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Entry version 172 (16 Oct 2019)
Sequence version 3 (18 May 2010)
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Protein

Stabilin-1

Gene

STAB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processInflammatory response

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3000497 Scavenging by Class H Receptors

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Stabilin-1
Alternative name(s):
Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 1
Short name:
FEEL-1
MS-1 antigen
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STAB1
Synonyms:FEEL1, KIAA0246
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18628 STAB1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608560 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NY15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 2478ExtracellularSequence analysisAdd BLAST2453
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2479 – 2499HelicalSequence analysisAdd BLAST21
Topological domaini2500 – 2570CytoplasmicSequence analysisAdd BLAST71

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23166

Open Targets

More...
OpenTargetsi
ENSG00000010327

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38610

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NY15

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
STAB1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452949

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000771026 – 2570Stabilin-1Add BLAST2545

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi112 ↔ 126By similarity
Disulfide bondi120 ↔ 136By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi133N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi138 ↔ 147By similarity
Disulfide bondi160 ↔ 171By similarity
Disulfide bondi164 ↔ 181By similarity
Disulfide bondi183 ↔ 192By similarity
Disulfide bondi199 ↔ 210By similarity
Disulfide bondi204 ↔ 217By similarity
Disulfide bondi236 ↔ 247By similarity
Disulfide bondi241 ↔ 257By similarity
Disulfide bondi259 ↔ 270By similarity
Glycosylationi286N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi312N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi413N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi606N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi673N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi712N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi732 ↔ 746By similarity
Disulfide bondi740 ↔ 756By similarity
Glycosylationi745N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi758 ↔ 767By similarity
Glycosylationi816N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi822 ↔ 837By similarity
Disulfide bondi831 ↔ 846By similarity
Disulfide bondi865 ↔ 879By similarity
Disulfide bondi873 ↔ 889By similarity
Disulfide bondi891 ↔ 902By similarity
Disulfide bondi908 ↔ 922By similarity
Disulfide bondi916 ↔ 932By similarity
Disulfide bondi934 ↔ 945By similarity
Disulfide bondi951 ↔ 964By similarity
Disulfide bondi958 ↔ 974By similarity
Glycosylationi1087N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1096N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1170N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1178N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1222N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1274N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1332 ↔ 1346By similarity
Disulfide bondi1340 ↔ 1356By similarity
Disulfide bondi1358 ↔ 1367By similarity
Glycosylationi1378N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1379 ↔ 1390By similarity
Disulfide bondi1383 ↔ 1400By similarity
Disulfide bondi1402 ↔ 1411By similarity
Disulfide bondi1420 ↔ 1430By similarity
Disulfide bondi1424 ↔ 1440By similarity
Disulfide bondi1442 ↔ 1453By similarity
Disulfide bondi1459 ↔ 1472By similarity
Disulfide bondi1466 ↔ 1482By similarity
Glycosylationi1471N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1484 ↔ 1495By similarity
Disulfide bondi1501 ↔ 1514By similarity
Disulfide bondi1508 ↔ 1524By similarity
Disulfide bondi1526 ↔ 1538By similarity
Disulfide bondi1544 ↔ 1557By similarity
Disulfide bondi1551 ↔ 1567By similarity
Disulfide bondi1569 ↔ 1581By similarity
Glycosylationi1626N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1727N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi1971 ↔ 1985By similarity
Disulfide bondi1979 ↔ 1995By similarity
Disulfide bondi1997 ↔ 2006By similarity
Disulfide bondi2018 ↔ 2029By similarity
Disulfide bondi2023 ↔ 2039By similarity
Disulfide bondi2041 ↔ 2050By similarity
Disulfide bondi2060 ↔ 2070By similarity
Disulfide bondi2064 ↔ 2076By similarity
Disulfide bondi2078 ↔ 2089By similarity
Disulfide bondi2095 ↔ 2108By similarity
Disulfide bondi2102 ↔ 2117By similarity
Glycosylationi2107N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2119 ↔ 2130By similarity
Disulfide bondi2136 ↔ 2150By similarity
Disulfide bondi2144 ↔ 2160By similarity
Disulfide bondi2162 ↔ 2173By similarity
Glycosylationi2222N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2230 ↔ 2299By similarity
Disulfide bondi2254 ↔ 2275By similarity
Glycosylationi2261N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2290N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2334N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2347N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi2379N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2393N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2400N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2424N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NY15

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NY15

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NY15

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NY15

PeptideAtlas

More...
PeptideAtlasi
Q9NY15

PRoteomics IDEntifications database

More...
PRIDEi
Q9NY15

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
83149 [Q9NY15-1]
83150 [Q9NY15-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
681

