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UniProtKB - Q9QXZ0 (MACF1_MOUSE)

Entry version 178 (16 Oct 2019)
Sequence version 2 (28 Jun 2011)
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Protein

Microtubule-actin cross-linking factor 1

Gene

Macf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Isoform 2: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:16815997, PubMed:18854161, PubMed:21295697). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (By similarity). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (PubMed:16815997). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (PubMed:18854161). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (By similarity). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (By similarity). Plays a key role in wound healing and epidermal cell migration (PubMed:21295697). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (PubMed:21295697). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (PubMed:26526844).By similarity4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi7014 – 70251PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi7050 – 70612PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
Biological processWnt signaling pathway
LigandCalcium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Microtubule-actin cross-linking factor 1
Alternative name(s):
Actin cross-linking family 7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Macf1
Synonyms:Acf7, Aclp7, Macf
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:108559 Macf1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice die at the gastrulation stage and display developmental retardation at 7.5 dpc with defects in the formation of the primitive streak, node, and mesoderm. Conditional knockdown results in markedly decreased dendritic branching of cortical and hippocampal pyramidal neurons, reduced density and aberrant morphology of dendritic spines, and impaired elongation of callosal axons in the brain (PubMed:26526844).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000734511 – 7354Microtubule-actin cross-linking factor 1Add BLAST7354

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei4PhosphoserineBy similarity1
Modified residuei35PhosphoserineCombined sources1
Modified residuei57PhosphoserineCombined sources1
Modified residuei280PhosphoserineCombined sources1
Modified residuei1122PhosphoserineBy similarity1
Modified residuei1367PhosphoserineBy similarity1
Modified residuei1376PhosphoserineCombined sources1
Modified residuei2051PhosphoserineBy similarity1
Modified residuei2077PhosphoserineCombined sources1
Modified residuei2081PhosphoserineCombined sources1
Modified residuei3082PhosphoserineCombined sources1
Modified residuei3085PhosphoserineCombined sources1
Modified residuei3889PhosphoserineCombined sources1
Modified residuei4458PhosphoserineCombined sources1
Modified residuei4483PhosphoserineCombined sources1
Modified residuei4921PhosphoserineBy similarity1
Modified residuei5394PhosphothreonineCombined sources1
Modified residuei5988PhosphoserineCombined sources1
Modified residuei6166N6-acetyllysineBy similarity1
Modified residuei6923PhosphoserineCombined sources1
Modified residuei7220PhosphothreonineBy similarity1
Modified residuei7245PhosphoserineBy similarity1
Modified residuei7258PhosphoserineBy similarity1
Modified residuei7296PhosphoserineCombined sources1
Modified residuei7299PhosphoserineCombined sources1
Isoform 4 (identifier: Q9QXZ0-4)
Modified residuei42PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on serine residues in the C-terminal tail by GSK3B. Phosphorylation inhibits microtubule-binding and this plays a critical role in bulge stem cell migration and skin wound repair. Wnt-signaling can repress phosphorylation.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9QXZ0

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9QXZ0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9QXZ0

PeptideAtlas

More...PeptideAtlasi		Q9QXZ0

PRoteomics IDEntifications database

More...PRIDEi		Q9QXZ0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9QXZ0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9QXZ0

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9QXZ0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Enriched in the hair follicle stem cells (at protein level). Isoform 1 and isoform 2 are ubiquitous expressed, with higher levels seen in lung, heart, thymus, spleen and brain.3 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoform 2 is highly expressed in neuronal tissues and the foregut of 8.5 dpc embryos and the head fold and primitive streak of 7.5 dpc embryos (at protein level). Isoform 1: Expressed throughout the development of the embryo.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Isoform 2:

Interacts with AXIN1, LRP6 and GOLGA4 (By similarity). Isoform 2:

Found in a complex composed of MACF1, APC, AXIN1, CTNNB1 and GSK3B (By similarity). Isoform 2:

Interacts with MAPRE1, CLASP1 AND CLASP2 (PubMed:18854161). Isoform 2:

Interacts with CAMSAP3.

By similarity1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q9QXZ0, 20 interactors

