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Entry version 166 (31 Jul 2019)
Sequence version 1 (01 Oct 2000)
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Protein

CCR4-NOT transcription complex subunit 2

Gene

CNOT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Repressor
Biological processRNA-mediated gene silencing, Transcription, Transcription regulation, Translation regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-429947 Deadenylation of mRNA
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CCR4-NOT transcription complex subunit 2
Alternative name(s):
CCR4-associated factor 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CNOT2
Synonyms:CDC36, NOT2
ORF Names:HSPC131, MSTP046
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7878 CNOT2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604909 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NZN8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
4848

Open Targets

More...
OpenTargetsi
ENSG00000111596

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26673

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4105920

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CNOT2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
46396017

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001983311 – 540CCR4-NOT transcription complex subunit 2Add BLAST540

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei93PhosphothreonineCombined sources1
Modified residuei126PhosphoserineCombined sources1
Modified residuei157PhosphoserineBy similarity1
Modified residuei165PhosphoserineCombined sources1
Modified residuei169PhosphoserineBy similarity1
Modified residuei242PhosphoserineCombined sources1
Modified residuei274PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NZN8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NZN8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NZN8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NZN8

PeptideAtlas

More...
PeptideAtlasi
Q9NZN8

PRoteomics IDEntifications database

More...
PRIDEi
Q9NZN8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
83462 [Q9NZN8-1]
83463 [Q9NZN8-2]
83464 [Q9NZN8-3]
83465 [Q9NZN8-4]
83466 [Q9NZN8-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NZN8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NZN8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in embryonic stem (ES) cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000111596 Expressed in 241 organ(s), highest expression level in intestine

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NZN8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NZN8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA067711

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. In the complex interacts directly with CNOT3.

Interacts with NCOR1, NCOR2. HDAC3 and GPS2.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110910, 70 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9NZN8

Database of interacting proteins

More...
DIPi
DIP-42656N

Protein interaction database and analysis system

More...
IntActi
Q9NZN8, 63 interactors

Molecular INTeraction database

More...
MINTi
Q9NZN8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000229195

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1540
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NZN8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni437 – 540Repressor domainAdd BLAST104

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CNOT2/3/5 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2151 Eukaryota
COG5601 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001285

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000246523

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NZN8

KEGG Orthology (KO)

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KOi
K12605

Identification of Orthologs from Complete Genome Data

More...
OMAi
TQDFSIH

Database of Orthologous Groups

More...
OrthoDBi
1273874at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NZN8

TreeFam database of animal gene trees

More...
TreeFami
TF313102

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.1020, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038635 CCR4-NOT_su2/3/5_N_sf
IPR040168 Not2/3/5
IPR007282 NOT2/3/5_C

The PANTHER Classification System

More...
PANTHERi
PTHR23326 PTHR23326, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04153 NOT2_3_5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 22 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NZN8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVRTDGHTLS EKRNYQVTNS MFGASRKKFV EGVDSDYHDE NMYYSQSSMF
60 70 80 90 100
PHRSEKDMLA SPSTSGQLSQ FGASLYGQQS ALGLPMRGMS NNTPQLNRSL
110 120 130 140 150
SQGTQLPSHV TPTTGVPTMS LHTPPSPSRG ILPMNPRNMM NHSQVGQGIG
160 170 180 190 200
IPSRTNSMSS SGLGSPNRSS PSIICMPKQQ PSRQPFTVNS MSGFGMNRNQ
210 220 230 240 250
AFGMNNSLSS NIFNGTDGSE NVTGLDLSDF PALADRNRRE GSGNPTPLIN
260 270 280 290 300
PLAGRAPYVG MVTKPANEQS QDFSIHNEDF PALPGSSYKD PTSSNDDSKS
310 320 330 340 350
NLNTSGKTTS STDGPKFPGD KSSTTQNNNQ QKKGIQVLPD GRVTNIPQGM
360 370 380 390 400
VTDQFGMIGL LTFIRAAETD PGMVHLALGS DLTTLGLNLN SPENLYPKFA
410 420 430 440 450
SPWASSPCRP QDIDFHVPSE YLTNIHIRDK LAAIKLGRYG EDLLFYLYYM
460 470 480 490 500
NGGDVLQLLA AVELFNRDWR YHKEERVWIT RAPGMEPTMK TNTYERGTYY
510 520 530 540
FFDCLNWRKV AKEFHLEYDK LEERPHLPST FNYNPAQQAF
Length:540
Mass (Da):59,738
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7183890F033E3B83
GO
Isoform 2 (identifier: Q9NZN8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-175: Missing.