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NY15

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NY15

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
Q9NY15

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

High levels found in spleen, lymph node, liver and placenta. Also expressed in endothelial cells.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000010327 Expressed in 194 organ(s), highest expression level in spleen

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NY15 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NY15 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA005434

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CHID1.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116778, 6 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q9NY15

Protein interaction database and analysis system

More...
IntActi
Q9NY15, 72 interactors

Molecular INTeraction database

More...
MINTi
Q9NY15

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000312946

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NY15

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini110 – 148EGF-like 1PROSITE-ProRule annotationCuratedAdd BLAST39
Domaini156 – 193EGF-like 2PROSITE-ProRule annotationCuratedAdd BLAST38
Domaini195 – 229EGF-like 3PROSITE-ProRule annotationCuratedAdd BLAST35
Domaini232 – 271EGF-like 4PROSITE-ProRule annotationCuratedAdd BLAST40
Domaini356 – 494FAS1 1PROSITE-ProRule annotationCuratedAdd BLAST139
Domaini506 – 641FAS1 2PROSITE-ProRule annotationCuratedAdd BLAST136
Domaini728 – 768EGF-like 5PROSITE-ProRule annotationCuratedAdd BLAST41
Domaini818 – 858EGF-like 6PROSITE-ProRule annotationCuratedAdd BLAST41
Domaini861 – 903EGF-like 7PROSITE-ProRule annotationCuratedAdd BLAST43
Domaini904 – 946EGF-like 8PROSITE-ProRule annotationCuratedAdd BLAST43
Domaini947 – 986EGF-like 9PROSITE-ProRule annotationCuratedAdd BLAST40
Domaini988 – 1118FAS1 3PROSITE-ProRule annotationCuratedAdd BLAST131
Domaini1128 – 1253FAS1 4PROSITE-ProRule annotationCuratedAdd BLAST126
Domaini1327 – 1392Laminin EGF-like 1CuratedAdd BLAST66
Domaini1416 – 1454EGF-like 10PROSITE-ProRule annotationCuratedAdd BLAST39
Domaini1455 – 1496EGF-like 11PROSITE-ProRule annotationCuratedAdd BLAST42
Domaini1497 – 1539EGF-like 12PROSITE-ProRule annotationCuratedAdd BLAST43
Domaini1540 – 1582EGF-like 13PROSITE-ProRule annotationCuratedAdd BLAST43
Domaini1582 – 1708FAS1 5PROSITE-ProRule annotationCuratedAdd BLAST127
Domaini1724 – 1864FAS1 6PROSITE-ProRule annotationCuratedAdd BLAST141
Domaini1966 – 2031Laminin EGF-like 2CuratedAdd BLAST66
Domaini2056 – 2090EGF-like 14PROSITE-ProRule annotationCuratedAdd BLAST35
Domaini2091 – 2131EGF-like 15PROSITE-ProRule annotationCuratedAdd BLAST41
Domaini2132 – 2174EGF-like 16PROSITE-ProRule annotationCuratedAdd BLAST43
Domaini2206 – 2301LinkPROSITE-ProRule annotationCuratedAdd BLAST96
Domaini2322 – 2459FAS1 7PROSITE-ProRule annotationCuratedAdd BLAST138

Keywords - Domaini

EGF-like domain, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IRWH Eukaryota
COG2335 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157928

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000154436

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NY15

KEGG Orthology (KO)