Molecular INTeraction database

More...MINTi		Q9QXZ0

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000119600

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9QXZ0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini78 – 181Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST104
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati148 – 171LRR 1Add BLAST24
Domaini194 – 298Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST105
Repeati377 – 399LRR 3Add BLAST23
Repeati441 – 464LRR 4Add BLAST24
Domaini868 – 925SH3PROSITE-ProRule annotationAdd BLAST58
Repeati1050 – 1073LRR 5Add BLAST24
Repeati1128 – 1154LRR 6Add BLAST27
Repeati1187 – 1210LRR 7Add BLAST24
Repeati1257 – 1282LRR 8Add BLAST26
Repeati1577 – 1619Plectin 1Add BLAST43
Repeati1654 – 1696Plectin 2Add BLAST43
Repeati1769 – 1809Plectin 3Add BLAST41
Repeati1811 – 1848Plectin 4Add BLAST38
Repeati1855 – 1885Plectin 5Add BLAST31
Repeati2276 – 2316Plectin 6Add BLAST41
Repeati2352 – 2393Plectin 7Add BLAST42
Repeati2394 – 2425Plectin 8Add BLAST32
Repeati2487 – 2528Plectin 9Add BLAST42
Repeati2671 – 2715Plectin 10Add BLAST45
Repeati3225 – 3244LRR 9Add BLAST20
Repeati3606 – 3630LRR 10Add BLAST25
Repeati3657 – 3681LRR 11Add BLAST25
Repeati3845 – 3920Spectrin 1Add BLAST76
Repeati3898 – 3920LRR 12Add BLAST23
Repeati3962 – 4070Spectrin 2Add BLAST109
Repeati4087 – 4112LRR 13Add BLAST26
Repeati4223 – 4249LRR 14Add BLAST27
Repeati4428 – 4536Spectrin 3Add BLAST109
Repeati4473 – 4496LRR 15Add BLAST24
Repeati4563 – 4583LRR 16Add BLAST21
Repeati4728 – 4751LRR 17Add BLAST24
Repeati4759 – 4863Spectrin 4Add BLAST105
Repeati5010 – 5035LRR 18Add BLAST26
Repeati5131 – 5153LRR 19Add BLAST23
Repeati5195 – 5300Spectrin 5Add BLAST106
Repeati5240 – 5263LRR 20Add BLAST24
Repeati5307 – 5409Spectrin 6Add BLAST103
Repeati5414 – 5506Spectrin 7Add BLAST93
Repeati5631 – 5735Spectrin 8Add BLAST105
Repeati5654 – 5678LRR 21Add BLAST25
Repeati5742 – 5844Spectrin 9Add BLAST103
Repeati5763 – 5787LRR 22Add BLAST25
Repeati5961 – 6066Spectrin 10Add BLAST106
Repeati6071 – 6175Spectrin 11Add BLAST105
Repeati6181 – 6284Spectrin 12Add BLAST104
Repeati6289 – 6395Spectrin 13Add BLAST107
Repeati6400 – 6503Spectrin 14Add BLAST104
Repeati6452 – 6475LRR 23Add BLAST24
Repeati6508 – 6614Spectrin 15Add BLAST107
Repeati6621 – 6722Spectrin 16Add BLAST102
Repeati6726 – 6830Spectrin 17Add BLAST105
Domaini7001 – 7036EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini7037 – 7072EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini7077 – 7155GARPROSITE-ProRule annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 295Actin-bindingAdd BLAST295
Regioni7077 – 7354C-terminal tailAdd BLAST278
Regioni7279 – 72944 X 4 AA tandem repeats of [GS]-S-R-[AR]Add BLAST16

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi700 – 703Poly-Glu4
Compositional biasi1414 – 1417Poly-Glu4
Compositional biasi1986 – 1989Poly-Leu4
Compositional biasi3521 – 3576Gln-richAdd BLAST56
Compositional biasi7188 – 7325Ser-richAdd BLAST138

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal tail is required for phosphorylation by GSK3B and for microtubule-binding.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the plakin or cytolinker family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0516 Eukaryota
COG5069 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000049054

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9QXZ0

Family and domain databases

Conserved Domains Database

More...CDDi		cd00014 CH, 2 hits
cd00051 EFh, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.418.10, 2 hits
3.30.920.20, 1 hit
3.90.1290.10, 6 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR041615 Desmoplakin_SH3
IPR041573 Desmoplakin_Spectrin-like
IPR029926 Dystonin-like
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR003108 GAR_dom
IPR036534 GAR_dom_sf
IPR035915 Plakin_repeat_sf
IPR001101 Plectin_repeat
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat

The PANTHER Classification System

More...PANTHERi		PTHR23169:SF24 PTHR23169:SF24, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00307 CH, 2 hits
PF13499 EF-hand_7, 1 hit
PF02187 GAS2, 1 hit
PF00681 Plectin, 8 hits
PF17902 SH3_10, 1 hit
PF00435 Spectrin, 18 hits
PF18373 Spectrin_like, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00033 CH, 2 hits
SM00054 EFh, 2 hits
SM00243 GAS2, 1 hit
SM00250 PLEC, 19 hits
SM00150 SPEC, 34 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF143575 SSF143575, 1 hit
SSF47473 SSF47473, 1 hit
SSF47576 SSF47576, 1 hit
SSF75399 SSF75399, 6 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits
PS51460 GAR, 1 hit
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 17 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9QXZ0-1) [UniParc]FASTAAdd to basket
Also known as: Macf1b

