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Entry version 184 (16 Oct 2019)
Sequence version 1 (01 May 2000)
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Protein

E3 ubiquitin-protein ligase RNF14

Gene

RNF14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates, which could be nuclear proteins. Could play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription.1 Publication

Caution

Lacks the His residue in the RING-type domain 2 that is one of the conserved features of the family.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.By similarity EC:2.3.2.31

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi220Zinc 1PROSITE-ProRule annotation1
Metal bindingi223Zinc 1PROSITE-ProRule annotation1
Metal bindingi238Zinc 2PROSITE-ProRule annotation1
Metal bindingi240Zinc 2; via pros nitrogenPROSITE-ProRule annotation1
Metal bindingi243Zinc 1PROSITE-ProRule annotation1
Metal bindingi246Zinc 1PROSITE-ProRule annotation1
Metal bindingi265Zinc 2PROSITE-ProRule annotation1
Metal bindingi270Zinc 2PROSITE-ProRule annotation1
Metal bindingi309Zinc 3PROSITE-ProRule annotation1
Metal bindingi314Zinc 3PROSITE-ProRule annotation1
Metal bindingi329Zinc 3PROSITE-ProRule annotation1
Metal bindingi332Zinc 3PROSITE-ProRule annotation1
Metal bindingi337Zinc 4PROSITE-ProRule annotation1
Metal bindingi340Zinc 4PROSITE-ProRule annotation1
Metal bindingi345Zinc 4; via tele nitrogenPROSITE-ProRule annotation1
Metal bindingi350Zinc 4PROSITE-ProRule annotation1
Metal bindingi404Zinc 5PROSITE-ProRule annotation1
Metal bindingi407Zinc 5PROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei417PROSITE-ProRule annotation1
Metal bindingi422Zinc 5PROSITE-ProRule annotation1
Metal bindingi425Zinc 5PROSITE-ProRule annotation1
Metal bindingi430Zinc 6PROSITE-ProRule annotation1
Metal bindingi433Zinc 6PROSITE-ProRule annotation1
Metal bindingi445Zinc 6; via tele nitrogenPROSITE-ProRule annotation1
Metal bindingi453Zinc 6PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri220 – 270RING-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri289 – 350IBR-typePROSITE-ProRule annotationAdd BLAST62
Zinc fingeri404 – 433RING-type 2; atypicalPROSITE-ProRule annotationAdd BLAST30

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processTranscription, Transcription regulation, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RNF14 (EC:2.3.2.31By similarity)
Alternative name(s):
Androgen receptor-associated protein 54
HFB30
RING finger protein 14
Triad2 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RNF14
Synonyms:ARA54
ORF Names:HRIHFB2038
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10058 RNF14

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605675 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9UBS8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi220C → S: Loss of interaction with UBE2E2 and of autoubiquitination. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
9604

Open Targets

More...
OpenTargetsi
ENSG00000013561

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34423

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9UBS8

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RNF14

Domain mapping of disease mutations (DMDM)

More...
DMDMi
17380293

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000560571 – 474E3 ubiquitin-protein ligase RNF14Add BLAST474

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei348PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

RING-type zinc finger-dependent and UBE2E2-dependent autoubiquitination.

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9UBS8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9UBS8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9UBS8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9UBS8

PeptideAtlas

More...
PeptideAtlasi
Q9UBS8

PRoteomics IDEntifications database

More...
PRIDEi
Q9UBS8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
2057
84052 [Q9UBS8-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9UBS8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9UBS8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000013561 Expressed in 227 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9UBS8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9UBS8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA008716

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the ubiquitin-conjugating enzymes UBE2E1 and UBE2E2.

Interacts with AR/androgen receptor; testosterone- and RNF6-regulated it promotes AR transcriptional activity.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114968, 31 interactors

Protein interaction database and analysis system

More...
IntActi
Q9UBS8, 19 interactors

Molecular INTeraction database

More...
MINTi
Q9UBS8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000378028

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9UBS8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini11 – 137RWDPROSITE-ProRule annotationAdd BLAST127

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni216 – 457TRIAD supradomainPROSITE-ProRule annotationAdd BLAST242
Regioni361 – 474Interaction with androgen receptorAdd BLAST114

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili351 – 395Sequence analysisAdd BLAST45

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi37 – 45D-box9

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway.By similarity
The RING-type zinc finger is essential for the interaction with UBE2E2.
Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT-type E3 enzymes: they bind E2s via the first RING domain, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved cysteine residue in the second RING domain.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RBR family. RNF14 subfamily.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri220 – 270RING-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri289 – 350IBR-typePROSITE-ProRule annotationAdd BLAST62
Zinc fingeri404 – 433RING-type 2; atypicalPROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1814 Eukaryota
ENOG410Y5R1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154507

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000237334

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9UBS8

KEGG Orthology (KO)

More...
KOi
K11971

Identification of Orthologs from Complete Genome Data

More...
OMAi
CQYAFCT

Database of Orthologous Groups

More...
OrthoDBi
1188714at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9UBS8

