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Entry version 163 (13 Nov 2019)
Sequence version 1 (01 May 2000)
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Protein

Phosphatidylinositol 3-kinase catalytic subunit type 3

Gene

vps-34

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate (PubMed:11927551). Together with bec-1, mediates the production of phosphatidylinositol 3-phosphate on intracellular vesicles and thereby regulates membrane trafficking (PubMed:11927551, PubMed:16111945). Plays a role in endosome-to-Golgi retrograde transport of mig-14 (PubMed:21183797). Involved in clearance of apoptotic cell corpses by phagosomes (PubMed:22272187). Phagosome maturation requires two sequential and non-overlapping pulses of phosphatidylinositol-3-phosphate (PI3P) on the vesicle surface which mediates recruitment of sortins snx-1 and lst-4 and small GTPases rab-5, rab-2 and rab-7, downstream of dynamin dyn-1 (PubMed:22272187, PubMed:18425118). The first pulse is initiated by piki-1, then maintained by vps-34 which also produces the second pulse (PubMed:22272187). Required for embryonic development (PubMed:22272187). Together with bec-1, involved in L3/L4 larval molting stage probably by regulating cuticle shedding (PubMed:11927551). Regulates the expansion of the nucleus outer membrane (PubMed:11927551). Involved in the secretion and localization of lrp-1 at the apical surface of hyp7 syncytium (PubMed:16111945). May regulate endocytosis in hypodermal cells (PubMed:11927551). May play a role in the formation of gut granules (a lysosome-related organelle) (PubMed:15843430). Plays a role in germ stem cell proliferation during larval development (PubMed:28285998).7 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mn2+1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by wortmannin.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
Biological processEndocytosis, Lipid biosynthesis, Lipid metabolism, Phagocytosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-1632852 Macroautophagy
R-CEL-1660514 Synthesis of PIPs at the Golgi membrane
R-CEL-1660516 Synthesis of PIPs at the early endosome membrane
R-CEL-1660517 Synthesis of PIPs at the late endosome membrane
R-CEL-5668599 RHO GTPases Activate NADPH Oxidases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9TXI7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatidylinositol 3-kinase catalytic subunit type 3By similarity (EC:2.7.1.137UniRule annotation1 Publication)
Short name:
PI3-kinase type 3By similarity
Short name:
PI3K type 3By similarity
Alternative name(s):
Phosphoinositide-3-kinase class 3By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:vps-34Imported
Synonyms:let-512Imported
ORF Names:B0025.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
B0025.1a ; CE24759 ; WBGene00006932 ; vps-34
B0025.1b ; CE24760 ; WBGene00006932 ; vps-34
B0025.1c ; CE37691 ; WBGene00006932 ; vps-34

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown causes a defect in the clearance of apoptotic cell corpses in gonads, a loss of rab-5 recruitment to cell corpse-containing nascent phagosomes and a decrease in PI3P levels on phagosome membranes (PubMed:18425118, PubMed:22272187). In addition, causes a reduction in mig-14 and rme-8 association with puncta structures as well as an increase in mig-14 protein levels (PubMed:21183797). RNAi-mediated knockdown results in reduced germ stem cell proliferation during larval development (PubMed:28285998).4 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004362971 – 901Phosphatidylinositol 3-kinase catalytic subunit type 3CuratedAdd BLAST901

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9TXI7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9TXI7

PeptideAtlas

More...
PeptideAtlasi
Q9TXI7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Highly expressed in embryos and at L2 larval stage, and to a lower extent in subsequent larval stages and in adults.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00006932 Expressed in 5 organ(s), highest expression level in multi-cellular organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with bec-1 (PubMed:16111945, PubMed:26783301). May interact with dyn-1 (PubMed:18425118).

1 Publication2 Publications

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.B0025.1a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9TXI7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 189C2 PI3K-typePROSITE-ProRule annotationAdd BLAST169
Domaini302 – 527PIK helicalPROSITE-ProRule annotationAdd BLAST226
Domaini642 – 900PI3K/PI4KPROSITE-ProRule annotationAdd BLAST259

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0906 Eukaryota
COG5032 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156943

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000174003

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9TXI7

KEGG Orthology (KO)

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KOi
K00914

Identification of Orthologs from Complete Genome Data

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OMAi
LHKFAQY

Database of Orthologous Groups

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OrthoDBi
204282at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9TXI7

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1070.11, 1 hit
1.25.40.70, 1 hit
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR035892 C2_domain_sf
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR001263 PI3K_accessory_dom
IPR042236 PI3K_accessory_sf
IPR002420 PI3K_C2_dom
IPR008290 PI3K_Vps34
IPR015433 PI_Kinase

