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Entry version 114 (16 Oct 2019)
Sequence version 2 (13 Sep 2004)
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Protein

Cytoplasmic dynein 2 heavy chain 1

Gene

DHC1B

Organism
Chlamydomonas reinhardtii (Chlamydomonas smithii)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as a motor for intraflagellar retrograde transport. Functions in flagellar biogenesis.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi150 – 157ATPSequence analysis8
Nucleotide bindingi1743 – 1750ATPSequence analysis8
Nucleotide bindingi2034 – 2041ATPSequence analysis8
Nucleotide bindingi2334 – 2341ATPSequence analysis8
Nucleotide bindingi2679 – 2686ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • dynein light chain binding Source: GO_Central
  • microtubule motor activity Source: InterPro
  • motor activity Source: BHF-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Motor protein
Biological processCilium biogenesis/degradation
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytoplasmic dynein 2 heavy chain 1
Alternative name(s):
Cytoplasmic dynein heavy chain 1b
Short name:
cDHC1b
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DHC1B
Synonyms:DHC2
ORF Names:CHLREDRAFT_24009
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiChlamydomonas reinhardtii (Chlamydomonas smithii)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3055 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeChlorophytaChlorophyceaeChlamydomonadalesChlamydomonadaceaeChlamydomonas

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Flagellum, Membrane, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Algae display short flagellar stumps filled with aberrant microtubules, raft-like particles and other amorphous material.2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003187471 – 4334Cytoplasmic dynein 2 heavy chain 1Add BLAST4334

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9SMH5

PRoteomics IDEntifications database

More...
PRIDEi
Q9SMH5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated during flagellum biogenesis.2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The cytoplasmic dynein complex 2 is probably composed by a DHC1B homodimer and a number of D1BLIC light intermediate chains.

Interacts with FAP133, FLA10 and LC8.

3 Publications

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3055.EDP08405

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9SMH5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 1704StemBy similarityAdd BLAST1704
Regioni1705 – 1929AAA 1By similarityAdd BLAST225
Regioni1996 – 2211AAA 2By similarityAdd BLAST216
Regioni2299 – 2544AAA 3By similarityAdd BLAST246
Regioni2641 – 2882AAA 4By similarityAdd BLAST242
Regioni2897 – 3185StalkBy similarityAdd BLAST289
Regioni3260 – 3492AAA 5By similarityAdd BLAST233
Regioni3701 – 3917AAA 6By similarityAdd BLAST217

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1026 – 1097Sequence analysisAdd BLAST72
Coiled coili2930 – 2998Sequence analysisAdd BLAST69
Coiled coili3120 – 3199Sequence analysisAdd BLAST80

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dynein heavy chain family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3595 Eukaryota
COG5245 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9SMH5