TreeFam database of animal gene trees

More...
TreeFami
TF314401

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.110.10, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031127 E3_UB_ligase_RBR
IPR002867 IBR_dom
IPR006575 RWD-domain
IPR016135 UBQ-conjugating_enzyme/RWD
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS

The PANTHER Classification System

More...
PANTHERi
PTHR11685 PTHR11685, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01485 IBR, 2 hits
PF05773 RWD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00647 IBR, 2 hits
SM00591 RWD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54495 SSF54495, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50908 RWD, 1 hit
PS51873 TRIAD, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9UBS8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSEDREAQE DELLALASIY DGDEFRKAES VQGGETRIYL DLPQNFKIFV
60 70 80 90 100
SGNSNECLQN SGFEYTICFL PPLVLNFELP PDYPSSSPPS FTLSGKWLSP
110 120 130 140 150
TQLSALCKHL DNLWEEHRGS VVLFAWMQFL KEETLAYLNI VSPFELKIGS
160 170 180 190 200
QKKVQRRTAQ ASPNTELDFG GAAGSDVDQE EIVDERAVQD VESLSNLIQE
210 220 230 240 250
ILDFDQAQQI KCFNSKLFLC SICFCEKLGS ECMYFLECRH VYCKACLKDY
260 270 280 290 300
FEIQIRDGQV QCLNCPEPKC PSVATPGQVK ELVEAELFAR YDRLLLQSSL
310 320 330 340 350
DLMADVVYCP RPCCQLPVMQ EPGCTMGICS SCNFAFCTLC RLTYHGVSPC
360 370 380 390 400
KVTAEKLMDL RNEYLQADEA NKRLLDQRYG KRVIQKALEE MESKEWLEKN
410 420 430 440 450
SKSCPCCGTP IEKLDGCNKM TCTGCMQYFC WICMGSLSRA NPYKHFNDPG
460 470
SPCFNRLFYA VDVDDDIWED EVED
Length:474
Mass (Da):53,837
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i529E3F5AF38A5DAD
GO
Isoform 2 (identifier: Q9UBS8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-126: Missing.

Note: No experimental confirmation available.
Show »
Length:348
Mass (Da):39,634
Checksum:iC43770874596DD0C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EP22E7EP22_HUMAN
RBR-type E3 ubiquitin transferase
RNF14
152Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBU3D6RBU3_HUMAN
E3 ubiquitin-protein ligase RNF14
RNF14
185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R996D6R996_HUMAN
E3 ubiquitin-protein ligase RNF14
RNF14
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RA38D6RA38_HUMAN
E3 ubiquitin-protein ligase RNF14
RNF14
278Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RDU6D6RDU6_HUMAN
E3 ubiquitin-protein ligase RNF14
RNF14
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RAS4D6RAS4_HUMAN
E3 ubiquitin-protein ligase RNF14
RNF14
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R988D6R988_HUMAN
E3 ubiquitin-protein ligase RNF14
RNF14
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBK4D6RBK4_HUMAN
E3 ubiquitin-protein ligase RNF14
RNF14
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RDK2D6RDK2_HUMAN
E3 ubiquitin-protein ligase RNF14
RNF14
15Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti32Q → R in CAG32983 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0457801 – 126Missing in isoform 2. 1 PublicationAdd BLAST126

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB022663 mRNA Translation: BAA78677.1
AF060544 mRNA Translation: AAD21842.1
AK023884 mRNA Translation: BAG51234.1
AK057868 mRNA No translation available.
CR456702 mRNA Translation: CAG32983.1
AC005740 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61895.1
CH471062 Genomic DNA Translation: EAW61896.1
CH471062 Genomic DNA Translation: EAW61897.1
BC126185 mRNA Translation: AAI26186.1
BC144061 mRNA Translation: AAI44062.1
AB015333 mRNA Translation: BAA34792.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4270.1 [Q9UBS8-1]
CCDS4271.1 [Q9UBS8-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001188294.1, NM_001201365.1 [Q9UBS8-1]
NP_004281.1, NM_004290.4 [Q9UBS8-1]
NP_899645.1, NM_183398.2 [Q9UBS8-2]
NP_899646.1, NM_183399.2 [Q9UBS8-1]
NP_899647.1, NM_183400.2 [Q9UBS8-1]
NP_899648.1, NM_183401.2 [Q9UBS8-1]
XP_005268593.1, XM_005268536.2
XP_005268594.1, XM_005268537.2
XP_005268596.1, XM_005268539.2 [Q9UBS8-2]
XP_005268597.1, XM_005268540.3 [Q9UBS8-2]
XP_005268598.1, XM_005268541.3 [Q9UBS8-2]
XP_011536016.1, XM_011537714.2 [Q9UBS8-1]
XP_016865559.1, XM_017010070.1
XP_016865560.1, XM_017010071.1 [Q9UBS8-2]
XP_016865561.1, XM_017010072.1 [Q9UBS8-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000347642; ENSP00000324956; ENSG00000013561 [Q9UBS8-1]
ENST00000356143; ENSP00000348462; ENSG00000013561 [Q9UBS8-1]
ENST00000394514; ENSP00000378022; ENSG00000013561 [Q9UBS8-2]
ENST00000394519; ENSP00000378027; ENSG00000013561 [Q9UBS8-1]
ENST00000394520; ENSP00000378028; ENSG00000013561 [Q9UBS8-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9604