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSSDEETLS ERSCRSERSC RSERSYRSER SGSLSPCPPG DTLPWNLPLH 
        60         70         80         90        100
EQKKRKSQDS VLDPAERAVV RVADERDRVQ KKTFTKWVNK HLMKVRKHIN 
       110        120        130        140        150
DLYEDLRDGH NLISLLEVLS GIKLPREKGR MRFHRLQNVQ IALDFLKQRQ 
       160        170        180        190        200
VKLVNIRNDD ITDGNPKLTL GLIWTIILHF QISDIYISGE SGDMSAKEKL 
       210        220        230        240        250
LLWTQKVTAG YTGVKCTNFS SCWSDGKMFN ALIHRYRPDL VDMERVQVQS 
       260        270        280        290        300
NRENLEQAFE VAERLGVTRL LDAEDVDVPS PDEKSVITYV SSIYDAFPKV 
       310        320        330        340        350
PEGGEGISAT EVDSRWQEYQ SRVDSLIPWI RQHTILMSDK SFPQNPVELK 
       360        370        380        390        400
ALYNQYIHFK ETEILAKERE KGRIKELYKL LEVWIEFGRI KLPQGYHPNH 
       410        420        430        440        450
VEEEWGKLIV EMLEREKSLR PAVERLELLL QIANKIQNGA LNCEEKLTLA 
       460        470        480        490        500
KNTLQADAAH LESGQPVQCE SDVIMYIQEC EGLIRQLQVD LQILRDEKYY 
       510        520        530        540        550
QLEELAFRVM RLQDELVTLR LECTNLYRKG HFSSLELVPP STLTTTHLKA 
       560        570        580        590        600
EPLNKTTHSS STSWFRKPMT RTELVSISSS EDEGNLRFVY ELLSWVEEMQ 
       610        620        630        640        650
MKLERAEWGN DLPSVELQLE TQQHIHTSVE ELGSSVKEAR LYEGKMSQNF 
       660        670        680        690        700
HTSYVETLGK LETQYCKLKE TSSFRMRHLQ SLHKFVSRAT AELIWLNGKE 
       710        720        730        740        750
EEELACDWSD SNPNISAKKT YFSELTMELE GKQDVFRSLQ DTAEVLSLEN 
       760        770        780        790        800
HPAKQTVEAY SAAVQSQLQW MKQLCLCVEQ HVKENAAYFQ FFSDARDLES 
       810        820        830        840        850
FLRNLQDSIK RKYTCDRSTS LSRLEDLLQD SMDEKEQLIQ SKSSVASLVG 
       860        870        880        890        900
RSKTIVQLKP RNPDHVLKST LSVKAICDYR QIEITICKND ECVLEDNSQR 
       910        920        930        940        950
TKWKVISPTG NEAMVPSVCF LIPPPNKEAI EMASRVEQSY QKVMALWHQL 
       960        970        980        990       1000
HINTKSLISW NYLRKDLDTV QTWSLEKLRS LAPGECHQVM KNLQAHYEDF 
      1010       1020       1030       1040       1050
LQDSHDSALF SVADRLRIEE EVEACKAHFQ HLMKSLENED KEETLAKVYI 
      1060       1070       1080       1090       1100
SELKNIRLLL EECEQRLLKQ IQSPASSKTD RDARQDITLR IAEQEHTQED 
      1110       1120       1130       1140       1150
LQHLRSDLDA ISMKCNVFLQ QSPSGSSATT LRSELNLMVE KMDHVYGLST 
      1160       1170       1180       1190       1200
VYLNKLKTID VIVRSMQDAE LLVKGYEIKL SQEEAVPADL SALESHRTTL 
      1210       1220       1230       1240       1250
QHWLSDVKDK NSVFSVLDEE ITKAKKVAEQ LRHPASEPNL DLERYQEKGS 
      1260       1270       1280       1290       1300
QLQERWHRVI AQLETRQSEV ESIQEVLRDY RACHGTLIKW IEETTAQQEM 
      1310       1320       1330       1340       1350
MKPGQAEDSR VLSEQLSQQT ELFAEIERNQ TKLDQCQKFS QQYSTIVKDY 
      1360       1370       1380       1390       1400
ELQLMTYKAF VESQQKSPGK RRRMISSSDA ITQEFMDLRT RYTALVTLTT 
      1410       1420       1430       1440       1450
QHVKYISDAL RRLEEEEKVV EEEKQEHVEK VKDLLGWVST LARNTQGTTT 
      1460       1470       1480       1490       1500
SSHTSASADI EKAILEQQVL AEELTTKKEQ VSEAIKTSQI FLAKHGHKLS 
      1510       1520       1530       1540       1550
EGEKEQISEQ LRVLNKTYHD LCDGSANQLQ QLQSELAQQT EQKGCRAVAG 
      1560       1570       1580       1590       1600
VIDLGTVEIF PIFRAMQKGL IDQDTGLVLL ESQIIMSGLI DPENSEKLSL 
      1610       1620       1630       1640       1650
EEGLTRNFIN LPIYQQLLGL RDSLSLVSRL TGTLGSLSVV EAIEKKIISE 
      1660       1670       1680       1690       1700
RLGLKVLEVH LATGGFSLPP SENCINLEEA FHQGFIASSL HSELQSHLRS 
      1710       1720       1730       1740       1750
SKNLIDPNTA EKVGLLDLMQ RCIIHQESGL KLLPVKQLAG GMVSLKSGRK 
      1760       1770       1780       1790       1800
VSIFRAVQEG LIDRQVTVRL LEAQLFAGGI VDPRTGHRLT VEEAVRHNLI 
      1810       1820       1830       1840       1850
DQDMACAILI RQLQTGGIID TVTGDRMTID EAVTNNLVAA KIALVILESL 