Database of Orthologous Groups

More...
OrthoDBi
26380at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.20.180.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR035699 AAA_6
IPR035706 AAA_9
IPR041658 AAA_lid_11
IPR042219 AAA_lid_11_sf
IPR042228 Dynein_2_C
IPR042222 Dynein_2_N
IPR041228 Dynein_C
IPR024743 Dynein_HC_stalk
IPR024317 Dynein_heavy_chain_D4_dom
IPR004273 Dynein_heavy_D6_P-loop
IPR013594 Dynein_heavy_dom-1
IPR013602 Dynein_heavy_dom-2
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12774 AAA_6, 1 hit
PF12780 AAA_8, 1 hit
PF12781 AAA_9, 1 hit
PF18198 AAA_lid_11, 1 hit
PF08385 DHC_N1, 1 hit
PF08393 DHC_N2, 1 hit
PF18199 Dynein_C, 1 hit
PF03028 Dynein_heavy, 1 hit
PF12777 MT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9SMH5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSDSRKTFV VTTIACAIAP AGQQDQYAAY LGQDENGAIA SFLDSTQNTL
60 70 80 90 100
QAGVSGLGTG QLQLKLSNAA EFPEGCEFSV VLSKLRAGPI RTEDVPAGVA
110 120 130 140 150
VATVAHSPLS SLYHTLKDVY SPLIKSQTAE GVPVLDKRLS ELLAQVQAGL
160 170 180 190 200
GTAVRKGVPA SAQEVADPNQ APLQEVVTPL DEINFWAELT NSPNAGPIKS
210 220 230 240 250
SALQVSSALE PLRQSFEQLS SDAPEGEGGS IGWEGAKELV DLTTNALRAA
260 270 280 290 300
WPVKLPIGGW AMGQKRADNF LRVVGAALAT YVQRRVDRLA AAGRGDLWSA
310 320 330 340 350
PFGEVRAVLV GASGLMTRWV QESTALVEDW RLGVDTGGHD WEGAAFADAY
360 370 380 390 400
VRSFQERLEE IYNMREMVDE LAKLVGREEA GSLGVQQVFA PFQGLQALQV
410 420 430 440 450
SDFNTHVWKA AHEDFERRMG PIEQRISQKL KELFASVIIP SLTSAIGPGR
460 470 480 490 500
GGDRAAAGGS LIQPQQVFAE IKRYSSLMGR KNIASALQSE KETLAKQVDR
510 520 530 540 550
HLDSVQAEFD AHRDSATGGA KVAPVGRVTA SIVERIMWCM QTLQKLGKVS
560 570 580 590 600
EVLKHMLRGG VAGDEGSGGA ALRNTLGVVS ELQKEVEIFR KEQYSAWEEW
610 620 630 640 650
MSEELGEMAN WKNSKLMTFD SQNSHVKTHF NDQLVLLLRE VRQLQSLGFG
660 670 680 690 700
VRKDILNEVE IANKFYRYGM VLKQRANFYN NIATEMVQCQ KPMMLKDALD
710 720 730 740 750
FEKVLMNPKD AQGKEITWRN AAALDGYVRR LNEVADRLAE KNRTLRKWHS
760 770 780 790 800
VLSDKVVTLA GTDLVRHKDK WAAGVKEMRE IFGRLEAEGY SRESQQVWRQ
810 820 830 840 850
HWDFQLYKAL EVQYLSGLEM INKTLPEVEV KMVFRQHRLQ YDPPLEELRI
860 870 880 890 900
RHVKDLLNTF LGLPLRMKGV SDLSERPGFF RPIVDANPTG IARVYAAAES
910 920 930 940 950
LFTQLADELK KYQDWMVLGT LDLDEFADAN LLEVSDWELN FRMLKAASRD
960 970 980 990 1000
AEKLPNEIRI ECYKVSLAPV KGSIDEHMKK LQDTLVASLR RKTVAEKDQI
1010 1020 1030 1040 1050
EDFMKNGREL FTRQANTVED IGLAGQEAKG LTAKLAEVQA ARRRIDEKNK
1060 1070 1080 1090 1100
LLRQMAGGGR DAAFAVVDLT EVNNSWDAFT NQLQQFDAHL EEQKGNLAVQ
1110 1120 1130 1140 1150
ISRQLEEFKG KVAGMNSRWQ ELKPKSGPSG NPAVVLAKIQ EYANAIKELR
1160 1170 1180 1190 1200
EESAKLYKEA EAFKIDVPDF ELMTEMETDV MATKAHWDRY ADFLRERDEM
1210 1220 1230 1240 1250
ANRDWLSMRD QVWKIEDFLA KWTKATAGKS DDPIAVILTQ EIDNYTLCLP