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9604

UCSC genome browser

More...
UCSCi
uc003lly.4 human [Q9UBS8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022663 mRNA Translation: BAA78677.1
AF060544 mRNA Translation: AAD21842.1
AK023884 mRNA Translation: BAG51234.1
AK057868 mRNA No translation available.
CR456702 mRNA Translation: CAG32983.1
AC005740 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61895.1
CH471062 Genomic DNA Translation: EAW61896.1
CH471062 Genomic DNA Translation: EAW61897.1
BC126185 mRNA Translation: AAI26186.1
BC144061 mRNA Translation: AAI44062.1
AB015333 mRNA Translation: BAA34792.1
CCDSiCCDS4270.1 [Q9UBS8-1]
CCDS4271.1 [Q9UBS8-2]
RefSeqiNP_001188294.1, NM_001201365.1 [Q9UBS8-1]
NP_004281.1, NM_004290.4 [Q9UBS8-1]
NP_899645.1, NM_183398.2 [Q9UBS8-2]
NP_899646.1, NM_183399.2 [Q9UBS8-1]
NP_899647.1, NM_183400.2 [Q9UBS8-1]
NP_899648.1, NM_183401.2 [Q9UBS8-1]
XP_005268593.1, XM_005268536.2
XP_005268594.1, XM_005268537.2
XP_005268596.1, XM_005268539.2 [Q9UBS8-2]
XP_005268597.1, XM_005268540.3 [Q9UBS8-2]
XP_005268598.1, XM_005268541.3 [Q9UBS8-2]
XP_011536016.1, XM_011537714.2 [Q9UBS8-1]
XP_016865559.1, XM_017010070.1
XP_016865560.1, XM_017010071.1 [Q9UBS8-2]
XP_016865561.1, XM_017010072.1 [Q9UBS8-2]

3D structure databases

SMRiQ9UBS8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi114968, 31 interactors
IntActiQ9UBS8, 19 interactors
MINTiQ9UBS8
STRINGi9606.ENSP00000378028

PTM databases

iPTMnetiQ9UBS8
PhosphoSitePlusiQ9UBS8

Polymorphism and mutation databases

BioMutaiRNF14
DMDMi17380293

Proteomic databases

EPDiQ9UBS8
jPOSTiQ9UBS8
MassIVEiQ9UBS8
PaxDbiQ9UBS8
PeptideAtlasiQ9UBS8
PRIDEiQ9UBS8
ProteomicsDBi2057
84052 [Q9UBS8-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9604

Genome annotation databases

EnsembliENST00000347642; ENSP00000324956; ENSG00000013561 [Q9UBS8-1]
ENST00000356143; ENSP00000348462; ENSG00000013561 [Q9UBS8-1]
ENST00000394514; ENSP00000378022; ENSG00000013561 [Q9UBS8-2]
ENST00000394519; ENSP00000378027; ENSG00000013561 [Q9UBS8-1]
ENST00000394520; ENSP00000378028; ENSG00000013561 [Q9UBS8-1]
GeneIDi9604
KEGGihsa:9604
UCSCiuc003lly.4 human [Q9UBS8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9604
DisGeNETi9604

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RNF14
HGNCiHGNC:10058 RNF14
HPAiHPA008716
MIMi605675 gene
neXtProtiNX_Q9UBS8
OpenTargetsiENSG00000013561
PharmGKBiPA34423

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1814 Eukaryota
ENOG410Y5R1 LUCA
GeneTreeiENSGT00940000154507
HOGENOMiHOG000237334
InParanoidiQ9UBS8
KOiK11971
OMAiCQYAFCT
OrthoDBi1188714at2759
PhylomeDBiQ9UBS8
TreeFamiTF314401

Enzyme and pathway databases

UniPathwayiUPA00143
ReactomeiR-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RNF14 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
RNF14

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9604
PharosiQ9UBS8

Protein Ontology

More...
PROi
PR:Q9UBS8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000013561 Expressed in 227 organ(s), highest expression level in testis
ExpressionAtlasiQ9UBS8 baseline and differential
GenevisibleiQ9UBS8 HS

Family and domain databases

Gene3Di3.10.110.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR031127 E3_UB_ligase_RBR
IPR002867 IBR_dom
IPR006575 RWD-domain
IPR016135 UBQ-conjugating_enzyme/RWD
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR11685 PTHR11685, 1 hit
PfamiView protein in Pfam
PF01485 IBR, 2 hits
PF05773 RWD, 1 hit
SMARTiView protein in SMART
SM00647 IBR, 2 hits
SM00591 RWD, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS50908 RWD, 1 hit
PS51873 TRIAD, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRNF14_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9UBS8
Secondary accession number(s): A0AV26
, A6NMR2, A8MTW5, B3KN72, B7ZLV2, D3DQE4, O94793, Q6IBV0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 1, 2000
Last modified: October 16, 2019
This is version 184 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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