Note: No experimental confirmation available.
Show »
Length:365
Mass (Da):40,818
Checksum:i27FC908ADA1A6201
GO
Isoform 3 (identifier: Q9NZN8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-349: Missing.

Note: May be due to an intron retention. No experimental confirmation available.
Show »
Length:191
Mass (Da):22,254
Checksum:i803037A4A6F670CC
GO
Isoform 4 (identifier: Q9NZN8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     465-475: FNRDWRYHKEE → YVQSILITFVL
     476-540: Missing.

Note: May be due to an intron retention. No experimental confirmation available.
Show »
Length:475
Mass (Da):51,537
Checksum:i5D5C630BB3E89F06
GO
Isoform 5 (identifier: Q9NZN8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     229-278: Missing.

Note: No experimental confirmation available.
Show »
Length:490
Mass (Da):54,306
Checksum:i7C6A4CC0F0992C9C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 22 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VV52F8VV52_HUMAN
CCR4-NOT transcription complex subu...
CNOT2
531Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VRS8F8VRS8_HUMAN
CCR4-NOT transcription complex subu...
CNOT2
276Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VP97F8VP97_HUMAN
CCR4-NOT transcription complex subu...
CNOT2
321Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W145F8W145_HUMAN
CCR4-NOT transcription complex subu...
CNOT2
309Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VQF4F8VQF4_HUMAN
CCR4-NOT transcription complex subu...
CNOT2
144Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VUB4F8VUB4_HUMAN
CCR4-NOT transcription complex subu...
CNOT2
520Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YH84H0YH84_HUMAN
CCR4-NOT transcription complex subu...
CNOT2
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YI11H0YI11_HUMAN
CCR4-NOT transcription complex subu...
CNOT2
182Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YHT6H0YHT6_HUMAN
CCR4-NOT transcription complex subu...
CNOT2
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YI80H0YI80_HUMAN
CCR4-NOT transcription complex subu...
CNOT2
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF29095 differs from that shown. Reason: Frameshift at position 474.Curated
The sequence AAQ13426 differs from that shown. Reason: Frameshift at positions 71, 76, 84, 98, 123, 370, 384 and 393.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048750460A → T. Corresponds to variant dbSNP:rs11178192Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0099131 – 349Missing in isoform 3. 1 PublicationAdd BLAST349
Alternative sequenceiVSP_0099121 – 175Missing in isoform 2. 1 PublicationAdd BLAST175
Alternative sequenceiVSP_009914229 – 278Missing in isoform 5. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_009915465 – 475FNRDWRYHKEE → YVQSILITFVL in isoform 4. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_009916476 – 540Missing in isoform 4. 1 PublicationAdd BLAST65

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF180473 mRNA Translation: AAF29827.1
AF113226 mRNA Translation: AAG39297.1
AF161480 mRNA Translation: AAF29095.1 Frameshift.
AK000662 mRNA Translation: BAA91313.1
AL137674 mRNA Translation: CAB70869.1
BX641116 mRNA Translation: CAE46054.1
BC002597 mRNA Translation: AAH02597.1
BC011826 mRNA Translation: AAH11826.1
AF044215 mRNA Translation: AAQ13426.1 Frameshift.

The Consensus CDS (CCDS) project

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CCDSi
CCDS31857.1 [Q9NZN8-1]

Protein sequence database of the Protein Information Resource

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PIRi
T46494

NCBI Reference Sequences

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RefSeqi
NP_001186231.1, NM_001199302.1 [Q9NZN8-1]
NP_001186232.1, NM_001199303.1 [Q9NZN8-1]
NP_055330.1, NM_014515.5 [Q9NZN8-1]
XP_011536701.1, XM_011538399.1 [Q9NZN8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000229195; ENSP00000229195; ENSG00000111596 [Q9NZN8-1]
ENST00000418359; ENSP00000412091; ENSG00000111596 [Q9NZN8-1]
ENST00000551043; ENSP00000449260; ENSG00000111596 [Q9NZN8-1]
ENST00000551483; ENSP00000448883; ENSG00000111596 [Q9NZN8-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
4848