1260 1270 1280 1290 1300
HLKSCLRGAG WEDTHWNQLF GLLGMKTSGP AAVSKETVTL THFLEKADLV
1310 1320 1330 1340 1350
VKHADVIKSL DAQAQGEAVI RKALTELKMW GMAREFTFTE STQSVAGRQR
1360 1370 1380 1390 1400
RTPLIKEWRD AMTEVGDNQS LVASLKQSSY YNMFKDEVSS WENKLSFLQE
1410 1420 1430 1440 1450
GLTLLNQIQR KWVYLEPIFG RGALPSQQQR FRNVDEEFRR TMTSLESTKK
1460 1470 1480 1490 1500
VVTFADIPGI RDKLPQMAQQ LDVCQRALAD FLEEKRSQFP RFYFLGDDDL
1510 1520 1530 1540 1550
LEILGQARNP AVIQSHLKKL FAGIQKVKFS QDQSTIQAMQ SMEGEVVDLA
1560 1570 1580 1590 1600
PTVRITEQIE TWLGDLTRSM KNTLQQQNEV LCAGRMNDEF RAAASQCLQL
1610 1620 1630 1640 1650
KEAVAFTEKA EVALKAGSSG LAKLVTEMRA QLMKLTGSDF TGHHLLQLKK
1660 1670 1680 1690 1700
QALVLDFIHY CDVAEYLAKD KIGGTTEWGW TRQLRYYHRA EGSVKVAMAE
1710 1720 1730 1740 1750
ATFDYTWEYQ GNAAKLVYTP LTDKCYLTLT QGMALGYGGN PYGPAGTGKT
1760 1770 1780 1790 1800
ESVKALGQAL ARQVLVFNCD EEFDFKSMGR IFVGLVKCGA WGCFDEFNRL
1810 1820 1830 1840 1850
DEEVLSAVSQ QIQTIQLALK EGAKTMMFMD KTVEVDKNAG IFVTLNPAGK
1860 1870 1880 1890 1900
GYGGRSKLPD NLKQLFRSIA MTVPNNELIA EVLLLSEGFN HAKDLARKLV
1910 1920 1930 1940 1950
SLFSLSRELL SPQQHYDWGL RALKTVLGIA GRELRDARKA GQNVDAEIEA
1960 1970 1980 1990 2000
EIIIRSVAAT KLPTLTFDDN SRFKALINDL FPGAKLTDAR NEALEKALAE
2010 2020 2030 2040 2050
AAAACKMELT QQQIDRMLQL HLACEQRIGV IIVGPSGSGK STLWELLEKA
2060 2070 2080 2090 2100
YERLGRKPIV YKMNPKAMPR QQLLGSMNMD TREWSDGVLT AAARKVVKEP
2110 2120 2130 2140 2150
LEQRSWIICD GDVDPEWIES LNSVLDDNRL LTMPNGERIQ FANNVNFIFE
2160 2170 2180 2190 2200
CHSLEFASPA TVSRCGMLFM SDEAMEVERM LQRWLKVQAT DNGDPGQMQS
2210 2220 2230 2240 2250
WMNDFFDKAF QWALSHPRAV ETTKGGILDS GLSHLKLGPG SKQEFMAGLC
2260 2270 2280 2290 2300
RGLGSNMNPD IRNQFYNDMA RMSGEGGIMD VGVATDPLIV LGDELRERGM
2310 2320 2330 2340 2350
DEADGGLVVT PEVTQNLLMM APWFKNRDPF LVVGPEGCGK GALLDYCFKR
2360 2370 2380 2390 2400
IMGVQVAVVN CSAQTSAANV VQKLVQVCGK PVTTTSGKAL RPPDNTRVIL
2410 2420 2430 2440 2450
YLKDLNLPRP DKYNTCQLIS FLQQLIAHHG YYDENLDFIR VERVQIVGSM
2460 2470 2480 2490 2500
TPPGSVGRHA LSTRFTALVR IVTMGYPDRE NLATIYTNMA QRVLANSKTA
2510 2520 2530 2540 2550
SSVSPAALSK AMLEVYSSVR ERFTPNDYPH YEFNARELSD WINGIQRYSL
2560 2570 2580 2590 2600
EGGLTLVQAI AHEGLRVFRD RLVGDHQEQF TSMLYGTLTS LLGYKPDATP
2610 2620 2630 2640 2650
WYTSTLGASA EERISGDLTK IKMLRWEQDT FAELVAEKLK GYEREHKELN
2660 2670 2680 2690 2700
LLLFPEVLER VSRFDRVLSQ QGGSLLLCGN SGVGRRSLML LLAYMHNMDF
2710 2720 2730 2740 2750
ITPKMTKNYD LKSFRNDLKE VLRRAGVEAK PVMLFLEDHQ LVNNAFLELV
2760 2770 2780 2790 2800
NSLLSGGEVP GLFTPEELAK ELAPLDKARD EDPLYTGPSN SYAFFSYRIR
2810 2820 2830 2840 2850
RNLHIVVSMD PSNEMFRSRC EANPALFTRC SVQWLEGWSV KGLQQIAAAR
2860 2870 2880 2890 2900
LTELVESSPE LMKLGRDKLI NHMIHIHASS GSQTTREYLA LVSLYGQIYN
2910 2920 2930 2940 2950
RKRTQVLEQQ NFLKGGLGKL AEAAVTVDTL SAEAEKQRVV LKAKQAEADE