      1860       1870       1880       1890       1900
WSFMGLLLPE SGEILPITDA LEQGIVSTEL AHKILHNRQQ IEALFLPTLT 
      1910       1920       1930       1940       1950
EIWSWEKATE SGILDKDLVN NLRSVCIPDM MPHIQLADSA EQSKVGFAAG 
      1960       1970       1980       1990       2000
KPPVSGPREE GSSHGEKLLF QLMTHSYIHA HTGQRLLLLD QELVEMLTSR 
      2010       2020       2030       2040       2050
DDCQVILPEV FEIQHQRLNT SEALQELYTG TISQISSAKH PRKPCESQFL 
      2060       2070       2080       2090       2100
SQNKDYPSQE NCTEAKGERS VVGIECSPAE SPERELFLKE QEAIIENVGS 
      2110       2120       2130       2140       2150
LKVINKVKLK LQRPLLGSRK EEQAETLREE NISGDPLLVE CPEESEGKDL 
      2160       2170       2180       2190       2200
STEKSKCQTP TKCSFTCHKE QVKTIKDIPS ETGTSLIKSQ NQMSQFQVDT 
      2210       2220       2230       2240       2250
SVGLRSEFKS EHDMNVNSLE KELKEELLVK DGHKQSQEGQ SVADGQTVAL 
      2260       2270       2280       2290       2300
EKTDTEDNAD EPALLHSSPF EDATLSTLSA QLQDGGIFNE ETGQKLLLNE 
      2310       2320       2330       2340       2350
AIAQGLVSSH TAVKLMGKLN MFRGFFDSQT CESLTTEEVI DEGLMDEKLL 
      2360       2370       2380       2390       2400
YNVLMSDKAI SGILDPRTHS LCSVKEAVAA GLLDKETATR ILEGQVITGG 
      2410       2420       2430       2440       2450
IVDLKRGKKL SVTLASNLGL VDTADQTELI NLEKATKGRG AEKAVKERLI 
      2460       2470       2480       2490       2500
ELQMETAGLM DPESKAPLTV LQSIDRGILE REAAVYLLTK QVLDGGIIHH 
      2510       2520       2530       2540       2550
ISGLRLSVDN AFKHGLIGED MARQLRKVEN FIHYQFFHPQ TKEALSFSEA 
      2560       2570       2580       2590       2600
IKLDLVSPDL KREIQEIQDF SGNLGDFIYG QKLTLAKTNK EESLANKTEL 
      2610       2620       2630       2640       2650
PSGVMHGVID PENCTIIPYS ELVKKCRIDT ESGWRYLEVI PFSDIKDEAG 
      2660       2670       2680       2690       2700
NNVLTPPEAI QLGKVDFASA LKVLEAQANT GGIIDMATGK RVTLASALEK 
      2710       2720       2730       2740       2750
KLLDENMARI IASHQMLSGG IIDIYSDQRV TLNDAVEKRL ISPELAAMIQ 
      2760       2770       2780       2790       2800
VDPLAEQGGT GVCELKGDFL RKELLSESSK TPRESYSKEK HEAVLQAGSL 
      2810       2820       2830       2840       2850
CAPEKAGIRG SNGEKAEKGR KISVEMEGQR QDEKASSDSK VSASILSPFG 
      2860       2870       2880       2890       2900
FEGESSYQVS VTHPCSESCD LKPREETRSC MKKCAVVERD KVVTQIKMVS 
      2910       2920       2930       2940       2950
HVKQSTSGLD AEEARERQGR MVSKEQGSHY ETAGNLLSER SVRVDRRVRR 
      2960       2970       2980       2990       3000
EMGGEQSVQM SREAAVLSEE ESDQEVTIGD EPDSFVKSQS MKMIGNDKGK 
      3010       3020       3030       3040       3050
EAGIEKDISV VCKIEGFPSQ MTSKDASLTN QDALPFYTEG ETKTVNLCSI 
      3060       3070       3080       3090       3100
LKPGEKLSQE TASTVQKEPL SSEIPRPERL NSQESDEEPQ ISDVPHISKG 
      3110       3120       3130       3140       3150
DMAAQITTRQ ETTDVQDLYI TSKSSETKDK IFPSKNYIEK LHQEIPMDPT 
      3160       3170       3180       3190       3200
RSHKLKEATI STLETEGISY LDSSDIKSLC EDSKADHKSC GHQKSKVTTT 
      3210       3220       3230       3240       3250
QAKKSLEVVD LLVRDTEEGS SEDRVGQRGP RVLASLLPEK LPTRTVQSEN 
      3260       3270       3280       3290       3300
IRQHDAVIPA ISEIREEMAL SLPCSVVKVD GKIPKEKHKE ILGDEQGPFM 
      3310       3320       3330       3340       3350
AIPSGKGIEG VNPEPCRATQ NVFTRRLCLE HDEKLVSYLS LLRDIEMRTK 
      3360       3370       3380       3390       3400
QIQPLELNVA ELQDLLGQAK ELDRELKDLS TVVSQELECV DRIVISQPQE 
      3410       3420       3430       3440       3450
VPAQLLKALE KDAKNLQKSL DSVSDSWSSR FLHLQSAVEV KKATVLNRHK 
      3460       3470       3480       3490       3500
ELQGKLQDLR AWVGRASLTL NSKGCDTETD ADSLSHTLQP YKDMKQSMAE 
      3510       3520       3530       3540       3550
RKSQLDALAL DIQLFISEHP QDLSLQQNQE MLQFLSELQR SFQGLVEHTA 
      3560       3570       3580       3590       3600
AQKDVVQGHL QQVQQEVQVK TLQKQQDTCH KKLEDLCNWV GQAERALERH 
      3610       3620       3630       3640       3650
QGGSSSGKSS LLCAEPKVDL KDLQGDIQSH STSFATAVKD IEGFLEENQT 
      3660       3670       3680       3690       3700