More...
KOi
K19020

Identification of Orthologs from Complete Genome Data

More...
OMAi
VCLEIDG

Database of Orthologous Groups

More...
OrthoDBi
6428at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NY15

TreeFam database of animal gene trees

More...
TreeFami
TF331489

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.180.10, 6 hits
3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR024731 EGF_dom
IPR036378 FAS1_dom_sf
IPR000782 FAS1_domain
IPR002049 Laminin_EGF
IPR000538 Link_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12947 EGF_3, 4 hits
PF02469 Fasciclin, 6 hits
PF00193 Xlink, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 23 hits
SM00179 EGF_CA, 6 hits
SM00180 EGF_Lam, 4 hits
SM00554 FAS1, 7 hits
SM00445 LINK, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56436 SSF56436, 1 hit
SSF82153 SSF82153, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 7 hits
PS01186 EGF_2, 16 hits
PS50026 EGF_3, 20 hits
PS01248 EGF_LAM_1, 2 hits
PS50213 FAS1, 7 hits
PS01241 LINK_1, 1 hit
PS50963 LINK_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q9NY15-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGPRGLLPL CLLAFCLAGF SFVRGQVLFK GCDVKTTFVT HVPCTSCAAI
60 70 80 90 100
KKQTCPSGWL RELPDQITQD CRYEVQLGGS MVSMSGCRRK CRKQVVQKAC
110 120 130 140 150
CPGYWGSRCH ECPGGAETPC NGHGTCLDGM DRNGTCVCQE NFRGSACQEC
160 170 180 190 200
QDPNRFGPDC QSVCSCVHGV CNHGPRGDGS CLCFAGYTGP HCDQELPVCQ
210 220 230 240 250
ELRCPQNTQC SAEAPSCRCL PGYTQQGSEC RAPNPCWPSP CSLLAQCSVS
260 270 280 290 300
PKGQAQCHCP ENYHGDGMVC LPKDPCTDNL GGCPSNSTLC VYQKPGQAFC
310 320 330 340 350
TCRPGLVSIN SNASAGCFAF CSPFSCDRSA TCQVTADGKT SCVCRESEVG
360 370 380 390 400
DGRACYGHLL HEVQKATQTG RVFLQLRVAV AMMDQGCREI LTTAGPFTVL
410 420 430 440 450
VPSVSSFSSR TMNASLAQQL CRQHIIAGQH ILEDTRTQQT RRWWTLAGQE
460 470 480 490 500
ITVTFNQFTK YSYKYKDQPQ QTFNIYKANN IAANGVFHVV TGLRWQAPSG
510 520 530 540 550
TPGDPKRTIG QILASTEAFS RFETILENCG LPSILDGPGP FTVFAPSNEA
560 570 580 590 600
VDSLRDGRLI YLFTAGLSKL QELVRYHIYN HGQLTVEKLI SKGRILTMAN
610 620 630 640 650
QVLAVNISEE GRILLGPEGV PLQRVDVMAA NGVIHMLDGI LLPPTILPIL
660 670 680 690 700
PKHCSEEQHK IVAGSCVDCQ ALNTSTCPPN SVKLDIFPKE CVYIHDPTGL
710 720 730 740 750
NVLKKGCASY CNQTIMEQGC CKGFFGPDCT QCPGGFSNPC YGKGNCSDGI
760 770 780 790 800
QGNGACLCFP DYKGIACHIC SNPNKHGEQC QEDCGCVHGL CDNRPGSGGV
810 820 830 840 850
CQQGTCAPGF SGRFCNESMG DCGPTGLAQH CHLHARCVSQ EGVARCRCLD
860 870 880 890 900
GFEGDGFSCT PSNPCSHPDR GGCSENAECV PGSLGTHHCT CHKGWSGDGR
910 920 930 940 950
VCVAIDECEL DMRGGCHTDA LCSYVGPGQS RCTCKLGFAG DGYQCSPIDP
960 970 980 990 1000
CRAGNGGCHG LATCRAVGGG QRVCTCPPGF GGDGFSCYGD IFRELEANAH
1010 1020 1030 1040 1050
FSIFYQWLKS AGITLPADRR VTALVPSEAA VRQLSPEDRA FWLQPRTLPN
1060 1070 1080 1090 1100
LVRAHFLQGA LFEEELARLG GQEVATLNPT TRWEIRNISG RVWVQNASVD
1110 1120 1130 1140 1150
VADLLATNGV LHILSQVLLP PRGDVPGGQG LLQQLDLVPA FSLFRELLQH
1160 1170 1180 1190 1200
HGLVPQIEAA TAYTIFVPTN RSLEAQGNSS HLDADTVRHH VVLGEALSME
1210 1220 1230 1240 1250
TLRKGGHRNS LLGPAHWIVF YNHSGQPEVN HVPLEGPMLE APGRSLIGLS
1260 1270 1280 1290 1300
GVLTVGSSRC LHSHAEALRE KCVNCTRRFR CTQGFQLQDT PRKSCVYRSG
1310 1320 1330 1340 1350
FSFSRGCSYT CAKKIQVPDC CPGFFGTLCE PCPGGLGGVC SGHGQCQDRF
1360 1370 1380 1390 1400
LGSGECHCHE GFHGTACEVC ELGRYGPNCT GVCDCAHGLC QEGLQGDGSC
1410 1420 1430 1440 1450
VCNVGWQGLR CDQKITSPQC PRKCDPNANC VQDSAGASTC ACAAGYSGNG
1460 1470 1480 1490 1500
IFCSEVDPCA HGHGGCSPHA NCTKVAPGQR TCTCQDGYMG DGELCQEINS
1510 1520 1530 1540 1550
CLIHHGGCHI HAECIPTGPQ QVSCSCREGY SGDGIRTCEL LDPCSKNNGG
1560 1570 1580 1590 1600
CSPYATCKST GDGQRTCTCD TAHTVGDGLT CRARVGLELL RDKHASFFSL
1610 1620 1630 1640 1650
RLLEYKELKG DGPFTIFVPH ADLMSNLSQD ELARIRAHRQ LVFRYHVVGC
1660 1670 1680 1690 1700
RRLRSEDLLE QGYATALSGH PLRFSEREGS IYLNDFARVV SSDHEAVNGI
1710 1720 1730 1740 1750
LHFIDRVLLP PEALHWEPDD APIPRRNVTA AAQGFGYKIF SGLLKVAGLL
1760 1770 1780 1790 1800
PLLREASHRP FTMLWPTDAA FRALPPDRQA WLYHEDHRDK LAAILRGHMI
1810 1820 1830 1840 1850
RNVEALASDL PNLGPLRTMH GTPISFSCSR TRAGELMVGE DDARIVQRHL
1860 1870 1880 1890 1900
PFEGGLAYGI DQLLEPPGLG ARCDHFETRP LRLNTCSICG LEPPCPEGSQ
1910 1920 1930 1940 1950
EQGSPEACWR FYPKFWTSPP LHSLGLRSVW VHPSLWGRPQ GLGRGCHRNC
1960 1970 1980 1990 2000
VTTTWKPSCC PGHYGSECQA CPGGPSSPCS DRGVCMDGMS GSGQCLCRSG
2010 2020 2030 2040 2050
FAGTACELCA PGAFGPHCQA CRCTVHGRCD EGLGGSGSCF CDEGWTGPRC
2060 2070 2080 2090 2100
EVQLELQPVC TPPCAPEAVC RAGNSCECSL GYEGDGRVCT VADLCQDGHG
2110 2120 2130 2140 2150
GCSEHANCSQ VGTMVTCTCL PDYEGDGWSC RARNPCTDGH RGGCSEHANC
2160 2170 2180 2190 2200
LSTGLNTRRC ECHAGYVGDG LQCLEESEPP VDRCLGQPPP CHSDAMCTDL
2210 2220 2230 2240 2250
HFQEKRAGVF HLQATSGPYG LNFSEAEAAC EAQGAVLASF PQLSAAQQLG
2260 2270 2280 2290 2300
FHLCLMGWLA NGSTAHPVVF PVADCGNGRV GIVSLGARKN LSERWDAYCF
2310 2320 2330 2340 2350
RVQDVACRCR NGFVGDGIST CNGKLLDVLA ATANFSTFYG MLLGYANATQ
2360 2370 2380 2390 2400
RGLDFLDFLD DELTYKTLFV PVNEGFVDNM TLSGPDLELH ASNATLLSAN
2410 2420 2430 2440 2450
ASQGKLLPAH SGLSLIISDA GPDNSSWAPV APGTVVVSRI IVWDIMAFNG
2460 2470 2480 2490 2500
IIHALASPLL APPQPQAVLA PEAPPVAAGV GAVLAAGALL GLVAGALYLR
2510 2520 2530 2540 2550
ARGKPMGFGF SAFQAEDDAD DDFSPWQEGT NPTLVSVPNP VFGSDTFCEP
2560 2570
FDDSLLEEDF PDTQRILTVK
Length:2,570
Mass (Da):275,482
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFA55D191D9D30FAD
GO
Isoform 21 Publication (identifier: Q9NY15-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     746-803: CSDGIQGNGA...RPGSGGVCQQ → VSPILSWGEV...IISHILIKNN
     804-2570: Missing.