2960 2970 2980 2990 3000
ALVHIQDSML KAADRRKEVE VLKKRTAIEE VEMKERRVKV EEELSEVQPL
3010 3020 3030 3040 3050
IDAARKAVGN IKKDNIAEIR SLKMPPDAIR DVLEGVLMVL GQQDTSWNNM
3060 3070 3080 3090 3100
KTFLGKGSVK DDIINYDAHK ITPEIRARCA KLLAAKGNSF EDAVIRRVSV
3110 3120 3130 3140 3150
AAAPMAQWFK ANLEFSKVLE RVSPLESELH RLQSSLEESQ RLIKQYEEEL
3160 3170 3180 3190 3200
VQLDAAVASL KAEFSKKTSE AETLKISVDK AESVLSSARQ LLDGLRGEKV
3210 3220 3230 3240 3250
RWEITVGTLG EQLKELPLSS LLAAAFITYL PSHPEEHRLK VTKDWCAYLG
3260 3270 3280 3290 3300
AAEFDVTRFL SSESEMLKWK AEGLPADGLS AQNAVVILNS TSRSPLIIDP
3310 3320 3330 3340 3350
STQASEWLKS HLRVTGQNVE VTTMADQRFT TTLELAVRFG KTLVVAEVDK
3360 3370 3380 3390 3400
VEPILYPLLR MDLDRQGPRF VVQIGDKATD YNDTFRLFLV TRNPDPYLPP
3410 3420 3430 3440 3450
DARSLLAVTN FTVTRSGLEG QLLGLTLQKE RPELEEQKST MLRQEDECKV
3460 3470 3480 3490 3500
ALAELERNLL QTLATSTGNI LENKDLLDKL NETKTRSATV EKALTESKTL
3510 3520 3530 3540 3550
QASLDQQREV YRPIAARGSV MYFLLADLQA LNQMYTFSLS VFLNLFKKAL
3560 3570 3580 3590 3600
DRDTPPGGDV TARIALLAES LLELVFAYVS RSLFNADRLT FGMHMARHLQ
3610 3620 3630 3640 3650
PSLFPEAQWA FFLGKPVPDS ASPPPKPSWV REEQAGAFSA LAAAFPQLVA
3660 3670 3680 3690 3700
AAELADSALW AQWASGATDA LPGKIAGGKV NPFQQLLLVK AFRPDRLQSA
3710 3720 3730 3740 3750
MSSFICGTLN IKSVSPPPFS LKALIEGETR PDEPVLFITT PGADPSQELS
3760 3770 3780 3790 3800
EYAAQTMGKE RWYFEVAMGQ GQAEKAVTLL RECAKNGDWL VLKNVHLAVS
3810 3820 3830 3840 3850
WLPSLEKELL MLQKHDNFRI FLTSEPHPKF PSTLLEMSLK VTFEAPPGMK
3860 3870 3880 3890 3900
KNLQRTYEAW SAEYLASGPP IRAQLLFVLA WFHAVVQERR TYIPQGWTKF
3910 3920 3930 3940 3950
YEFSFADLRS GMDVITLATR AGTAPQWPLL LGLLDDAIYG GRLDNPFDSQ
3960 3970 3980 3990 4000
VLLTFLRRLF SAETVGAAGG KVRPLPGSKV VVPTTNHRAD YVSIISALPD
4010 4020 4030 4040 4050
VDTPGLFCMP DNIDRTAQQV NSARVISQLK AMSLRADAAG GFNRAQWQAQ
4060 4070 4080 4090 4100
LGPLLRLWDQ LMSGASALKA AMKDIRARGT TDKGGAPIEN FVALERYKGA
4110 4120 4130 4140 4150
SLVALIDRTL GAIARVLKGT DTLSSGVQSS GAALLADVIP GSWDAAWEGP
4160 4170 4180 4190 4200
EAPMDYCRAV VAKALAIEGH WARCQQPGGG GLLDGSGGAG PLELSSVFHP
4210 4220 4230 4240 4250
GTFLNALRQQ SARTLGCSMD MLKAVTSWET AKLKAAAGGA PVALLGGLIM
4260 4270 4280 4290 4300
QGATFDGSRL SPVAAEAPAF RAVPAMSMAW LHKDSPMAYA SYMEAPLYMT
4310 4320 4330
SDRSKLLARV QLPVSGPEEM DGWVLAGLSL FLSV
Length:4,334
Mass (Da):481,652
Last modified:September 13, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE2DA5EAE0E8605B0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2005C → L in AAC99457 (PubMed:9971742).Curated1
Sequence conflicti3762Missing in EDP08405 (PubMed:17932292).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ132478 Genomic DNA Translation: CAB56748.2
DS496110 Genomic DNA Translation: EDP08405.1
AF096277 mRNA Translation: AAC99457.1