The PANTHER Classification System

More...
PANTHERi
PTHR10048 PTHR10048, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00454 PI3_PI4_kinase, 2 hits
PF00792 PI3K_C2, 1 hit
PF00613 PI3Ka, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000587 PI3K_Vps34, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00142 PI3K_C2, 1 hit
SM00145 PI3Ka, 1 hit
SM00146 PI3Kc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51547 PI3K_C2, 1 hit
PS51545 PIK_HELICAL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform aImported (identifier: Q9TXI7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIPGMRATPT ESFSFVYSCD LQTNVQVKVA EFEGIFRDVL NPVRRLNQLF
60 70 80 90 100
AEITVYCNNQ QIGYPVCTSF HTPPDSSQLA RQKLIQKWNE WLTLPIRYSD
110 120 130 140 150
LSRDAFLHIT IWEHEDDEIV NNSTFSRRLV AQSKLSMFSK RGILKSGVID
160 170 180 190 200
VQMNVSTTPD PFVKQPETWK YSDAWGDEID LLFKQVTRQS RGLVEDVPWL
210 220 230 240 250
DPFASRRIEM IRAKYKYSSP DRHVFLVLEM AAIRLGPTFY KVVYYEDETK
260 270 280 290 300
NMRVSTSVNG GVGIVSACTR YCVADPELLL ESLAEVKHSA MTRRIRDVED
310 320 330 340 350
ERHRQVKPNK QAKDRLETIV NLPSSQVLTR EQRDLVWKFR HYLRQFPKAL
360 370 380 390 400
NKYLRSVNWV HPQEVKTALA LMNDWELIEA EDALELLSSA FTHPAVRAYS
410 420 430 440 450
VSRLLEAASP EQVLLYLPQL VQALKYEQGQ QLPEEGNPVP VVSEEEGKIP
460 470 480 490 500
SVATTPTEEL EGRDMTVVTK KEARKAASGD LATFLIDYAL ASPKVSNYLY
510 520 530 540 550
WHLKTEIEST KESKEEHSKM YQNIQDRLME ALVKRPDTRA QVDSLHQQQI
560 570 580 590 600
FVEDLIILMN EAKARGGRLN ESKSAEFRTM LSRAKHMLDL KGVHLPLDPS
610 620 630 640 650
FRLSSVIPDT ASFFKSEMMP AKISFKVLQP NGKADRNIPE EYTVIFKTGD
660 670 680 690 700
DLRQDQLIQQ MVRLIDIILK KGQLDLKLTP YLVLSTGVGQ GFVQCIKSKP
710 720 730 740 750
LRAIQEQYKA HKMDCIREAM KELRPGDGPF GIEPNVIDNY VRSLAGYSVI
760 770 780 790 800
MYILGLGDRH LDNLLLCENG KLFHVDFGFI LGRDPKPMPP PMKLTSEMVQ
810 820 830 840 850
VMGGVKSKQF LEFVQHVDSA YRILRRHSNV LLNLFSLMLD AGIPDIAAEP
860 870 880 890 900
DKAIFKIEQR LRLDLSDEAA TKHIFTQIES SLNAKMAMIS DIIHAYKQNL

M
Note: No experimental confirmation available.Curated
Length:901
Mass (Da):103,059
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3B490B64FD3F5E78
GO
Isoform bImported (identifier: Q9TXI7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-251: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:650
Mass (Da):73,799
Checksum:i6C0514526F3FFDFE
GO
Isoform cImported (identifier: Q9TXI7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: Missing.

Show »
Length:897
Mass (Da):102,660
Checksum:i97EB1179DCE2FCA3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti8T → R in CAA73142 (PubMed:11927551).Curated1
Sequence conflicti180D → H in CAA73142 (PubMed:11927551).Curated1
Sequence conflicti220P → A in CAA73142 (PubMed:11927551).Curated1
Sequence conflicti516E → A in CAA73142 (PubMed:11927551).Curated1
Sequence conflicti526D → H in CAA73142 (PubMed:11927551).Curated1
Sequence conflicti530E → D in CAA73142 (PubMed:11927551).Curated1
Sequence conflicti641E → A in CAA73142 (PubMed:11927551).Curated1
Sequence conflicti715C → R in CAA73142 (PubMed:11927551).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0583401 – 251Missing in isoform b. CuratedAdd BLAST251
Alternative sequenceiVSP_0583411 – 4Missing in isoform c. Curated4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y12543 mRNA Translation: CAA73142.1
BX284601 Genomic DNA Translation: CCD61194.1
BX284601 Genomic DNA Translation: CCD61195.1
BX284601 Genomic DNA Translation: CCD61196.1