Show »
Length:803
Mass (Da):87,026
Checksum:i1A833922D0F223FB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C4W7H7C4W7_HUMAN
Stabilin-1
STAB1
177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA13377 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti913R → G in CAB61827 (PubMed:11829752).Curated1
Sequence conflicti2200L → Q in CAB61827 (PubMed:11829752).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_060338672L → M. Corresponds to variant dbSNP:rs12636502Ensembl.1
Natural variantiVAR_060339912M → V4 PublicationsCorresponds to variant dbSNP:rs9835659Ensembl.1
Natural variantiVAR_0557741127G → R. Corresponds to variant dbSNP:rs2286786Ensembl.1
Natural variantiVAR_0603401833A → P3 PublicationsCorresponds to variant dbSNP:rs7630214Ensembl.1
Natural variantiVAR_0557752282I → V1 PublicationCorresponds to variant dbSNP:rs4434138Ensembl.1
Natural variantiVAR_0190782506M → T. Corresponds to variant dbSNP:rs13303Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_050764746 – 803CSDGI…GVCQQ → VSPILSWGEVWGTQGLLHRL ASDWLCVWAKPATLALGFSY LCSGKLDQIISHILIKNN in isoform 2. 1 PublicationAdd BLAST58
Alternative sequenceiVSP_050765804 – 2570Missing in isoform 2. 1 PublicationAdd BLAST1767