Protein sequence database of the Protein Information Resource

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PIRi
T34340

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132478 Genomic DNA Translation: CAB56748.2
DS496110 Genomic DNA Translation: EDP08405.1
AF096277 mRNA Translation: AAC99457.1
PIRiT34340

3D structure databases

SMRiQ9SMH5
ModBaseiSearch...

Protein-protein interaction databases

STRINGi3055.EDP08405

Proteomic databases

PaxDbiQ9SMH5
PRIDEiQ9SMH5

Phylogenomic databases

eggNOGiKOG3595 Eukaryota
COG5245 LUCA
InParanoidiQ9SMH5
OrthoDBi26380at2759

Family and domain databases

Gene3Di1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.20.180.20, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR035699 AAA_6
IPR035706 AAA_9
IPR041658 AAA_lid_11
IPR042219 AAA_lid_11_sf
IPR042228 Dynein_2_C
IPR042222 Dynein_2_N
IPR041228 Dynein_C
IPR024743 Dynein_HC_stalk
IPR024317 Dynein_heavy_chain_D4_dom
IPR004273 Dynein_heavy_D6_P-loop
IPR013594 Dynein_heavy_dom-1
IPR013602 Dynein_heavy_dom-2
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF12774 AAA_6, 1 hit
PF12780 AAA_8, 1 hit
PF12781 AAA_9, 1 hit
PF18198 AAA_lid_11, 1 hit
PF08385 DHC_N1, 1 hit
PF08393 DHC_N2, 1 hit
PF18199 Dynein_C, 1 hit
PF03028 Dynein_heavy, 1 hit
PF12777 MT, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 3 hits
SUPFAMiSSF52540 SSF52540, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDYHC2_CHLRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9SMH5
Secondary accession number(s): A8HYT6, Q9ZSS7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: September 13, 2004
Last modified: October 16, 2019
This is version 114 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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