KLSPQELTAL REKLHQAKEQ YEVLQERTRV AQKELEEAVT SALQQETEKS 
      3710       3720       3730       3740       3750
KAATELAENK RKIDALLDWV GLLWGHLRES HRLAFQEWSS SLELAMEKQT 
      3760       3770       3780       3790       3800
LAATDGHVDV NQVPETLDRQ YELMKARHQE LLSQQQNFIV ATQSVQSFLD 
      3810       3820       3830       3840       3850
QHSHNLTPEE RQKLQEKLGE LKEQYAASLA RSEAELKQTQ ALRDELQKFL 
      3860       3870       3880       3890       3900
QDHKEFENWL QQSENELDSM HKGGSSPEAL NSLLKRQGSF SEDVISHKGD 
      3910       3920       3930       3940       3950
LRFVTISGQK VLETENNFEE GQEPSATRNL VNEKLKDATE RYTTLHSKCI 
      3960       3970       3980       3990       4000
RLGSHLSMLL GQYQQFQSSA DSLQAWVLTC EASVGKLLSD TVASDPGVLQ 
      4010       4020       4030       4040       4050
QQLATTKQLQ EELAEHQVPV EKLQKAAHDL LDIEGEPALD CRPIQETTDS 
      4060       4070       4080       4090       4100
ISSRFQNLSC SLDERSALLQ KAIAQSQSVQ ESMESLLQSI REVEQNLERD 
      4110       4120       4130       4140       4150
QVASLSSGVI QEALANNMKL KQDIARQKSS LEATHDMVTR FMETADSNSA 
      4160       4170       4180       4190       4200
SVLQGKLAEL SQRFQQLQLQ QQEKESNLKK LLPQAEMFEQ LSNKLQQFME 
      4210       4220       4230       4240       4250
NKSRLLASGN QPDQDIAHFS QQIQELTLAM EDQKENLDTL EHLVTTLGSC 
      4260       4270       4280       4290       4300
GFALDLSQHQ DKIQNLKKDF TELQKTVQER EKDASTCQEQ LDEFRKLIRT 
      4310       4320       4330       4340       4350
FQKWLKETEG NVPPAKTFVS AKELEKQIEH LKDLISDWES KGALLGEINA 
      4360       4370       4380       4390       4400
KGTALESLIM DITAPDSQAK TGSILPPVGS SVGSVNGYHT CKDLTEIQCD 
      4410       4420       4430       4440       4450
MFDVNSKYEK LWEVLRERQE SLQTVFSRME EVQKEASSVL QWLESKEEVL 
      4460       4470       4480       4490       4500
KAMDATLSPT KTETVKAQAE SNKAFLAELE QNSPKIQKVK EALAGLLKTY 
      4510       4520       4530       4540       4550
PNSQEAENWK KMQEDLNSRW EKATEVTVAR QKQLEESASH LACFQAAESQ 
      4560       4570       4580       4590       4600
LRPWLMEKEL MMGVLGPLSI DPNMLKQQVQ FMLKEFEARR QQHEQLNEAA 
      4610       4620       4630       4640       4650
QGILTGPGDM SPSASQVHKD LQSISQKWVE LTDKLNSRSS QIDQAIVKST 
      4660       4670       4680       4690       4700
QYQDLLQDLS EKVKAIGQRL SGQSAISTQP EAVKQQLEET SEIRSDLGQL 
      4710       4720       4730       4740       4750
DNEIKEAQTL CQELSLLIGE QYLKDELKKR LETVALPLQG LEDLAADRMN 
      4760       4770       4780       4790       4800
RLQAALASTQ QFQQMFDELR TWLDEKQSQQ AKNCPISAKL ERLQCQLQEN 
      4810       4820       4830       4840       4850
EEFQKNLNQH SGSYEVIVAE GEALLLSVPP GEEKKTLQNQ LVELRSHWED 
      4860       4870       4880       4890       4900
LSKKTANRQS RLKDCMQKAQ KYQGHVEDLV PWIDECKSKM SELQVTLDPV 
      4910       4920       4930       4940       4950
QLESSLLRSK AMLNEAEKRR SLLEILNSAA DILINSSEID EDEIRDEKAG 
      4960       4970       4980       4990       5000
LNQNMDAITE ELQAKTSSLE EMTQRLKEFQ ESFKNIEKKV EGAKHQLEIF 
      5010       5020       5030       5040       5050
DALGSQACSN KNLEKLKAQQ EVLQALEPQV DYLRNFTQGL VEDAPDGSDA 
      5060       5070       5080       5090       5100
SPLVHQAEVA QQEFLEVKQR VSSSCLTMEN KLEGIGQFHC RVREMFSQLA 
      5110       5120       5130       5140       5150
DLDDELDGMG AIGRDTDSLQ SQIEDVRLFL NKIQALRFDI EDSEAECRKM 
      5160       5170       5180       5190       5200
LEEEGTLDLL GLKRELEALN KQCGKLTERG KVRQEQLELT LGRVEDFYRK 
      5210       5220       5230       5240       5250
LKALNDAATA AEEGEALQWI VGTEVDVINQ QLADFKLFQK DQVDPLQVKL 
      5260       5270       5280       5290       5300
QQVNGLGQGL IQSAGKNCDV QGLEHDMDEI NTRWNTLNKK VAQRIAQLQE 
      5310       5320       5330       5340       5350
ALLHCGKFQD ALEPLLSWLT DTEELIANQK PPSAEYKVVK AQIQEQKLLQ 
      5360       5370       5380       5390       5400
RLLDDRKATV DMLQAEGGRI AQSAELADRE KITGQLESLE RRWTDLLSKA 
      5410       5420       5430       5440       5450
AARQKQLEDI LVLAKQFHET AEPISDFLSV TANKLANSEP VGTQTAKIHQ 
      5460       5470       5480       5490       5500
QIIRHKALNE EIINRKKNVD QAIKNGQALL KQTTGEEVLL IQEKLDGIKT 
      5510       5520       5530       5540       5550