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:4848

UCSC genome browser

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UCSCi
uc001svv.4 human [Q9NZN8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF180473 mRNA Translation: AAF29827.1
AF113226 mRNA Translation: AAG39297.1
AF161480 mRNA Translation: AAF29095.1 Frameshift.
AK000662 mRNA Translation: BAA91313.1
AL137674 mRNA Translation: CAB70869.1
BX641116 mRNA Translation: CAE46054.1
BC002597 mRNA Translation: AAH02597.1
BC011826 mRNA Translation: AAH11826.1
AF044215 mRNA Translation: AAQ13426.1 Frameshift.
CCDSiCCDS31857.1 [Q9NZN8-1]
PIRiT46494
RefSeqiNP_001186231.1, NM_001199302.1 [Q9NZN8-1]
NP_001186232.1, NM_001199303.1 [Q9NZN8-1]
NP_055330.1, NM_014515.5 [Q9NZN8-1]
XP_011536701.1, XM_011538399.1 [Q9NZN8-1]

3D structure databases

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Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4C0DX-ray3.20B344-540[»]
4C0FX-ray2.40A/B/C/D429-540[»]
5FU6X-ray2.90B/E350-540[»]
5FU7X-ray3.10B/F350-540[»]
SMRiQ9NZN8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi110910, 70 interactors
CORUMiQ9NZN8
DIPiDIP-42656N
IntActiQ9NZN8, 63 interactors
MINTiQ9NZN8
STRINGi9606.ENSP00000229195

Chemistry databases

ChEMBLiCHEMBL4105920

PTM databases

iPTMnetiQ9NZN8
PhosphoSitePlusiQ9NZN8

Polymorphism and mutation databases

BioMutaiCNOT2
DMDMi46396017

Proteomic databases

EPDiQ9NZN8
jPOSTiQ9NZN8
MaxQBiQ9NZN8
PaxDbiQ9NZN8
PeptideAtlasiQ9NZN8
PRIDEiQ9NZN8
ProteomicsDBi83462 [Q9NZN8-1]
83463 [Q9NZN8-2]
83464 [Q9NZN8-3]
83465 [Q9NZN8-4]
83466 [Q9NZN8-5]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
4848
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000229195; ENSP00000229195; ENSG00000111596 [Q9NZN8-1]
ENST00000418359; ENSP00000412091; ENSG00000111596 [Q9NZN8-1]
ENST00000551043; ENSP00000449260; ENSG00000111596 [Q9NZN8-1]
ENST00000551483; ENSP00000448883; ENSG00000111596 [Q9NZN8-3]
GeneIDi4848
KEGGihsa:4848
UCSCiuc001svv.4 human [Q9NZN8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4848
DisGeNETi4848

GeneCards: human genes, protein and diseases

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GeneCardsi
CNOT2
HGNCiHGNC:7878 CNOT2
HPAiHPA067711
MIMi604909 gene
neXtProtiNX_Q9NZN8
OpenTargetsiENSG00000111596
PharmGKBiPA26673

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2151 Eukaryota
COG5601 LUCA
GeneTreeiENSGT00390000001285
HOGENOMiHOG000246523
InParanoidiQ9NZN8
KOiK12605
OMAiTQDFSIH
OrthoDBi1273874at2759
PhylomeDBiQ9NZN8
TreeFamiTF313102

Enzyme and pathway databases

ReactomeiR-HSA-429947 Deadenylation of mRNA
R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CNOT2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CNOT2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4848

Protein Ontology

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PROi
PR:Q9NZN8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000111596 Expressed in 241 organ(s), highest expression level in intestine
ExpressionAtlasiQ9NZN8 baseline and differential
GenevisibleiQ9NZN8 HS

Family and domain databases

Gene3Di2.30.30.1020, 1 hit
InterProiView protein in InterPro
IPR038635 CCR4-NOT_su2/3/5_N_sf
IPR040168 Not2/3/5
IPR007282 NOT2/3/5_C
PANTHERiPTHR23326 PTHR23326, 1 hit
PfamiView protein in Pfam
PF04153 NOT2_3_5, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCNOT2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NZN8
Secondary accession number(s): Q9H3E0
, Q9NSX5, Q9NWR6, Q9P028
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2000
Last modified: July 31, 2019
This is version 166 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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