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ275213 mRNA Translation: CAB61827.1
AB052956 mRNA Translation: BAC15606.1
AB052957 mRNA Translation: BAC15607.1
D87433 mRNA Translation: BAA13377.2 Different initiation.
AC006208 Genomic DNA No translation available.
AC112215 Genomic DNA No translation available.
BC150250 mRNA Translation: AAI50251.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33768.1 [Q9NY15-1]

NCBI Reference Sequences

More...
RefSeqi
NP_055951.2, NM_015136.2 [Q9NY15-1]

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23166

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23166

UCSC genome browser

More...
UCSCi
uc003dej.4 human [Q9NY15-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ275213 mRNA Translation: CAB61827.1
AB052956 mRNA Translation: BAC15606.1
AB052957 mRNA Translation: BAC15607.1
D87433 mRNA Translation: BAA13377.2 Different initiation.
AC006208 Genomic DNA No translation available.
AC112215 Genomic DNA No translation available.
BC150250 mRNA Translation: AAI50251.1
CCDSiCCDS33768.1 [Q9NY15-1]
RefSeqiNP_055951.2, NM_015136.2 [Q9NY15-1]

3D structure databases

SMRiQ9NY15
ModBaseiSearch...

Protein-protein interaction databases

BioGridi116778, 6 interactors
ELMiQ9NY15
IntActiQ9NY15, 72 interactors
MINTiQ9NY15
STRINGi9606.ENSP00000312946

PTM databases

GlyConnecti681
iPTMnetiQ9NY15
PhosphoSitePlusiQ9NY15
UniCarbKBiQ9NY15

Polymorphism and mutation databases

BioMutaiSTAB1
DMDMi296452949

Proteomic databases

EPDiQ9NY15
jPOSTiQ9NY15
MassIVEiQ9NY15
PaxDbiQ9NY15
PeptideAtlasiQ9NY15
PRIDEiQ9NY15
ProteomicsDBi83149 [Q9NY15-1]
83150 [Q9NY15-2]

Genome annotation databases

GeneIDi23166
KEGGihsa:23166
UCSCiuc003dej.4 human [Q9NY15-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23166
DisGeNETi23166

GeneCards: human genes, protein and diseases

More...
GeneCardsi
STAB1
HGNCiHGNC:18628 STAB1
HPAiHPA005434
MIMi608560 gene
neXtProtiNX_Q9NY15
OpenTargetsiENSG00000010327
PharmGKBiPA38610

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IRWH Eukaryota
COG2335 LUCA
GeneTreeiENSGT00940000157928
HOGENOMiHOG000154436
InParanoidiQ9NY15
KOiK19020
OMAiVCLEIDG
OrthoDBi6428at2759
PhylomeDBiQ9NY15
TreeFamiTF331489

Enzyme and pathway databases

ReactomeiR-HSA-3000497 Scavenging by Class H Receptors

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
STAB1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
STAB1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23166
PharosiQ9NY15

Protein Ontology

More...
PROi
PR:Q9NY15

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000010327 Expressed in 194 organ(s), highest expression level in spleen
ExpressionAtlasiQ9NY15 baseline and differential
GenevisibleiQ9NY15 HS

Family and domain databases

Gene3Di2.30.180.10, 6 hits
3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR024731 EGF_dom
IPR036378 FAS1_dom_sf
IPR000782 FAS1_domain
IPR002049 Laminin_EGF
IPR000538 Link_dom
PfamiView protein in Pfam
PF12947 EGF_3, 4 hits
PF02469 Fasciclin, 6 hits
PF00193 Xlink, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 23 hits
SM00179 EGF_CA, 6 hits
SM00180 EGF_Lam, 4 hits
SM00554 FAS1, 7 hits
SM00445 LINK, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
SSF82153 SSF82153, 7 hits
PROSITEiView protein in PROSITE
PS00022 EGF_1, 7 hits
PS01186 EGF_2, 16 hits
PS50026 EGF_3, 20 hits
PS01248 EGF_LAM_1, 2 hits
PS50213 FAS1, 7 hits
PS01241 LINK_1, 1 hit
PS50963 LINK_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTAB1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NY15
Secondary accession number(s): A7E297
, Q8IUH0, Q8IUH1, Q93072
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: May 18, 2010
Last modified: October 16, 2019
This is version 172 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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