RYADITLTSS KALRTLEQAR QLATKFHSTY EELTGWLREA EEELAASGGQ 
      5560       5570       5580       5590       5600
SPTGEQIPQF QQRQKELKKE VMEHRLVLDT VNEVSHALLE LVPWRAREGL 
      5610       5620       5630       5640       5650
DKLVSDANEQ YKLISDTVGQ RVDEIDAAIQ RSQQYEQAAD AELAWVAETK 
      5660       5670       5680       5690       5700
RKLMALGPIR LEQDQTTAQL QVQKAFSIDI IRHKDSMDEL FSHRGEIFST 
      5710       5720       5730       5740       5750
CGEEQKAVLQ EKTECLIQQY EAVSLLNSER YARLERAQVL VNQFWETYEE 
      5760       5770       5780       5790       5800
LSPWAEETLA LIAQLPPPAV DHEQLRQQQE EMRQLRESIA EHKPHIDKIL 
      5810       5820       5830       5840       5850
KIGPQLKELN PEEGKMVEEK YQKAENMYAQ IKDEVRQRAL ALDEAVSQSA 
      5860       5870       5880       5890       5900
QFHDKIEPML ETLENLSSRL RMPPLIPAEV DKIRECISDN KSATVELEKL 
      5910       5920       5930       5940       5950
QPSFEALKRR GEELIGRSQG ADKDLAAKEI QDKLDQMVFF WEDIKARSEE 
      5960       5970       5980       5990       6000
REIKFLDVLE LAEKFWYDMA ALLTTIKDTQ DIVHDLESPG IDPSIIKQQV 
      6010       6020       6030       6040       6050
EAAETIKEET DGLHEELEFI RILGADLIFA CGETEKPEVK KSIDEMNNAW 
      6060       6070       6080       6090       6100
ENLNKTWKER LEKLEDAMQA AVQYQDTLQA MFDWLDNTVI KLCTMPPVGT 
      6110       6120       6130       6140       6150
DLNTVKDQLN EMKEFKVEVY QQQIEMEKLN HQGELMLKKA TDETDRDIIR 
      6160       6170       6180       6190       6200
EPLTELKHLW ENLGEKIAHR QHKLEGALLA LGQFQHALEE LMSWLTHTEE 
      6210       6220       6230       6240       6250
LLDAQRPISG DPKVIEVELA KHHVLKNDVL AHQATVATVN KAGSELLESS 
      6260       6270       6280       6290       6300
AGDDASSLRS RLETMNQCWE SVLQKTEERE QQLQSTLQQA QGFHSEIEDF 
      6310       6320       6330       6340       6350
LLELNRMENQ LSASKPTGGL PETAREQLDT HMELHSQLRA KEEIYNQLLD 
      6360       6370       6380       6390       6400
KGRLMLLSRG DSGSGSKTEQ SVALLEQKWH AVSSKVEERK SKLEEALSLA 
      6410       6420       6430       6440       6450
TEFQNSLQEF INWLTLAEQS LNIASPPSLI LNTVLSQIEE HKVFANEVND 
      6460       6470       6480       6490       6500
HRDQIIELDQ TGNQLKFLSQ KQDVVLIKNL LVSVQSRWEK VVQRSIERGR 
      6510       6520       6530       6540       6550
SLDDARKRAK QFHEAWKKLI DWLEDAESHL DSELEISNDP DKIKLQLSKH 
      6560       6570       6580       6590       6600
KEFQKTLGGK QPVYDTTIRT GRALKEKTLL AGDTQKLDNL LGEVRDKWDT 
      6610       6620       6630       6640       6650
VCGKSVERQH KLEEALLFSG QFMDALQALV DWLYKVEPQL AEDQPVHGDL 
      6660       6670       6680       6690       6700
DLVMNLMDAH KVFQKELGKR TGTVQVLKRS GRELIEGSRD DTTWVKGQLQ 
      6710       6720       6730       6740       6750
ELSTRWDTVC KLSVSKQSRL EQALKQAEEF RDTVHMLLEW LSEAEQTLRF 
      6760       6770       6780       6790       6800
RGALPDDTEA LQSLIDTHKE FMKKVEEKRV DVNTAVAMGE AILAVCHPDC 
      6810       6820       6830       6840       6850
ITTIKHWITI IRARFEEVLT WAKQHQQRLE TALSELVANA ELLEELLAWI 
      6860       6870       6880       6890       6900
QWAETTLIQR DQEPIPQNID RVKALITEHQ SFMEEMTRKQ PDVDRVTKTY 
      6910       6920       6930       6940       6950
KRKSVEPTHA PFMEKSRSGS RKSLNQPTPP PMPILSQSEA KNPRINQLSA 
      6960       6970       6980       6990       7000
RWQQVWLLAL ERQRKLNDAL DRLEELCPEL KEFANFDFDV WRKKYMRWMN 
      7010       7020       7030       7040       7050
HKKSRVMDFF RRIDKDQDGK ITRQEFIDGI LASKFPTTKL EMTAVADIFD 
      7060       7070       7080       7090       7100
RDGDGYIDYY EFVAALHPNK DAYRPTTDAD KIEDEVTRQV AQCKCAKRFQ 
      7110       7120       7130       7140       7150
VEQIGENKYR FFLGNQFGDS QQLRLVRILR STVMVRVGGG WMALDEFLVK 
      7160       7170       7180       7190       7200
NDPCRARGRT NIELREKFIL PEGASQGMTP FRSRGRRSKP SSRAASPTRS 
      7210       7220       7230       7240       7250
SSSASQSNHS CTSMPSSPAT PASGTKVISS SGSKLKRPTP AFHSSRTSLA 
      7260       7270       7280       7290       7300
GDTSNSSSPA STGAKANRAD PKKSASRPGS RAGSRAGSRA SSRRGSDASD 
      7310       7320       7330       7340       7350
FDLLETQSAC SDTSESSAAG GQGSSRRGLT KPSKIPTMSK KTTTASPRTP 