Protein sequence database of the Protein Information Resource

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PIRi
T43628

NCBI Reference Sequences

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RefSeqi
NP_001020953.1, NM_001025782.2 [Q9TXI7-2]
NP_001020954.1, NM_001025783.2 [Q9TXI7-3]
NP_491741.1, NM_059340.4 [Q9TXI7-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
B0025.1a.1; B0025.1a.1; WBGene00006932 [Q9TXI7-1]
B0025.1b.1; B0025.1b.1; WBGene00006932 [Q9TXI7-2]
B0025.1c.1; B0025.1c.1; WBGene00006932 [Q9TXI7-3]
B0025.1c.2; B0025.1c.2; WBGene00006932 [Q9TXI7-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
172280

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cel:CELE_B0025.1

UCSC genome browser

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UCSCi
B0025.1b.2 c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12543 mRNA Translation: CAA73142.1
BX284601 Genomic DNA Translation: CCD61194.1
BX284601 Genomic DNA Translation: CCD61195.1
BX284601 Genomic DNA Translation: CCD61196.1
PIRiT43628
RefSeqiNP_001020953.1, NM_001025782.2 [Q9TXI7-2]
NP_001020954.1, NM_001025783.2 [Q9TXI7-3]
NP_491741.1, NM_059340.4 [Q9TXI7-1]

3D structure databases

SMRiQ9TXI7
ModBaseiSearch...

Protein-protein interaction databases

STRINGi6239.B0025.1a

Proteomic databases

EPDiQ9TXI7
PaxDbiQ9TXI7
PeptideAtlasiQ9TXI7

Genome annotation databases

EnsemblMetazoaiB0025.1a.1; B0025.1a.1; WBGene00006932 [Q9TXI7-1]
B0025.1b.1; B0025.1b.1; WBGene00006932 [Q9TXI7-2]
B0025.1c.1; B0025.1c.1; WBGene00006932 [Q9TXI7-3]
B0025.1c.2; B0025.1c.2; WBGene00006932 [Q9TXI7-3]
GeneIDi172280
KEGGicel:CELE_B0025.1
UCSCiB0025.1b.2 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
172280
WormBaseiB0025.1a ; CE24759 ; WBGene00006932 ; vps-34
B0025.1b ; CE24760 ; WBGene00006932 ; vps-34
B0025.1c ; CE37691 ; WBGene00006932 ; vps-34

Phylogenomic databases

eggNOGiKOG0906 Eukaryota
COG5032 LUCA
GeneTreeiENSGT00940000156943
HOGENOMiHOG000174003
InParanoidiQ9TXI7
KOiK00914
OMAiLHKFAQY
OrthoDBi204282at2759
PhylomeDBiQ9TXI7

Enzyme and pathway databases

ReactomeiR-CEL-1632852 Macroautophagy
R-CEL-1660514 Synthesis of PIPs at the Golgi membrane
R-CEL-1660516 Synthesis of PIPs at the early endosome membrane
R-CEL-1660517 Synthesis of PIPs at the late endosome membrane
R-CEL-5668599 RHO GTPases Activate NADPH Oxidases
SignaLinkiQ9TXI7

Miscellaneous databases

Protein Ontology

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PROi
PR:Q9TXI7

Gene expression databases

BgeeiWBGene00006932 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
1.25.40.70, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR035892 C2_domain_sf
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR001263 PI3K_accessory_dom
IPR042236 PI3K_accessory_sf
IPR002420 PI3K_C2_dom
IPR008290 PI3K_Vps34
IPR015433 PI_Kinase
PANTHERiPTHR10048 PTHR10048, 1 hit
PfamiView protein in Pfam
PF00454 PI3_PI4_kinase, 2 hits
PF00792 PI3K_C2, 1 hit
PF00613 PI3Ka, 1 hit
PIRSFiPIRSF000587 PI3K_Vps34, 1 hit
SMARTiView protein in SMART
SM00142 PI3K_C2, 1 hit
SM00145 PI3Ka, 1 hit
SM00146 PI3Kc, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00915 PI3_4_KINASE_1, 1 hit
PS00916 PI3_4_KINASE_2, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51547 PI3K_C2, 1 hit
PS51545 PIK_HELICAL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPK3C3_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9TXI7
Secondary accession number(s): Q5TYK9, Q9TXI6, Q9XZR0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 11, 2016
Last sequence update: May 1, 2000
Last modified: November 13, 2019
This is version 163 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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