWQ8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 16ExtracellularSequence analysisAdd BLAST16
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei17 – 37Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST21
Topological domaini38 – 432CytoplasmicSequence analysisAdd BLAST395

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi105Y → F: No effect on interaction with FYN or CSK. 1 Publication1
Mutagenesisi163Y → F: No effect on interaction with FYN or CSK. 1 Publication1
Mutagenesisi181Y → F: No effect on interaction with FYN or CSK. 1 Publication1
Mutagenesisi227Y → F: No effect on interaction with FYN or CSK. 1 Publication1
Mutagenesisi299Y → F: No effect on interaction with FYN or CSK. 1 Publication1
Mutagenesisi317Y → F: No effect on interaction with FYN. Abolishes interaction with CSK. 1 Publication1
Mutagenesisi341Y → F: No effect on interaction with FYN or CSK. 1 Publication1
Mutagenesisi359Y → F: No effect on interaction with FYN or CSK. 1 Publication1
Mutagenesisi387Y → F: No effect on interaction with FYN or CSK. 1 Publication1
Mutagenesisi417Y → F: No effect on interaction with FYN or CSK. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
55824

Open Targets

More...
OpenTargetsi
ENSG00000076641

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671201

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PAG1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
84029384

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000833381 – 432Phosphoprotein associated with glycosphingolipid-enriched microdomains 1Add BLAST432

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi37S-palmitoyl cysteine1 Publication1
Lipidationi40S-palmitoyl cysteine1 Publication1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei50PhosphoserineBy similarity1
Modified residuei61PhosphoserineBy similarity1
Modified residuei105Phosphotyrosine; by LYNBy similarity1
Modified residuei163PhosphotyrosineBy similarity1
Modified residuei181PhosphotyrosineBy similarity1
Modified residuei227PhosphotyrosineCombined sources1
Modified residuei229PhosphoserineCombined sources1
Modified residuei317Phosphotyrosine; by FYN and LYNCombined sources2 Publications1
Modified residuei354PhosphoserineBy similarity1
Modified residuei359PhosphotyrosineCombined sources1
Modified residuei380PhosphoserineBy similarity1
Modified residuei387PhosphotyrosineCombined sources1
Modified residuei417PhosphotyrosineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Palmitoylated.1 Publication
Phosphorylated by FYN on Tyr-317 in resting T-cells; which promotes interaction with CSK. Dephosphorylated by PTPRC/CD45 upon TCR activation; which leads to CSK dissociation. May also be dephosphorylated by PTPN11. Hyperphosphorylated in mast cells upon FCER1 activation. Phosphorylated by LYN.2 Publications

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NWQ8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NWQ8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NWQ8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NWQ8

PeptideAtlas

More...
PeptideAtlasi
Q9NWQ8

PRoteomics IDEntifications database

More...
PRIDEi
Q9NWQ8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
82961

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q9NWQ8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NWQ8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NWQ8

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9NWQ8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed. Present in germinal center B-cells, plasma cells, T-cells, monocytes and platelets (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000076641 Expressed in 204 organ(s), highest expression level in secondary oocyte

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NWQ8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA001632
HPA066527

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FYN. When phosphorylated, interacts with CSK.

Interacts with SLC9A3R1/EBP50. In resting T-cells, part of a PAG1-SLC9A3R1-MSN complex which is disrupted upon TCR activation.

Interacts with LYN on plasma membrane lipid rafts.

Identified in a complex with LYN and STAT3.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120931, 42 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9NWQ8

Protein interaction database and analysis system

More...
IntActi
Q9NWQ8, 11 interactors

Molecular INTeraction database

More...
MINTi
Q9NWQ8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000220597

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NWQ8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni317 – 320Interaction with CSK1 Publication4
Regioni430 – 432Interaction with SLC9A3R11 Publication3

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFZ3 Eukaryota
ENOG4111TW0 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000002061

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000290651

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NWQ8

Identification of Orthologs from Complete Genome Data

More...
OMAi
PKCHQSR

Database of Orthologous Groups

More...
OrthoDBi
1104680at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NWQ8