GPKR
Length:7,354
Mass (Da):831,878
Last modified:June 28, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2B68195989DE15C7
GO
Isoform 2 (identifier: Q9QXZ0-2) [UniParc]FASTAAdd to basket
Also known as: Macf1a

The sequence of this isoform differs from the canonical sequence as follows:
     1543-3569: Missing.

Show »
Length:5,327
Mass (Da):607,947
Checksum:i5E74E7C618CF0371
GO
Isoform 3 (identifier: Q9QXZ0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: MSSSDEETLS...PAERAVVRVA → EKEFVQAYEDVLERYK
     1543-3569: Missing.

Note: Incomplete sequence.
Show »
Length:5,270
Mass (Da):601,744
Checksum:iB0135FD543CEAD3A
GO
Isoform 4 (identifier: Q9QXZ0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-181: MSSSDEETLS...LIWTIILHFQ → MGNSLGCVKE...SEEDGTLSLE
     1543-3569: Missing.

Show »
Length:5,478
Mass (Da):622,158
Checksum:i1B7ECC46D414444A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PVY8E9PVY8_MOUSE
Microtubule-actin cross-linking fac...
Macf1
7,355Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MQA6A0A0A0MQA6_MOUSE
Microtubule-actin cross-linking fac...
Macf1
5,328Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1ARU4B1ARU4_MOUSE
Microtubule-actin cross-linking fac...
Macf1
7,353Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7ACR9F7ACR9_MOUSE
Microtubule-actin cross-linking fac...
Macf1
5,333Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QA63E9QA63_MOUSE
Microtubule-actin cross-linking fac...
Macf1
7,351Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QNP1E9QNP1_MOUSE
Microtubule-actin cross-linking fac...
Macf1
5,478Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6Q750F6Q750_MOUSE
Microtubule-actin cross-linking fac...
Macf1
4,429Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1ARU1B1ARU1_MOUSE
Microtubule-actin cross-linking fac...
Macf1
5,895Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6YKN8F6YKN8_MOUSE
Microtubule-actin cross-linking fac...
Macf1
544Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6RCJ3F6RCJ3_MOUSE
Microtubule-actin cross-linking fac...
Macf1
452Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC52989 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence CAM18553 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAM20969 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti242D → N in AAD32244 (PubMed:10601340).Curated1
Sequence conflicti242D → N in AAC52988 (PubMed:8954775).Curated1
Sequence conflicti242D → N in AAC52989 (PubMed:8954775).Curated1
Sequence conflicti242D → N in AAC52990 (PubMed:8954775).Curated1
Sequence conflicti393P → L in AAD32244 (PubMed:10601340).Curated1
Sequence conflicti393P → L in AAY78553 (PubMed:16076900).Curated1
Sequence conflicti393P → L in AAC52988 (PubMed:8954775).Curated1
Sequence conflicti393P → L in AAC52989 (PubMed:8954775).Curated1
Sequence conflicti794D → N in AAY78553 (PubMed:16076900).Curated1
Sequence conflicti815C → A in AAD32244 (PubMed:10601340).Curated1
Sequence conflicti815C → A in AAC52988 (PubMed:8954775).Curated1
Sequence conflicti815C → A in AAC52989 (PubMed:8954775).Curated1
Sequence conflicti815C → A in AAC52990 (PubMed:8954775).Curated1
Sequence conflicti928E → G in AAD32244 (PubMed:10601340).Curated1
Sequence conflicti928E → G in AAY78553 (PubMed:16076900).Curated1
Sequence conflicti3795V → A in AAD32244 (PubMed:10601340).Curated1
Sequence conflicti3795V → A in AAY78553 (PubMed:16076900).Curated1
Sequence conflicti3909Q → H in AAC52988 (PubMed:8954775).Curated1
Sequence conflicti3909Q → H in AAC52989 (PubMed:8954775).Curated1
Sequence conflicti3909Q → H in AAC52990 (PubMed:8954775).Curated1
Sequence conflicti4735A → V in AAD32244 (PubMed:10601340).Curated1
Sequence conflicti4735A → V in AAY78553 (PubMed:16076900).Curated1
Sequence conflicti4750N → S in AAD32244 (PubMed:10601340).Curated1
Sequence conflicti4750N → S in AAY78553 (PubMed:16076900).Curated1
Sequence conflicti4891S → F in AAD32244 (PubMed:10601340).Curated1
Sequence conflicti4891S → F in AAY78553 (PubMed:16076900).Curated1
Sequence conflicti5587A → V in AAD32244 (PubMed:10601340).Curated1
Sequence conflicti5587A → V in AAY78553 (PubMed:16076900).Curated1
Sequence conflicti5603L → R in AAD32244 (PubMed:10601340).Curated1
Sequence conflicti5603L → R in AAY78553 (PubMed:16076900).Curated1
Sequence conflicti5971A → V in AAD32244 (PubMed:10601340).Curated1
Sequence conflicti5971A → V in AAY78553 (PubMed:16076900).Curated1
Sequence conflicti6309N → T in AAD32244 (PubMed:10601340).Curated1
Sequence conflicti6309N → T in AAY78553 (PubMed:16076900).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0413941 – 181MSSSD…ILHFQ → MGNSLGCVKEPKESIAVPEK APISPKKRVRFKRKWRGKKI LTPEASHREEALEGTGVIEE TETLTKLTARLPKEPGVGGA EHPPSDIFLPGDSAPNSGVG DQGMIVQVKESFQAEIQTAH LLLENESSVVGGAWDSLEEG MTVIAHLLDNPAERNCEKSV SQLVEFPRTASCSSRAVLLP LQGETAVEQGGTLLRHRHRS STLPRTDYPSETVDQDQPSE GWSVGGRTKSVPSAPPTGSW IAKCSVASSIPKQSGDPIHT EPTHVGLVSCKGPIMPASQS DLSVSGITVSILPSSSGYGS DGLRLHGIRPEDTEPEKTST PFSEEDGTLSLE in isoform 4. 1 PublicationAdd BLAST181
Alternative sequenceiVSP_0413951 – 73MSSSD…VVRVA → EKEFVQAYEDVLERYK in isoform 3. CuratedAdd BLAST73
Alternative sequenceiVSP_0413961543 – 3569Missing in isoform 2, isoform 3 and isoform 4. 2 PublicationsAdd BLAST2027

