Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 145 (18 Sep 2019)
Sequence version 2 (27 Jan 2003)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Cingulin

Gene

CGN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cingulin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CGN
Synonyms:KIAA1319
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17429 CGN

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609473 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9P2M7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Tight junction

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57530

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134938123

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9P2M7

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CGN

Domain mapping of disease mutations (DMDM)

More...
DMDMi
27923755

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000897631 – 1197CingulinAdd BLAST1197

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei89PhosphoserineBy similarity1
Modified residuei90PhosphoserineBy similarity1
Modified residuei129PhosphoserineCombined sources1
Modified residuei131PhosphoserineCombined sources1
Modified residuei134PhosphoserineCombined sources1
Modified residuei149PhosphoserineCombined sources1
Modified residuei159PhosphoserineCombined sources1
Modified residuei208PhosphoserineCombined sources1
Modified residuei211PhosphoserineCombined sources1
Modified residuei252PhosphoserineCombined sources1
Modified residuei270PhosphoserineCombined sources1
Modified residuei332PhosphoserineBy similarity1
Modified residuei345PhosphoserineBy similarity1
Modified residuei573N6-acetyllysineCombined sources1
Modified residuei706PhosphothreonineCombined sources1
Modified residuei1169PhosphoserineCombined sources1
Modified residuei1170PhosphoserineCombined sources1
Modified residuei1176PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9P2M7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9P2M7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9P2M7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9P2M7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9P2M7

PeptideAtlas

More...
PeptideAtlasi
Q9P2M7

PRoteomics IDEntifications database

More...
PRIDEi
Q9P2M7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
83849 [Q9P2M7-1]
83850 [Q9P2M7-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9P2M7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9P2M7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Localized on the cytoplasmic face of tight junctions of polarized epithelia and some endothelia. Expressed in pancreas, kidney, liver and lung, but not in skeletal muscle, placenta, brain or heart.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000143375 Expressed in 154 organ(s), highest expression level in mucosa of transverse colon

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9P2M7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9P2M7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB017193
HPA027586
HPA027587
HPA027657

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (By similarity).

Interacts with TJP1/ZO-1.

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P631043EBI-79537,EBI-347088

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121589, 105 interactors

Database of interacting proteins

More...
DIPi
DIP-30947N

Protein interaction database and analysis system

More...
IntActi
Q9P2M7, 30 interactors

Molecular INTeraction database

More...
MINTi
Q9P2M7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000271636

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9P2M7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 351HeadAdd BLAST351
Regioni106 – 400Interaction with ZO-2Add BLAST295
Regioni1155 – 1197TailAdd BLAST43

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili352 – 1154Sequence analysisAdd BLAST803

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi42 – 56ZIMAdd BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi363 – 836Glu-richAdd BLAST474

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Deletion of the ZO-1 interaction motif (ZIM) decreases but does not abolish colocalization with ZO-1.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cingulin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGSJ Eukaryota
ENOG410YEC7 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9P2M7

KEGG Orthology (KO)

More...
KOi
K06102

Database of Orthologous Groups

More...
OrthoDBi
110948at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9P2M7

TreeFam database of animal gene trees

More...
TreeFami
TF332247

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002928 Myosin_tail

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01576 Myosin_tail_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9P2M7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEPRGPVDH GVQIRFITEP VSGAEMGTLR RGGRRPAKDA RASTYGVAVR
60 70 80 90 100
VQGIAGQPFV VLNSGEKGGD SFGVQIKGAN DQGASGALSS DLELPENPYS
110 120 130 140 150
QVKGFPAPSQ SSTSDEEPGA YWNGKLLRSH SQASLAGPGP VDPSNRSNSM
160 170 180 190 200
LELAPKVASP GSTIDTAPLS SVDSLINKFD SQLGGQARGR TGRRTRMLPP
210 220 230 240 250
EQRKRSKSLD SRLPRDTFEE RERQSTNHWT SSTKYDNHVG TSKQPAQSQN
260 270 280 290 300
LSPLSGFSRS RQTQDWVLQS FEEPRRSAQD PTMLQFKSTP DLLRDQQEAA
310 320 330 340 350
PPGSVDHMKA TIYGILREGS SESETSVRRK VSLVLEKMQP LVMVSSGSTK
360 370 380 390 400
AVAGQGELTR KVEELQRKLD EEVKKRQKLE PSQVGLERQL EEKTEECSRL
410 420 430 440 450
QELLERRKGE AQQSNKELQN MKRLLDQGED LRHGLETQVM ELQNKLKHVQ
460 470 480 490 500
GPEPAKEVLL KDLLETRELL EEVLEGKQRV EEQLRLRERE LTALKGALKE
510 520 530 540 550
EVASRDQEVE HVRQQYQRDT EQLRRSMQDA TQDHAVLEAE RQKMSALVRG
560 570 580 590 600
LQRELEETSE ETGHWQSMFQ KNKEDLRATK QELLQLRMEK EEMEEELGEK
610 620 630 640 650
IEVLQRELEQ ARASAGDTRQ VEVLKKELLR TQEELKELQA ERQSQEVAGR
660 670 680 690 700
HRDRELEKQL AVLRVEADRG RELEEQNLQL QKTLQQLRQD CEEASKAKMV
710 720 730 740 750
AEAEATVLGQ RRAAVETTLR ETQEENDEFR RRILGLEQQL KETRGLVDGG
760 770 780 790 800
EAVEARLRDK LQRLEAEKQQ LEEALNASQE EEGSLAAAKR ALEARLEEAQ
810 820 830 840 850
RGLARLGQEQ QTLNRALEEE GKQREVLRRG KAELEEQKRL LDRTVDRLNK
860 870 880 890 900
ELEKIGEDSK QALQQLQAQL EDYKEKARRE VADAQRQAKD WASEAEKTSG
910 920 930 940 950
GLSRLQDEIQ RLRQALQASQ AERDTARLDK ELLAQRLQGL EQEAENKKRS
960 970 980 990 1000
QDDRARQLKG LEEKVSRLET ELDEEKNTVE LLTDRVNRGR DQVDQLRTEL
1010 1020 1030 1040 1050
MQERSARQDL ECDKISLERQ NKDLKTRLAS SEGFQKPSAS LSQLESQNQL
1060 1070 1080 1090 1100
LQERLQAEER EKTVLQSTNR KLERKVKELS IQIEDERQHV NDQKDQLSLR
1110 1120 1130 1140 1150
VKALKRQVDE AEEEIERLDG LRKKAQREVE EQHEVNEQLQ ARIKSLEKDS
1160 1170 1180 1190
WRKASRSAAE SALKNEGLSS DEEFDSVYDP SSIASLLTES NLQTSSC
Length:1,197
Mass (Da):136,386
Last modified:January 27, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0C9375283ABAAF3D
GO
Isoform 2 (identifier: Q9P2M7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     698-771: KMVAEAEATV...QRLEAEKQQL → RGVGTGLRRW...KRLAGGSCSL
     772-1197: Missing.

