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UniProtKB - Q9P3A8 (CAND1_SCHPO)

Entry version 106 (13 Nov 2019)
Sequence version 1 (01 Oct 2000)
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Protein

Cullin-associated NEDD8-dissociated protein 1

Gene

knd1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor (Probable).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-SPO-6798695 Neutrophil degranulation
R-SPO-8951664 Neddylation
R-SPO-917937 Iron uptake and transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cullin-associated NEDD8-dissociated protein 1
Alternative name(s):
Cullin-associated and neddylation-dissociated protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:knd1
ORF Names:SPAC1565.07c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		FungiDB:SPAC1565.07c

Schizosaccharomyces pombe database

More...PomBasei		SPAC1565.07c knd1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003740191 – 1220Cullin-associated NEDD8-dissociated protein 1Add BLAST1220

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9P3A8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9P3A8

PRoteomics IDEntifications database

More...PRIDEi		Q9P3A8

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		279217, 60 interactors

STRING: functional protein association networks

More...STRINGi		4896.SPAC1565.07c.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1 – 35HEAT 1Add BLAST35
Repeati42 – 79HEAT 2Add BLAST38
Repeati121 – 157HEAT 3Add BLAST37
Repeati259 – 295HEAT 4Add BLAST37
Repeati365 – 410HEAT 5Add BLAST46
Repeati615 – 650HEAT 6Add BLAST36
Repeati680 – 700HEAT 7Add BLAST21
Repeati701 – 737HEAT 8Add BLAST37
Repeati738 – 775HEAT 9Add BLAST38
Repeati810 – 847HEAT 10Add BLAST38
Repeati850 – 887HEAT 11Add BLAST38
Repeati1020 – 1057HEAT 12Add BLAST38

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CAND family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9P3A8

KEGG Orthology (KO)

More...KOi		K17263

Identification of Orthologs from Complete Genome Data

More...OMAi		QNLAIKC

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9P3A8

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016024 ARM-type_fold
IPR039852 CAND1/CAND2
IPR013932 TATA-bd_TIP120

The PANTHER Classification System

More...PANTHERi		PTHR12696 PTHR12696, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08623 TIP120, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9P3A8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEGILLKKY VESSDKDIRY MALSDLAARL NDANHLKNLK LESFPDTLDV 
        60         70         80         90        100
LLQALSDASP EVQQEAVRCV AIISSKIPQD KLKSTVENLL SGVAGKKSKN 
       110        120        130        140        150
YLSALSLLLS NSNVQPFVNK FYTSTVFPSF LQILKQYNVA QEEFFAILCV 
       160        170        180        190        200
VCDSLEIYHS NLSTLLPNNF ELCIDVFQKC TTQCQRELII KKACYLLSDV 
       210        220        230        240        250
SLYGPRFAYK YIIEVLDRGL GPSTQMSEVN ISIKLLNEIL LSSKKEKDSS 
       260        270        280        290        300
TSFISTAVAD YTNKILSLLK KEEAPDELTQ KLLEVLGLLL EYQQVNILKI 
       310        320        330        340        350
WPELHGLLIS KISYDPNLIS DTNDEDDIAD FLEEMSDYSS IYEDEEDVSW 
       360        370        380        390        400
IVRRESLKVV LSVILSRLEY LPIVLQALGT SVVSKLNDRE ESVCLISIEV 
       410        420        430        440        450
LKQAFLHVPR WIEVYATSND RKRRYEGLPS DRSAISDTSI YLVSVIGKHV 
       460        470        480        490        500
SKLSDKTPLS IVSELLNLVT VIFSSRDLGV QSEFSNLSSI IYRFPDFSTL 
       510        520        530        540        550
DIKIKLNLVR LISAIISCGC EEIENMESKM STILSLAVQN NYPQLSYEAL 
       560        570        580        590        600
ITELSFCKYI HKKQPTNVST DFSTMIDSSL QLLESKISDL KVRLALIDLV 
       610        620        630        640        650
SQYVILFYEP DFDSIFLRRV LIILCKKLQE EPTRSAAARA LCDIFMSVTD 
       660        670        680        690        700
ITKIENGTKI YEEILQDCCR HIDKSGNEFT TAYLELLEVL LKVGQKYLAE 
       710        720        730        740        750
SLLEHILGLL IETLKRNTEN TVAILKCLLI IPLSILLKSK NLLIDTIISH 
       760        770        780        790        800
LQSSTIHLNE ESVCLLSRII AVISKEEDLE LIINSFTCAQ KPVEEMVTLA 
       810        820        830        840        850
LIAAQLICIF QSKAIVTSLN KSFMSPKSEV RIKVFTTLIF GQLDYGKLTL 
       860        870        880        890        900
PANEYFDTIA SNLNSPNADV MKAAAIALGS LTSQSEKFIK ELCALYVSDA 
       910        920        930        940        950
YDKELLLISF LTFLKKSKID YETADKIWDI LSKDIENIKD FSTSPFRTLL 
       960        970        980        990       1000
SECLGLLICN ESSSLYYKLE LLSSSEASNH MLLSLSVFRF SLTLDCPKLK 
      1010       1020       1030       1040       1050
AYEKQFFEKA YKLFQNPDLE VSQETLQVII SVIKNRRSCI ADVYNELLQG 
      1060       1070       1080       1090       1100
LISKSSVDSS NVHVVQMGPF QHVVDNSINQ RQLVFETLYS LLDIPESLNH 
      1110       1120       1130       1140       1150
LTHFLQVSVM GLEDEHYIKL VSLSILEKLV DCSPSIIDEQ VDTILEALRK 
      1160       1170       1180       1190       1200
IIELRKTEKT LKTDSDNILD LVRSALRVLF TMKLKCDNPV ISEFESQVQK 
      1210       1220
GPYSLEYEGI KNEIKTTIKT
Length:1,220
Mass (Da):137,883
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE9F81C96B9DA193B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB99274.1

NCBI Reference Sequences

More...RefSeqi		NP_593286.1, NM_001018716.2

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		SPAC1565.07c.1; SPAC1565.07c.1:pep; SPAC1565.07c

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2542767

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		spo:SPAC1565.07c

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB99274.1
RefSeqiNP_593286.1, NM_001018716.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGridi279217, 60 interactors
STRINGi4896.SPAC1565.07c.1

Proteomic databases

MaxQBiQ9P3A8
PaxDbiQ9P3A8
PRIDEiQ9P3A8

Genome annotation databases

EnsemblFungiiSPAC1565.07c.1; SPAC1565.07c.1:pep; SPAC1565.07c
GeneIDi2542767
KEGGispo:SPAC1565.07c

Organism-specific databases

EuPathDBiFungiDB:SPAC1565.07c
PomBaseiSPAC1565.07c knd1

Phylogenomic databases

InParanoidiQ9P3A8
KOiK17263
OMAiQNLAIKC
PhylomeDBiQ9P3A8

Enzyme and pathway databases

ReactomeiR-SPO-6798695 Neutrophil degranulation
R-SPO-8951664 Neddylation
R-SPO-917937 Iron uptake and transport

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q9P3A8

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR039852 CAND1/CAND2
IPR013932 TATA-bd_TIP120
PANTHERiPTHR12696 PTHR12696, 1 hit
PfamiView protein in Pfam
PF08623 TIP120, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAND1_SCHPO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9P3A8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: October 1, 2000
Last modified: November 13, 2019
This is version 106 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
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