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF150755 mRNA Translation: AAD32244.1
DQ067088 mRNA Translation: AAY78553.1
AL606932, AL606918 Genomic DNA Translation: CAM18553.1 Sequence problems.
AL606918, AL606932 Genomic DNA Translation: CAM20969.1 Sequence problems.
U67203 mRNA Translation: AAC52988.1
U67204 mRNA Translation: AAC52989.1 Different initiation.
U67205 mRNA Translation: AAC52990.1

Protein sequence database of the Protein Information Resource

More...PIRi		T30847
T30849
T42725

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF150755 mRNA Translation: AAD32244.1
DQ067088 mRNA Translation: AAY78553.1
AL606932, AL606918 Genomic DNA Translation: CAM18553.1 Sequence problems.
AL606918, AL606932 Genomic DNA Translation: CAM20969.1 Sequence problems.
U67203 mRNA Translation: AAC52988.1
U67204 mRNA Translation: AAC52989.1 Different initiation.
U67205 mRNA Translation: AAC52990.1
PIRiT30847
T30849
T42725

3D structure databases

SMRiQ9QXZ0
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9QXZ0, 20 interactors
MINTiQ9QXZ0
STRINGi10090.ENSMUSP00000119600

PTM databases

iPTMnetiQ9QXZ0
PhosphoSitePlusiQ9QXZ0
SwissPalmiQ9QXZ0

Proteomic databases

EPDiQ9QXZ0
jPOSTiQ9QXZ0
PaxDbiQ9QXZ0
PeptideAtlasiQ9QXZ0
PRIDEiQ9QXZ0

Organism-specific databases

MGIiMGI:108559 Macf1

Phylogenomic databases

eggNOGiKOG0516 Eukaryota
COG5069 LUCA
HOGENOMiHOG000049054
InParanoidiQ9QXZ0

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Macf1 mouse

Protein Ontology

More...PROi		PR:Q9QXZ0

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Family and domain databases

CDDicd00014 CH, 2 hits
cd00051 EFh, 1 hit
Gene3Di1.10.418.10, 2 hits
3.30.920.20, 1 hit
3.90.1290.10, 6 hits
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR041615 Desmoplakin_SH3
IPR041573 Desmoplakin_Spectrin-like
IPR029926 Dystonin-like
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR003108 GAR_dom
IPR036534 GAR_dom_sf
IPR035915 Plakin_repeat_sf
IPR001101 Plectin_repeat
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
PANTHERiPTHR23169:SF24 PTHR23169:SF24, 2 hits
PfamiView protein in Pfam
PF00307 CH, 2 hits
PF13499 EF-hand_7, 1 hit
PF02187 GAS2, 1 hit
PF00681 Plectin, 8 hits
PF17902 SH3_10, 1 hit
PF00435 Spectrin, 18 hits
PF18373 Spectrin_like, 1 hit
SMARTiView protein in SMART
SM00033 CH, 2 hits
SM00054 EFh, 2 hits
SM00243 GAS2, 1 hit
SM00250 PLEC, 19 hits
SM00150 SPEC, 34 hits
SUPFAMiSSF143575 SSF143575, 1 hit
SSF47473 SSF47473, 1 hit
SSF47576 SSF47576, 1 hit
SSF75399 SSF75399, 6 hits
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 1 hit
PS50021 CH, 2 hits
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits
PS51460 GAR, 1 hit
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMACF1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9QXZ0
Secondary accession number(s): B1ARU3
, P97394, P97395, P97396, Q4PLL5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 28, 2011
Last modified: October 16, 2019
This is version 178 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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