TreeFam database of animal gene trees

More...
TreeFami
TF336170

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032748 PAG

The PANTHER Classification System

More...
PANTHERi
PTHR16322 PTHR16322, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15347 PAG, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9NWQ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGPAGSLLGS GQMQITLWGS LAAVAIFFVI TFLIFLCSSC DREKKPRQHS
60 70 80 90 100
GDHENLMNVP SDKEMFSRSV TSLATDAPAS SEQNGALTNG DILSEDSTLT
110 120 130 140 150
CMQHYEEVQT SASDLLDSQD STGKPKCHQS RELPRIPPES AVDTMLTARS
160 170 180 190 200
VDGDQGLGME GPYEVLKDSS SQENMVEDCL YETVKEIKEV AAAAHLEKGH
210 220 230 240 250
SGKAKSTSAS KELPGPQTEG KAEFAEYASV DRNKKCRQSV NVESILGNSC
260 270 280 290 300
DPEEEAPPPV PVKLLDENEN LQEKEGGEAE ESATDTTSET NKRFSSLSYK
310 320 330 340 350
SREEDPTLTE EEISAMYSSV NKPGQLVNKS GQSLTVPEST YTSIQGDPQR
360 370 380 390 400
SPSSCNDLYA TVKDFEKTPN STLPPAGRPS EEPEPDYEAI QTLNREEEKA
410 420 430
TLGTNGHHGL VPKENDYESI SDLQQGRDIT RL
Length:432
Mass (Da):46,981
Last modified:December 20, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE86272A0B7E3328C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti4A → V in AAH90931 (PubMed:15489334).Curated1
Sequence conflicti36L → P in BAA91321 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF240634 mRNA Translation: AAF67343.1
AK000680 mRNA Translation: BAA91321.1
AK289818 mRNA Translation: BAF82507.1
CH471068 Genomic DNA Translation: EAW87086.1
BC090931 mRNA Translation: AAH90931.1
BC112159 mRNA Translation: AAI12160.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6227.1

NCBI Reference Sequences

More...
RefSeqi
NP_060910.3, NM_018440.3
XP_016869129.1, XM_017013640.1
XP_016869130.1, XM_017013641.1
XP_016869131.1, XM_017013642.1
XP_016869132.1, XM_017013643.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000220597; ENSP00000220597; ENSG00000076641

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55824

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55824

UCSC genome browser

More...
UCSCi
uc003ybz.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF240634 mRNA Translation: AAF67343.1
AK000680 mRNA Translation: BAA91321.1
AK289818 mRNA Translation: BAF82507.1
CH471068 Genomic DNA Translation: EAW87086.1
BC090931 mRNA Translation: AAH90931.1
BC112159 mRNA Translation: AAI12160.1
CCDSiCCDS6227.1
RefSeqiNP_060910.3, NM_018440.3
XP_016869129.1, XM_017013640.1
XP_016869130.1, XM_017013641.1
XP_016869131.1, XM_017013642.1
XP_016869132.1, XM_017013643.1

3D structure databases

SMRiQ9NWQ8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi120931, 42 interactors
CORUMiQ9NWQ8
IntActiQ9NWQ8, 11 interactors
MINTiQ9NWQ8
STRINGi9606.ENSP00000220597

PTM databases

iPTMnetiQ9NWQ8
PhosphoSitePlusiQ9NWQ8
SwissPalmiQ9NWQ8

Polymorphism and mutation databases

BioMutaiPAG1
DMDMi84029384

Proteomic databases

EPDiQ9NWQ8
jPOSTiQ9NWQ8
MaxQBiQ9NWQ8
PaxDbiQ9NWQ8
PeptideAtlasiQ9NWQ8
PRIDEiQ9NWQ8
ProteomicsDBi82961
TopDownProteomicsiQ9NWQ8

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
55824
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000220597; ENSP00000220597; ENSG00000076641
GeneIDi55824
KEGGihsa:55824
UCSCiuc003ybz.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55824
DisGeNETi55824

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PAG1
HGNCiHGNC:30043 PAG1
HPAiHPA001632
HPA066527
MIMi605767 gene
neXtProtiNX_Q9NWQ8
OpenTargetsiENSG00000076641
PharmGKBiPA142671201

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFZ3 Eukaryota
ENOG4111TW0 LUCA
GeneTreeiENSGT00390000002061
HOGENOMiHOG000290651
InParanoidiQ9NWQ8
OMAiPKCHQSR
OrthoDBi1104680at2759
PhylomeDBiQ9NWQ8
TreeFamiTF336170

Enzyme and pathway databases

ReactomeiR-HSA-180292 GAB1 signalosome
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains
SignaLinkiQ9NWQ8

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PAG1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PAG1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55824

Protein Ontology

More...
PROi
PR:Q9NWQ8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
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Gene expression databases

BgeeiENSG00000076641 Expressed in 204 organ(s), highest expression level in secondary oocyte
GenevisibleiQ9NWQ8 HS

Family and domain databases

InterProiView protein in InterPro
IPR032748 PAG
PANTHERiPTHR16322 PTHR16322, 1 hit
PfamiView protein in Pfam
PF15347 PAG, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPHAG1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NWQ8
Secondary accession number(s): A8K1A3
, Q2M1Z9, Q5BKU4, Q9NYK0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: July 3, 2019
This is version 141 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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