Note: May be due to an intron retention.
Show »
Length:771
Mass (Da):87,047
Checksum:iF289EA3694E4CEC1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y4A8H0Y4A8_HUMAN
Cingulin
CGN
131Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A6PVU7A6PVU7_HUMAN
Cingulin
CGN
291Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A3M4A2A3M4_HUMAN
Cingulin
CGN
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF74498 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI52446 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA92557 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAF82696 differs from that shown. Reason: Erroneous initiation.Curated
The sequence EAW53434 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_057809479R → Q. Corresponds to variant dbSNP:rs12038198Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_037039698 – 771KMVAE…EKQQL → RGVGTGLRRWRLRVSGGLRS QRVWKVTCHGYVLTSSWVLG MWFKEARIWQGEDTCICVGV GFSEKRLAGGSCSL in isoform 2. 1 PublicationAdd BLAST74
Alternative sequenceiVSP_037040772 – 1197Missing in isoform 2. 1 PublicationAdd BLAST426

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF263462 mRNA Translation: AAF74498.1 Different initiation.
AB037740 mRNA Translation: BAA92557.1 Different initiation.
AK290007 mRNA Translation: BAF82696.1 Different initiation.
AL365436 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53434.1 Different initiation.
BC146657 mRNA Translation: AAI46658.1
BC152445 mRNA Translation: AAI52446.1 Different initiation.

NCBI Reference Sequences

More...
RefSeqi
NP_065821.1, NM_020770.2
XP_005245422.1, XM_005245365.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000271636; ENSP00000271636; ENSG00000143375

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57530

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57530

UCSC genome browser

More...
UCSCi
uc009wmw.4 human [Q9P2M7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF263462 mRNA Translation: AAF74498.1 Different initiation.
AB037740 mRNA Translation: BAA92557.1 Different initiation.
AK290007 mRNA Translation: BAF82696.1 Different initiation.
AL365436 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53434.1 Different initiation.
BC146657 mRNA Translation: AAI46658.1
BC152445 mRNA Translation: AAI52446.1 Different initiation.
RefSeqiNP_065821.1, NM_020770.2
XP_005245422.1, XM_005245365.4

3D structure databases

SMRiQ9P2M7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi121589, 105 interactors
DIPiDIP-30947N
IntActiQ9P2M7, 30 interactors
MINTiQ9P2M7
STRINGi9606.ENSP00000271636

PTM databases

iPTMnetiQ9P2M7
PhosphoSitePlusiQ9P2M7

Polymorphism and mutation databases

BioMutaiCGN
DMDMi27923755

Proteomic databases

EPDiQ9P2M7
jPOSTiQ9P2M7
MassIVEiQ9P2M7
MaxQBiQ9P2M7
PaxDbiQ9P2M7
PeptideAtlasiQ9P2M7
PRIDEiQ9P2M7
ProteomicsDBi83849 [Q9P2M7-1]
83850 [Q9P2M7-2]

Genome annotation databases

EnsembliENST00000271636; ENSP00000271636; ENSG00000143375
GeneIDi57530
KEGGihsa:57530
UCSCiuc009wmw.4 human [Q9P2M7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57530
DisGeNETi57530

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CGN
HGNCiHGNC:17429 CGN
HPAiCAB017193
HPA027586
HPA027587
HPA027657
MIMi609473 gene
neXtProtiNX_Q9P2M7
PharmGKBiPA134938123

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGSJ Eukaryota
ENOG410YEC7 LUCA
InParanoidiQ9P2M7
KOiK06102
OrthoDBi110948at2759
PhylomeDBiQ9P2M7
TreeFamiTF332247

Enzyme and pathway databases

ReactomeiR-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CGN human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Cingulin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
57530
PharosiQ9P2M7

Protein Ontology

More...
PROi
PR:Q9P2M7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000143375 Expressed in 154 organ(s), highest expression level in mucosa of transverse colon
ExpressionAtlasiQ9P2M7 baseline and differential
GenevisibleiQ9P2M7 HS

Family and domain databases

InterProiView protein in InterPro
IPR002928 Myosin_tail
PfamiView protein in Pfam
PF01576 Myosin_tail_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCING_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P2M7
Secondary accession number(s): A6H8L3
, A7MD22, Q5T386, Q9NR25
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: January 27, 2003
Last modified: September 18, 2019
This is version 145 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again